The invention relates to a folate-targeted reduction sensitive 
drug-carrying 
polymer nano-
micelle as well as a preparation method and application thereof. The delivery carrier is prepared by taking anamphiphilic triblock 
copolymer PCL-ss-PEG-ss-PCL as a material, and a chemotherapeutic 
drug adriamycin amycin and a 
photosensitizer indocyanine green are entrapped in a hydrophobic core of the 
micelle. Besides, 
phospholipid DSPE-PEG-NH2 with an 
active group is introduced into the preparation process, the DSPE end of the 
phospholipid has strong hydrophobic property and is inserted into the hydrophobic PCL core of the 
polymer micelle, the flexible hydrophilic PEG 
long chain exists on the outer surface of the micelle, FA with a targeting effect is connected to a PEG active distal end of the surface of the 
polymer micelle, and functions of active 
tumor targeting and reduction response 
drug release are integrated. The folate-targeted reduction sensitive drug-carrying polymer nano-micelle disclosed by the invention has the advantages of being small in particle size, high in dispersion property, high in drug loading capacity and encapsulation efficiency and excellent in 
photothermal conversion effect, can realize reduced trigger 
drug release, 
fluorescence imaging of tumor sites, 
tumor targeting drug delivery and 
chemotherapy-photothermal 
combination therapy and improve the 
tumor inhibition effect, and has wide application prospects in the targeted 
combination therapy aspect of tumors.