Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

External-use and oral-use composition comprising tranexamic acid

A technology of tranexamic acid and composition, which is applied in the field of compositions for external use and internal use, can solve problems such as a large number of components, and achieve the effect of inhibiting crystal precipitation

Active Publication Date: 2013-05-15
ROHTO PHARM CO LTD
View PDF6 Cites 21 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the compositions described in these documents have a large number of components to be added in order to suppress the crystallization of tranexamic acid, and there are great limitations.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • External-use and oral-use composition comprising tranexamic acid
  • External-use and oral-use composition comprising tranexamic acid
  • External-use and oral-use composition comprising tranexamic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 16

[0176] Embodiment 16: lotion

[0177] The ingredients in Table 7 below were mixed, dissolved and adjusted in purified water. The pH is 6.7.

[0178] [Table 7]

[0179] Tranexamic acid

Embodiment 17

[0180] Example 17: Emulsion

[0181] The composition shown in Table 8 below is a mixture of tranexamic acid, gluconic acid, glycerin, 1,3-butanediol, SEPIGEL 305, polyoxyethylene sorbitan isostearate (20EO), xanthan gum, hydroxyl Benzyl ester, disodium edetate and purified water were used as the water phase, and tri(caprylyl caprylic acid) glycerin, stearyl alcohol, glyceryl monostearate and propylparaben were mixed as the oil phase, and each phase was After heating and stirring to make it uniform, the water phase and the oil phase are mixed to emulsify, and after cooling, spices are added for adjustment. The pH is 4.7.

[0182] [Table 8]

[0183] Tranexamic acid

Embodiment 18

[0184] Example 18: Gel

[0185] The ingredients in Table 9 below were mixed in purified water for adjustment. The pH is 5.8.

[0186] [Table 9]

[0187] Tranexamic acid

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an external-use and oral-use composition. The composition comprises a tranexamic acid or a pharmaceutically-acceptable salt thereof, and a polyhydroxy acid or a pharmaceutically-acceptable salt, and also comprises polyhydric alcohol and / or a water-soluble polymer according to the condition.

Description

technical field [0001] The present invention relates to an external and internal composition containing tranexamic acid or a pharmaceutically acceptable salt thereof. Background technique [0002] Tranexamic acid has a hemostatic effect and an anti-inflammatory effect, and is used as an active ingredient in pharmaceutical oral preparations, injections, and external preparations, and is also used as an active ingredient in toothpaste and the like. In addition, it has the effect of improving rough skin, so it can also be mixed into cosmetics. In addition, tranexamic acid has an effect of inhibiting pigmentation, so it is also widely used as a cosmetic whitening ingredient. [0003] However, tranexamic acid has very high crystallinity, and when it is mixed into a water-containing composition such as an external skin preparation or an internal administration preparation, crystals tend to precipitate near the mouth of the container during repeated use. Among them, when the cont...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/195A61K47/12A61P7/04A61P29/00A61K8/44A61K8/365A61Q1/00
Inventor 近田佳奈稻冈贤大野琴水垂阳子
Owner ROHTO PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com