5-amino-8-methoxy quinolone carboxylic acid derivatives and its preparation

A technology for protecting groups of methoxy and amino groups, applied in the field of 5-amino-8-methoxyquinolone carboxylic acid derivatives and their preparation methods
CN1491944AInactive Publication Date: 2004-04-28MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2004-04-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to new quinolone compounds with excellent antiseptic activity and its preparation process, and antiseptic and feed additive containing the compounds. Specifically, the present invention is a new kind of quinolinecarboxylic acid derivative with amino radical in Place 5 of quinolone kernel, various cyclic amino substituent in Place 7 and methoxy radical in Place 8. Compared with available quinolone antiseptic with weak resisting activity to Gram-positive bacteria, the quinolinecarboxylic acid derivative has excellent resisting activity to Gram-positive bacteria and wide spectrum antiseptic activity.
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Description

technical field

[0001] The present invention relates to a new quinolone compound with excellent antibacterial activity and a preparation method thereof, and relates to an antibacterial pharmaceutical composition and a feed additive containing them. Background technique

[0002] Quinolones were from nalidixic acid (nalidixic acid, see G.Y.Lesher et al., J.Med.Chem.5,1063-1065 (1962)) in 1962 to moxifloxacin (moxifloxacin) listed in 1999, Chinese patent disclosure NO. 1074218 (1993)), in terms of antibacterial activity, it has undergone a transition from being only effective against most Gram-negative bacteria to broad-spectrum antibacterial.

[0003] According to the existing structure-activity relationship of quinolones, the 5-position substituent is NH 2 It can improve the activity of the compound against Gram-positive bacteria while reducing the phototoxicity of the compound.

[0004] Sanchez J.P. etc. report in J.Med.Chem.1995,38,4478-4487: a series of 8-alkoxy groups a...

Claims

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