External-use and oral-use composition comprising tranexamic acid

A technology of tranexamic acid and composition, which is applied in the field of compositions for external use and internal use, can solve problems such as a large number of components, and achieve the effect of inhibiting crystal precipitation

Active Publication Date: 2013-05-15
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the compositions described in these documents have a large number of components to b

Method used

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  • External-use and oral-use composition comprising tranexamic acid
  • External-use and oral-use composition comprising tranexamic acid
  • External-use and oral-use composition comprising tranexamic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 16

[0176] Embodiment 16: lotion

[0177] The ingredients in Table 7 below were mixed, dissolved and adjusted in purified water. The pH is 6.7.

[0178] [Table 7]

[0179] Tranexamic acid

Embodiment 17

[0180] Example 17: Emulsion

[0181] The composition shown in Table 8 below is a mixture of tranexamic acid, gluconic acid, glycerin, 1,3-butanediol, SEPIGEL 305, polyoxyethylene sorbitan isostearate (20EO), xanthan gum, hydroxyl Benzyl ester, disodium edetate and purified water were used as the water phase, and tri(caprylyl caprylic acid) glycerin, stearyl alcohol, glyceryl monostearate and propylparaben were mixed as the oil phase, and each phase was After heating and stirring to make it uniform, the water phase and the oil phase are mixed to emulsify, and after cooling, spices are added for adjustment. The pH is 4.7.

[0182] [Table 8]

[0183] Tranexamic acid

Embodiment 18

[0184] Example 18: Gel

[0185] The ingredients in Table 9 below were mixed in purified water for adjustment. The pH is 5.8.

[0186] [Table 9]

[0187] Tranexamic acid

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PUM

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Abstract

The invention discloses an external-use and oral-use composition. The composition comprises a tranexamic acid or a pharmaceutically-acceptable salt thereof, and a polyhydroxy acid or a pharmaceutically-acceptable salt, and also comprises polyhydric alcohol and/or a water-soluble polymer according to the condition.

Description

technical field [0001] The present invention relates to an external and internal composition containing tranexamic acid or a pharmaceutically acceptable salt thereof. Background technique [0002] Tranexamic acid has a hemostatic effect and an anti-inflammatory effect, and is used as an active ingredient in pharmaceutical oral preparations, injections, and external preparations, and is also used as an active ingredient in toothpaste and the like. In addition, it has the effect of improving rough skin, so it can also be mixed into cosmetics. In addition, tranexamic acid has an effect of inhibiting pigmentation, so it is also widely used as a cosmetic whitening ingredient. [0003] However, tranexamic acid has very high crystallinity, and when it is mixed into a water-containing composition such as an external skin preparation or an internal administration preparation, crystals tend to precipitate near the mouth of the container during repeated use. Among them, when the cont...

Claims

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Application Information

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IPC IPC(8): A61K31/195A61K47/12A61P7/04A61P29/00A61K8/44A61K8/365A61Q1/00
Inventor 近田佳奈稻冈贤大野琴水垂阳子
Owner ROHTO PHARM CO LTD
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