95 results about "Cyclic acid" patented technology

The present invention discloses a method for recovering vanadium by deep leaching from vanadium extraction tailings. The vanadium extraction tailings are subjected to low-pH acid leaching and reduction to reduce the vanadium to a low-valent state. The vanadium concentration is then continuously increased through cyclic acid leaching. Finally, the vanadium is oxidized to a pentavalent state by adjusting the pH and adding an oxidant. Ultimately, a stable and high-concentration pentavalent vanadium is obtained.

The invention discloses a preparation method and application of autologous fibrin glue, and belongs to the field of biomedical materials. The preparation method comprises the following five steps: collecting autologous venous blood, adding a sodium citrate anticoagulant with the volume ratio of 1: (8-12), and storing at 4-6 DEG C for not more than 2 hours; performing step-by-step centrifugation at the speed of 1500 to 2000 r / min and the speed of 3500 to 4000 r / min to obtain a fibrinogen concentrate; the thrombin-calcium chloride activation solution A and the tranexamic acid activation solution B are mixed according to the ratio of 1: (2-3) to form a composite activation system; mixing the two components according to a mass ratio of 1: (0.8-1.2), and reacting at 25-37 DEG C for 3-5 minutes to form colloid; and pre-freezing at-40 to-60 DEG C, performing vacuum freeze-drying, and storing at 4-8 DEG C. During application, the colloid can be coated on an operation wound surface after being redissolved, or mixed with a growth factor to prepare a dressing for covering a chronic wound surface. The colloid is high in purity, stable in coagulation time, long in storage period, suitable for scenes such as surgical hemostasis and the like, and high in clinical value.

The invention provides tranexamic acid-glutathione-containing compound emulsifiable paste and a preparation method thereof.W1 / O / W double emulsion phase structural design is adopted, reduced glutathione is encapsulated in an acidic inner water core, an oil phase is stabilized through hydrogenated lecithin and sorbitan sesquioleate, an outer water phase contains tranexamic acid, a layered gel network is constructed, and the tranexamic acid-glutathione-containing compound emulsifiable paste is prepared. A submicron dispersion system with the particle size D50 of 0.30-0.80 microns, the polydispersity index of 0.15-0.25 and the viscosity of 2.0-8.0 Pa seconds is realized, the encapsulation efficiency of glutathione is not lower than 70%, the oxygen content of a head space is not higher than 1.0%, and the encapsulation efficiency of glutathione is not lower than 70%. The three technical contradictions of coupling conflict between a high-yield viscoelastic structure and low-shear damage kernel integrity, coexistence of fresh and cool low-viscosity skin feeling and high-barrier anti-oxidation and anti-leakage and opposite low-surface-activity sensitive skin compatibility and submicron low-PDI dispersion stability are solved; the traditional Chinese medicine composition has wide application values of improving skin color unevenness, fading color spots, brightening skin color, soothing and repairing.

The invention discloses a microneedle-tranexamic acid nanofiber membrane and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: preparing a soluble microneedle (DMN) by utilizing a hydrophilic polymer polyvinylpyrrolidone (PVP), fixing the microneedle on an electrostatic spinning receiver, and carrying out electrostatic spinning by using an electrostatic spinning solution containing tranexamic acid TA to prepare a microneedle-tranexamic acid nanofiber membrane, namely TA-PVP-DMN. The prepared microneedle-tranexamic acid nanofiber membrane is simple in process and high in epidermal permeability, meanwhile, the safety problem caused by systemic administration of tranexamic acid can be avoided, and finally the purposes of safely and effectively improving facial pigmentation and treating chloasma can be achieved.

Disclosed in the present invention is a method for removing inclusions inside roughing quartz particles of hematite tailings. The method comprises the following steps: S1: roasting and water quenching: roasting the roughing quartz particles of hematite tailings at 650-700 °C for 2-5 hours, followed by water quenching; S2: grinding: grinding the water-quenched quartz particles in step S1 to 500-400 meshes; S3: magnetic separation: removing mineral inclusions from the quartz particles obtained in step S2 by means of a superconducting high-gradient magnetic separator; S4: roasting: roasting the quartz particles obtained in step S3 at 1000-1250 °C for 2-5 hours, followed by cooling, and then roasting at 750-1000 °C for 4-5 hours, the step being repeated 3-5 times; and S5: acid leaching: subjecting the quartz particles obtained in step S4 to three-stage cyclic acid leaching to remove mineral and gas-liquid inclusions from the quartz particles, so as to obtain high-purity quartz sand. The high-purity quartz prepared by the present invention has a SiO2 grade as high as 99.9% or above, which meets the standard of refined quartz sand, thereby effectively achieving the purpose of high-value and resource utilization of hematite tailings.

The invention relates to a composition for expanding and increasing yield of rhizome crops, a soluble concentrate and application of the soluble concentrate, and belongs to the technical field of plant growth regulators. The composition consists of a prohexadione active substance and a dihydrojasmonic acid active substance, the mass ratio of the prohexadione active substance to the dihydrojasmonic acid active substance is (0.5-25): 1; the prohexadione active substance is prohexadione and / or a soluble salt thereof; the dihydrojasmonic acid active substance is dihydrojasmonic acid and / or soluble salt thereof. The composition is taken as an effective component, a growth regulator is provided, water is taken as a solvent, and auxiliary agents known by technicians in the field are supplemented, so that a soluble concentrate is prepared. The soluble concentrate has the advantages of being environmentally friendly, convenient to process, convenient to use and the like while efficiently achieving swelling and yield increasing effects of root crops, and the problems that special dosage forms need to be prepared in the using process of prohexadione calcium, so that the production cost is high, and use is inconvenient are effectively solved.

The application relates to a preparation method of 2-amino-6-hydroxypyridine compounds and intermediates thereof, and belongs to the field of organic synthesis. The preparation method of the 2-amino-6-hydroxypyridine compounds comprises the following steps: 1) in a first organic solvent, compound II is reacted with a cyclic acid anhydride reagent A to prepare compound III; 2) in a second organic solvent, in the presence of an oxidizing reagent, compound III is subjected to an oxidation reaction to prepare compound IV; 3) in a third organic solvent, in the presence of an acid anhydride dehydrating reagent, compound IV is subjected to a reaction to prepare compound V; 4) in a fourth solvent, in the presence of a reducing agent, compound V is subjected to a reduction reaction to prepare compound I; and compound I is a 2-amino-6-hydroxypyridine compound. The preparation method of the 2-amino-6-hydroxypyridine compounds provided by the application can obtain a higher yield through mild reaction conditions, and is simple and convenient to operate, and is beneficial to industrial utilization.

The invention discloses a preparation process of trans-tranexamic acid, which comprises the following steps: S1, enzymatic conversion of cyanobenzoic acid: adding tap water into a reaction flask, adding a substrate terephthalonitrile, stirring and dispersing, adding an immobilized enzyme, reacting for 4 hours, filtering, collecting filtrate, and carrying out suction filtration to obtain a filter cake which is the immobilized enzyme, collecting and putting into the next batch of reaction; s2, hydrogenating p-cyanobenzoic acid to prepare aminomethylbenzoic acid; s3, hydrogenating aminomethylbenzoic acid to prepare cis-trans-tranexamic acid; and S4, performing high-temperature transformation to obtain trans-tranexamic acid. According to the preparation method of trans-tranexamic acid, by optimizing reaction conditions and technological processes, the yield and purity of a target product can be improved, generation of by-products is reduced, and the subsequent purification difficulty is lowered; cleaner raw materials are used, less harmful solvents are used, less wastes are generated, and the influence on the environment is favorably reduced; the high-efficiency process can complete production under low energy consumption, reduces energy consumption, and meets the requirements of green chemistry.

The present application provides an organosilicon thermally conductive phase-change material and a preparation method thereof. The organosilicon thermally conductive phase-change material comprises, by mass, 100 parts of ethylene cyclocarbonate-modified organopolysiloxane, 64-115 parts of amino-modified organopolysiloxane, 5.5-12 parts of cyclic acid anhydride, 2-5 parts of antioxidant, 1.5-3 parts of silane coupling agent, and 300-800 parts of thermally conductive powder. The present application does not contain a phase-change material, fundamentally solving the problem of easy leakage of phase-change materials. The cross-linked network is formed by the reaction of ethylene cyclocarbonate-modified organopolysiloxane and amino-modified organopolysiloxane. The cyclic carbonate group reacts with the amino group to produce carbamate groups and hydroxyl groups, and the cyclic acid anhydride reacts with the amino group to produce amide groups and carboxyl groups. As a result, the cross-linked network contains a large number of polar groups. At room temperature, these polar groups further form a cross-linked network. When heated, the cross-linked network weakens, and the phase-change material becomes viscous, achieving the phase-change function.

The invention relates to a preparation method of a tranexamic acid hydrogel microneedle. The preparation method comprises the following steps: 1) preparing a PDMS microneedle female template; 2) preparing a blank hydrogel microneedle; 3) preparation of the drug-containing hydrogel microneedle: dissolving tranexamic acid and derivatives or analogues thereof in ultrapure water, with the content range of the tranexamic acid and derivatives or analogues thereof being 0.1-30 mg / tablet, and preparing a drug solution with the mass concentration of the tranexamic acid and derivatives or analogues thereof being 0.1 g / mL, and (3) uniformly pouring the medicine solution into the blank hydrogel microneedle mold prepared in the step (2), then drying and forming at 37 DEG C, and finally, demolding the dried microneedle from the mold to obtain the tranexamic acid hydrogel microneedle. According to the tranexamic acid hydrogel microneedle, tranexamic acid can directly reach a skin basal layer, the tranexamic acid hydrogel microneedle can load and deliver more tranexamic acid, the treatment effect is remarkably enhanced, long-time slow release is achieved, and the tranexamic acid hydrogel microneedle has remarkable social and economic benefits.

A method for enhancing solubility of tranexamic acid comprising the following steps:a) Initially dissolving tranexamic acid in water;b) Measuring a pH value of the solution obtained in Step (a);c) Addition of a strong acid (that dissociates completely in water) to the solution obtained in Step (a) and simultaneously monitoring the decrease in the pH value of the solution until approximately pH 4.5 or less than pH 4.5 is reached, to increase solubility of tranexamic acid;d) Addition of tranexamic acid to reach the pH value of the solution obtained in Step (c) above the pH 2.0; ande) Repeating Steps (c) and (d) until a desired amount of tranexamic acid is added to the solution of Step (a), that is a desired concentration of tranexamic acid in the final solution is reached.

The present application relates to the field of cosmetic technology, and more particularly to a full-link whitening and freckle-removing liposome and a preparation method thereof, the liposome comprising the following components: an aqueous phase, a membrane material and an oil phase. In the preparation process, 4-butyl resorcinol, nonapeptide-1, acetylchitosamine and ascorbic acid tetraisopalmitate are combined to form a full-link effect of signal inhibition-synthesis blockage-blocked conversion-metabolic acceleration, and a multi-target whitening and freckle-removing system is constructed. In addition, tranexamic acid, hydrolyzed yeast protein and schizophyllan are combined to synergistically make the finished product have excellent soothing and moisturizing effects. Furthermore, the finished product is prepared into a liposome capable of encapsulating active ingredients, which effectively improves the stability of the active ingredients, prevents their oxidation and inactivation, and the liposome structure is highly similar to the human cell membrane, is easy to penetrate the keratin layer gap, realizes targeted delivery to the deep layer of the epidermis, and makes the active ingredients truly act on the required site.

The present disclosure relates to the technical field of concrete additive, and particularly relates to a concrete retarding water reducing agent and a preparation method and application thereof; the concrete retarding water reducing agent comprises a compound A, a component B, a component C and a solvent D; wherein the structural formula of the compound A comprises a polyphosphate chain segment and a polyether chain segment; the polyphosphate chain segment and the polyether chain segment are connected through a residue of a cyclic acid anhydride; the component B comprises the following: sodium lignosulfonate, sodium dodecyl sulfate, sodium gluconate and at least one organic acid; the component C comprises at least two of the following: borax, calcium silicate, fiber, magnesium sulfate and calcium chloride; and the solvent D is a mixture of water and an organic solvent. The present disclosure provides a novel concrete-based additive which can simultaneously play a good retarding and water reducing role.

The invention belongs to the field of plant growth regulators, and particularly relates to prohexadione soluble powder and a preparation method thereof. The preparation method of the prohexadione soluble powder comprises the following steps: mixing prohexadione and inorganic base in a solvent until the solution is clear, and then carrying out any one of the following treatments: (1) removing the solvent, and then uniformly mixing with an anti-caking agent; and (2) adding anhydrous magnesium sulfate, uniformly mixing, and drying. The prohexadione and the inorganic base are mixed to enhance the water solubility, and then the anti-caking agent and the anhydrous magnesium sulfate are used for treatment to improve the heat storage stability; the prohexadione soluble powder prepared by the method is good in water solubility, does not separate out, is good in normal temperature and heat storage stability, and meets the use and storage requirements of typical soluble powder.

By preparing an external preparation containing (A) at least one selected from tranexamic acid, tranexamic acid derivatives, and salts thereof, and (B) at least one selected from arginine, aspartic acid, glutamic acid, glycine, proline, serine, threonine, γ-aminobutyric acid, their derivatives, and salts of their derivatives, crystallization of tranexamic acid can be inhibited.

The application discloses an amino acid surfactant with hemostatic function and a preparation method thereof. The method is to make the tranexamic acid and long aliphatic acyl chloride undergo condensation reaction under the action of alkali, and then perform acidification and esterification reaction to obtain the amino acid surfactant with hemostatic function. Compared with the long-chain fatty acyl thrombin acid salt reported in the prior art, the amino acid surfactant has good fat solubility, better transdermal permeability and better toner dispersibility. The preparation method has mild reaction conditions, simple operation, simple product separation and purification and high yield, and is suitable for industrial production.

To provide a pharmaceutical composition having excellent anti-inflammatory action.SOLUTION: A pharmaceutical composition contains (a) fexofenadine or salt thereof; (b) tranexamic acid or salt thereof; and (c) one or more selected from ephedrine or a derivative thereof or a salt thereof, and caffeine.SELECTED DRAWING: None

Concentrated tranexamic acid compositions suitable for intramuscular administration via auto-injector are provided. The concentrated tranexamic acid compositions enable the use of a syringe and an auto-injector to facilitate rapid, reliable, and simple self or buddy administration, under extreme duress on the battlefield, by minimally trained users. Methods of treating non-compressible hemorrhage are also provided. Kits and auto-injectors comprising the tranexamic acid compositions are further provided.

The invention belongs to the technical field of skin care products, and particularly relates to a skin care mask and a preparation method thereof. The skin care mask is prepared from the following raw materials: glycerol, low-molecular sodium hyaluronate, high-molecular sodium hyaluronate, allantoin, nicotinamide, arbutin, tranexamic acid, glucose, squalane, tocopherol, carbomer, resveratrol, panthenol, 1, 3-butanediol, triethanolamine, citric acid, an emulsifier, a preservative and deionized water. The mask product is comprehensive in effect and has the functions of moisturizing, whitening and brightening, resisting oxidation and the like; the composition is mild and stable and adapts to sensitive skin; and the cream is light in texture, good in ductility, non-sticky in thick application and good in use feeling.

The invention relates to a high-efficiency hemostatic antibacterial gel dressing, which is prepared from the following raw materials: 4-carboxyphenylboronic acid-based chitosan, drug aldehyde, methacrylic acid esterified gelatin and tranexamic acid, wherein the 4-carboxyphenylboronic acid-based chitosan and the methacrylic acid esterified gelatin are dissolved in water to form a solution A; protocatechuic aldehyde and tranexamic acid are dissolved in water to form a solution B, the solution A and the solution B are rapidly and uniformly mixed to form a pre-injection solution before treatment, the pre-injection solution is injected to the surface of a wound surface so that the dressing can be cured and formed in situ, after forming, the dressing can effectively adhere to the skin and release drugs, rapid hemostasis and antibiosis are achieved, and the dressing can be degraded in about 10 days in a physiological solution environment; the gel dressing can be widely applied to treatment of different trauma wounds.

The application provides a tranexamic acid-glutathione compound cream and a preparation method thereof, adopts a W1 / O / W double emulsion phase structure design, encapsulates reduced glutathione in an acidic inner water core, stabilizes an oil phase by using hydrogenated lecithin and sorbitan sesquioleate, and constructs a lamellar gel network in an outer water phase containing tranexamic acid, so as to realize a sub-micron dispersion system with a particle size D50 of 0.30-0.80 microns, a polydispersity index of 0.15-0.25 and a viscosity of 2.0-8.0 Pa seconds, the encapsulation rate of glutathione is not less than 70%, and the headspace oxygen content is not higher than 1.0%, three technical contradictions of a high yield viscoelastic structure and a low shear damage inner core integrity coupling conflict, a smooth low skin feeling and a high barrier anti-oxidation and anti-leakage coexistence problem and a low surface activity sensitive skin compatibility and a sub-micron low PDI dispersion stability are solved, and the application has wide application values of improving uneven skin color, lightening color spots, brightening skin color and soothing and repairing.

The invention discloses a relapse anti-pigment and anti-scar drug dressing and a preparation method and a use method thereof, and relates to the technical field of medical dressings, the relapse anti-pigment and anti-scar drug dressing comprises a dressing matrix drug bag and a supplement bag, the dressing matrix drug bag is filled with dressing matrix drug slurry, and the amount of the supplement bag is calculated according to each part of the dressing. The dressing matrix medicine slurry is composed of 1-2 g of tranexamic acid, 1-3 g of vitamin B3, 1-3 g of vitamin E, 8-12 g of gallnut, 12-16 g of salvia miltiorrhiza, 4-8 g of angelica sinensis, 4-5 g of moutan bark and 15-30 ml of sterilized normal saline, and 1-3 g of vitamin C and 8-12 g of xanthan gum are contained in the supplement bag. The dressing obtained by the invention has excellent depigmentation and scar prevention effects on burnt and healed skin.

The application discloses the use of a bifunctional chiral palladium catalyst that enables remote γ- and d-methylene C-H (hetero)arylation of cyclic carbocyclic acids. Specifically, the application discloses methods of enantioselective remote γ-C-H arylation or heteroarylation, δ-C-H arylation or heteroarylation, or sequential γ-methylene C-H arylation or heteroarylation of diverse free cycloalkane carboxylic acids comprising the use of palladium catalysts with chiral oxazoline-pyridone ligands.

The present disclosure is generally directed to solutions comprising tranexamic acid (TXA). The invention is also directed to the use of the solutions comprising tranexamic acid provided herein for the treatment of hemorrhage in a subject.

The invention provides a recombinant collagen patch for treating facial dermatitis and eczema and fading pigmentation and a preparation method of the recombinant collagen patch. The application comprises a base material layer and a functional composition loaded on the base material layer, wherein the functional composition comprises recombinant human collagen III, an anti-inflammatory active component and a whitening active component. Wherein the anti-inflammatory active component is a compound of ganoderma sinensis spore powder zymolyte, dipotassium glycyrrhizinate and asiaticoside in a specific mass ratio, and the whitening active component is an alpha-arbutin-ferulic acid condensate and a compound of tranexamic acid and glabridin in a specific mass ratio. And the base material layer is alginate-sodium carboxymethyl cellulose composite hydrogel which is modified by gamma-ray irradiation. Through the synergistic effect of all the active ingredients and the optimized preparation process, the multiple effects of resisting inflammation, repairing a barrier and fading hyperpigmentation are achieved, and the product is good in biocompatibility and remarkable in effect.

This invention discloses a tetrahedral framework nucleic acid complex carrying tranexamic acid and its applications. The complex is formed by mixing tetrahedral framework nucleic acid and tranexamic acid; the molar ratio of tetrahedral framework nucleic acid to tranexamic acid is 1:(150-170). Research shows that the tetrahedral framework nucleic acid can successfully bind to tranexamic acid and exhibits a significant synergistic effect; the complex can effectively reduce melanin content, inhibit skin pigmentation, and protect skin structure, thus improving skin pigmentation-related diseases. This invention provides a novel tranexamic acid delivery strategy, offering a new technical means for developing products that effectively improve skin pigmentation and protect skin structure.

The present application discloses a method for synthesizing a high-silica mordenite zeolite molecular sieve with better accessibility of reactive sites and its application, belonging to the field of molecular sieves. A method for synthesizing a high-silica mordenite zeolite molecular sieve with better accessibility of reactive sites includes the following steps: S1, obtaining a silicon-boron precursor made from a mother liquor concentrate and a boron source; S2, obtaining an aluminum-containing alkaline solution; S3, hydrothermally crystallizing a mixture containing the silicon-boron precursor and the alkaline solution to obtain a product; S4, performing heat treatment and / or acid treatment on the above product under water vapor to obtain the high-silica mordenite zeolite molecular sieve. This method improves the acid strength and the proportion of 8-membered ring acids while making the low-temperature activity of the reaction better; the solid waste in the molecular sieve synthesis is greatly reduced; the sewage treatment cost in the large-scale production of the molecular sieve is reduced; the initial reaction temperature is significantly lower than the current one under the same conditions; the single-pass life of the catalyst can be greatly improved.

This invention provides a novel method for producing crystals composed of ibuprofen and tranexamic acid. [Solution] A method for producing crystals consisting of ibuprofen and tranexamic acid, (1 ) An aqueous solution containing ethanol at a concentration of 65 w / w% or more and less than 100 w / w%, containing ibuprofen and Add a mixed powder of ibuprofen and tranexamic acid, or add the aqueous solution to the mixed powder, The ratio of the content of the aqueous solution to the total mass of fen and tranexamic acid is 0.09 mL. (1) To obtain a mixture that is 1 / g or more, and (2) To produce the crystals from the obtained mixture. A manufacturing method that includes [the ingredient].

The invention discloses a tranexamic acid and peptomidol composition and a preparation. The composition is formed by compounding tranexamic acid and peptidomil, the tranexamic acid and the peptidomil have a synergistic effect, the whitening and freckle-removing effects on skin are better, a preparation containing the composition has better skin compatibility, better stability and an in-vitro release effect during use, and the composition can be used for preparing freckle-removing and whitening cosmetics or medicines.

To provide a tranexamic acid -, ascorbic acid -, calcium pantothenate -, L-cysteine - and pyridoxine hydrochloride-containing tablet suppressed in discoloration and free from tableting trouble.SOLUTION: The tablet contains a granulated material A and a granulated material B and has a water content of ≤ 2%, wherein the granulated material A contains tranexamic acid and calcium pantothenate, the granulated material B contains ascorbic acid, and the granulated materials A and B separately contain L-cysteine and pyridoxine hydrochloride.SELECTED DRAWING: None