Tiopronin soft capsule

A technology of tiopronin and soft capsules, applied in the directions of capsule delivery, digestive system, organic active ingredients, etc., can solve the problems of inability to eliminate gastrointestinal irritation, low bioavailability, large individual differences, etc., and achieve high biological Availability, fast onset, low gastrointestinal irritant effect
CN1615835AInactive Publication Date: 2005-05-18上海华源医药科技发展有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
上海华源医药科技发展有限公司
Publication Date
2005-05-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a kind of new preparation of hepatitis B treating medicine, and is especially hepatitis B treating soft Tiopronin capsule preparation suitable for being taken orally. The soft capsule contains physiologically effective Tiopronin and medicine carrier suitable for soft capsule, and the pharmaceutically acceptable carrier includes dispersing medium, antioxidant, metal chelate and / or medicine release regulating material.
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Description

Technical field:

[0001] The invention relates to a new preparation of anti-hepatitis B medicine, in particular to a soft capsule preparation of anti-hepatitis B medicine tiopronin which is suitable for oral administration. Background technique:

[0002] Tiopronin is a glycine derivative of free thiol, which can reduce the activity of mitochondrial ATPase, increase the content of ATP in cells, improve cell structure and function, participate in cell metabolism, maintain the concentration of glutathione in liver cells, and inhibit peroxidation Liposome formation prevents accumulation of triglycerides and protects liver cell membranes. Therefore, the clinical indications of tiopronin include (Matsuura K., et al, Pharmacokinetics of Tiopronin after Oral Administration in Healthy Volunteers, Pharmacy and Pharmacology Communications, 1999; 5 (5): 345-347): 1. It is used to improve the liver function of various acute and chronic hepatitis and early cirrhosis; 2. It is used for the...

Claims

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