Frozen powder injection of tiopronin

A technology of tiopronin and freeze-dried powder injection, applied in the field of new tiopronin freeze-dried powder injection and its preparation, can solve the problems of thermal instability, poor stability, instability, etc.
CN100393310CInactive Publication Date: 2008-06-11江西欧氏药业有限责任公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
江西欧氏药业有限责任公司
Publication Date
2008-06-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

A freeze-dried powder injection of tiopronin is prepared from tiopronin and the excipient chosen from amino acid, the salt of amino acid, and phosphate through proportionally and respectively dissolving them in the water for injecting, mixing, stirring, sterilizing, pouring in containers and freeze drying.
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Description

technical field

[0001] The invention relates to a novel freeze-dried powder injection of tiopronin and a preparation method thereof. Background technique

[0002] Tiopronin N-(2-mercaptopropionyl)-glycine can activate metabolic enzymes, improve protein metabolism, promote liver function repair, and can integrate with toxic substances that hinder the activity of HS-enzyme, thus having a detoxification effect. In addition, this product has a significant inhibitory effect on cellular immunity and has a certain preventive effect on liver fibrosis.

[0003] Tiopronin is a white crystalline powder, easily soluble in water, and extremely unstable in water, so it is directly prepared into water injections with poor stability. The melting point of this product is 96-99°C, and it is also unstable to heat. The above properties Limit the possibility that tiopronin can be directly made into injection.

[0004] Chinese patent CN 1404827 "tiopronin preparation" discloses a freeze-dried p...

Claims

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