Methods for preparing purified lipopeptides

a technology of lipopeptides and purified water, which is applied in the direction of peptide/protein ingredients, drug compositions, antibacterial agents, etc., can solve the problems of no simple and robust method, no method disclosed in these u.s. patents, and no effective method
US20060014674A1Inactive Publication Date: 2006-01-19CUBIST PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
CUBIST PHARMA INC
Publication Date
2006-01-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present application claims the benefit of U.S. Provisional Application No. 60 / 256,268, filed Dec. 18, 2000; Ser. No. 60 / 274,741, filed Mar. 9, 2001; Ser. No. filed Dec. 13, 2001; and Ser. No. filed Dec. 13, 2001, the contents of which are incorporated herein by reference.TECHNICAL FIELD OF THE INVENTION

[0002] The present invention relates to crystalline and crystalline-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to processes for preparing crystalline or crystal-like forms of the lipopeptide and to methods of purifying lipopeptides including daptomycin. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions. BACKGROUND OF THE INVENTION [0003...

Claims

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