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Anti-bacterial-adhesion conductive hydrogel and preparation method and application thereof

A conductive hydrogel and reactant technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve problems such as wound infection or immune response, human health threat, inflammatory response, etc., to increase stability and environmental adaptability, The effect of high water content and good processing properties

Active Publication Date: 2019-08-13
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the recently developed hydrogel-based wound dressings have promoted wound healing to a certain extent, these traditional hydrogels are prone to absorb microorganisms and are susceptible to infection by a large number of pathogenic bacteria parasitic on the surface of human skin, thereby triggering an inflammatory response. , wound infection or immune response, posing a direct threat to human health

Method used

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  • Anti-bacterial-adhesion conductive hydrogel and preparation method and application thereof
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  • Anti-bacterial-adhesion conductive hydrogel and preparation method and application thereof

Examples

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Embodiment 1

[0021] (1) A solution of silver nitrate (0.1mM, 97mL), sodium citrate (180mm, 1mL), polyvinylpyrrolidone (4.2mM, 1mL) and hydrogen peroxide (30wt.%, 0.24mL) was mixed and heated at room temperature Stir vigorously under the open lid. Sodium borohydride (100 mm, 0.30 mL) was then quickly added to the above mixed solution. After reacting for 30 minutes, a blue colloidal solution of silver nanoparticles in a triangular shape was obtained.

[0022] (2) 95 mg of dopamine was dissolved in the above-prepared silver nanoparticle aqueous solution. The pH of the system was adjusted to 8.5 by adding NaOH solution (1 M) dropwise, and vigorously stirred at room temperature for 2 hours to obtain dopamine-coated silver nanoparticles.

[0023] (3) Preparation of antibacterial adhesive conductive hydrogel. Take 9 mL of the dopamine-coated silver nanoparticle solution prepared above, add 1 g of polyvinyl alcohol, and stir at 90° C. until completely dissolved. Then 200 μL of aniline, 75 mg o...

Embodiment 2

[0025] (1) A solution of silver nitrate (0.1mM, 97mL), sodium citrate (180mm, 1mL), polyvinylpyrrolidone (4.2mM, 1mL) and hydrogen peroxide (30wt.%, 0.24mL) was mixed and heated at room temperature Stir vigorously under the open lid. Sodium borohydride (100 mm, 0.30 mL) was then quickly added to the above mixed solution. After reacting for 30 minutes, a blue colloidal solution of silver nanoparticles in a triangular shape was obtained.

[0026] (2) 95 mg of tannic acid was dissolved in the silver nanoparticle aqueous solution prepared above. The pH of the system was adjusted to 8.5 by adding NaOH solution (1 M) dropwise, and vigorously stirred at room temperature for 2 hours to obtain silver nanoparticles coated with tannic acid.

[0027] (3) Preparation of antibacterial adhesive conductive hydrogel. Take 9 mL of the tannic acid-coated silver nanoparticle solution prepared above, add 1 g of agar, and stir at 90° C. until completely dissolved. Then 200 μL of aniline, 75 mg ...

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Abstract

The invention provides an anti-bacterial-adhesion conductive hydrogel and a preparation method and application thereof, and belongs to the technical field of functional polymer materials. According tothe method, silver nanoparticles modified by synthesized polydopamine are compounded in a solution of a conductive polymer monomer and polyvinyl alcohol, polymerization is initiated by using an initiator, and the conductive hydrogel is prepared in situ. The hydrogel has good biocompatibility, high bioadhesiveness, excellent electrical conductivity, excellent antibacterial properties for Gram-negative bacteria and Gram-positive bacteria and adjustable mechanical properties. The anti-bacterial-adhesion conductive hydrogel can be used as a novel medical polymer wound dressing, which has potential biological and medical application value in promoting wound healing of the body.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to an antibacterial and adhesive conductive hydrogel, a preparation method and its application on wound dressings. Background technique [0002] The skin is the largest organ of the human body. It protects the human body from damage, prevents microbial invasion, and maintains the balance of body fluids and electrolytes. Once there are serious defects in the skin, the wound will seriously affect people's life and health. Wounds, especially extensive full-thickness wounds, take a long time to repair, and acute and chronic wounds have been a major clinical problem. Therefore, it is of great clinical value to develop wound dressings that can quickly close wounds, promote wound healing and prevent bacterial growth. To date, a variety of biomaterials, including electrospun nanofibers, porous foams, polymer membranes, and functional hydrogels, have been used in dres...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08L5/12C08L79/02C08K9/10C08K3/08C08G73/02A61L26/00
CPCC08J3/075C08G73/0266A61L26/008A61L26/0061A61L26/0085A61L26/0066A61L26/0014A61L26/0023A61L26/0019C08J2329/04C08J2405/12C08J2479/02C08K9/10C08K2003/0806C08K2201/011A61L2300/104A61L2300/404A61L2400/12C08L29/04C08L5/12C08L79/02
Inventor 林权赵月刘厚赵玥琪杨喆杨柏
Owner JILIN UNIV
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