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Anti-hepatitis medical combination

A composition and drug technology, applied in the field of medicine, to achieve the effect of improving liver cell function, scavenging free radicals, and remarkable effect

Inactive Publication Date: 2007-10-31
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, the interaction of one or more of glycyrrhizic acid or its pharmaceutically acceptable salt, tiopronin, matrine and silybin or its derivatives or silymarin with rhodiola rosea or rhodiola rosea polysaccharide Function, compatible prescription, used to prepare medicines for treating liver diseases, has not been reported yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0170] The preparation of embodiment 1 rhodiola rosea polysaccharide

[0171] Take rhodiola rosea medicinal material, crush it, pass through a 40-mesh sieve, add 10 times the amount of water, soak for half an hour, put it into an ultrasonic extraction tank, extract by ultrasonic oscillation for 40 minutes, and the oscillation frequency is 60kHz, extract 3 times, combine the extracts, and filter , and the filtrate was concentrated under reduced pressure into an extract. Add 30 times the amount of water at 60°C to the extract, stir, stand still, pour out the supernatant, concentrate under reduced pressure until 1ml of the medicinal solution contains 1g of medicinal material, add ethanol until the alcohol content is 80%, and let stand for 24 hours. Filter, collect the precipitate, add 30 times the amount of water to dissolve the precipitate, add 1% tannic acid dropwise under stirring, heat, boil, and centrifuge to remove the precipitate, continue to add tannic acid until the solu...

Embodiment 2

[0183] The preparation of embodiment 2HG, HL, HK, HS composition powder injection

[0184] 1. Prescription:

[0185] Prescription 1:

[0186] Rhodiola polysaccharide 20g (equivalent to 1kg Rhodiola)

[0187] Monoammonium Glycyrrhizinate 40g

[0188] Polysorbate 80 35g

[0189] Mannitol 300g

[0190] Add sterile water for injection to 5000ml

[0191] A total of 1000 sticks were prepared

[0192] Prescription 2:

[0193]Rhodiola polysaccharide 20g (equivalent to 1kg Rhodiola)

[0194] Tiopronin 100g

[0195] Polysorbate 80 35g

[0196] Mannitol 300g

[0197] Add sterile water for injection to 5000ml

[0198] A total of 1000 sticks were prepared

[0199] Prescription 3:

[0200] Rhodiola polysaccharide 20g (equivalent to 1kg Rhodiola)

[0201] Matrine 400g

[0202] Polysorbate 80 35g

[0203] Mannitol 300g

[0204] Add sterile water for injection to 5000ml

[0205] A total of 1000 sticks were prepared

[0206] Prescription 4:

[0207] Rhodiola polysaccharide 2...

Embodiment 3

[0224] The preparation of embodiment 3HG, HL, HK, HS composition aqueous injection

[0225] 1. Prescription:

[0226] Prescription 1:

[0227] Rhodiola polysaccharide 20g (equivalent to 1kg Rhodiola)

[0228] Diammonium Glycyrrhizinate 150g

[0229] Add water for injection to 5000ml

[0230] A total of 1000 sticks were prepared

[0231] Prescription 2:

[0232] Rhodiola polysaccharide 20g (equivalent to 1kg Rhodiola)

[0233] Tiopronin 100g

[0234] Add water for injection to 5000ml

[0235] A total of 1000 sticks were prepared

[0236] Prescription 3:

[0237] Rhodiola polysaccharide 20g (equivalent to 1kg Rhodiola)

[0238] Matrine 400g

[0239] Add water for injection to 5000ml

[0240] A total of 1000 sticks were prepared

[0241] Prescription 4:

[0242] Rhodiola polysaccharide 20g (equivalent to 1kg Rhodiola)

[0243] Silybin Meglumine 100g

[0244] Add water for injection to 5000ml

[0245] A total of 1000 sticks were prepared

[0246] 2. Specific step...

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PUM

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Abstract

Disclosed is a novel pharmaceutical composition for treating liver diseases and process for preparation, wherein the pharmaceutical composition mainly comprises glycyrrhizic acid or its pharmaceutically acceptable salts, tiopronin, kurarinone, one or more of silybin or its derivatives or silymarin, rhodiola rosea or rhodiola rosea, the composition can be prepared into any one of the pharmaceutically acceptable dosage forms, preferably injections and oral preparations.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a combination of glycyrrhizic acid or a pharmaceutically acceptable salt thereof, tiopronin, matrine and silybin or one or more of its derivatives or silymarin and red Pharmaceutical composition made from sedum rosea or rhodiola rosea extract and its preparation method. 2. Background technology [0002] Liver diseases generally include hepatitis, cirrhosis, and liver cancer. Viral hepatitis caused by hepatitis virus has always been one of the serious infectious diseases in the world. More and more, such as hepatitis B, hepatitis C and other common viral hepatitis has become a clinical refractory disease, and has even become the main cause of liver cirrhosis and liver cancer. Due to the many etiologies of this type of disease, the difficulty in turning the virus negative, the long course of the disease, and the poor prognosis of some patients, it has caused great physical and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61K31/715A61P1/16A61K31/704A61K31/357A61K31/4375A61K31/197
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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