Tiopronin freeze-dried powder injection

A technology for tiopronin and injection for injection is applied in the field of liver protection drug tiopronin and freeze-dried powder injection and preparation thereof, and can solve the problems of inappropriateness, short validity period of use, poor stability of tiopronin and the like, and achieve good stability. Sexuality, ease of use, excellent curative effect
CN1194678CInactive Publication Date: 2005-03-30上海凯宝新谊(新乡)药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
上海凯宝新谊(新乡)药业有限公司
Publication Date
2005-03-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention refers to a Tiopronin freeze-dried powder-form injection for treating chronic liver diseases. It comprises active Tiopronin compound 1-1000mg, like 50mg, 100mg or 200mg, and the receivable carrier of drug is selected from one or multiple of low-molecular dextran, mannite, cyclodextrin, soluble amylum, glucide, NaCl, benzoic acid, cellulose or water. It also refers to the making method including the steps of preparing medical liquid, eliminating heat source, sterilizing, canning and freeze-drying.
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Description

technical field

[0001] The invention relates to the field of medicines and preparations thereof. Specifically, the invention relates to a hepatoprotective medicine tiopronin and a freeze-dried powder injection thereof and a preparation method thereof. Background technique

[0002] Tiopronin (English name: Tiopronin) is a metabolic improvement antidote, its molecular formula: C 5 h 9 NO 3 S, molecular weight: 163.20, structural formula as follows:

[0003]

[0004] It is mainly used for the improvement of liver function in chronic liver disease. Oral and aqueous injections of the product are currently on the market. Existing injection is the aqueous solution of the tiopronin sodium salt of 2ml or 5ml concentration 5% in every 1 ampoule, because tiopronin has poor stability in water, oxidation reaction easily occurs, so the aqueous solution injection has the shortcoming of storage time, The short validity period affects the safe and effective use ...

Claims

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