Nitrogen and sulfur co-doped carbon dot as well as preparation method and application thereof

A technology of co-doping and carbon dots, applied in the field of nanomaterials, can solve the problem of low sensitivity and achieve good dispersion compatibility

Active Publication Date: 2020-10-30
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, unmodified and specifically constructed CDs are often not sensitive enough to detect metal ions.
In terms of disease treatment, carbon dots with antibacterial funct...

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  • Nitrogen and sulfur co-doped carbon dot as well as preparation method and application thereof
  • Nitrogen and sulfur co-doped carbon dot as well as preparation method and application thereof
  • Nitrogen and sulfur co-doped carbon dot as well as preparation method and application thereof

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[0030] Some embodiments of the present invention provide a method for preparing carbon dots co-doped with nitrogen and sulfur, which includes: preparing carbon dots by heating a carbon source and a nitrogen source in a solvent, wherein the solvent includes mercaptoglycerol.

[0031] Specifically, in some embodiments, the solvent further includes glycerol, that is, the solvent includes mercaptoglycerol and glycerol, wherein the mass ratio of mercaptoglycerol to glycerin may be 1:1.

[0032] By using sulfur-containing mercaptoglycerol as a sulfur source to participate in the reaction, compared with the existing inorganic sulfur salt as a sulfur source, it is safe and non-toxic. At the same time, mercaptoglycerol itself can be used as a solvent for the reaction system. Nitrogen sources have good dispersion compatibility, and during the process of generating carbon dots, hydrophilic thiols are bound to the surface atoms of carbon dots, and at the same time stabilize the dispersion ...

Embodiment 1

[0054] (1) Disperse 0.2 g of glucose, 0.2 g of polyethyleneimine, and 0.5 g of citric acid in 1.5 mL of glycerin and 1.5 mL of 1-thioglycerol in a 10 mL round bottom flask, and then stir evenly to obtain a mixed solution A. Put the mixed solution in an oil bath and heat it at 120°C for 80 minutes, and after the reaction, nitrogen and sulfur co-doped carbon dots are obtained.

[0055] (2) Dissolve the carbon dots obtained in step (1) and dilute to 10mL ultrapure water, centrifuge directly through a 3kD ultrafiltration tube, collect the supernatant and filter it with a 0.2μm nylon membrane, and then filter it with a 500Da filter at room temperature The dialysis bag with molecular weight cut-off was dialyzed for 48 hours to remove tiny impurities. Then freeze-dry to obtain purified nitrogen and sulfur co-doped carbon dots.

Embodiment 2

[0057] (1) Disperse 0.1 g of glucose, 0.2 g of polyethyleneimine, and 0.3 g of citric acid in 1.5 mL of glycerin and 1.5 mL of 1-thioglycerol in a 10 mL round bottom flask, and then stir evenly to obtain mixed solution A. Put the mixed solution in an oil bath and heat it at 120°C for 80 minutes, and after the reaction, nitrogen and sulfur co-doped carbon dots are obtained.

[0058] (2) Dissolve the carbon dots obtained in step (1) and dilute to 10mL ultrapure water, centrifuge directly through a 3kD ultrafiltration tube, collect the supernatant and filter it with a 0.2μm nylon membrane, and then filter it with a 500Da filter at room temperature The dialysis bag with molecular weight cut-off was dialyzed for 48 hours to remove tiny impurities. Then freeze-dry to obtain purified nitrogen and sulfur co-doped carbon dots.

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Abstract

The invention discloses a nitrogen and sulfur co-doped carbon dot as well as a preparation method and application thereof. The preparation method comprises the steps: heating a carbon source and a nitrogen source in a solvent containing mercaptoglycerol to prepare the carbon dot. Sulfur-containing mercaptoglycerol is used as a sulfur source to participate in the reaction, and mercaptoglycerol canalso be used as a solvent of a reaction system, so that dispersion compatibility among various substances participating in the reaction is good, hydrophilic mercaptan is combined to carbon dot surfaceatoms, and dispersion of carbon dots in a polar solvent is stabilized at the same time. The nitrogen and sulfur co-doped carbon dots are prepared by adopting mercaptoglycerol as the sulfur source, sothat not only can copper ions be detected in a trace amount, but also tiopronin can be further detected, and therefore, the nitrogen and sulfur co-doped carbon dots can be used for constructing a dual-detection sensor capable of simultaneously detecting the contents of the copper ions and tiopronin. The carbon dots are also proved to have low toxicity and good biocompatibility, have differentialantibacterial ability to gram-positive bacteria (including drug-resistant bacteria) and gram-negative bacteria, and have the potential of treating biological bacterial infection.

Description

[0001] This application claims the priority of the Chinese patent application with the application number 202010865092.5 and titled "Nitrogen and sulfur co-doped carbon dots and its preparation method and application" submitted to the China Patent Office on August 25, 2020, the entire content of which is passed References are incorporated in this application. technical field [0002] The invention relates to the technical field of nanomaterials, in particular to a nitrogen and sulfur co-doped carbon dot and its preparation method and application. Background technique [0003] As a new type of fluorescent material, fluorescent carbon dots (CDs) have many advantages such as excellent optical properties, good water solubility, low toxicity, environmental friendliness, wide source of raw materials, low cost, and good biocompatibility. Carbon dots have a wide range of applications in the field of biomedicine. In recent years, the use of heteroatom doping to improve the performan...

Claims

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Application Information

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IPC IPC(8): C09K11/65B82Y20/00B82Y30/00B82Y40/00A01N59/00A01P3/00A01P1/00G01N21/64
CPCC09K11/65B82Y20/00B82Y30/00B82Y40/00A01N59/00G01N21/643G01N2021/6432
Inventor 赵丹张蕊郝健
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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