Tiopronin amidate and its prepn

A technology of tiopronin amino acid salt and amino acid, which can be applied in pharmaceutical formulations, medical preparations containing active ingredients, digestive system, etc. And other issues
CN1887859AInactive Publication Date: 2007-01-03GRAND PHARM (CHINA) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GRAND PHARM (CHINA) CO LTD
Publication Date
2007-01-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to one kind of Tiopronin amidate for treating acute and chronic hepatosis and its preparation process. The general expression of Tiopronin amidate is shown. The present invention changes Tiopronin with easy oxidation, degradation, volatilation and decomposition into stable Tiopronin amidate with raised smelting point and raised medicinal effect. The Tiopronin amidate may be further used to prepare other medicine preparation.
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Description

technical field

[0001] The invention relates to an amino acid salt used for preparing medicine and a preparation method thereof, in particular to a tiopronin amino acid salt used for treating acute and chronic liver diseases and a preparation method thereof. Background technique

[0002] Tiopronin (English name Tiopronin, chemical name: N-(2-mercaptopropionyl) glycine) is a metabolic improvement antidote, its molecular formula: C 5 h 9 NO 3 S, molecular weight: 163.20, structural formula as follows:

[0003]

[0004] It can activate metabolic enzymes, improve protein metabolism, and promote liver function repair. It is mainly used for the treatment of acute and chronic liver diseases. Since the 1990s, my country has successfully developed the API of tiopronin, and after that, various preparations of tiopronin have been listed on the market: including tablets, capsules, aqueous injections and freeze-dried powder injections, etc., which are now widel...

Claims

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