390 results about "Tranhexamic acid" patented technology

Provided are a whitening and freckle-removing composition, a gel, a preparation method therefor, and a use thereof, relating to the technical field of skin-care products. The whitening and freckle-removing composition comprises tranexamic acid, nicotinamide, 4-butylresorcinol, licorice extract, 3-o-ethyl ascorbic acid, and glutathione. For the whitening composition, by inhibiting the activity of tyrosinase, blocking the transfer of melanin from melanocytes to keratinocytes, and inhibiting the formation and accumulation of melanin by means of multiple mechanisms including oxidation resistance, and by means of the synergistic action of all components, cosmetic benefits of whitening and freckle-removing are achieved. The whitening and freckle-removing gel has a simple preparation method, has a mild and non-sensitizing formula, is safe and non-irritating, and is suitable for large-scale production and application.

The invention provides a whitening composition, a whitening product, a preparation method and application. The invention provides application of the milk exosome and nicotinamide in improving the autophagy ability of tranexamic acid activated melanocytes. The whitening composition provided by the invention is prepared from the following components in parts by weight: 1 to 50 parts of milk exosome, 5 to 40 parts of tranexamic acid and 0.5 to 30 parts of nicotinamide. The provided whitening composition is an active composition capable of activating the autophagy function of melanocytes of a human body, melanin synthesis in the melanocytes can be reduced by inducing generation of autophagy-related protein and activating an autophagy system, dullness of the skin is improved, the skin color is brightened through an internal channel, and the product is free of irritation and high in safety.

Provided in the present invention is an analysis and detection method for simultaneously detecting tretinoin and tranexamic acid, and the use of the analysis and detection method. The method comprises: analyzing a sample to be tested comprising tretinoin and tranexamic acid by using an ultra-high performance liquid chromatography-triple quadrupole mass spectrum, so as to achieve the qualitative and quantitative detection of tretinoin and tranexamic acid. The analysis and detection method provided in the present invention has the characteristics of a high sensitivity and high precision, good repeatability, high accuracy, high stability, etc. The detection method of the present invention can be relatively easily transferred and applied to the detection of the two compounds in biological samples such as plasma and tissue homogenates, and can satisfy the requirements for drug concentration monitoring.

The invention provides anti-aging moisturizing essence and a preparation method thereof, and belongs to the technical field of cosmetics. The essence is prepared from a plant extract, sodium pyrrolidone carboxylate, hexapeptide, nicotinamide mononucleotide, vitamin B5, galactose yeast fermentation product filtrate, b-glucan, sodium hyaluronate, glycerol, tranexamic acid, blue copper peptide, arbutin, nicotinamide, vitrin, a bifidus yeast fermentation product, a bifidus yeast fermentation lysate and the like. Wherein the plant extract is prepared by mixing rosemary, frankincense resin, tea flowers, sandalwood and jasmine flowers through ultrasonic extraction, comprehensive skin care is achieved from multiple angles of anti-aging, whitening, moisturizing and repairing, the overall health of the skin is guaranteed, and the skin care cream is suitable for various skin types.

The invention belongs to the technical field of cosmetic preparations, and particularly relates to a microcapsule emulsion containing collagen and a preparation method thereof. According to the invention, tranexamic acid is utilized to adjust the pH value and Zeta potential value of a collagen solution system, so that the collagen shows the characteristics of lowest solubility and lowest conductivity in a state close to an isoelectric point, the microcapsule preparation containing the collagen is successfully prepared, and the purposes of improving the stability and transdermal absorbability of the collagen and improving the bioavailability of the collagen are achieved. And the skin state is improved in a slow-release manner.

Aiming at the inadequacy of existing hemostatic materials for large-scale trauma and serious bleeding, the present invention provides a silk fibroin complex loaded with a polyhydroxy phenolic compound and a preparation method therefor. The complex is prepared by self-assembly of the polyhydroxy phenolic compound and the silk fibroin. The silk fibroin is subjected to a β-sheet conformation transformation process. The polyhydroxy phenolic compound is preferably an indissoluble compound, most preferably ellagic acid. The feeding ratio of the polyhydroxy phenolic compound to the silk fibroin is a mass ratio of ˂ 1:1, preferably 1:2 to 1:16, more preferably 1:4. The hemostatic ability of the complex is significantly superior to that of the polyhydroxy phenolic compound, the silk fibroin, Yunnan Baiyao, tranexamic acid, chitosan hemostatic powder, and the like. Meanwhile, the complex has a larger particle size and mass than the silk fibroin, and can rapidly settle to a bleeding site in blood. The complex exhibits no cytotoxicity, is blood-insoluble, and is capable of self-degradation in vivo, demonstrating high safety. Meanwhile, the complex has the characteristics of wound healing, antibiosis, infection resistance, adhesion resistance, and the like, and can be applied to the preparation of corresponding formulations.

The invention belongs to the technical field of cosmetics, and provides a whitening and spot-fading active composition, application of the whitening and spot-fading active composition in cosmetics, a skin care product containing the whitening and spot-fading active composition and a preparation method of the whitening and spot-fading active composition. The whitening and spot-fading active composition is prepared by compounding the following components in percentage by mass: 15%-25% of nicotinamide, 15%-25% of tranexamic acid, 0.1%-0.4% of beta-glucan, 0.5%-1% of nano-coated phenylethyl resorcinol and the balance of water. The skin care product prepared by the invention has both product safety and whitening and spot-fading effectiveness, and meanwhile, the cost investment is effectively reduced.

The invention relates to a composition with soothing and moisturizing effects and application of the composition. The composition comprises a piper nigrum extract, an oat kernel extract, schizophyllan and tranexamic acid. According to the invention, when the kava pepper extract, the oat kernel extract, the schizophyllan and the tranexamic acid are creatively combined for use, synergistic interaction can be realized in the aspects of soothing skin, moisturizing and repairing skin barrier, and the soothing and moisturizing effects of the product are further improved. The composition with the soothing and moisturizing effects has the specific effects of increasing the water content of the skin, calming and soothing the skin, improving the facial redness condition and reducing the inflammatory response, is very suitable for skin care products, and is mild, free of irritation and good in stability.

The embodiment of the invention discloses a color-stable whitening composition and a skin whitening product. The color-stable whitening composition comprises arbutin, tranexamic acid and a color stabilizer, and the color stabilizer comprises ascorbyl glucoside and ergothioneine. The whitening composition is stable in color and not prone to discoloring, and meanwhile the good skin whitening and anti-oxidation effects can be achieved.

The invention relates to the field of cosmetics, in particular to the field of A61K8, in particular to a multi-effect skin-care liposome whitening composition and a preparation method thereof. The multi-effect skin-care lipidosome whitening composition is prepared from the following raw materials: a whitening functional component, polyhydric alcohols, an emulsifier, a plant extract, lipidoids and deionized water, wherein the whitening functional component is prepared from glabridin, tranexamic acid, nicotinamide, acetylchitosamine, diglucosyl gallic acid, ectoin and ergothioneine. The multiple-effect skin-care liposome whitening composition has the effects of inhibiting the activity of tyrosinase, improving the DPPH clearance rate, inhibiting hyaluronidase and the like, and it is guaranteed that the product has excellent whitening and skin-care effects.

The invention provides a silk fibroin hemostatic sponge loaded with polyhydroxy phenolic compounds and a preparation method of the silk fibroin hemostatic sponge, aiming at the defect that hemostatic materials have poor effects on large wounds and serious bleeding, and the silk fibroin hemostatic sponge loaded with the polyhydroxy phenolic compounds is prepared from silk fibroin compounds loaded with the polyhydroxy phenolic compounds, wherein the silk fibroin compound loaded with the polyhydroxy phenolic compound is prepared from the polyhydroxy phenolic compound and silk fibroin according to the feeding mass ratio of 1t; the material is prepared in a 1: 1 self-assembly mode. The polyhydroxy phenolic compound is preferably insoluble and most preferably ellagic acid, and the feeding ratio of the polyhydroxy phenolic compound to the silk fibroin is preferably 1: 2-1: 16 and more preferably 1: 4. The hemostatic capacity of the silk fibroin compound loaded with the polyhydroxy phenolic compound is remarkably superior to that of silk fibroin, Yunnan Baiyao, tranexamic acid, chitosan hemostatic powder and the like, and the silk fibroin compound is free of cytotoxicity, free of hemolysis, capable of being self-degraded and high in safety. The silk fibroin hemostatic sponge loaded with the polyhydroxy phenolic compound has excellent hemostatic performance, is easy to peel, does not cause secondary damage, and can be self-degraded.

The invention relates to the technical field of skin care products, and discloses an anti-aging and whitening composition and a preparation method thereof.The anti-aging and whitening composition comprises anti-aging and whitening components, whitening synergistic components, moisturizing and repairing components and deionized water, and the anti-aging and whitening components comprise botryine, ergothioneine and Ectoine; wherein the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2 to 2.0) to (0.4 to 0.7) to (1.0 to 1.5); the whitening synergistic component comprises one or more of nicotinamide, glabridin and tranexamic acid; the moisturizing and repairing component is prepared from one or more of sodium hyaluronate, ceramide NP, glycerol and 1, 3-butanediol. Experiments show that the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2-2.0): (0.4-0.7): (1.0-1.5), so that the glassine, the ergothioneine and the ectoine show a remarkable synergistic effect (in some cases, the synergistic index CIlt is 0.85), and the anti-aging and whitening functions of the composition containing the glassine, the ergothioneine and the ectoine are improved.

The invention relates to an anti-aging composition for strengthening a skin supporting network and application thereof, and the anti-aging composition comprises the following components: a golden camellia flower extract, a saffron crocus extract, camellia seed oil, tranexamic acid and epigallocatechin gallate glucoside, the weight ratio of the golden camellia flower extract to the saffron crocus extract to the camellia seed oil to the tranexamic acid to the epigallocatechin gallate glucoside is (0.1 to 5) to (0.01 to 5) to (0.1 to 10) to (0.01 to 2) to (0.001 to 0.1). The composition provided by the invention can synergistically strengthen a skin support network and comprehensively improve skin elasticity and compactness by promoting growth of two core structural proteins and three macromolecular adhesives of skin, and is mild, non-irritant and suitable for people with sensitive skin.

The invention provides a novel composition and a preparation. The composition and the preparation comprise tranexamic acid and a vitamin A acid alcohol amine compound or a vitamin A acid fatty amine compound. After the composition is prepared into a preparation, the solubility of the vitamin A acid can be improved, the loss of the vitamin A acid in the preparation process is reduced, the content uniformity of the preparation is improved, and the stability of the preparation is improved; the composition can significantly increase the intradermal retention amount of vitamin A acid and tranexamic acid, and does not significantly increase the transdermal penetration amount of tranexamic acid. The composition and the preparation provided by the invention can significantly improve the curative effect and avoid aggravation of toxic and side effects in the treatment of hyperpigmentation and chloasma.

The present invention discloses a composition for improving chloasma, and its preparation method and application, for solving the problem that when oral tranexamic acid is stopped for a period of time during the treatment of chloasma, the problem of recurrence will occur after a short time. A composition for improving chloasma, in parts by weight, comprising the following raw material components: 1-10 parts of tomato seed oil, 10-15 parts of grape seed extract, 1-10 parts of Guanshan cherry, 1-15 parts of beeswax, 20-60 parts of vegetable oil, 20-60 parts of gel peel; wherein, the gel peel is composed of gelatin, glycerin and water. The composition provided by the application has a synergistic effect on inhibiting the production of melanin among the components. A preparation method for improving chloasma composition, the preparation method is simple, the steps are controllable, and the quality and stability of the composition for improving chloasma are improved. An application is also provided, the composition for improving chloasma has excellent inhibition of melanin production, and is rich in a variety of antioxidant active substances, and has a very excellent effect on freckle removal and whitening.

The invention discloses external emulsifiable paste for directionally delivering tranexamic acid to an epidermal layer, which is prepared from the following raw materials in percentage by weight: 1-15% of tranexamic acid, 0.5-7% of alpha-arbutin, 0.3-4% of edetate disodium, 1-5% of azone, 1-5% of sodium dodecyl benzene sulfonate and the balance of water. The skin care product is prepared from, by weight, 0.1%-2% of salicylic acid, 1%-10% of glycerin, 2%-15% of propylene glycol, 0.1%-4% of tween-80 or 0.4%-2% of sorbitan oleate, 0.5%-5% of alpha-tocopherol, 0.5%-5% of diisostearyl alcohol malate, 0.5%-6% of soybean phospholipid, 1%-10% of glycerin monostearate, 0.5%-10% of tetradecanol, 0.02%-0.1% of propyl hydroxybenzoate, 1%-10% of stearic acid, 0.5%-6% of stearyl alcohol and the balance water. Meanwhile, the invention also discloses a preparation method, experiments show that the external cream prepared by the invention has strong capacity of delivering tranexamic acid to the epidermal layer and can ensure that the tranexamic acid can be quickly absorbed by cells to take effect, and the defect that tranexamic acid is difficult to pass through skin cuticle obstacles due to strong hydrophilicity is overcome.

The invention discloses a preparation method and application of autologous fibrin glue, and belongs to the field of biomedical materials. The preparation method comprises the following five steps: collecting autologous venous blood, adding a sodium citrate anticoagulant with the volume ratio of 1: (8-12), and storing at 4-6 DEG C for not more than 2 hours; performing step-by-step centrifugation at the speed of 1500 to 2000 r / min and the speed of 3500 to 4000 r / min to obtain a fibrinogen concentrate; the thrombin-calcium chloride activation solution A and the tranexamic acid activation solution B are mixed according to the ratio of 1: (2-3) to form a composite activation system; mixing the two components according to a mass ratio of 1: (0.8-1.2), and reacting at 25-37 DEG C for 3-5 minutes to form colloid; and pre-freezing at-40 to-60 DEG C, performing vacuum freeze-drying, and storing at 4-8 DEG C. During application, the colloid can be coated on an operation wound surface after being redissolved, or mixed with a growth factor to prepare a dressing for covering a chronic wound surface. The colloid is high in purity, stable in coagulation time, long in storage period, suitable for scenes such as surgical hemostasis and the like, and high in clinical value.

The invention provides tranexamic acid-glutathione-containing compound emulsifiable paste and a preparation method thereof.W1 / O / W double emulsion phase structural design is adopted, reduced glutathione is encapsulated in an acidic inner water core, an oil phase is stabilized through hydrogenated lecithin and sorbitan sesquioleate, an outer water phase contains tranexamic acid, a layered gel network is constructed, and the tranexamic acid-glutathione-containing compound emulsifiable paste is prepared. A submicron dispersion system with the particle size D50 of 0.30-0.80 microns, the polydispersity index of 0.15-0.25 and the viscosity of 2.0-8.0 Pa seconds is realized, the encapsulation efficiency of glutathione is not lower than 70%, the oxygen content of a head space is not higher than 1.0%, and the encapsulation efficiency of glutathione is not lower than 70%. The three technical contradictions of coupling conflict between a high-yield viscoelastic structure and low-shear damage kernel integrity, coexistence of fresh and cool low-viscosity skin feeling and high-barrier anti-oxidation and anti-leakage and opposite low-surface-activity sensitive skin compatibility and submicron low-PDI dispersion stability are solved; the traditional Chinese medicine composition has wide application values of improving skin color unevenness, fading color spots, brightening skin color, soothing and repairing.

A majority of military casualties occur during the pre-hospital period. The cause of death is largely associated with massive traumatic bleeding that leads to organ damage due to sustained hypoxia. Currently, therapeutics are lacking at the point of injury to mitigate hypoxic damage and maintain the survivability of severe hemorrhage prior to reaching medical facilities. This invention addresses that by introducing a method of co-administering prolyl hydroxylase domain inhibitor (PHDi, MK-8617), anti-fibrinolytic agent (tranexamic acid), and bradykinin receptor antagonist (icatibant) as anti-hemorrhage agents in combination with resuscitation fluid treatment with colloid solution of 25% human albumin that has an advantage of relatively small volume requirement to maintain blood volume. In addition, a kit comprising anti-hemorrhage agents that can be easily carried to the battlefield is also provided here. The therapeutic application of those agents on or near the point of injury can stabilize hypoxia inducible factor-1 alpha and enhance blood clot formation, which improves the patient's cellular adaptation to hypoxia and reduce hemorrhage, and thus can decrease organ failure and increase the patient's survivability.

The invention discloses an external preparation of a microsphere-loaded medicine for treating chloasma and a preparation method of the external preparation. The preparation method comprises the following steps: preparing polyvinyl alcohol acrylate microspheres, loading a tranexamic acid medicine and adding a matrix to prepare the external preparation of the microsphere-loaded medicine. By means of oleophylic and hydrophilic segments on the polyvinyl alcohol acrylate microspheres, fusion with skin lipid components is increased, permeability of the medicine is improved, meanwhile, due to the large specific surface area of the microspheres, the medicine can be more evenly loaded on the microspheres, and due to the hydrophilicity of the microspheres, moisture can be kept for a longer time; and the problem of crystallization of tranexamic acid caused by moisture volatilization is well solved. The ointment or gel external preparation prepared by the invention is relatively good in character and stability, good in in-vitro permeation and in-vitro release performance and remarkable in treatment effect on chloasma of mice.

The invention discloses a microneedle-tranexamic acid nanofiber membrane and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: preparing a soluble microneedle (DMN) by utilizing a hydrophilic polymer polyvinylpyrrolidone (PVP), fixing the microneedle on an electrostatic spinning receiver, and carrying out electrostatic spinning by using an electrostatic spinning solution containing tranexamic acid TA to prepare a microneedle-tranexamic acid nanofiber membrane, namely TA-PVP-DMN. The prepared microneedle-tranexamic acid nanofiber membrane is simple in process and high in epidermal permeability, meanwhile, the safety problem caused by systemic administration of tranexamic acid can be avoided, and finally the purposes of safely and effectively improving facial pigmentation and treating chloasma can be achieved.

The invention provides whitening and moisturizing essence as well as a preparation process and application thereof, and belongs to the technical field of cosmetics. The essence is prepared from tranexamic acid, nicotinamide, macromolecular hyaluronic acid, micromolecular hyaluronic acid, hexapeptide-2, an althaea rosea flower extract, a rhodiola sachalinensis extract, a glycyrrhiza glabra extract, a coast pine needle extract, a polyhydric alcohol humectant, vegetable fat and the like. Wherein the hollyhock flower extract, the rhodiola sachalinensis extract, the glycyrrhiza glabra extract and the coast pine needle extract are respectively obtained by adopting a special enzymolysis method. The tranexamic acid and the nicotinamide are used for synergistically whitening, the hyaluronic acid, the polyhydric alcohols and the vegetable fat are used for jointly moisturizing, the plant extract is used for enhancing oxidation resistance, whitening and safety, the components are ensured to be uniform and stable through a reasonable preparation process, and the effect of the essence is favorably improved.

The invention relates to the field of external cosmetics for eyes, in particular to double-resistance eye cream and a preparation method thereof. The double-resistance eye cream is prepared from the following components in percentage by mass: 4-hydroxyethyl piperazine ethanesulfonic acid, betaine, dipropylene glycol, allantoin, a chelating agent and water, an ammonium acryloyldimethyl taurate / VP copolymer; the invention relates to a skin care product which is prepared from the following raw materials: cetostearyl alcohol wheat straw glycoside, cetostearyl alcohol, glyceryl stearate, PEG-100 stearate, caprylic / capric triglyceride, emblic leafflower fruit extract, polydimethylsiloxane, tocopheryl acetate and behenyl alcohol. Tranexamic acid; a whitening supplement; a bacteriostatic agent; and pine mushroom extract. Aiming at three causes causing periorbital problems, such as skin oxidation, skin saccharification and inflammatory reaction, through a multi-section target spot effect, multiple chains snip dark eyes, refine and lighten wrinkles, and restore elasticity, smoothness and brightness.

The invention relates to a whitening composition and a preparation method and application thereof, and belongs to the technical field of whitening products.The whitening composition contains a tea extract, raspberry ketone glucoside, an ascorbic acid derivative, nicotinamide, tranexamic acid, hydroxyethyl piperazine ethanesulfonic acid, an opuntia streptacantha stem extract and a saxifraga stolonifera extract. The tea leaf extract, the opuntia streptacantha stem extract and the saxifraga stolonifera extract are products which are obtained through step-by-step enzymolysis of specific enzymes and are less than 2kDa. On the basis that an existing whitening product generally only has a single path and is poor in whitening effect, multiple whitening active raw materials are matched, multiple whitening paths with different action mechanisms are combined, the synergistic effect is achieved, the skin pigment problem caused by multiple factors is better solved, and safety and high efficiency are achieved.

The invention belongs to the technical field of cosmetic preparations, and particularly relates to a composition containing triethanolamine and tranexamic acid modified hydroxytyrosol as well as a preparation method and application of the composition. According to the invention, hydroxytyrosol is modified by using triethanolamine and tranexamic acid through etherification and esterification reactions, the processing mode obviously enhances the electrification capability of hydroxytyrosol, and further obviously enhances the antibacterial strength of hydroxytyrosol, so that hydroxytyrosol is compounded with triethanolamine and tranexamic acid to replace a traditional preservative, and the antibacterial property of hydroxytyrosol is improved. And adverse reactions such as irritation and allergy of common preservatives are improved. According to the invention, the hydroxytyrosol is modified by using triethanolamine and tranexamic acid, and triethanolamine and tranexamic acid are functional components, so that triethanolamine and tranexamic acid can play roles in resisting oxidation, whitening and the like together with hydroxytyrosol in a cosmetic matrix while playing a role in improving the bacteriostasis of hydroxytyrosol.

The invention provides an analysis and detection method for simultaneously detecting tretinoin and tranexamic acid and application thereof, and the method comprises the following steps: analyzing a to-be-detected sample containing tretinoin and tranexamic acid by using ultra-high performance liquid chromatography-triple quadrupole mass spectrometry to realize qualitative and quantitative detection of tretinoin and tranexamic acid. The analysis and detection method provided by the invention has the characteristics of high sensitivity and precision, good repeatability, high accuracy, strong stability and the like. The detection method disclosed by the invention can be easily transferred and applied to detection of two compounds in biological samples such as plasma and tissue homogenate, and can meet the requirement on drug concentration monitoring.

The present invention addresses the problem of improving the change in smell of stearyl glycyrrhetinate,. This composition is characterized by containing components (A)–(C). (A) Stearyl glycyrrhetinate, (B) niacinamide or tranexamic acid, and (C) at least one compound selected from the group that consists of anisyl alcohol, farnesol, eugenol, citronellol, α-pinene, 1-hexanol (hexen-1-ol), linalool, cedryl acetate, Iso E Super, Sandalore, Ambroxan, γ-terpinene, ambrettolide, β-ionone, borneol, isobutyl quinoline, citral, guaiacol, patchouli alcohol, cedrol, ethyl vanillin, maltol, linalyl acetate, α-terpineol, benzyl benzoate, damascenone, anisaldehyde, benzaldehyde, Magnolan, Mayol, phenylacetaldehyde dimethyl acetal, nerol, dimethyl benzyl carbinol, Bacdanol, methyl anthranilate, Muscenone, benzyl acetate, phenylethyl alcohol, phenylethyl acetate, and heliotropine.

The invention provides a multi-stage synergistic wound repair nanofiber membrane and a preparation method thereof. The composite fiber membrane sequentially comprises an electrostatic spinning pullulan / tannic acid / tranexamic acid nanofiber membrane for promoting the formation of blood clots, a polydopamine / calcium chloride modified electrostatic spinning cellulose acetate membrane with coagulating, antibacterial and repairing effects, and a chitosan composite cellulose non-woven fabric, and the electrostatic spinning pullulan / tannic acid / tranexamic acid nanofiber membrane is a wound surface contact layer. The nanofiber membrane has the functions of a physical hemostasis barrier and continuously releasing regeneration promoting biological signals, and a dynamic hemostasis healing process is formed.

The invention belongs to the technical field of cosmetics, and particularly relates to whitening and freckle-removing essence oil and a preparation method thereof. According to the invention, adamantane formyl is introduced into an alpha-arbutin benzene ring to obtain the adamantane formyl modified alpha-arbutin derivative, so that the compatibility of alpha-arbutin and base oil is enhanced; the alpha-arbutin is prevented from being converted into hydroquinone by utilizing the large steric effect of adamantane formyl, so that the safety of the whitening and freckle-removing essence oil is improved; the tranexamic acid is wrapped by the ceramide nano-emulsion, so that the skin allergy risk caused by ingestion of the tranexamic acid is reduced; the ceramide nano-emulsion and tranexamic acid act together to repair skin collagenous fibers, block melanin transfer and inhibit melanin synthesis; trilinolein and glabridin are catalyzed by lipase to form a compound, so that the molecular compatibility and photo-thermal stability of glabridin are enhanced; glycerin promotes transdermal absorption of glabridin and enhances the efficacy of the whitening and freckle-removing essence oil.

The invention relates to the technical field of skin care products, in particular to a composition with a whitening effect, which is prepared from the following components in percentage by weight: 15 to 40.0 percent of tranexamic acid, 20.0 to 30.0 percent of hydroxyethyl piperazine ethanesulfonic acid, 1.0 to 10.0 percent of carnosine and 0.01 to 0.1 percent of nonapeptide-1. According to the composition disclosed by the invention, tranexamic acid, carnosine and nonapeptide-1 are compounded according to a specific proportion and have a synergistic effect, the activity of tyrosinase is inhibited, and then cutin is mildly exfoliated through hydroxyethyl piperazine ethanesulfonic acid, so that the composition can whiten skin more quickly and mildly. In addition, the composition with the whitening effect has the effect of temporarily brightening the skin color, has the whitening effect after being used for a long time, and is mild and non-irritant to the skin, safe to use and good in stability.