Preparation method of tiopronin tablets

A technology of tiopronin tablets and tiopronin, which is applied in the direction of pill delivery, digestive system, peptide/protein components, etc., can solve the problems of unsuitable tiopronin tablets, achieve good drug stability, prevent damp heat damage, The effect of low production cost
CN103705482AInactive Publication Date: 2014-04-09YICHANG HEC CHANGJIANG PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YICHANG HEC CHANGJIANG PHARMA CO LTD
Publication Date
2014-04-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method of tiopronin tablets. The method comprises the following steps: (1) pelleting auxiliary materials, namely adding a diluent and a disintegrating agent into a binder, and pelleting the mixture by adopting a wet process; (2) drying and finishing pellets; (3) adding raw material tiopronin and additional auxiliary materials, and mixing; (4), tabletting to form tiopronin blank tablets; and (5) coating to form the tiopronin coated tablets. According to the preparation method of the tiopronin tablets, which is provided by the invention, the auxiliary materials, the diluent and the disintegrating agent are pelleted with the binder and are dried, and the raw material tiopronin and the additional auxiliary materials are added, mixed and tabletted, therefore, active ingredients in tiopronin can be protected against destroy due to wet and heat in a traditional wet method pelleting process, good stability of the tiopronin tablets is kept, and the problem that the traditional wet method pelleting process is not suitable for producing the tiopronin tablets is solved. The prepared tiopronin tablets are low in production cost, and the preparation operation is simple.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of tiopronin tablets. Background technique

[0002] Tiopronin, chemical name: N-(2-mercaptopropionyl)-glycine, has a detoxification effect, protects liver tissue and cells, has a significant repair effect on alcohol-induced liver damage, and improves liver function. The pharmacological action is that tiopronin is a thiol-containing drug similar in nature to penicillamine, and has the effect of protecting liver tissue and cells. Animal experiments have shown that tiopronin can prevent liver damage caused by carbon tetrachloride, ethionine, acetaminophen, etc. by providing sulfhydryl groups, and can inhibit the accumulation of triglycerides in chronic liver damage; tiopronin It can reduce the activity of ATPase in the mitochondria of liver cells, thereby protecting the structure of liver mitochondria and improving liver function. In addition, tiopro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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