Pronin medicinal composition and its preparing method

A technology of tiopronin and medicine, which is applied in the field of tiopronin combination medicine and its preparation, can solve the problems of reduced drug efficacy, toxic and side effects, etc., and achieve the effects of improving curative effect, reducing the occurrence of proteinuria, and reducing the amount of distribution

Inactive Publication Date: 2007-10-31
HUNAN KANGDU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the existing tiopronin drug, because no effective antioxidant is added, the 2-mercaptopropionyl structure of tiopronin is easily oxidized, which leads to a reduction in drug efficacy and further produces toxic and side effects

Method used

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  • Pronin medicinal composition and its preparing method
  • Pronin medicinal composition and its preparing method
  • Pronin medicinal composition and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The present embodiment adopts the mouse of acute hepatitis disease model as experimental animal, carries out comparative experiment with tiopronin combination medicine provided by the present invention and tiopronin monomer medicine respectively, compares grouping, every group 100, body weight 18-20g . In this embodiment and the following examples, the usage and dosage of the tiopronin monomer drug refer to the usage and dosage of the tiopronin combination drug used in the comparative experiment.

[0035] The raw materials that present embodiment adopts and the parts by weight of each raw material are as follows:

[0036] Tiopronin 120;

[0037] Cystine 8;

[0038] Liposome 160;

[0039] Vitamin C 240;

[0040] Monosodium Glutamate 500.

[0041] The preparation method is as follows:

[0042] 1) Get the above-mentioned liposome solution containing 160g liposome.

[0043] 2) Add 120g of tiopronin and 8g of cystine into the liposome solution, stir it ultrasonically ...

Embodiment 2

[0053] The present embodiment adopts the mouse of acute hepatitis disease model as experimental animal, carries out comparative experiment with tiopronin combination medicine provided by the present invention and tiopronin monomer medicine respectively, compares grouping, every group 100, body weight 18-20g .

[0054] The raw materials that present embodiment adopts and the parts by weight of each raw material are as follows:

[0055] Tiopronin 260;

[0056] Cystine 4;

[0057] Liposome 300;

[0058] Vitamin C 120;

[0059] Monosodium Glutamate 800.

[0060] The preparation method is as follows:

[0061] 1) Get the above-mentioned liposome solution containing 300g liposome.

[0062] 2) Add 260g of tiopronin and 4g of cystine into the liposome solution, stir it ultrasonically for 10 minutes, and dissolve it completely.

[0063] 3) Add 120g vitamin C and 800g sodium glutamate to the solution obtained in step 2), dissolve and adjust the pH value between 2.5-7.0.

[0064] ...

Embodiment 3

[0072]In this example, the mice of the acute hepatitis disease model were used as experimental animals, and the tiopronin combination drug provided by the present invention and the tiopronin single drug were used for comparative experiments, and the comparison was divided into groups, each group of 100 mice, weighing 18-20g .

[0073] The raw materials used in this embodiment and the parts by weight of each raw material are as follows:

[0074] Tiopronin 120;

[0075] Cystine 4;

[0076] Liposome 300;

[0077] Vitamin C 240;

[0078] Sodium Glutamate 500.

[0079] The preparation method is as follows:

[0080] 1) Take the above-mentioned liposome solution containing 300 g of liposomes.

[0081] 2) 120 g of tiopronin and 4 g of cystine were added to the liposome solution, and ultrasonically stirred for 10 minutes to completely dissolve.

[0082] 3) Add 240 g of vitamin C and 500 g of sodium glutamate to the solution obtained in step 2), dissolve, and adjust the pH value ...

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Abstract

The invention discloses a pharmaceutical composition of tiopronin and its preparing process, wherein the composition is prepared from the following raw materials: tiopronin 100-300, anti-oxidizing agent 2-10. liposome 100-400, vitamin C 100-300, sodium glutamate 400-1000. The invention also provides the process for preparing the pharmaceutical composition.

Description

technical field [0001] The invention relates to a tiopronin combination medicine and a preparation method thereof. Background technique [0002] Tiopronin (tiopronin), chemical name is N-(2-mercaptopropionyl)-glycine, molecular formula C 5 h 9 NO 3 S, as a drug for improving liver function, has been applied clinically. The drug can comprehensively and obviously improve the liver function indexes and related symptoms of viral hepatitis and alcoholic liver injury, and has the characteristics of definite curative effect and the like. [0003] It is used to treat viral hepatitis, alcoholic hepatitis, drug-induced hepatitis, heavy metal poisoning hepatitis, fatty liver and early liver cirrhosis; it can reduce the toxic and side effects of radiotherapy and chemotherapy, increase white blood cells and accelerate the recovery of liver cells, and reduce bone marrow chromosomal aberrations rate and the occurrence of skin ulcers, and can prevent the occurrence of secondary tumors c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K9/19A61P1/16
Inventor 蔡海德
Owner HUNAN KANGDU PHARMA
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