35 results about "Cyclic acid" patented technology

The present application relates to the field of cosmetic technology, and more particularly to a full-link whitening and freckle-removing liposome and a preparation method thereof, the liposome comprising the following components: an aqueous phase, a membrane material and an oil phase. In the preparation process, 4-butyl resorcinol, nonapeptide-1, acetylchitosamine and ascorbic acid tetraisopalmitate are combined to form a full-link effect of signal inhibition-synthesis blockage-blocked conversion-metabolic acceleration, and a multi-target whitening and freckle-removing system is constructed. In addition, tranexamic acid, hydrolyzed yeast protein and schizophyllan are combined to synergistically make the finished product have excellent soothing and moisturizing effects. Furthermore, the finished product is prepared into a liposome capable of encapsulating active ingredients, which effectively improves the stability of the active ingredients, prevents their oxidation and inactivation, and the liposome structure is highly similar to the human cell membrane, is easy to penetrate the keratin layer gap, realizes targeted delivery to the deep layer of the epidermis, and makes the active ingredients truly act on the required site.

The present disclosure relates to the technical field of concrete additive, and particularly relates to a concrete retarding water reducing agent and a preparation method and application thereof; the concrete retarding water reducing agent comprises a compound A, a component B, a component C and a solvent D; wherein the structural formula of the compound A comprises a polyphosphate chain segment and a polyether chain segment; the polyphosphate chain segment and the polyether chain segment are connected through a residue of a cyclic acid anhydride; the component B comprises the following: sodium lignosulfonate, sodium dodecyl sulfate, sodium gluconate and at least one organic acid; the component C comprises at least two of the following: borax, calcium silicate, fiber, magnesium sulfate and calcium chloride; and the solvent D is a mixture of water and an organic solvent. The present disclosure provides a novel concrete-based additive which can simultaneously play a good retarding and water reducing role.

Concentrated tranexamic acid compositions suitable for intramuscular administration via auto-injector are provided. The concentrated tranexamic acid compositions enable the use of a syringe and an auto-injector to facilitate rapid, reliable, and simple self or buddy administration, under extreme duress on the battlefield, by minimally trained users. Methods of treating non-compressible hemorrhage are also provided. Kits and auto-injectors comprising the tranexamic acid compositions are further provided.

The invention relates to a high-efficiency hemostatic antibacterial gel dressing, which is prepared from the following raw materials: 4-carboxyphenylboronic acid-based chitosan, drug aldehyde, methacrylic acid esterified gelatin and tranexamic acid, wherein the 4-carboxyphenylboronic acid-based chitosan and the methacrylic acid esterified gelatin are dissolved in water to form a solution A; protocatechuic aldehyde and tranexamic acid are dissolved in water to form a solution B, the solution A and the solution B are rapidly and uniformly mixed to form a pre-injection solution before treatment, the pre-injection solution is injected to the surface of a wound surface so that the dressing can be cured and formed in situ, after forming, the dressing can effectively adhere to the skin and release drugs, rapid hemostasis and antibiosis are achieved, and the dressing can be degraded in about 10 days in a physiological solution environment; the gel dressing can be widely applied to treatment of different trauma wounds.

The application provides a tranexamic acid-glutathione compound cream and a preparation method thereof, adopts a W1 / O / W double emulsion phase structure design, encapsulates reduced glutathione in an acidic inner water core, stabilizes an oil phase by using hydrogenated lecithin and sorbitan sesquioleate, and constructs a lamellar gel network in an outer water phase containing tranexamic acid, so as to realize a sub-micron dispersion system with a particle size D50 of 0.30-0.80 microns, a polydispersity index of 0.15-0.25 and a viscosity of 2.0-8.0 Pa seconds, the encapsulation rate of glutathione is not less than 70%, and the headspace oxygen content is not higher than 1.0%, three technical contradictions of a high yield viscoelastic structure and a low shear damage inner core integrity coupling conflict, a smooth low skin feeling and a high barrier anti-oxidation and anti-leakage coexistence problem and a low surface activity sensitive skin compatibility and a sub-micron low PDI dispersion stability are solved, and the application has wide application values of improving uneven skin color, lightening color spots, brightening skin color and soothing and repairing.

The invention provides a recombinant collagen patch for treating facial dermatitis and eczema and fading pigmentation and a preparation method of the recombinant collagen patch. The application comprises a base material layer and a functional composition loaded on the base material layer, wherein the functional composition comprises recombinant human collagen III, an anti-inflammatory active component and a whitening active component. Wherein the anti-inflammatory active component is a compound of ganoderma sinensis spore powder zymolyte, dipotassium glycyrrhizinate and asiaticoside in a specific mass ratio, and the whitening active component is an alpha-arbutin-ferulic acid condensate and a compound of tranexamic acid and glabridin in a specific mass ratio. And the base material layer is alginate-sodium carboxymethyl cellulose composite hydrogel which is modified by gamma-ray irradiation. Through the synergistic effect of all the active ingredients and the optimized preparation process, the multiple effects of resisting inflammation, repairing a barrier and fading hyperpigmentation are achieved, and the product is good in biocompatibility and remarkable in effect.

This invention discloses a tetrahedral framework nucleic acid complex carrying tranexamic acid and its applications. The complex is formed by mixing tetrahedral framework nucleic acid and tranexamic acid; the molar ratio of tetrahedral framework nucleic acid to tranexamic acid is 1:(150-170). Research shows that the tetrahedral framework nucleic acid can successfully bind to tranexamic acid and exhibits a significant synergistic effect; the complex can effectively reduce melanin content, inhibit skin pigmentation, and protect skin structure, thus improving skin pigmentation-related diseases. This invention provides a novel tranexamic acid delivery strategy, offering a new technical means for developing products that effectively improve skin pigmentation and protect skin structure.

This invention provides a novel method for producing crystals composed of ibuprofen and tranexamic acid. [Solution] A method for producing crystals consisting of ibuprofen and tranexamic acid, (1 ) An aqueous solution containing ethanol at a concentration of 65 w / w% or more and less than 100 w / w%, containing ibuprofen and Add a mixed powder of ibuprofen and tranexamic acid, or add the aqueous solution to the mixed powder, The ratio of the content of the aqueous solution to the total mass of fen and tranexamic acid is 0.09 mL. (1) To obtain a mixture that is 1 / g or more, and (2) To produce the crystals from the obtained mixture. A manufacturing method that includes [the ingredient].

The present invention relates to a solid composition, an ibuprofen slow release improving agent, and a method for improving slow release of ibuprofen. The present invention addresses the problem of providing a solid composition containing ibuprofen and tranexamic acid, the dissolution persistence of which is improved. [Solution] A solid composition containing (A) ibuprofen, (B) at least one substance selected from the group consisting of dextromethorphan and salts thereof, and (C) tranexamic acid.

The application discloses a preparation method of pyrazoline, which comprises the following steps: (1) mixing a ketone hydrazine raw material with a Lewis acid catalyst, and heating to perform a reaction to obtain a reaction mixture; and (2) cooling and filtering the reaction mixture, and purifying to obtain a pyrazoline product. In the application, the Lewis acid catalyst acts as an electron pair acceptor, coordinates with a nitrogen atom or an oxygen atom in the ketone hydrazine, and activates the ketone hydrazine molecule; the activated ketone hydrazine molecule is more prone to intramolecular cyclization reaction, and forms a pyrazoline ring; the Lewis acid does not provide a proton, and thus the hydrolysis of the ketone hydrazine and side reactions caused by a protonic acid catalyst are avoided, and the selectivity and yield of the product are improved; in addition, the Lewis acid catalyst can be filtered and recycled for reuse, meets the principle of green chemistry, and reduces environmental pollution and resource waste; and the preparation method has low requirements on reaction conditions, is simple to operate, and is suitable for industrial production.

The invention discloses a tranexamic acid tablet and a preparation method thereof. The tranexamic acid tablet comprises tranexamic acid, corn starch, polyvinyl alcohol, low-substituted hydroxypropyl cellulose and hydrogenated castor oil. The preparation method of the tranexamic acid tablet comprises the following steps: preparing a polyvinyl alcohol aqueous solution as an adhesive, adding hydrogenated castor oil into the polyvinyl alcohol aqueous solution, carrying out wet granule preparation, fluidized drying and granule finishing on tranexamic acid, corn starch and low-substituted hydroxypropyl cellulose by using the adhesive in a fluidized granulation coating machine, mixing dry granules with magnesium stearate, and tabletting. The tranexamic acid tablet prepared by the preparation method disclosed by the invention is free from sticking and astringent rushing problems, solves the problem that the tranexamic acid medicine is relatively fast to dissolve out and release, and relieves the irritation to gastrointestinal tracts; the technological operation is simple, the production efficiency is high, and industrial production is facilitated; the quality is consistent with that of a reference preparation, clinical substitution of the reference preparation is realized, the treatment cost is reduced, and the accessibility of a patient is improved.

A polymer modification method comprises: (a) contacting a polymer with at least one carboxylic acid selected from C2-C40 aliphatic, aromatic, or cyclic acids; (b) introducing free radicals via thermal, photochemical, or chemical decomposition; (c) adding at least one nitrogen compound; and (d) optionally incorporating a metallocene catalyst. The method enhances polymer properties (tensile strength, elongation, impact resistance) by 25-250%, reduces energy consumption 20-45% compared to virgin production, and enables processing of mixed polymer wastes. Applications include automotive components (20-40% recycled content), food-grade packaging (up to 35% recycled HOPE), construction materials, and waste valorization. The predictive radical chemistry enables controlled property enhancement through mathematical correlation between radical concentration, reaction kinetics, and polymer modification degree.

This invention belongs to the field of oil-based drilling fluid technology for oil and gas field drilling, specifically relating to a water-in-oil drilling fluid with a synergistic thickening effect of temperature and pressure and its application. The drilling fluid comprises a base oil phase, a brine phase, organic clay, a high-temperature resistant emulsifier, a wetting agent, a thickening regulator, a flow stabilizer, an alkaline substance, a filtration loss reducer, a plugging material, and a weighting material. The thickening regulator is a compound composition of a cyclic polyacid or its modified organic cyclic acid and an amidation product of an organic amine, possessing a multi-branched or network structure, which can significantly improve the low-shear rate viscosity and dynamic shear force of the drilling fluid under high temperature and high pressure. The plugging material in this invention is a temperature-sensitive intelligent polymer microsphere with temperature-responsive characteristics, capable of shrinking and agglomerating at high temperatures to achieve adaptive plugging. The drilling fluid of this invention exhibits excellent rheological stability, suspension capacity, and plugging performance under high temperature and high pressure conditions, making it suitable for the development of deep, ultra-deep, and extra-deep oil and gas wells.

The application belongs to the technical field of organic synthesis, and more particularly relates to a method for efficiently preparing tranexamic acid. The preparation method comprises the following steps: pretreating aminomethylbenzoic acid, then performing hydrogenation reaction, conversion reaction, decolorization and impurity removal, and crude product concentration. According to the application, the starting material is purified, and the conditions of hydrogenation reaction and conversion reaction are optimized, so that each reaction can be effectively controlled to smoothly proceed, the reaction energy consumption is low, the reaction time is greatly shortened, the purity of the obtained tranexamic acid is high, and the yield is good.

The application relates to a preparation method of a biotin intermediate cyclic anhydride, which comprises the following steps: under the condition of a catalyst, carrying out a dehydration reaction on a cyclic acid metal salt (II) and acetic anhydride in an aromatic hydrocarbon solvent to generate the cyclic anhydride (I). The method replaces the cyclic acid in the current process with the cyclic acid metal salt with better stability, omits the use of hydrochloric acid in the production of the cyclic acid, reduces the side reaction in the cyclic anhydride synthesis reaction process, effectively improves the purity and yield of the cyclic anhydride, and has a wide industrial application prospect.

The group of inventions relates to the field of medicine, and more particularly to haemostatics and drugs for providing temporary haemostasis in the case of non-major bleeds. Proposed are a pharmaceutical composition containing tranexamic acid, chlorhexidine digluconate, bupivacaine, and water, in the following proportions: 13-16 wt.% tranexamic acid, 2.00 wt.% chlorhexidine digluconate, 0.5 wt.% bupivacaine, and 81.5-84.5 wt.% water, and a drug in aerosol or spray form comprising said pharmaceutical composition. Use of the group of inventions makes it possible to stop bleeds very quickly and reduce the risk of renewed bleeding. In addition, providing the drug in the form of an aerosol or spray allows easy and convenient use. The proposed composition and drug can be used for providing temporary haemostasis in the case of non-major bleeds in the fields of dentistry, veterinary medicine, military field medicine, disaster medicine, and the like.

The invention relates to an anorectal dressing with lubricating and healing promoting functions. The anorectal dressing comprises a dressing body made of polyurethane foam, the composite coating is coated on at least part of the surface of the dressing body; the composite coating comprises a bioactive component; the bioactive component comprises alginate, bletilla striata polysaccharide and a hemostatic and anti-inflammatory component selected from phyllostachys sieboldii saponin, tranexamic acid or a combination of phyllostachys sieboldii saponin and tranexamic acid. By compounding the functional coating on the surface, multiple effects of lubrication, hemostasis, anti-inflammation and wound healing promotion are achieved, so that the experience of a patient is improved, postoperative recovery is accelerated, the postoperative recovery is fast, and the effect is more stable, safer and more effective.

This invention relates to a composition containing protoplasts of ginseng as an active ingredient, which improves aging caused by the deepening of wrinkles or loss of firmness in the skin. Specifically, the present invention contains protoplasts of ginseng as an active ingredient and can improve aging caused by deep wrinkles or loss of firmness of the skin. Furthermore, by including one or more components selected from the group consisting of phloretin, oryzanol, tranexamic acid, and pyridoxine, the stability of the composition can be enhanced and the effect of improving skin wrinkles and firmness can be strengthened by suppressing the clumping or cell membrane defects of the ginseng protoplasts in the composition.

Hydrogels are provided formed from a first polymer comprising a plurality of amine moieties and a second polymer comprising a plurality of cyclic acid anhydride moieties. Water filtration systems comprising the hydrogels and methods for removing phosphate from a water source using the hydrogels are also provided.

On the basis of the concept of physical penetration drug delivery-biochemical synergistic treatment, hydrophilic tranexamic acid is confined and encapsulated in a hydrophobic resveratrol-magnesium ion network through metal-polyphenol coordination self-assembly to form amorphous nanospheres (TXA (at) Res-Mg), and then the microneedle patch is prepared by taking chitosan and polyvinylpyrrolidone as a composite matrix. The obtained microneedle array is high in mechanical strength, can effectively penetrate through the stratum corneum, and realizes quick release of drugs within 10 minutes. After entering subcutaneous tissues, the system efficiently clears active oxygen by virtue of enzyme-like catalytic activity and relieves oxidative stress and inflammation, and meanwhile, the inhibition rates on tyrosinase activity and melanin generation both exceed 98%. The'nano assembly + microneedle transdermal 'strategy overcomes the defects of indissolvability and transdermal barrier of a single drug, multi-dimensional synergy of antioxidation, antibiosis and targeted blackness inhibition is realized, and an innovative platform is provided for safe and efficient treatment of chloasma.

This invention discloses a diaphragm-type silk fibroin microneedle patch, comprising a drug storage layer, a diaphragm layer, and a blank microneedle layer. The blank microneedle layer is composed of silk fibroin and includes a matrix and needles extending outward from the matrix. The drug storage layer covers the side of the diaphragm layer away from the needles. The drug storage layer comprises silk fibroin and tranexamic acid, and the diaphragm layer is located between the drug storage layer and the blank microneedle layer. This invention's tranexamic acid-loaded diaphragm-type silk fibroin microneedle patch with a drug storage layer can increase the release time (14 hours in vitro, 24 hours in vivo) and create a large tranexamic acid concentration gradient between the microneedles and the skin, providing a stable driving force for the transdermal release of tranexamic acid, achieving a stable drug release rate after a certain period, thereby achieving long-term stable drug delivery.

Provided is a method for producing a solid preparation containing (A) at least one selected from the group consisting of loxoprofen, salts thereof, and hydrates thereof and (B) at least one selected from the group consisting of tranexamic acid and salts thereof, the method comprising: a wet granulation step in which a granulation is obtained by supplying water to a raw material powder containing components (A) and (B), wherein, when the addition rate of the water supplied in the wet granulation step is set to X, the plastic limit water addition rate of the raw material powder is set to PL, and the granulation index represented by X / PL is set to Ig, X is adjusted so as to satisfy 0.20 ≤ Ig ≤ 0.99.

The application discloses a Lewis acid-base pair catalytic system and application thereof. The catalytic system comprises a Lewis base, a cyclic acid anhydride and a Lewis acid; wherein the molar ratio of the Lewis base, the cyclic acid anhydride and the Lewis acid is 1:0.1-10:0.25-10. The cyclic acid anhydride, the Lewis base, an epoxide and the Lewis acid are sequentially added into a reaction kettle, and then a carbon monomer is added, and then the reaction is carried out under a closed condition at 25-150 DEG C for 0.1-36 hours to obtain an epoxy copolymer. The application can enhance the reaction activity of the Lewis acid-base pair catalytic system, selectivity and high activity under a low catalyst concentration, and the highest turnover frequency (TOF) is 78000 h ‑1 .

The invention provides a separation and purification method for cis-1, 3-dibenzylimidazole-2-ketone-4, 5-dicarboxylic acid in a cyclic acid crude product. The separation and purification method comprises the following steps: S1, dissolving a cyclic acid crude product in an ethanol solution to obtain a mixed solution; s2, dropwise adding a sodium hydroxide solution into the mixed solution to adjust the pH value to 12.8-13.2, carrying out an isomerization reaction, then adjusting the pH value to 6.3-6.7, and filtering to obtain a clear filtrate; s3, calcium salt is added into the clarified filtrate for selective precipitation, and metal salt precipitation is obtained; s4, mixing and pulping the metal salt precipitate and water, adding hydrochloric acid for acidification, filtering, and washing a filter cake with cold water to obtain a cis-cyclic acid crude product; and S5, dissolving the cis-cyclic acid crude product in a mixed solvent of acetone and water, dropwise adding an alkaline solution to adjust the pH value to 4.0-4.8, cooling, crystallizing, and drying in vacuum to obtain the high-purity cis-cyclic acid. According to HPLC analysis, the purity of the product obtained through purification reaches 99% or above, trans-isomer impurities are strictly controlled to be 0.5% or below, and the product is in a regular crystal form and is good in consistency.

1. The name of the design product: packing bottle (Kangxian tranexamic acid nicotinamide essence). 2. The use of the design product: bottle for packing cosmetics. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: front view.

The invention discloses tranexamic acid ionic liquid, a micro-capsule as well as a preparation method and application of the micro-capsule, and relates to the field of daily chemical products. The ionic liquid comprises a tranexamic acid hydrogen bond donor and a hydrogen bond receptor, and the hydrogen bond receptor comprises at least one of citric acid, glycolic acid and malic acid; the microcapsule is prepared by mixing and homogenizing grease, an emulsifier, tranexamic acid ionic liquid and water at a specific temperature. The tranexamic acid is used as a hydrogen bond donor to prepare the form of the ionic liquid, the solubility of the tranexamic acid is improved, meanwhile, the emulsifier, the grease and the water are combined to achieve the effect of the ionic liquid in water, whitening components can be promoted to efficiently permeate in the skin, the whitening effect is enhanced, meanwhile, irritation is reduced, the prepared micro-capsule is smaller in particle size, and the skin whitening effect is improved. Whitening active ingredients are high in storage and temperature-resistant stability, the encapsulation efficiency of the active ingredients is remarkably improved, the permeability, stability and safety of tranexamic acid are comprehensively improved, and the whitening effect is good.

The invention discloses self-gelation expandable self-propelling coagulation-promoting portable hemostatic powder as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The hemostatic powder adopts a composite strategy of polyethyleneimine / polyacrylic acid loaded dopamine modified montmorillonite powder with ultrafast self-setting and wet adhesion characteristics to synergistically enhance the adhesion performance and hemostatic ability of the material; meanwhile, a foaming mechanism of organic acid protonated tranexamic acid and sodium carbonate is introduced, and a self-gelation and expandable self-propelling hemostatic powder system is constructed. According to the design, the composite system has the characteristics of rapid wet adhesion, efficient hemostasis and controllable foaming, rapid closing and blood coagulation regulation of complex wounds can be achieved through the synergistic effect of physical crosslinking and chemical foaming, and the composite system has good application potential in the fields of wound first aid, surgical hemostasis and the like.

Disclosed in the present invention is a method for removing inclusions inside roughing quartz particles of hematite tailings. The method comprises the following steps: S1: roasting and water quenching: roasting the roughing quartz particles of hematite tailings at 650-700 °C for 2-5 hours, followed by water quenching; S2: grinding: grinding the water-quenched quartz particles in step S1 to 500-400 meshes; S3: magnetic separation: removing mineral inclusions from the quartz particles obtained in step S2 by means of a superconducting high-gradient magnetic separator; S4: roasting: roasting the quartz particles obtained in step S3 at 1000-1250 °C for 2-5 hours, followed by cooling, and then roasting at 750-1000 °C for 4-5 hours, the step being repeated 3-5 times; and S5: acid leaching: subjecting the quartz particles obtained in step S4 to three-stage cyclic acid leaching to remove mineral and gas-liquid inclusions from the quartz particles, so as to obtain high-purity quartz sand. The high-purity quartz prepared by the present invention has a SiO2 grade as high as 99.9% or above, which meets the standard of refined quartz sand, thereby effectively achieving the purpose of high-value and resource utilization of hematite tailings.

Provided is an aqueous transparent gel-like composition which contains tranexamic acid and has excellent durability of moisture retention and excellent hardness stability. An aqueous transparent gel-like composition containing: a compound represented by formula (1); tranexamic acid; an anionic surfactant containing an amide bond; a polyol in an amount of 10-50 mass% relative to the total amount of the aqueous transparent gel-like composition; and water. The content of the salt-forming compound is 0.3-10% by mass relative to the total amount of the aqueous transparent gel-like composition. In formula (1), the details of R1, R2, R3, n, and m are shown in the description.

This invention provides a technology for suppressing discoloration during the manufacturing of solid compositions containing tranexamic acids and improving the uniformity of their appearance. [Solution] A solid composition comprising: component (A): at least one selected from the group consisting of tranexamic acid and its salts, and component (B): isomalt.