Fibrous protein compound hemostatic material and preparation method thereof

Abstract

The invention discloses a fibrous protein compound hemostatic material and a preparation method thereof. The fibrous protein compound hemostatic material is prepared from, by mass, 5-10 parts of carboxymethylcellulose, 2-4 parts of carboxyethyl cellulose, 1-5 parts of chitosan, 3-8 parts of starch, 1-3 parts of sodium trimetaphosphate, 1-4 parts of sodium alga acid, 3-8 parts of gelatin, 8-12 parts of soy isolate protein, 2-5 parts of amino acid and 20-40 parts of water. The amino acid is basic amino acid. The fibrous protein compound hemostatic material can stop bleeding rapidly and effectively, the amount of bleeding is reduced, and the fibrous protein compound hemostatic material is safe to use; the preparation method is simple, and the prepared membrane-shaped compound hemostatic material is convenient to use and store.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a fibrin composite hemostatic material and a preparation method thereof. Background technique [0002] The traditional methods of hemostasis mainly include suturing, pressing and dressing. The main hemostatic products include first aid kits, four-head bands, hemostatic gauze, tourniquets and bandages. The main method, but there will be great defects in the process of use or after use, so it is greatly limited in clinical application. For example, suture hemostasis is very effective for traumatic bleeding in soft tissues and large blood vessels, but it is not ideal for hemostasis in solid organs with high fragility and rich blood flow, and it is very easy to cause needle holes or hemorrhagic tissue damage. This affects the normal functions of the kidneys, brain and other substantial organs; pressing to stop bleeding requires pressing the capillaries for tens of minute...

AI Technical Summary

Problems solved by technology

[0002] The traditional methods of hemostasis mainly include suturing, pressing and dressing. The main hemostatic products include first aid kits, four-head bands, hemostatic gauze, tourniquets and bandages. The main method, but there will be great defects during or after use, so it is greatly limited in clinical application

For example, suture hemostasis is very effective for traumatic bleeding of soft tissues and large blood vessels, but the effect of hemostasis on solid organs with high fragility and rich blood flow is not ideal, and it is very easy to cause needle holes or hemorrhagic tissue damage. This affects the normal functions of the kidneys, brain and other substantial organs; pressing to stop bleeding requires pressing the capillaries for tens of minutes to promote the aggregation of platelets, which is the most direct way to stop bleeding on the body surface. A lot of bleeding but the hemostatic effect is not ideal

There are also many defects in the process of using the tourniquet: if the tourniquet is not properly treated for the wound or the time and pressure are not correctly grasped, it may cause pain near the wound, nerve damage, and even tissue necrosis in severe cases; For special and relatively common trauma, such as irregular shape, deep, narrow, arterial rupture and other wounds, the hemostatic effect is not good; the tourniquet is easy to fall off, causing secondary bleeding; the use of the tourniquet will induce soft tissue around the surgical wound. Reactive hyperemia, significant drop in oxygen content, etc.

In an environment with high humidity, its hemostatic effect will be greatly reduced

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