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Antiviral hydrogel as well as preparation method and application thereof

A hydrogel and anti-virus technology, applied in the field of supramolecular chemistry and biomaterials, achieves the effect of simple preparation method, convenient preparation method and safe material

Active Publication Date: 2020-10-27
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of these drugs are taken orally or ointment preparations in clinical practice, and the drugs are only mixed with various drug excipients through physical mixing.

Method used

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  • Antiviral hydrogel as well as preparation method and application thereof
  • Antiviral hydrogel as well as preparation method and application thereof
  • Antiviral hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: the preparation of entecavir hydrogel

[0050] Weigh 4.68 mg of Entecavir, add 0.4 mL of potassium chloride solution (60 mM), shake fully for 1 minute, and then heat in a water bath at 90 ° C. After Entecavir is completely dissolved until the solution is clear, take it out, and let it cool at room temperature. About 2 minutes into a gel, the drug concentration is 30mM.

Embodiment 2

[0051] Embodiment 2: the preparation of ganciclovir hydrogel

[0052] Weigh 6.12mg of ganciclovir drug, add 0.4mL potassium chloride solution (120mM), fully shake for 1 minute, and then heat it in a water bath at 90°C, and take it out after the ganciclovir is completely dissolved until the solution is clear. Let stand at room temperature to cool, and form a gel in about 2 minutes, with a drug concentration of 60mM.

Embodiment 3

[0053] Embodiment 3: the preparation of penciclovir hydrogel

[0054] Weigh 8.1mg of penciclovir drug, add 0.4mL potassium chloride solution (160mM), fully shake for 1 minute, then place in a 90°C water bath and heat, wait until the ganciclovir is completely dissolved until the solution is clear, then take it out. Let stand at room temperature to cool, and form a gel in about 2 minutes, with a drug concentration of 80mM.

[0055] The gel obtained in embodiment 1 to embodiment 3 is as follows figure 1 As shown, from left to right are entecavir hydrogel, ganciclovir hydrogel, and penciclovir hydrogel.

[0056] This type of antiviral hydrogel is a hydrogel formed due to the self-assembly of nucleoside antiviral drugs to form nanofibers, and then the intertwining between nanofibers. The formation mechanism is as follows: figure 2 shown.

[0057] Subsequent embodiments mainly use entecavir as an example for illustration.

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Abstract

The invention discloses an antiviral hydrogel as well as a preparation method and application thereof. The hydrogel is directly formed by stacking and assembling nucleoside antiviral drugs layer by layer in the presence of metal ions. The antiviral hydrogel provided by the invention has antiviral activity equivalent to that of a free drug, can be prepared into a gel dosage form, and has a clinicalantiviral infection treatment application prospect.

Description

technical field [0001] The invention belongs to the technical field of supramolecular chemistry and biological materials, and in particular relates to the preparation and application of an antiviral hydrogel. Background technique [0002] Human beings are often infected by viruses in daily life, such as influenza, rubella, hepatitis, herpes and other diseases are all caused by virus infection. Among the current clinical drugs for the treatment of viral infections, nucleoside drugs are a very important category. Nucleosides and deoxynucleosides are the basic components of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA), and their derivatives also have a variety of biological activities, among which many drugs have significant inhibitory activity against viruses. For example, ganciclovir, acyclovir, penciclovir, and famciclovir in guanosine antiviral drugs can become active triphosphates through phosphorylation after entering virus-infected cells, and further interfere...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/02A61K31/522A61P31/22A61P31/20A61P1/02A61P15/08A61P1/16
CPCA61K9/06A61K31/522A61K47/02A61P1/02A61P1/16A61P15/08A61P31/20A61P31/22
Inventor 程义云胡婧婧胡倩瑜
Owner EAST CHINA NORMAL UNIV
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