Hemostatic antibacterial healing-promoting medical dressing containing lamiophlomis rotata iridoid glycoside composite activated carbon fibers (ACF) as well as preparation method and application of medical dressing

Abstract

The invention discloses a hemostatic antibacterial healing-promoting medical dressing containing lamiophlomis rotata iridoid glycoside active ingredient composite medical ACF and belongs to the technical field of preparation of medical dressings. The medical dressing is composed of the following components in percentage by weight: 1-20% of lamiophlomis rotata iridoid glycosides, 0.01-1% of hexadecyl trimethyl ammonium chloride, 1-5% of polyvinyl alcohol or collagen and the balance of a medical ACF matrix. The lamiophlomis rotata iridoid glycoside active ingredients and polyvinyl alcohol or collagen and the like are combined to be prepared into a solution dosage form and a gel dosage form, and the dosage forms are compounded with medical ACFs so as to prepare a series of external medical dressings. By utilizing the strong effects of the ACF for adsorbing wound exudates, activating a clotting mechanism and accelerating hemostasis, the 'synergistic effect' between the two is achieved, and the medical dressing can be used for treating infectious wounds, surgical trauma bleeding and the like, has excellent hemostatic antibacterial healing-promoting effects and also has wide application prospects. The medical dressing disclosed by the invention is reasonable in formula and convenient in preparation and has the effects of controlling the wound infection and promoting healing of the wound. The hemostasis models for wounds at artery and ventral aorta in ears of large-ear white rabbits and human-mouse livers prove that the effective rate reaches 95% or higher.

Description

technical field [0001] The invention relates to a plant medical material, in particular to a hemostatic, antibacterial, and healing-promoting medical dressing containing a single iridoid glycoside active ingredient composite activated carbon fiber, a preparation method and its application, and is suitable for various Trauma bleeding treatment. Background technique [0002] As a new development status of activated carbon fiber activated carbon fiber (activated carbon fiber, ACF) dressing is another new type of polymer medical dressing developed in recent years. It has large specific surface area, high effective adsorption capacity, fast adsorption and desorption speed, easy regeneration, low ash content, strong chemical stability, good flexibility and strength. The strong adsorption of activated carbon fibers and the presence of various functional groups on the surface can undergo oxidation-reduction reactions with various coagulation factors in the wound, activate the coagu...

AI Technical Summary

Problems solved by technology

There are many varieties of existing hemostatic drugs with complex mechanisms, but research on new hemostatic drugs has always been a hot topic