Anti-bacterial-adhesion conductive hydrogel and preparation method and application thereof
A conductive hydrogel and reactant technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve problems such as wound infection or immune response, human health threat, inflammatory response, etc., to increase stability and environmental adaptability, The effect of high water content and good processing properties
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[0020] Example 1:
[0021] (1) Mix the solutions of silver nitrate (0.1mM, 97mL), sodium citrate (180mm, 1mL), polyvinylpyrrolidone (4.2mM, 1mL) and hydrogen peroxide (30wt.%, 0.24mL), and at room temperature Stir vigorously under the lower opening. Then sodium borohydride (100mm, 0.30mL) was quickly added to the above mixed solution. After reacting for 30 minutes, a blue colloidal solution of silver nanoparticles with a triangular shape was obtained.
[0022] (2) 95 mg of dopamine was dissolved in the silver nanoparticle aqueous solution prepared above. The pH of the system is adjusted to 8.5 by adding NaOH solution (1M) dropwise, and the dopamine-coated silver nanoparticles can be obtained by vigorously stirring at room temperature for 2 hours.
[0023] (3) Preparation of antibacterial adhesive conductive hydrogel. Take 9 mL of the dopamine-coated silver nanoparticle solution prepared above, add 1 g of polyvinyl alcohol, and stir at 90° C. until it is completely dissolved. The...
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[0024] Example 2:
[0025] (1) Mix the solutions of silver nitrate (0.1mM, 97mL), sodium citrate (180mm, 1mL), polyvinylpyrrolidone (4.2mM, 1mL) and hydrogen peroxide (30wt.%, 0.24mL), and at room temperature Stir vigorously under the lower opening. Then sodium borohydride (100mm, 0.30mL) was quickly added to the above mixed solution. After reacting for 30 minutes, a blue colloidal solution of silver nanoparticles with a triangular shape was obtained.
[0026] (2) 95 mg of tannic acid was dissolved in the silver nanoparticle aqueous solution prepared above. By adding NaOH solution (1M) dropwise, the pH of the system was adjusted to 8.5, and the tannic acid coated silver nanoparticles were obtained by vigorously stirring at room temperature for 2 hours.
[0027] (3) Preparation of antibacterial adhesive conductive hydrogel. Take 9 mL of the tannic acid-coated silver nanoparticle solution prepared above, add 1 g of agar, and stir at 90° C. until it is completely dissolved. Then ad...
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