Tiopronin amino salt, and its preparing method

A technology of tiopronin amino acid salt and arginine salt, which is applied in the field of tiopronin amino acid salt and its preparation, and can solve the problems of easy oxidative degradation, limitation of tiopronin, thermal stability of tiopronin easy oxidative degradation, etc.
CN1850797AActive Publication Date: 2006-10-25WUHAN WUYAO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WUHAN WUYAO PHARMA
Publication Date
2006-10-25

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Abstract

This invention relates tiopronin amino acid salt used to cure chronic hepatitis and its preparation method. Its constitutional formula is shown as follow; R is 1-20 carbon atoms straight chain or branched chain alkyl radical. This invention solves the problem of tiopronin oxidation degradation in water, and volatilization decomposition in heat. The tiopronin in this invention is prepared into amino acid salt, it prevent the tiopronin combining with oxygen, and its oxidation. Medical using substance melting point is improved, so its thermal stability is greatly improved, so its medical effect as effective constituent is greatly improved.
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Description

technical field

[0001] The invention relates to an amino acid salt used for preparing medicine and a preparation method thereof, in particular to a tiopronin amino acid salt used for treating acute and chronic liver diseases and a preparation method thereof. Background technique

[0002] Tiopronin (English name Tiopronin, chemical name: N-(2-mercaptopropionyl) glycine) is a metabolic improvement antidote, its molecular formula: C 5 h 9 NO 3 S, molecular weight: 163.20, structural formula as follows:

[0003]

[0004] It can activate metabolic enzymes, improve protein metabolism, and promote liver function repair. It is mainly used for the treatment of acute and chronic liver diseases. Since the 1990s, my country has successfully developed the API of tiopronin, and after that, various preparations of tiopronin have been listed on the market: including tablets, capsules, aqueous injections and freeze-dried powder injections, etc., which are now widel...

Claims

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