221 results about "Tranhexamic acid" patented technology

Provided are a whitening and freckle-removing composition, a gel, a preparation method therefor, and a use thereof, relating to the technical field of skin-care products. The whitening and freckle-removing composition comprises tranexamic acid, nicotinamide, 4-butylresorcinol, licorice extract, 3-o-ethyl ascorbic acid, and glutathione. For the whitening composition, by inhibiting the activity of tyrosinase, blocking the transfer of melanin from melanocytes to keratinocytes, and inhibiting the formation and accumulation of melanin by means of multiple mechanisms including oxidation resistance, and by means of the synergistic action of all components, cosmetic benefits of whitening and freckle-removing are achieved. The whitening and freckle-removing gel has a simple preparation method, has a mild and non-sensitizing formula, is safe and non-irritating, and is suitable for large-scale production and application.

The invention provides anti-aging moisturizing essence and a preparation method thereof, and belongs to the technical field of cosmetics. The essence is prepared from a plant extract, sodium pyrrolidone carboxylate, hexapeptide, nicotinamide mononucleotide, vitamin B5, galactose yeast fermentation product filtrate, b-glucan, sodium hyaluronate, glycerol, tranexamic acid, blue copper peptide, arbutin, nicotinamide, vitrin, a bifidus yeast fermentation product, a bifidus yeast fermentation lysate and the like. Wherein the plant extract is prepared by mixing rosemary, frankincense resin, tea flowers, sandalwood and jasmine flowers through ultrasonic extraction, comprehensive skin care is achieved from multiple angles of anti-aging, whitening, moisturizing and repairing, the overall health of the skin is guaranteed, and the skin care cream is suitable for various skin types.

The invention relates to the technical field of skin care products, and discloses an anti-aging and whitening composition and a preparation method thereof.The anti-aging and whitening composition comprises anti-aging and whitening components, whitening synergistic components, moisturizing and repairing components and deionized water, and the anti-aging and whitening components comprise botryine, ergothioneine and Ectoine; wherein the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2 to 2.0) to (0.4 to 0.7) to (1.0 to 1.5); the whitening synergistic component comprises one or more of nicotinamide, glabridin and tranexamic acid; the moisturizing and repairing component is prepared from one or more of sodium hyaluronate, ceramide NP, glycerol and 1, 3-butanediol. Experiments show that the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2-2.0): (0.4-0.7): (1.0-1.5), so that the glassine, the ergothioneine and the ectoine show a remarkable synergistic effect (in some cases, the synergistic index CIlt is 0.85), and the anti-aging and whitening functions of the composition containing the glassine, the ergothioneine and the ectoine are improved.

The invention relates to an anti-aging composition for strengthening a skin supporting network and application thereof, and the anti-aging composition comprises the following components: a golden camellia flower extract, a saffron crocus extract, camellia seed oil, tranexamic acid and epigallocatechin gallate glucoside, the weight ratio of the golden camellia flower extract to the saffron crocus extract to the camellia seed oil to the tranexamic acid to the epigallocatechin gallate glucoside is (0.1 to 5) to (0.01 to 5) to (0.1 to 10) to (0.01 to 2) to (0.001 to 0.1). The composition provided by the invention can synergistically strengthen a skin support network and comprehensively improve skin elasticity and compactness by promoting growth of two core structural proteins and three macromolecular adhesives of skin, and is mild, non-irritant and suitable for people with sensitive skin.

The present invention discloses a composition for improving chloasma, and its preparation method and application, for solving the problem that when oral tranexamic acid is stopped for a period of time during the treatment of chloasma, the problem of recurrence will occur after a short time. A composition for improving chloasma, in parts by weight, comprising the following raw material components: 1-10 parts of tomato seed oil, 10-15 parts of grape seed extract, 1-10 parts of Guanshan cherry, 1-15 parts of beeswax, 20-60 parts of vegetable oil, 20-60 parts of gel peel; wherein, the gel peel is composed of gelatin, glycerin and water. The composition provided by the application has a synergistic effect on inhibiting the production of melanin among the components. A preparation method for improving chloasma composition, the preparation method is simple, the steps are controllable, and the quality and stability of the composition for improving chloasma are improved. An application is also provided, the composition for improving chloasma has excellent inhibition of melanin production, and is rich in a variety of antioxidant active substances, and has a very excellent effect on freckle removal and whitening.

The invention discloses a preparation method and application of autologous fibrin glue, and belongs to the field of biomedical materials. The preparation method comprises the following five steps: collecting autologous venous blood, adding a sodium citrate anticoagulant with the volume ratio of 1: (8-12), and storing at 4-6 DEG C for not more than 2 hours; performing step-by-step centrifugation at the speed of 1500 to 2000 r / min and the speed of 3500 to 4000 r / min to obtain a fibrinogen concentrate; the thrombin-calcium chloride activation solution A and the tranexamic acid activation solution B are mixed according to the ratio of 1: (2-3) to form a composite activation system; mixing the two components according to a mass ratio of 1: (0.8-1.2), and reacting at 25-37 DEG C for 3-5 minutes to form colloid; and pre-freezing at-40 to-60 DEG C, performing vacuum freeze-drying, and storing at 4-8 DEG C. During application, the colloid can be coated on an operation wound surface after being redissolved, or mixed with a growth factor to prepare a dressing for covering a chronic wound surface. The colloid is high in purity, stable in coagulation time, long in storage period, suitable for scenes such as surgical hemostasis and the like, and high in clinical value.

The invention provides tranexamic acid-glutathione-containing compound emulsifiable paste and a preparation method thereof.W1 / O / W double emulsion phase structural design is adopted, reduced glutathione is encapsulated in an acidic inner water core, an oil phase is stabilized through hydrogenated lecithin and sorbitan sesquioleate, an outer water phase contains tranexamic acid, a layered gel network is constructed, and the tranexamic acid-glutathione-containing compound emulsifiable paste is prepared. A submicron dispersion system with the particle size D50 of 0.30-0.80 microns, the polydispersity index of 0.15-0.25 and the viscosity of 2.0-8.0 Pa seconds is realized, the encapsulation efficiency of glutathione is not lower than 70%, the oxygen content of a head space is not higher than 1.0%, and the encapsulation efficiency of glutathione is not lower than 70%. The three technical contradictions of coupling conflict between a high-yield viscoelastic structure and low-shear damage kernel integrity, coexistence of fresh and cool low-viscosity skin feeling and high-barrier anti-oxidation and anti-leakage and opposite low-surface-activity sensitive skin compatibility and submicron low-PDI dispersion stability are solved; the traditional Chinese medicine composition has wide application values of improving skin color unevenness, fading color spots, brightening skin color, soothing and repairing.

The invention discloses a microneedle-tranexamic acid nanofiber membrane and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: preparing a soluble microneedle (DMN) by utilizing a hydrophilic polymer polyvinylpyrrolidone (PVP), fixing the microneedle on an electrostatic spinning receiver, and carrying out electrostatic spinning by using an electrostatic spinning solution containing tranexamic acid TA to prepare a microneedle-tranexamic acid nanofiber membrane, namely TA-PVP-DMN. The prepared microneedle-tranexamic acid nanofiber membrane is simple in process and high in epidermal permeability, meanwhile, the safety problem caused by systemic administration of tranexamic acid can be avoided, and finally the purposes of safely and effectively improving facial pigmentation and treating chloasma can be achieved.

The invention provides a multi-stage synergistic wound repair nanofiber membrane and a preparation method thereof. The composite fiber membrane sequentially comprises an electrostatic spinning pullulan / tannic acid / tranexamic acid nanofiber membrane for promoting the formation of blood clots, a polydopamine / calcium chloride modified electrostatic spinning cellulose acetate membrane with coagulating, antibacterial and repairing effects, and a chitosan composite cellulose non-woven fabric, and the electrostatic spinning pullulan / tannic acid / tranexamic acid nanofiber membrane is a wound surface contact layer. The nanofiber membrane has the functions of a physical hemostasis barrier and continuously releasing regeneration promoting biological signals, and a dynamic hemostasis healing process is formed.

The invention belongs to the technical field of cosmetics, and particularly relates to whitening and freckle-removing essence oil and a preparation method thereof. According to the invention, adamantane formyl is introduced into an alpha-arbutin benzene ring to obtain the adamantane formyl modified alpha-arbutin derivative, so that the compatibility of alpha-arbutin and base oil is enhanced; the alpha-arbutin is prevented from being converted into hydroquinone by utilizing the large steric effect of adamantane formyl, so that the safety of the whitening and freckle-removing essence oil is improved; the tranexamic acid is wrapped by the ceramide nano-emulsion, so that the skin allergy risk caused by ingestion of the tranexamic acid is reduced; the ceramide nano-emulsion and tranexamic acid act together to repair skin collagenous fibers, block melanin transfer and inhibit melanin synthesis; trilinolein and glabridin are catalyzed by lipase to form a compound, so that the molecular compatibility and photo-thermal stability of glabridin are enhanced; glycerin promotes transdermal absorption of glabridin and enhances the efficacy of the whitening and freckle-removing essence oil.

The invention belongs to the technical field of biological medicine, and particularly relates to a reagent for improving ovarian development and a preparation method and application thereof. The reagent for improving ovarian development is prepared by mixing the following raw materials in parts by weight: 20-30 parts of N-acetylcysteine; 5 to 10 parts of tranexamic acid; 3 to 8 parts of creatine; and 3000 parts of water. According to the reagent, the mRNA expression of PKD1P6 and follicle stimulating hormone receptors (FSHR) in ovarian tissues is up-regulated, the activity and functions of cumulus granular cells are enhanced, and apoptosis of the cumulus granular cells is inhibited, so that the effects of effectively promoting follicle development and inhibiting the apoptosis of the cumulus granular cells are achieved.

The invention discloses a whitening and spot-fading composition and application thereof, and belongs to the technical field of cosmetics. The whitening and spot-fading composition is prepared from the following components in percentage by mass: 0.1 to 5.0 percent of nicotinamide, 0.0001 to 3.0 percent of tranexamic acid, 0.0001 to 1.0 percent of glycyrrhiza glabra root extract, 0.0001 to 0.4 percent of phenethyl resorcinol, 0.0001 to 2.0 percent of ascorbyl tetraisopalmitate, 0 to 1.0 percent (not including 0) of radix gentianae extract, 0.15 to 4.0 percent of emulsifier, 0.1 to 2.5 percent of antioxidant and the balance of water. By matching with various whitening active ingredients, the comprehensive whitening, brightening and skin improving effects are realized in the aspects of inhibiting melanin generation, blocking melanin transfer, accelerating melanin metabolism and the like; the combination of the specific emulsifier and the thickener can effectively improve the component stability of the composition. The composition is mild in performance, free of irritation to skin and good in market value.

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing at least one substance selected from the group consisting of tepiperidine and salts thereof, and at least one substance selected from the group consisting of tranexamic acid and salts thereof, in which the dissolution of tepiperidine is improved. [Solution] A solid composition containing the following components: (A) at least one substance selected from the group consisting of tepiperidine and salts thereof; (B) at least one substance selected from the group consisting of tranexamic acid and salts thereof; and (C) at least one compound selected from the group consisting of ibuprofen and salts thereof, in which the solid composition does not include a solid composition comprising levocetirizine or loratadine.

The invention discloses an anti-oxidation, whitening and brightening composition as well as a preparation method and application thereof. The anti-oxidation, whitening and brightening composition is prepared from the following components in parts by weight: 2 to 6 parts of nicotinamide, 0.5 to 5 parts of tranexamic acid, 1 to 5 parts of nonapeptide-1 solution, 0.5 to 1 part of tetrahydromethylpyrimidine carboxylic acid, 0.5 to 2 parts of pink red plum compound essence, 0.01 to 0.5 part of hydroxyethyl piperazine ethanesulfonic acid, 0.01 to 0.5 part of glabridin and 0.0001 to 0.2 part of glutathione. According to the invention, the composition prepared from nicotinamide, tranexamic acid, nonapeptide-1, tetrahydromethylpyrimidine carboxylic acid, pink-red plum composite essence, hydroxyethyl piperazine ethanesulfonic acid, glabridin and glutathione is prepared into the essence, and the clearance rate of the essence to ABTS free radicals reaches 58% or above, which shows that the essence has very good antioxidant ability; the cell tyrosinase activity inhibition rate of the composition under the concentration of 1.2% (v / v) reaches 51% or above, which shows that the composition has very good whitening and brightening effects.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention provides a mild whitening composition and application thereof, and relates to the technical field of cosmetics. The nicotinamide, the tranexamic acid, the Grass rose extract, the bisabolol and the plant zymolyte are matched, the optimal compatibility dosage is given, all the components take effect in a synergistic mode, irritation of a traditional whitening component can be obviously reduced, and the whitening effect is improved. The invention also finds that the Grass rose extract, the bisabolol and the plant zymolyte are added into the whitening component, so that the whitening effect of the whitening component can be obviously improved.

The invention provides a whitening and spot-fading skin care composition and a preparation method thereof, and belongs to the technical field of whitening and skincare, and the composition comprises modified glabridin, a nicotinamide-tranexamic acid co-coating, an alhagi sparsifolia flower extract and an artemisia desertorum seed extract. The modified glabridin is obtained by modifying glabridin with tocopherol succinate, polyethylene glycol and artemisia desertorum seed gum. The nicotinamide-tranexamic acid co-coating is obtained by coating a mixture of nicotinamide and tranexamic acid with sodium alginate and chitosan hydrochloride. The alhagi sparsifolia extract is obtained by carrying out common enzymolysis on alhagi sparsifolia dry powder through compound enzyme and glucosidase and purifying through a mixed filler adsorption column, and the artemisia desertorum seed extract is obtained by fermenting artemisia desertorum seed powder through aspergillus oryzae, removing impurities through ADS-7 resin and purifying through a polyamide resin column. The effective components are prepared by adopting a special preparation and purification method and are matched according to a specific ratio for use, and the whitening effects of inhibiting tyrosinase, blocking melanin generation, scavenging free radicals and the like are achieved through multi-effect synergism.

The invention provides a whitening composition containing a jasmine extract as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The whitening composition is prepared from the following components in parts by weight: 1 to 10 parts of nicotinamide; 0.1 to 5 parts of taurine; 0.1 to 3 parts of lecithin; 0.01 to 2 parts of inositol; 0.01 to 1 part of ceramide NP; 0.1 to 3 parts of tranexamic acid; 0.01-2 parts of glutathione, 0.1-5 parts of a jasmine flower lactobacillus fermentation extract and 20-60 parts of water. By controlling the types and mass ratio of the specific components, especially the mass ratio of lecithin to tranexamic acid, inositol to glutathione, and nicotinamide to taurine to jasmine lactic acid bacteria fermentation extract, the obtained composition not only can inhibit melanin generation and transport, but also can promote permeation of effective components, so that the anti-aging effect of the composition is improved, and the anti-aging effect of the composition is improved. The content of effective components in the skin is increased, so that the absorption effect and the bioavailability of the product are improved.

This invention provides tranexamic acid liposomes, their preparation method, and applications, relating to the field of nanoliposome technology. This invention utilizes a simple process to prepare tranexamic acid liposomes by rationally combining the ratios of tranexamic acid, phospholipids, and cholesterol. This invention achieves high loading capacity and high loading rate for the active ingredient tranexamic acid, maintaining its stability for a long time under various temperature conditions. The tranexamic acid liposomes prepared by this invention have a particle size between 10-50 nm, enabling better penetration into the stratum corneum and targeting the basal layer of the skin, providing a long-lasting and stable effect. Compared to liposomes prepared by other processes, they exhibit excellent transdermal permeability and skin retention, which is more conducive to the efficacy of the active ingredient, significantly improving its bioavailability and resulting in a greater skin-lightening effect.

The invention discloses a preparation process of trans-tranexamic acid, which comprises the following steps: S1, enzymatic conversion of cyanobenzoic acid: adding tap water into a reaction flask, adding a substrate terephthalonitrile, stirring and dispersing, adding an immobilized enzyme, reacting for 4 hours, filtering, collecting filtrate, and carrying out suction filtration to obtain a filter cake which is the immobilized enzyme, collecting and putting into the next batch of reaction; s2, hydrogenating p-cyanobenzoic acid to prepare aminomethylbenzoic acid; s3, hydrogenating aminomethylbenzoic acid to prepare cis-trans-tranexamic acid; and S4, performing high-temperature transformation to obtain trans-tranexamic acid. According to the preparation method of trans-tranexamic acid, by optimizing reaction conditions and technological processes, the yield and purity of a target product can be improved, generation of by-products is reduced, and the subsequent purification difficulty is lowered; cleaner raw materials are used, less harmful solvents are used, less wastes are generated, and the influence on the environment is favorably reduced; the high-efficiency process can complete production under low energy consumption, reduces energy consumption, and meets the requirements of green chemistry.

This invention provides a novel method for producing crystals composed of ibuprofen and tranexamic acid. [Solution] A method for producing crystals comprising ibuprofen and tranexamic acid, comprising: (1) adding a mixed powder of ibuprofen and tranexamic acid to an aqueous solution containing 65 w / w% or more and less than 100 w / w% ethanol, or adding the aqueous solution to the mixed powder to obtain a mixture in which the ratio of the content of the aqueous solution to the total mass of ibuprofen and tranexamic acid is 0.09 mL / g or more; and (2) generating the crystals from the obtained mixture.

A patch composition for targeting herpes virus comprising the following ingredients: a patch base, trisodium phosphate, malic acid, sorbitol, sodium benzoate, cellulose gum, peppermint, sodium saccharin, naringin, wind wheel grass extract, xanthan gum, polyethylene glycol-8, calcium carbonate, hydroxyethyl cellulose, hydroxypropyl guar gum, sodium nitrate, hydrated silica, sodium lauryl sulfate, strontium chloride hexahydrate, tranexamic acid, two-faced needle extract, sodium monofluorophosphate, sea salt, potassium nitrate, sodium chloride, and purified water q.s.

The invention relates to a preparation method of a tranexamic acid hydrogel microneedle. The preparation method comprises the following steps: 1) preparing a PDMS microneedle female template; 2) preparing a blank hydrogel microneedle; 3) preparation of the drug-containing hydrogel microneedle: dissolving tranexamic acid and derivatives or analogues thereof in ultrapure water, with the content range of the tranexamic acid and derivatives or analogues thereof being 0.1-30 mg / tablet, and preparing a drug solution with the mass concentration of the tranexamic acid and derivatives or analogues thereof being 0.1 g / mL, and (3) uniformly pouring the medicine solution into the blank hydrogel microneedle mold prepared in the step (2), then drying and forming at 37 DEG C, and finally, demolding the dried microneedle from the mold to obtain the tranexamic acid hydrogel microneedle. According to the tranexamic acid hydrogel microneedle, tranexamic acid can directly reach a skin basal layer, the tranexamic acid hydrogel microneedle can load and deliver more tranexamic acid, the treatment effect is remarkably enhanced, long-time slow release is achieved, and the tranexamic acid hydrogel microneedle has remarkable social and economic benefits.

The present invention provides a solid composition containing: crystals composed of ibuprofen and tranexamic acid; and a surfactant.

The invention belongs to the technical field of pharmaceutical chemistry, and provides a tranexamic acid crystal and a preparation method and application thereof, the tranexamic acid crystal has characteristic peaks in an X-ray powder diffraction pattern under Cu-K alpha radiation when diffraction angles 2 theta are 10.52 + / -0.2 degrees, 17.54 + / -0.2 degrees, 17.90 + / -0.2 degrees, 20.86 + / -0.2 degrees and 21.24 + / -0.2 degrees. The tranexamic acid crystal is of a novel crystal structure, is high in purity and good in stability, can simultaneously meet EP11.0, USP-NF2025 and tranexamic acid quality standards of the current edition of Chinese Pharmacopoeia, can be kept stable under severe conditions of high temperature, high humidity, strong acid, strong alkali, illumination, oxidation and the like, and is convenient to produce and store. The preparation method of the tranexamic acid crystal is simple to operate, the used crystallization reagent is safe, the production cost is low, and industrial production is easy.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

A method for enhancing solubility of tranexamic acid comprising the following steps:a) Initially dissolving tranexamic acid in water;b) Measuring a pH value of the solution obtained in Step (a);c) Addition of a strong acid (that dissociates completely in water) to the solution obtained in Step (a) and simultaneously monitoring the decrease in the pH value of the solution until approximately pH 4.5 or less than pH 4.5 is reached, to increase solubility of tranexamic acid;d) Addition of tranexamic acid to reach the pH value of the solution obtained in Step (c) above the pH 2.0; ande) Repeating Steps (c) and (d) until a desired amount of tranexamic acid is added to the solution of Step (a), that is a desired concentration of tranexamic acid in the final solution is reached.

The invention discloses a medical sponge for laparoscopic surgery and a preparation method thereof, and relates to the field of medical sponges, a sponge matrix is composed of polyvinyl alcohol, gelatin for the matrix, collagen and sodium alginate for the matrix, and is provided with directionally arranged macroporous channels; the drug-loaded porous microspheres are composed of gelatin for microspheres and sodium alginate for microspheres and are loaded with tranexamic acid, an antibacterial agent and hemostatic active ingredients, oriented microporous channels are formed in the microspheres, and macroporous channels of the sponge matrix and microporous channels of the drug-loaded microspheres form a communicated cross-scale pore network; a hierarchical porous structure with the average diameter of a macroporous channel being 12-40 microns and the average diameter of a microporous channel being 3.0-8.0 microns is realized, the diameter of the drug-loaded microspheres is 50-90 microns, the drug-loaded microspheres are uniformly dispersed according to the proportion of 25%-35% of the dry weight of a matrix, the total drug loading capacity of active drugs reaches 1.5%-4.0% of the weight of the microspheres, and the problems that traditional medical sponge drug release is uncontrollable and the hemostatic and antibacterial effects are poor are solved. The clinical application value is wide.

The present application relates to the field of cosmetic technology, and more particularly to a full-link whitening and freckle-removing liposome and a preparation method thereof, the liposome comprising the following components: an aqueous phase, a membrane material and an oil phase. In the preparation process, 4-butyl resorcinol, nonapeptide-1, acetylchitosamine and ascorbic acid tetraisopalmitate are combined to form a full-link effect of signal inhibition-synthesis blockage-blocked conversion-metabolic acceleration, and a multi-target whitening and freckle-removing system is constructed. In addition, tranexamic acid, hydrolyzed yeast protein and schizophyllan are combined to synergistically make the finished product have excellent soothing and moisturizing effects. Furthermore, the finished product is prepared into a liposome capable of encapsulating active ingredients, which effectively improves the stability of the active ingredients, prevents their oxidation and inactivation, and the liposome structure is highly similar to the human cell membrane, is easy to penetrate the keratin layer gap, realizes targeted delivery to the deep layer of the epidermis, and makes the active ingredients truly act on the required site.

The invention belongs to the technical field of medical dressings, and discloses a recombinant human collagen combined nano-silver ionic liquid-containing dressing and a preparation method thereof. The invention discloses a liquid dressing. Comprising the following raw materials: 8 to 15 parts of polyvinyl alcohol, 3 to 6 parts of calcium alginate, 1 to 3 parts of polydimethylsiloxane, 0.1 to 0.5 part of an antibacterial agent, 2 to 5 parts of bioactive protein, 1 to 4 parts of sodium hyaluronate, 2 to 5 parts of chitosan, 0.5 to 2 parts of tranexamic acid, 0.3 to 1 part of polypeptide, 0.2 to 0.8 part of an anti-inflammatory agent, 0.5 to 1.5 parts of ethylhexylglycerin, 10 to 20 parts of glycerin, 0.5 to 1.2 parts of carbomer, 0.1 to 0.3 part of biguanide hydrochloride and 40 to 60 parts of deionized water. The comprehensive improvement of the liquid dressing on the aspects of antibiosis, repair promotion, stability and safety is realized. All the components are matched to achieve the effects of broad-spectrum antibacterial property, healing time shortening and activity protection. Temperature gradient control, microwave activation and high-pressure homogenization are adopted in the process, the compatibility of all the raw materials is improved, the dressing is stable in physical performance, free of layering during storage and high in safety, and the requirements for skin wound protection and repair are met.