103 results about "Positive gram bacteria" patented technology

The invention discloses an antibacterial antifouling agent as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out chemical grafting on an amino terephthalic acid compound by adopting benzisothiazolinone to prepare a functional ligand; and carrying out a reaction on a metal salt and the functional ligand to prepare the antibacterial antifouling agent. The antibacterial antifouling agent disclosed by the invention shows broad-spectrum antibacterial activity on gram-negative bacteria and gram-positive bacteria, and has anti-algae performance and good biocompatibility; meanwhile, the antibacterial and antifouling agent is compounded into water-based acrylic resin, the obtained coating still has excellent antibacterial and anti-algae performance, the ligand engineering strategy effectively breaks through the bottleneck that traditional MOFs ligands are insufficient in antibacterial activity, and an innovative path is provided for developing long-acting, synergistic and practical MOF-based antibacterial and antifouling materials.

The invention discloses a preparation method and application of sodium gallate-polyphenol chitosan antibacterial hydrogel, firstly, gallic acid and sodium acetate are used as raw materials, a high-purity sodium gallate complex 5-carboxyl-2, 3-sodium dihydroxyphenolate is prepared at normal temperature and normal pressure, then a polyphenol compound and chitosan are cross-linked through Schiff base reaction, and the sodium gallate-polyphenol chitosan antibacterial hydrogel is obtained. And finally, carrying out rotary evaporation treatment, so that the sodium gallate is loaded in the polyphenol chitosan hydrogel system to obtain the antibacterial hydrogel. Sodium gallate is used as a functional component, uniform loading of sodium gallate in a polyphenol chitosan hydrogel system is realized through dual effects of physical adsorption and chemical bonding, the loading mechanism can effectively avoid aggregation and burst release of sodium gallate, stable release of antibacterial components is ensured, and the antibacterial property of the hydrogel is improved. The slow release time of the antibacterial hydrogel under the conditions that the pH values are 5.5 and 7.2 respectively exceeds 24 hours; and the antibacterial hydrogel has an inhibition effect on both gram-positive bacteria and gram-negative bacteria.

The present application relates to the technical field of polysaccharide modification, and specifically discloses amino acid modified astragalus polysaccharide, a preparation method thereof and antibacterial application. The present application uses astragalus polysaccharide, formaldehyde and specific amino acids as raw materials, and prepares amino acid grafted modified astragalus polysaccharide through a Mannich reaction. The amino acid grafting site only occurs on the fifth carbon of the sugar ring. Not only does this retain the amino and carboxyl groups of the amino acid, so that the biological activity of the amino acid is retained, but also the active carboxyl group of the astragalus polysaccharide can be retained, so that the antibacterial property of the synthesized amino acid modified astragalus polysaccharide is significantly improved, and broad-spectrum antibacterial property can be achieved. The amino acid modified astragalus polysaccharide has excellent antibacterial activity on gram-positive bacteria and gram-negative bacteria, is a green new type of efficient antibacterial material, and is expected to become a substitute for antibiotics. The amino acid modified astragalus polysaccharide has important significance for solving the problems of increasing bacterial drug resistance and environmental accumulation caused by antibiotics, and has good application prospect.

The invention discloses an application of a naphthoquinone furan piperidone derivative in preparation of a medicine for inhibiting bacteria. The naphthoquinone furan piperidone derivative disclosed by the invention has remarkable antibacterial activity on a plurality of gram-positive bacteria. The naphthoquinone furan piperidone derivative disclosed by the invention can be used for remarkably inhibiting the growth of MRSA (Methicillin-Resistant Staphylococcus Aureus) and shows relatively low drug resistance within 30 days. The naphthoquinone furan piperidone derivative can protect MRSA infected mice and improve the survival rate of the infected mice. The naphthoquinone furan piperidone derivative disclosed by the invention shows good safety and biocompatibility while keeping high antibacterial activity.

Disclosed are compositions and methods for the treatment of tuberculosis and other mycobacterial and gram-positive bacterial infections. These compositions comprise highly potent and selective oxazolidinones encapsulated with high efficiency to maximize the potential for low-toxicity drug delivery and are stable in the presence of plasma. The compositions are long-circulating and retain their encapsulated drug while in circulation following intravenous delivery to allow effective accumulation at the site of bacterial or mycobacterial infection. The high doses achievable and the long-circulating nature of the drug combined with the high stability of the formulation allow for a reduction in the frequency of administration compared to the once-daily or twice-daily administration of other drugs commonly used to treat these infections.

The invention discloses an alpha-aminophosphoryl derivative as well as a preparation method and application thereof. The method comprises the following steps: by taking a quinoline derivative as a raw material and tetrahydrofuran (THF) as a solvent, adding boron trifluoride diethyl etherate in a nitrogen system at the reaction temperature of 0 DEG C, stirring for 15 minutes, reducing the temperature of the reaction system to T1 (-60 DEG C to-30 DEG C), adding a Grignard reagent into the reaction system, and reacting for 30 minutes to obtain a solution A; dissolving a phosphorus reagent in the organic solvent at room temperature in a nitrogen atmosphere to obtain a solution B; and adding the solution A into the solution B, reacting for 6-15 hours at the reaction temperature T2 (0-50 DEG C), and after the reaction is finished, extracting, concentrating and carrying out column chromatography to obtain the target product alpha-aminophosphoryl derivative. The invention provides a novel synthetic route for preparing the alpha-aminophosphonyl derivative, and various phosphorus reagents such as diaryl phosphorus oxide and phosphite ester can be compatible with the reaction. The alpha-aminophosphoryl derivative synthesized by the invention has a good antibacterial effect on gram-positive bacteria, especially staphylococcus aureus.

The application discloses copper porphyrin doped COFs, a preparation method and application thereof. The preparation method of the copper porphyrin doped COFs is as follows: 1) preparation of copper porphyrin modified aldehyde monomers; and 2) preparation of copper porphyrin doped COFs. The copper porphyrin doped COFs disclosed by the application can inhibit gram-negative bacteria and gram-positive bacteria under dark conditions; and under the irradiation of 100 mW / cm 2 of white light, efficient sterilization of the gram-negative bacteria and the gram-positive bacteria is realized within 90 min.

The present application relates to a kind of polypeptides with inhibitory activity to gram-negative bacteria and gram-positive bacteria represented by escherichia coli and staphylococcus aureus derived from Daqu.The amino acid sequence is Tyr-Pro-Leu-Gly-Gln-Gly-Ser-Phe-Arg-Pro.Polypeptide YPLGQGSFRP has good inhibitory activity to gram-negative bacteria and gram-positive bacteria, as natural safe antibacterial agent, it has good application prospect in preparing medicine and / or health care product for preventing and / or reducing intestinal infectious disease caused by escherichia coli and staphylococcus aureus.

This invention relates to an endogenous antimicrobial peptide from bovine milk and its applications. The antimicrobial polypeptide compound VAVALARPKHPIK is derived from endogenously enzymatically hydrolyzed bovine casein, with the amino acid sequence Val-Ala-Val-Ala-Leu-Ala-Arg-Pro-Lys-His-Pro-Ile-Lys. It exhibits broad inhibitory activity against both Gram-positive and Gram-negative bacteria, including *Porphyromonas gingivalis*, *Escherichia coli*, and *Staphylococcus aureus*. This antimicrobial peptide shows promising applications as a health supplement and / or medical device or pharmaceutical for the prevention and / or reduction of infectious diseases, as a food antimicrobial agent, in novel functional foods, pet food and animal feed additives, and in daily chemical products.

The present application relates to a kind of chlorella-nanose complex hydrogel and its preparation method and application, belong to nanose antibacterial technical field.The chlorella-nanose complex hydrogel includes hydrogel matrix, and the chlorella and photo-thermal nanose loaded on the hydrogel matrix.The present application also provides the preparation method of the complex hydrogel, and the application in the preparation of antibacterial drug or dressing and the killing gram-negative bacteria and gram-positive bacteria.The present application combines chlorella and nanose for the first time, and constructs a self-oxygen supply antibacterial platform.The chlorella in the chlorella-nanose complex hydrogel can carry out photosynthesis under illumination, continuously produce oxygen, provide sufficient substrate for nanose oxidase-like reaction, overcome the low activity defect of traditional nanose in anoxic environment.

The application discloses a full-gorge hard tick-derived defensin polypeptide and application thereof. The defensin polypeptide is IpDf3, and the amino acid sequence is shown as SEQ ID NO:1. The defensin polypeptide has different degrees of antibacterial activity on four gram-positive bacteria and two gram-negative bacteria. Bactericidal kinetics and scanning electron microscope experiments show that 3*MIC IpDf3 can quickly down-regulate the bacterial number by 1-4 logarithmic units in 60 min, and can cause irregular bulges or depressions on the surface of gram-positive bacteria, and even rupture of the cell membrane, indicating that the antibacterial mechanism may be closely related to the direct damage of the cell membrane. The defensin polypeptide not only has the activity of traditional defensin against gram-positive bacteria, but also has certain antibacterial activity against gram-negative bacteria, has a wide antibacterial spectrum, strong activity, fast bactericidal speed, and is expected to provide a candidate for the research and development of new antibacterial drugs, and has important application prospects.

The application discloses a food-borne pathogenic bacteria detection method based on composite nanomaterials and belongs to the technical field of food safety detection. The method is characterized by the following steps: synthesizing cerium-based nanomaterial DPA-Ce-GMP with enzyme-like activity based on Ce(CH3COO)3, guanosine-5'-monophosphate disodium (GMP) and 2,6-pyridine dicarboxylic acid (DPA); taking Prussian blue as a carrier; using vancomycin to identify gram-positive bacteria; and constructing a composite nanomaterial PB@DPA-Ce-GMP@Van with targeting and oxidase characteristics, namely PCV. The PCV can be precisely adsorbed on the surface of gram-positive bacteria to form a PCV / gram-positive bacteria composite. The residual PCV in the supernatant after centrifugation can quench the fluorescence of scopolamine (SC) and increase the fluorescence intensity of fluorescent red dye (AR) at the same time. The fluorescence intensity ratio (SC / AR) is used as a detection signal output. The application realizes a composite nanometer platform for rapid detection of bacteria, has high sensitivity and strong anti-interference ability, and has a detection range of 10 1 ~ 10 7 CFU / mL and a detection limit of 5 CFU / mL.

The application belongs to the technical field of anti-infection of antibacterial peptide drugs, and provides an antibacterial peptide and application thereof.The antibacterial peptide takes an olefin functionalized amino acid as a monomer, and is obtained through a free radical polymerization reaction.The antibacterial peptide shows no inhibition on growth of gram-positive bacteria and gram-negative bacteria, but has an effect of clearing bacterial biofilms, and has excellent biocompatibility and no toxicity.The raw materials and reagents of the application are easy to obtain, and the preparation process is simple, so that the application has wide prospects in the fields of clinical infection treatment, environmental protection and food safety.

The invention provides a nano-enzyme system based on an Ag-polydopamine nano-microsphere (at) MOF-74 structure as well as a preparation method and application of the nano-enzyme system, and belongs to the technical field of biological medicines. The nano-enzyme system takes a polydopamine microsphere as a core, and an MOF-74 shell layer grows on the surface of the polydopamine microsphere in situ to form a composite microsphere with a core-shell structure; and by utilizing the reduction property of polydopamine, Ag nanoparticles are reduced in situ and uniformly dispersed in the MOF-74 framework, so that the composite nano material with the enzyme-like activity and the photo-thermal function is constructed. The system shows excellent horse radish peroxidase-like activity, and can effectively promote electron transfer between hydrogen peroxide and a substrate and catalyze a chromogenic reaction. Meanwhile, the composite system has good photo-thermal conversion performance, shows a remarkable photo-thermal sterilization effect on gram-negative bacteria and gram-positive bacteria, and can effectively inhibit and destroy the formation of bacterial biofilms. An in-vitro antibacterial experiment result shows that the MOF-74-based nano enzyme system has relatively high antibacterial activity.

The application discloses a kind of smelly danchang dots and preparation method and application, belong to medical technical field.The preparation method of smelly danchang dot includes: smelly danchang fine powder is dispersed in distilled water, and is stirred pyrolysis on heating table;Pyrolysis product is diluted with distilled water, and supernatant is obtained by centrifugation, filter membrane filtration, dialysis, freeze-drying, to obtain carbon dot.The average particle size of obtained carbon dot is 4.51±1.04nm.The smelly danchang dot prepared in the application shows strong inhibitory activity to a variety of gram-positive bacteria (such as listeria, methicillin-resistant staphylococcus aureus MRSA) and fungi (such as Candida albicans), especially to clinically tricky drug-resistant strains, such as vancomycin-resistant enterococci (VRE) and MRSA effective, can be applied to the preparation of antibacterial drugs, antibacterial dressing, disinfectant or preservative, with the advantages of wide raw material source, simple preparation method, low cost, environment-friendly and the like.

The application prepares L-selenomethionine, and applies the L-selenomethionine to synthesis of tripeptide and tetrapeptide, and prepares new selenium-containing polypeptide compounds; the selenium-containing polypeptide compounds have antibacterial activity, and have good inhibition effect on gram-positive bacteria; the results obtained by the application show that the selenium-containing polypeptide compounds have wide application prospect in a drug development system, and provide a new and wider idea for synthesis and screening of selenium-containing polypeptide drug.

The application discloses a kind of high-efficiency low temperature, low noble metal load multi-element bacteriostatic material for organ static cold preservation and its preparation method and application, belong to biomedical materials and organ transplantation technical field.The bacteriostatic material is loaded on TiO2-MO x Low noble metal multi-element bacteriostatic system on composite carrier, general formula is Ag-N / TiO2-MO x Wherein N is one of Cu, Co, Mn, MO x It is one of CeO2, WO3, MoO3.The bacteriostatic efficiency of the material in the present application is greater than 90% in the low temperature interval of 0-40 DEG C to gram-positive bacteria and gram-negative bacteria, effectively overcome the problems of high cost of existing Ag bacteriostatic material and insufficient activity and stability of non-noble metal material, with high bacteriostatic activity, excellent anti-poisoning capacity and low cost advantage, especially suitable for static cold preservation of organ in vitro in organ transplantation, can significantly inhibit bacterial growth, prolong the organ survival time.

The application belongs to the technical field of biological medicine, and particularly relates to application of pantothenic acid or a pharmaceutically acceptable salt thereof in preparation of a medicine for enhancing sensitivity of pathogenic bacteria to daptomycin. It is found for the first time that addition of pantothenic acid or a pharmaceutically acceptable salt thereof can improve the sensitivity of gram-positive bacteria including Staphylococcus aureus, Streptococcus agalactiae and Corynebacterium diphtheriae to daptomycin, significantly improve the bactericidal effect, and further research shows that pantothenic acid or a pharmaceutically acceptable salt thereof can promote the clearance, formation and reduction of pathogenic bacteria biofilm by daptomycin. The finding opens up a new way for overcoming antibiotic resistance and optimizing anti-infection treatment strategies.

The invention discloses an application of an aggregation-induced emission (AIE) photosensitizer in preparation of a drug-resistant bacterium resisting product. The AIE photosensitizer disclosed by the invention has high active oxygen generation efficiency and can be applied to preparation of anti-drug-resistant bacteria type fibers. The AIE photosensitizer and the fiber prepared from the AIE photosensitizer have strong killing activity on a plurality of pathogenic microorganisms including drug-resistant gram-negative bacteria, gram-positive bacteria and the like. In addition, the pathogens can be efficiently and rapidly killed under the illumination of white light with extremely low power density; and even under the condition that illumination is not added, a good killing effect is also achieved on pathogens. Meanwhile, the AIE photosensitizer disclosed by the invention has good photobleaching resistance, good biocompatibility and pathogen capturing capacity, and can be applied to textile raw materials, medical materials and the like.

The invention belongs to the technical field of molecular biology, and relates to a truncated fish peptidoglycan recognition protein and application thereof. The amino acid sequence of the truncated fish peptidoglycan recognition protein is as shown in SEQ ID NO. 1 in the table. Compared with a natural peptidoglycan recognition protein, the truncated fish peptidoglycan recognition protein provided by the invention has higher expression efficiency and higher yield in a prokaryotic expression system; in addition, the binding capacity with main components, namely peptidoglycan (PGN) and lipopolysaccharide (LPS), of cell walls of gram-positive bacteria and gram-negative bacteria is higher; the bacteriostasis and agglutination capacities on gram-positive bacteria and gram-negative bacteria are obviously improved. The characteristics show that the truncated fish peptidoglycan recognition protein has the development potential as an aquatic product immunopotentiator, and important support is provided for subsequent application research.

This invention relates to the field of biomedical technology and discloses a broad-spectrum antimicrobial peptide and its applications. The invention obtains a broad-spectrum antimicrobial peptide H by mining non-classical open reading frames (ncORFs) in the human genome. Experimental verification shows that the broad-spectrum antimicrobial peptide H has significant inhibitory effects on both Gram-positive bacteria (Staphylococcus aureus ATCC 29213) and Gram-negative bacteria (Escherichia coli K88). Furthermore, the broad-spectrum antimicrobial peptide H can form an α-helix. The α-helix structure projection diagram shows that one side is rich in positively charged hydrophilic amino acid residues, and the other side is rich in hydrophobic amino acid residues, exhibiting good amphiphilicity. In addition, the broad-spectrum antimicrobial peptide H provided by this invention has low hemolytic activity and no cytotoxicity, ensuring in vivo safety while achieving highly efficient bactericidal activity. It also features a short synthetic sequence, small molecular weight, and is easy to chemically synthesize.

The invention relates to the technical field of aggregation-induced emission materials and antibiosis, in particular to an AIE conjugated polymer of a benzobithiadiazole receptor, a preparation method of the AIE conjugated polymer, a polymer nano preparation and application of the polymer nano preparation. The AIE active conjugated polymer has the following structural formula. According to the invention, programmable design of photodynamic-photothermal performance is realized by accurately regulating the position of the side chain of the receptor at the ortho-position or meta-position, the ortho-substituted FToBBr has a high-plane structure, radiation transition is promoted by limiting intramolecular motion, and excellent ROS generation capability is shown; meta-substituted FTmBBr maintains the degree of freedom of motion in molecules due to a low-plane structure, mainly generates non-radiative transition and shows a remarkable photothermal effect. The polymer nano preparation is FToBBr NPs and FTmBBr NPs, can achieve 99.9% of broad-spectrum antibacterial efficiency under low concentration, covers gram-positive bacteria and gram-negative bacteria, and has good biocompatibility.

Compositions for identifying a pathogenic bacterial infection include a mannitol compound with one or more substituents including radioisotopes. These radiopharmaceuticals, such as a positron-emitting mannitol analogue, [18F]fluoromannitol ([18F]FMtl), are rapidly taken up by gram-positive and gram-negative bacteria such as E. coli, S. aureus, A. baumannii, S. epidermis, P. mirabilis, S. enterica, K. pneumonia, E. faecium, E. cloacae, and M. marinum, but not non-active infection sites such as sterile inflammatory sites, cancer sites, etc. Administration of these radiopharmaceuticals to and subsequent imaging of patients, e.g., via positron emission tomography (PET), enables detection of deep-seated and difficult to manage bacterial infections, such as osteomyelitis and prosthetic joint infection, or in patients with sickle cell disease. [18F]FMtl injection detects and differentiates infection rapidly. The radiolabeled mannitol compounds can be produced via nucleophilic substitution reactions that are deployable on commercially available synthesizers, facilitating straightforward and wide accessibility, and counteracting unnecessary antibiotic use.

The application provides an earthworm antibacterial peptide derived from a popular cavity earthworm and application thereof in broad-spectrum antibacterial aspects. The amino acid sequence of the antibacterial peptide is shown in SEQ ID NO. 1 or SEQ ID NO. 2, and both have 13 amino acid residues and isoelectric points of 10.31 or 10.06. The application adopts a bioinformatics method, finds a new earthworm antibacterial peptide through a machine learning algorithm, optimizes the amino acid sequence according to the prediction result, and finally obtains an antibacterial peptide with better antibacterial effect. The obtained antibacterial peptide has good antibacterial activity on gram-negative bacteria represented by escherichia coli and gram-positive bacteria represented by staphylococcus aureus, and various drug-resistant bacterial variants of the two kinds of bacteria, and can be applied to the preparation of antibacterial products, including antibacterial drugs, additives and preservatives and the like.

The invention discloses a composite nano particle as well as a preparation method and application thereof, and relates to the technical field of biological medicines and nano materials. The invention particularly discloses a composite nano particle obtained by coordination self-assembly of ginsenoside and transition metal ions. According to the present invention, through the multiple synergistic mechanisms such as biological membrane physical structure destroying, catalytic generation of a large amount of reactive oxygen species (ROS), bacterial metabolism interference and the like, a variety of bacteria including gram-positive bacteria and gram-negative bacteria can be efficiently killed, particularly, the excellent removal ability on intractable biological membranes is provided, and the good biocompatibility and the good application prospect are provided.

The invention discloses a broad-spectrum efficient antibacterial polymer composite material as well as a preparation method and application thereof, and particularly relates to the technical field of production of polymer composite materials. According to the broad-spectrum efficient antibacterial polymer composite material, PA6 is used as a main body, an organic antibacterial pyridine ring and an inorganic antibacterial material metal silver are synthesized into an antibacterial agent, then long-chain quaternary ammonium salt is grafted, N-butylbenzenesulfonamide, thymol and the like are further compounded to serve as the antibacterial agent, and the broad-spectrum property and the high efficiency of the antibacterial property of the material are remarkably improved. The defects that a traditional antibacterial material is few in antibacterial variety, slow in effect taking time and short in acting time are effectively overcome; the antibacterial rate of gram-positive bacteria in 24 hours is larger than or equal to 99%, the virus titer of the film is reduced by 4.2 log10, the antibacterial rate in 1 hour reaches 92.1%, the dynamic friction coefficient is 0.2-0.4, the tensile strength is larger than or equal to 35 MPa, the hand feeling is not lost while the tensile strength and the antibacterial property are guaranteed, and the film is suitable for the fields of medical dressings, artificial joints, environment, industry and the like.

The application discloses application of BMS-833923 and derivatives thereof and a medicine, and belongs to the technical field of antibiotics. The BMS-833923 and the derivatives thereof can be used as colistin adjuvants to jointly inhibit or eliminate gram-negative bacteria, and can also independently inhibit or eliminate gram-positive bacteria. The gram-negative bacteria can include at least one of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, pan-drug-resistant strains BAA-1800, BAA-1794 and BAA-1792, and the gram-positive bacteria can include at least one of Staphylococcus aureus and Bacillus subtilis. By taking the BMS-833923 and the derivatives thereof as adjuvants of colistin, the therapeutic index of the colistin can be effectively expanded, and lower, non-toxic doses of the colistin can be used in clinical treatment of effective treatment of drug-resistant bacterial infections.

The invention relates to the technical field of medicine synthesis, in particular to ergosterol amino alcohol derivatives with antibacterial activity and a preparation method and application thereof. The structure is as shown in general formula (I). The ergosterol amino alcohol derivative disclosed by the invention is high in gram-positive bacterium and gram-negative bacterium resisting activity, and the antibacterial activity of the derivative with the optimal activity on staphylococcus aureus and escherichia coli is improved by 64 times and 32 times respectively, so that the ergosterol amino alcohol derivative is obviously superior to that of lead compound ergosterol and compounds reported in literatures. The IC50 values of the human body normal cells HK-2 (near-end renal tubular epithelial cells) and HEK-293 (human embryo renal epithelial cells) are obviously higher, and when MIC < lt > is less than MIC < lt >, MIC < lt > is less than MIC < lt >; the ergosterol amine alcohol derivative has the selectivity index SI of more than or equal to 6.0 when the molecular weight of the ergosterol amine alcohol derivative is 32 [mu] g mL <-1 >, has the characteristics of high efficiency and low toxicity, and has potential application value in the aspect of anti-infection drug development.

The invention discloses a self-assembled nanofiber antibacterial peptide based on a coiled spiral structure and a preparation method and application thereof, and belongs to the technical field of biology, and the amino acid sequence is as shown in SEQ ID No.1. The preparation method comprises the following steps: adopting an alpha-spiral heptapeptide repetitive sequence (abcdefg) 4 template, and selecting lysine to provide positive charges at positions b and c; leucine and isoleucine are respectively filled to a position a and a position d to provide intermolecular hydrophobic force, and lysine and glutamic acid are selected to be respectively filled to a position e and a position g to provide intermolecular electrostatic force; the position f of the center of the hydrophilic surface of the polypeptide is filled with tryptophan to optimize the hydrophobicity of the polypeptide, and the sequence is repeated for four times on the basis. The invention further discloses application of the antibacterial peptide in preparation of drugs for treating gram-positive bacteria or / and gram-negative bacteria infectious diseases. The antibacterial peptide disclosed by the invention has relatively strong antibacterial activity and good biocompatibility, and provides an effective technical support for developing a novel antibacterial drug.

This invention relates to the field of nonwoven fabric preparation technology, specifically to a biochemically modified antibacterial nonwoven fabric and its preparation method. This invention modifies nano-zinc oxide and nano-titanium dioxide using the silane coupling agent KH-570, improving the dispersibility of the nanoparticles. Under light or contact conditions, the nanoparticles release reactive oxygen species to disrupt bacterial cell membranes and inhibit their metabolism, thereby giving the antibacterial modified polypropylene masterbatch stable antibacterial properties. Furthermore, this invention stabilizes the loading through a polydopamine coating, thus stabilizing the antibacterial properties of lysozyme. Lysozyme specifically hydrolyzes the peptidoglycan layer of bacterial cell walls, leading to bacterial lysis. Thiourea dioxide, as a reducing agent, maintains lysozyme activity, preventing oxidative inactivation, while simultaneously inhibiting bacterial metabolic enzyme activity. Through the synergistic effect of inorganic and biological dual-effects, this invention can cover Gram-positive bacteria, Gram-negative bacteria, and fungi, thereby improving the antibacterial properties of the nonwoven fabric to a certain extent.