Fibrous protein compound hemostatic material and preparation method thereof

A technology of hemostatic material and fibrin, which is applied in the field of medical materials, can solve problems such as easy detachment of the tourniquet, reduced hemostatic effect, and decreased oxygen content, achieving rapid and effective hemostasis, simple preparation method, and reduced bleeding volume

Inactive Publication Date: 2016-06-01
SUZHOU BEC BIOLOGICAL TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The traditional methods of hemostasis mainly include suturing, pressing and dressing. The main hemostatic products include first aid kits, four-head bands, hemostatic gauze, tourniquets and bandages. The main method, but there will be great defects during or after use, so it is greatly limited in clinical application
For example, suture hemostasis is very effective for traumatic bleeding of soft tissues and large blood vessels, but the effect of hemostasis on solid organs with high fragility and rich blood flow is not ideal, and it is very easy to cause needle holes or hemorrhagic tissue damage. This affects the normal functions of the kidneys, brain and other substantial organs; pressing to stop bleeding requires pressing the capillaries for tens of minutes to promote the aggregation of platelets, whic

Method used

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  • Fibrous protein compound hemostatic material and preparation method thereof

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Embodiment 1

[0020] A fibrin composite hemostatic material prepared from the following raw materials in parts by mass: 5 parts of carboxymethyl cellulose, 2 parts of carboxyethyl cellulose, 1 part of chitosan, 3 parts of starch, and 1 part of sodium trimetaphosphate , 1 part of sodium alginate, 3 parts of gelatin, 8 parts of soy protein isolate, 2 parts of lysine, and 20 parts of water.

[0021] The preparation method comprises the steps of:

[0022] 1) Add starch and chitosan to water, put in a constant temperature water bath, add sodium trimetaphosphate and stir, the temperature of the constant temperature water bath is 65°C, and the water bath is 40min;

[0023] 2) Add sodium alginate, gelatin, soybean protein isolate and amino acid to the solution in step 1), stir at 35°C for cross-linking reaction, and react for 12 hours;

[0024] 3) Add carboxymethyl cellulose and carboxyethyl cellulose to the solution in step 2), pour the film on a glass plate, freeze-dry, and peel off the film to ...

Embodiment 2

[0026] A fibrin composite hemostatic material, prepared from the following raw materials in parts by mass: 10 parts of carboxymethyl cellulose, 4 parts of carboxyethyl cellulose, 5 parts of chitosan, 8 parts of starch, and 3 parts of sodium trimetaphosphate , 4 parts of sodium alginate, 8 parts of gelatin, 12 parts of soy protein isolate, 5 parts of lysine, and 40 parts of water.

[0027] The preparation method comprises the steps of:

[0028] 1) Add starch and chitosan to water, add sodium trimetaphosphate and stir in a constant temperature water bath; the temperature of the constant temperature water bath is 65°C, and the water bath is 40 minutes;

[0029] 2) Add sodium alginate, gelatin, soybean protein isolate and amino acid to the solution in step 1), stir at 35°C for cross-linking reaction, and react for 12 hours;

[0030] 3) Add carboxymethyl cellulose and carboxyethyl cellulose to the solution in step 2), pour the film on a glass plate, freeze-dry, and peel off the fi...

Embodiment 3

[0032] A fibrin composite hemostatic material, prepared from the following raw materials in parts by mass: 6 parts of carboxymethyl cellulose, 3.2 parts of carboxyethyl cellulose, 2 parts of chitosan, 5 parts of starch, and 1.8 parts of sodium trimetaphosphate , 2 parts of sodium alginate, 5 parts of gelatin, 10 parts of soy protein isolate, 3 parts of arginine, and 25 parts of water.

[0033] The preparation method comprises the steps of:

[0034] 1) Add starch and chitosan to water, put in a constant temperature water bath, add sodium trimetaphosphate and stir, the temperature of the constant temperature water bath is 65°C, and the water bath is 40min;

[0035] 2) Add sodium alginate, gelatin, soybean protein isolate and amino acid to the solution in step 1), stir at 35°C for cross-linking reaction, and react for 12 hours;

[0036] 3) Add carboxymethyl cellulose and carboxyethyl cellulose to the solution in step 2), pour the film on a glass plate, freeze-dry, and peel off t...

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Abstract

The invention discloses a fibrous protein compound hemostatic material and a preparation method thereof. The fibrous protein compound hemostatic material is prepared from, by mass, 5-10 parts of carboxymethylcellulose, 2-4 parts of carboxyethyl cellulose, 1-5 parts of chitosan, 3-8 parts of starch, 1-3 parts of sodium trimetaphosphate, 1-4 parts of sodium alga acid, 3-8 parts of gelatin, 8-12 parts of soy isolate protein, 2-5 parts of amino acid and 20-40 parts of water. The amino acid is basic amino acid. The fibrous protein compound hemostatic material can stop bleeding rapidly and effectively, the amount of bleeding is reduced, and the fibrous protein compound hemostatic material is safe to use; the preparation method is simple, and the prepared membrane-shaped compound hemostatic material is convenient to use and store.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a fibrin composite hemostatic material and a preparation method thereof. Background technique [0002] The traditional methods of hemostasis mainly include suturing, pressing and dressing. The main hemostatic products include first aid kits, four-head bands, hemostatic gauze, tourniquets and bandages. The main method, but there will be great defects in the process of use or after use, so it is greatly limited in clinical application. For example, suture hemostasis is very effective for traumatic bleeding in soft tissues and large blood vessels, but it is not ideal for hemostasis in solid organs with high fragility and rich blood flow, and it is very easy to cause needle holes or hemorrhagic tissue damage. This affects the normal functions of the kidneys, brain and other substantial organs; pressing to stop bleeding requires pressing the capillaries for tens of minute...

Claims

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Application Information

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IPC IPC(8): A61L24/02A61L24/08A61L24/10C08J3/24C08J5/18
CPCA61L24/08A61L24/0015A61L24/02A61L24/104A61L24/108A61L2300/418A61L2400/04C08J3/246C08J5/18C08J2389/00C08J2401/28C08L1/26C08L5/08C08L3/02C08L5/04
Inventor 李苏杨李文遐徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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