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Folate-targeted reduction sensitive drug-carrying polymer nano-micelle as well as preparation method and application thereof

The invention relates to a folate-targeted reduction sensitive drug-carrying polymer nano-micelle as well as a preparation method and application thereof. The delivery carrier is prepared by taking anamphiphilic triblock copolymer PCL-ss-PEG-ss-PCL as a material, and a chemotherapeutic drug adriamycin amycin and a photosensitizer indocyanine green are entrapped in a hydrophobic core of the micelle. Besides, phospholipid DSPE-PEG-NH2 with an active group is introduced into the preparation process, the DSPE end of the phospholipid has strong hydrophobic property and is inserted into the hydrophobic PCL core of the polymer micelle, the flexible hydrophilic PEG long chain exists on the outer surface of the micelle, FA with a targeting effect is connected to a PEG active distal end of the surface of the polymer micelle, and functions of active tumor targeting and reduction response drug release are integrated. The folate-targeted reduction sensitive drug-carrying polymer nano-micelle disclosed by the invention has the advantages of being small in particle size, high in dispersion property, high in drug loading capacity and encapsulation efficiency and excellent in photothermal conversion effect, can realize reduced trigger drug release, fluorescence imaging of tumor sites, tumor targeting drug delivery and chemotherapy-photothermal combination therapy and improve the tumor inhibition effect, and has wide application prospects in the targeted combination therapy aspect of tumors.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI

Planar illumination device

It is an object to provide a planar illumination device that is thin and light weight, and can emit uniform illumination light with little brightness unevenness and can be enlarged in size. It is to provide a planar illumination device comprising: a first light source and a second light source which are arranged at predetermined intervals; and a light guide plate which is arranged between the first light source and the second light source and has: a light exit surface; a first light incident surface which is opposed to the first light source and includes a side of the light exit surface; a second light incident surface which is opposed to the second light source and includes an opposite side to the side; and a rear surface which is formed to be opposed to the light exit surface, wherein a cross section on a plane perpendicular to the side, of the rear surface of the light guide plate has a curved line in which a distance from the light exit surface increases with a shift from the first light incident surface and the second light incident surface to a center, an inclined angle relative to the light exit surface reduces with a shift from the first light incident surface or the second light incident surface to the center, and the inclined angle relative to the light exit surface is zero degrees at the center.
Owner:FUJIFILM CORP
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