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Broad-spectrum antibacterial wound nursing membrane and preparation method thereof

A wound care, antibacterial technology, used in fiber treatment, filament/thread forming, bandages, etc., can solve problems such as affecting wound healing, bacterial resistance, and lack of broad-spectrum resistance.

Active Publication Date: 2016-11-30
北京市创伤骨科研究所 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the wound care film containing antibiotics has good antibacterial effect, a single antibiotic only has antibacterial and bactericidal effects on limited bacteria, and does not have broad-spectrum drug resistance, and the uncontrolled release of antibiotics will cause bacterial drug resistance. affect wound healing
Nano-silver has broad-spectrum antibacterial properties, but as the use time increases, nano-silver is continuously dissolved and released into the human body, and the physiological toxicity caused by the accumulation of nano-silver in the body cannot be ignored

Method used

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  • Broad-spectrum antibacterial wound nursing membrane and preparation method thereof
  • Broad-spectrum antibacterial wound nursing membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] [1] Dissolve 1.68g of polycaprolactone in 20g of trifluoroethanol, stir magnetically at room temperature for 6h to dissolve to obtain solution A.

[0027] [2] Dissolve 0.72g of gelatin in 10g of trifluoroethanol, stir magnetically at room temperature for 6h to dissolve to obtain solution B.

[0028] [3] Mix solution A and solution B, and stir magnetically at room temperature for 6 hours to make them evenly mixed to obtain solution C.

[0029] [4] Dissolve 0.24g of 3‐(trimethoxysilyl)propyldimethyloctadecylammonium chloride in 7.6g of trifluoroethanol, and stir magnetically at room temperature to obtain solution D.

[0030] [5] Mix solution C and solution D, and stir magnetically at 60°C for 6 hours to fully hydrolyze 3‐(trimethoxysilyl)propyldimethyloctadecylammonium chloride and combine with polycaprolactone and Gelatin is cross-linked to obtain solution E, the polymer concentration in solution E is 6%, the mass ratio of polycaprolactone and gelatin is 70:30, 3‐(trime...

Embodiment 2

[0034] [1] Dissolve 2.56g of polycaprolactone in 20g of trifluoroethanol, stir magnetically at room temperature for 24 hours to dissolve to obtain solution A.

[0035] [2] Dissolve 0.64g of chitosan in 10g of trifluoroethanol, stir magnetically at room temperature for 24 hours to dissolve to obtain solution B.

[0036] [3] Mix solution A and solution B, and stir magnetically at room temperature for 24 hours to make them evenly mixed to obtain solution C.

[0037] [4] Dissolve 0.16g of 3-(trimethoxysilyl)propyl dimethyl dodecyl ammonium chloride in 6.8g of trifluoroethanol, and stir magnetically at room temperature to obtain solution D.

[0038] [5] Mix solution C and solution D, and stir magnetically at 60°C for 24 hours to fully hydrolyze 3-(trimethoxysilyl)propyl dimethyl dodecyl ammonium chloride and combine with polycaprolactone and Chitosan is cross-linked to obtain solution E, the polymer concentration in solution E is 8%, the mass ratio of polycaprolactone and chitosan i...

Embodiment 3

[0042] [1] Dissolve 2.28g of polylactic acid in 20g of hexafluoroisopropanol, stir magnetically at room temperature for 8 hours to dissolve to obtain solution A.

[0043] [2] Dissolve 0.12g of gelatin in 10g of hexafluoroisopropanol, stir magnetically at room temperature for 6 hours to dissolve to obtain solution B.

[0044] [3] Mix solution A and solution B, and stir magnetically at room temperature for 12 hours to make them evenly mixed to obtain solution C.

[0045] [4] Dissolve 0.36g of 3-(triethoxysilyl)propyl dimethyl cetyl ammonium chloride in 7.6g of hexafluoroisopropanol, and stir magnetically at room temperature to obtain solution D.

[0046] [5] Mix solution C and solution D, and stir magnetically at 60°C for 12 hours to fully hydrolyze 3‐(triethoxysilyl)propyldimethylhexadecylammonium chloride and mix with polylactic acid and gelatin Cross-linking occurs to obtain solution E, the polymer concentration in solution E is 6%, the mass ratio of polylactic acid and gela...

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Abstract

The invention relates to a broad-spectrum antibacterial wound nursing membrane and a preparation method thereof and belongs to the field of biological materials. The broad-spectrum antibacterial wound nursing membrane takes degradable aliphatic polyester and degradable natural polymers as main raw materials, a non-dissolving type cation antibacterial agent is added, the antibacterial agent and a polymer undergo chemical crosslinking effects, so that antibacterial groups are bonded to a spinning matrix, and an antibacterial nanofiber membrane is prepared through an electrostatic spinning method to be used for the wound nursing membrane. The wound nursing membrane has broad-spectrum antibacterial property, has obvious killing and inhibiting effects on gram-positive bacteria, gram-negative bacteria, saccharomycetes and fungi in an infection period and can effectively inhibit bacterial infection to the wound part; an antibacterial mechanism is cation antibiosis, the wound nursing membrane has low drug resistance, and a non-dissolving type antibacterial agent has a lasting antibacterial effect. Besides, the wound nursing membrane has excellent biocompatibility, mechanical property, breathability and water absorption property. The broad-spectrum antibacterial wound nursing membrane can serve as a wound nursing membrane.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a wound care film with degradable aliphatic polyester as the main base material and loaded with non-elution cationic antibacterial agent and a preparation method thereof. Background technique [0002] The skin is the first line of defense to protect the human body from external aggression. In daily life, it is inevitable that external factors such as trauma and burns or human diseases and other factors will cause skin defects to form wounds. If the wound is healing, Bacteria invade the injured part and the proliferation density reaches 10 5 CFU / mL, it will cause inflammation and infection. Continuous inflammatory stimulation will lead to an increase in the number of macrophages and neutrophils, and the level of associated matrix metalloproteinases will increase, and matrix metalloproteinases will cause extracellular matrix and some growth The degradation of factor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/32A61L15/28A61L15/46A61L15/62D04H1/728D01D5/00
CPCA61L15/26A61L15/28A61L15/32A61L15/46A61L15/62A61L2300/208A61L2300/404D01D5/003D01D5/0076D01D5/0092D04H1/728C08L67/04C08L89/06C08L5/08
Inventor 石锐耿欢田伟张立群
Owner 北京市创伤骨科研究所
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