Frozen powder injection of tiopronin

Abstract

A freeze-dried powder injection of tiopronin is prepared from tiopronin and the excipient chosen from amino acid, the salt of amino acid, and phosphate through proportionally and respectively dissolving them in the water for injecting, mixing, stirring, sterilizing, pouring in containers and freeze drying.

Description

technical field

[0001] The invention relates to a novel tiopronin freeze-dried powder injection and a preparation method thereof. Background technique

[0002] Tiopronin N-(2-mercaptopropionyl)-glycine can activate metabolic enzymes, improve protein metabolism, promote liver function repair, and can integrate with toxic substances that hinder the activity of HS-enzyme, and has a detoxification effect. In addition, this product has a significant inhibitory effect on cellular immunity, and has a certain preventive effect on liver fibrosis.

[0003] Tiopronin is a white crystalline powder, easily soluble in water, and extremely unstable in water. Therefore, it has poor stability when it is directly prepared into a water injection. The melting point of this product is 96-99 °C, and it is also unstable to heat. The above properties The possibility of directly preparing tiopronin for injection is limited.

[0004] Chinese patent CN 1404827 "Tiopronin preparation" discloses a fre...