Tiopronin amino salt, and its preparing method

A technology of tiopronin amino acid salt and arginine salt, which is applied in the field of tiopronin amino acid salt and its preparation, and can solve the problems of easy oxidative degradation, limitation of tiopronin, thermal stability of tiopronin easy oxidative degradation, etc.

Active Publication Date: 2006-10-25
WUHAN WUYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But tiopronin has its major defect, that is, it is very unstable, and it is easy to oxidize and degrade in the presence of water, which affects the curative effect and safety of its clinical treatment.
Moreover, the melting point of tiopronin is relatively low at 96-99°C, so it is also unstable to heat.
The physical and chemical properties of tiopronin directly limit its use in the preparation of various pharmaceutical preparations
Therefore, in order to improve the use effect of tiopronin, many researchers prepare it and other components into a composition, and its use effect is still not good
For example, the invention patent application with publication date of February 23, 200

Method used

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  • Tiopronin amino salt, and its preparing method
  • Tiopronin amino salt, and its preparing method
  • Tiopronin amino salt, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of tiopronin arginine salt

[0023] raw material name

Feeding amount

mole ratio

Tiopronin

L-Arginine

Methanol (95%)

100g

112g

600ml

1

1.05

[0024] operate:

[0025] Put tiopronin, L-arginine, and ethanol into a 1000ml three-necked reaction flask, stir, heat to 50°C for reflux, and after 3 hours of reflux reaction, filter while hot, and place the filtrate in a refrigerator at 5-10°C to cool and crystallize. After 5 hours, it was filtered to obtain white crystals, which were dried in an oven at 80°C for 6 hours to obtain 196 g of white crystalline solids, yield 94.8%, mp 197-200°C.

[0026] The infrared absorption spectrum data of the sample:

[0027] Absorption peak (cm -1 ): 2957.92, 1647.58, 1604.88, 1525.77, 1457.23, 1407.90, 1386.21, 1357.38, 1335.77, 1313.99, 1246.37, 1159.37, 1012.96, 670.43, 555.97.

Embodiment 2

[0028] Embodiment 2: the preparation of tiopronin lysine salt

[0029] raw material name

Feeding amount

mole ratio

Tiopronin

L-Lysine

Ethanol (95%)

100g

94g

600ml

1

1.0

[0030] The operation method is the same as in Example 1: 177g of white crystalline solid was obtained, yield 93.4%, mp 172-175°C.

[0031] The infrared absorption spectrum data of the sample:

[0032] Absorption peak (cm -1 ): 3328.57, 2939.20, 1646.85, 1593.90, 1521.17, 1405.00, 1357.70, 1316.94, 1023.31, 904.87, 701.58, 550.03, 420.12.

Embodiment 3

[0034] Put tiopronin and phenylalanine salt into a 1000ml three-necked reaction flask at a ratio of 1:0.8, then add 650ml of ethyl acetate for stirring, heat to reflux at 100°C, and after 3 hours of reflux reaction, filter while hot, and place the filtrate in Cool and crystallize in the refrigerator at 5-10°C. After 5 hours, it was filtered to obtain white crystals, which were dried in an oven at 80° C. for 6 hours to obtain 196 g of white crystalline solids, yield 94.2%, mp 195-200° C.

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Abstract

This invention relates tiopronin amino acid salt used to cure chronic hepatitis and its preparation method. Its constitutional formula is shown as follow; R is 1-20 carbon atoms straight chain or branched chain alkyl radical. This invention solves the problem of tiopronin oxidation degradation in water, and volatilization decomposition in heat. The tiopronin in this invention is prepared into amino acid salt, it prevent the tiopronin combining with oxygen, and its oxidation. Medical using substance melting point is improved, so its thermal stability is greatly improved, so its medical effect as effective constituent is greatly improved.

Description

technical field [0001] The invention relates to an amino acid salt used for preparing medicine and a preparation method thereof, in particular to a tiopronin amino acid salt used for treating acute and chronic liver diseases and a preparation method thereof. Background technique [0002] Tiopronin (English name Tiopronin, chemical name: N-(2-mercaptopropionyl) glycine) is a metabolic improvement antidote, its molecular formula: C 5 h 9 NO 3 S, molecular weight: 163.20, structural formula as follows: [0003] [0004] It can activate metabolic enzymes, improve protein metabolism, and promote liver function repair. It is mainly used for the treatment of acute and chronic liver diseases. Since the 1990s, my country has successfully developed the API of tiopronin, and after that, various preparations of tiopronin have been listed on the market: including tablets, capsules, aqueous injections and freeze-dried powder injections, etc., which are now widel...

Claims

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Application Information

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IPC IPC(8): C07C323/25C07C319/12
Inventor 周建明杨波黄璐穆惠芳蔡莉
Owner WUHAN WUYAO PHARMA
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