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Temperature sensing instant type gel system

A temperature-sensitive, systemic technology, applied in the direction of medical preparations of non-active ingredients, drug delivery, pharmaceutical formulations, etc., can solve the problems of difficult swelling of solid-containing polymer materials, filtration and other process effects, and achieve adjustable temperature The effect of large scope and cost reduction

Inactive Publication Date: 2006-11-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most commonly used regulator at home and abroad is Poloxamer 188, with a dosage of about 10%, and the dosage of Poloxamer 407 is also about 20%, as disclosed in the Chinese invention patent application CN02109503. This is the case in "Ophthalmic In Situ Gel Preparations with Transition Temperature". Both types of poloxamers are waxy solids. Excessively high solid content makes it difficult to swell polymer materials, and causes great difficulties in filtration and other processes. big impact

Method used

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  • Temperature sensing instant type gel system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] In terms of mass percentage, respectively prepare:

[0021] Contains 18% Poloxamer 407;

[0022] With 18% Poloxamer 407 and 2% Polysorbate-20;

[0023] With 18% Poloxamer 407 and 5% Polysorbate-20;

[0024] For aqueous solutions containing 18% poloxamer 407 and 8% polysorbate-20, the gelling temperatures of the solutions were measured to be 25.4°C, 23.6°C, 27.6°C and 38.5°C, respectively.

Embodiment 2

[0026] In terms of mass percentage, respectively prepare:

[0027] Contains 22% Poloxamer 407;

[0028] With 22% Poloxamer 407 and 2% Polysorbate-80;

[0029] With 22% Poloxamer 407 and 6.5% Polysorbate-80;

[0030] For aqueous solutions containing 22% poloxamer 407 and 10% polysorbate-80, the gelling temperatures of each solution were measured to be 20.0°C, 18.2°C, 16.4°C and 18.4°C, respectively.

Embodiment 3

[0032] In terms of mass percentage, respectively prepare:

[0033] Contains 18% Poloxamer 407;

[0034] With 18% Poloxamer 407 and 1% Polysorbate-80;

[0035] With 18% Poloxamer 407 and 2% Polysorbate-80;

[0036] With 18% Poloxamer 407 and 3.5% Polysorbate-80;

[0037] With 18% Poloxamer 407 and 5% Polysorbate-80;

[0038] With 18% Poloxamer 407 and 6.5% Polysorbate-80;

[0039] With 18% Poloxamer 407 and 8% Polysorbate-80;

[0040] Aqueous solution containing 18% poloxamer 407 and 10% polysorbate-80, the gelation temperature of each solution was measured as figure 1 shown. It can be seen from the figure that with the increase of the amount of polysorbate-80, the gelation temperature of the system first decreased, and then increased instead.

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Abstract

The invention discloses a temperature sensitive type instant molding gel system that includes poly-sorbate as gelatinizing temperature adjusting agent, and also could use poly-sorbate with other gelatinizing temperature adjusting agent. By adjusting the content of poly-sorbate, the adjustable range of gelling temperature would be expanded, and the solid content in system would be decreased, and the cost would be lowered. The invention could be used in normal medicine.

Description

technical field [0001] The present invention relates to an instant gel system, especially a temperature-sensitive instant gel system containing polysorbate. Background technique [0002] Instant gel systems are a class of systems containing environmentally sensitive special polymer materials, which have unique solution-gel phase transition characteristics. In practical applications, it is often required to have good fluidity before use, and it will be transformed into a gel under the influence of the environment. For example, in the field of medicine, placing the drug in this system facilitates the dosage and the penetration of the drug to the lesion site, and the administration is convenient. The controlled release performance is of great significance. The so-called "environmentally sensitive" refers to the response of polymer materials to the external environment, causing the polymer to undergo reversible changes in the dispersion state or conformation under specific con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L101/14A61K9/00A61K47/30
Inventor 王华李士敏袁京群楼键
Owner ZHEJIANG UNIV
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