66 results about "Cyclic acid" patented technology

The invention discloses a preparation method and application of autologous fibrin glue, and belongs to the field of biomedical materials. The preparation method comprises the following five steps: collecting autologous venous blood, adding a sodium citrate anticoagulant with the volume ratio of 1: (8-12), and storing at 4-6 DEG C for not more than 2 hours; performing step-by-step centrifugation at the speed of 1500 to 2000 r / min and the speed of 3500 to 4000 r / min to obtain a fibrinogen concentrate; the thrombin-calcium chloride activation solution A and the tranexamic acid activation solution B are mixed according to the ratio of 1: (2-3) to form a composite activation system; mixing the two components according to a mass ratio of 1: (0.8-1.2), and reacting at 25-37 DEG C for 3-5 minutes to form colloid; and pre-freezing at-40 to-60 DEG C, performing vacuum freeze-drying, and storing at 4-8 DEG C. During application, the colloid can be coated on an operation wound surface after being redissolved, or mixed with a growth factor to prepare a dressing for covering a chronic wound surface. The colloid is high in purity, stable in coagulation time, long in storage period, suitable for scenes such as surgical hemostasis and the like, and high in clinical value.

The invention provides tranexamic acid-glutathione-containing compound emulsifiable paste and a preparation method thereof.W1 / O / W double emulsion phase structural design is adopted, reduced glutathione is encapsulated in an acidic inner water core, an oil phase is stabilized through hydrogenated lecithin and sorbitan sesquioleate, an outer water phase contains tranexamic acid, a layered gel network is constructed, and the tranexamic acid-glutathione-containing compound emulsifiable paste is prepared. A submicron dispersion system with the particle size D50 of 0.30-0.80 microns, the polydispersity index of 0.15-0.25 and the viscosity of 2.0-8.0 Pa seconds is realized, the encapsulation efficiency of glutathione is not lower than 70%, the oxygen content of a head space is not higher than 1.0%, and the encapsulation efficiency of glutathione is not lower than 70%. The three technical contradictions of coupling conflict between a high-yield viscoelastic structure and low-shear damage kernel integrity, coexistence of fresh and cool low-viscosity skin feeling and high-barrier anti-oxidation and anti-leakage and opposite low-surface-activity sensitive skin compatibility and submicron low-PDI dispersion stability are solved; the traditional Chinese medicine composition has wide application values of improving skin color unevenness, fading color spots, brightening skin color, soothing and repairing.

Disclosed in the present invention is a method for removing inclusions inside roughing quartz particles of hematite tailings. The method comprises the following steps: S1: roasting and water quenching: roasting the roughing quartz particles of hematite tailings at 650-700 °C for 2-5 hours, followed by water quenching; S2: grinding: grinding the water-quenched quartz particles in step S1 to 500-400 meshes; S3: magnetic separation: removing mineral inclusions from the quartz particles obtained in step S2 by means of a superconducting high-gradient magnetic separator; S4: roasting: roasting the quartz particles obtained in step S3 at 1000-1250 °C for 2-5 hours, followed by cooling, and then roasting at 750-1000 °C for 4-5 hours, the step being repeated 3-5 times; and S5: acid leaching: subjecting the quartz particles obtained in step S4 to three-stage cyclic acid leaching to remove mineral and gas-liquid inclusions from the quartz particles, so as to obtain high-purity quartz sand. The high-purity quartz prepared by the present invention has a SiO2 grade as high as 99.9% or above, which meets the standard of refined quartz sand, thereby effectively achieving the purpose of high-value and resource utilization of hematite tailings.

The invention relates to a composition for expanding and increasing yield of rhizome crops, a soluble concentrate and application of the soluble concentrate, and belongs to the technical field of plant growth regulators. The composition consists of a prohexadione active substance and a dihydrojasmonic acid active substance, the mass ratio of the prohexadione active substance to the dihydrojasmonic acid active substance is (0.5-25): 1; the prohexadione active substance is prohexadione and / or a soluble salt thereof; the dihydrojasmonic acid active substance is dihydrojasmonic acid and / or soluble salt thereof. The composition is taken as an effective component, a growth regulator is provided, water is taken as a solvent, and auxiliary agents known by technicians in the field are supplemented, so that a soluble concentrate is prepared. The soluble concentrate has the advantages of being environmentally friendly, convenient to process, convenient to use and the like while efficiently achieving swelling and yield increasing effects of root crops, and the problems that special dosage forms need to be prepared in the using process of prohexadione calcium, so that the production cost is high, and use is inconvenient are effectively solved.

The application relates to a preparation method of 2-amino-6-hydroxypyridine compounds and intermediates thereof, and belongs to the field of organic synthesis. The preparation method of the 2-amino-6-hydroxypyridine compounds comprises the following steps: 1) in a first organic solvent, compound II is reacted with a cyclic acid anhydride reagent A to prepare compound III; 2) in a second organic solvent, in the presence of an oxidizing reagent, compound III is subjected to an oxidation reaction to prepare compound IV; 3) in a third organic solvent, in the presence of an acid anhydride dehydrating reagent, compound IV is subjected to a reaction to prepare compound V; 4) in a fourth solvent, in the presence of a reducing agent, compound V is subjected to a reduction reaction to prepare compound I; and compound I is a 2-amino-6-hydroxypyridine compound. The preparation method of the 2-amino-6-hydroxypyridine compounds provided by the application can obtain a higher yield through mild reaction conditions, and is simple and convenient to operate, and is beneficial to industrial utilization.

A method for enhancing solubility of tranexamic acid comprising the following steps:a) Initially dissolving tranexamic acid in water;b) Measuring a pH value of the solution obtained in Step (a);c) Addition of a strong acid (that dissociates completely in water) to the solution obtained in Step (a) and simultaneously monitoring the decrease in the pH value of the solution until approximately pH 4.5 or less than pH 4.5 is reached, to increase solubility of tranexamic acid;d) Addition of tranexamic acid to reach the pH value of the solution obtained in Step (c) above the pH 2.0; ande) Repeating Steps (c) and (d) until a desired amount of tranexamic acid is added to the solution of Step (a), that is a desired concentration of tranexamic acid in the final solution is reached.

The present application relates to the field of cosmetic technology, and more particularly to a full-link whitening and freckle-removing liposome and a preparation method thereof, the liposome comprising the following components: an aqueous phase, a membrane material and an oil phase. In the preparation process, 4-butyl resorcinol, nonapeptide-1, acetylchitosamine and ascorbic acid tetraisopalmitate are combined to form a full-link effect of signal inhibition-synthesis blockage-blocked conversion-metabolic acceleration, and a multi-target whitening and freckle-removing system is constructed. In addition, tranexamic acid, hydrolyzed yeast protein and schizophyllan are combined to synergistically make the finished product have excellent soothing and moisturizing effects. Furthermore, the finished product is prepared into a liposome capable of encapsulating active ingredients, which effectively improves the stability of the active ingredients, prevents their oxidation and inactivation, and the liposome structure is highly similar to the human cell membrane, is easy to penetrate the keratin layer gap, realizes targeted delivery to the deep layer of the epidermis, and makes the active ingredients truly act on the required site.

The present disclosure relates to the technical field of concrete additive, and particularly relates to a concrete retarding water reducing agent and a preparation method and application thereof; the concrete retarding water reducing agent comprises a compound A, a component B, a component C and a solvent D; wherein the structural formula of the compound A comprises a polyphosphate chain segment and a polyether chain segment; the polyphosphate chain segment and the polyether chain segment are connected through a residue of a cyclic acid anhydride; the component B comprises the following: sodium lignosulfonate, sodium dodecyl sulfate, sodium gluconate and at least one organic acid; the component C comprises at least two of the following: borax, calcium silicate, fiber, magnesium sulfate and calcium chloride; and the solvent D is a mixture of water and an organic solvent. The present disclosure provides a novel concrete-based additive which can simultaneously play a good retarding and water reducing role.

The invention belongs to the field of plant growth regulators, and particularly relates to prohexadione soluble powder and a preparation method thereof. The preparation method of the prohexadione soluble powder comprises the following steps: mixing prohexadione and inorganic base in a solvent until the solution is clear, and then carrying out any one of the following treatments: (1) removing the solvent, and then uniformly mixing with an anti-caking agent; and (2) adding anhydrous magnesium sulfate, uniformly mixing, and drying. The prohexadione and the inorganic base are mixed to enhance the water solubility, and then the anti-caking agent and the anhydrous magnesium sulfate are used for treatment to improve the heat storage stability; the prohexadione soluble powder prepared by the method is good in water solubility, does not separate out, is good in normal temperature and heat storage stability, and meets the use and storage requirements of typical soluble powder.

The application discloses an amino acid surfactant with hemostatic function and a preparation method thereof. The method is to make the tranexamic acid and long aliphatic acyl chloride undergo condensation reaction under the action of alkali, and then perform acidification and esterification reaction to obtain the amino acid surfactant with hemostatic function. Compared with the long-chain fatty acyl thrombin acid salt reported in the prior art, the amino acid surfactant has good fat solubility, better transdermal permeability and better toner dispersibility. The preparation method has mild reaction conditions, simple operation, simple product separation and purification and high yield, and is suitable for industrial production.

Concentrated tranexamic acid compositions suitable for intramuscular administration via auto-injector are provided. The concentrated tranexamic acid compositions enable the use of a syringe and an auto-injector to facilitate rapid, reliable, and simple self or buddy administration, under extreme duress on the battlefield, by minimally trained users. Methods of treating non-compressible hemorrhage are also provided. Kits and auto-injectors comprising the tranexamic acid compositions are further provided.

The invention belongs to the technical field of skin care products, and particularly relates to a skin care mask and a preparation method thereof. The skin care mask is prepared from the following raw materials: glycerol, low-molecular sodium hyaluronate, high-molecular sodium hyaluronate, allantoin, nicotinamide, arbutin, tranexamic acid, glucose, squalane, tocopherol, carbomer, resveratrol, panthenol, 1, 3-butanediol, triethanolamine, citric acid, an emulsifier, a preservative and deionized water. The mask product is comprehensive in effect and has the functions of moisturizing, whitening and brightening, resisting oxidation and the like; the composition is mild and stable and adapts to sensitive skin; and the cream is light in texture, good in ductility, non-sticky in thick application and good in use feeling.

The invention relates to a high-efficiency hemostatic antibacterial gel dressing, which is prepared from the following raw materials: 4-carboxyphenylboronic acid-based chitosan, drug aldehyde, methacrylic acid esterified gelatin and tranexamic acid, wherein the 4-carboxyphenylboronic acid-based chitosan and the methacrylic acid esterified gelatin are dissolved in water to form a solution A; protocatechuic aldehyde and tranexamic acid are dissolved in water to form a solution B, the solution A and the solution B are rapidly and uniformly mixed to form a pre-injection solution before treatment, the pre-injection solution is injected to the surface of a wound surface so that the dressing can be cured and formed in situ, after forming, the dressing can effectively adhere to the skin and release drugs, rapid hemostasis and antibiosis are achieved, and the dressing can be degraded in about 10 days in a physiological solution environment; the gel dressing can be widely applied to treatment of different trauma wounds.

The application provides a tranexamic acid-glutathione compound cream and a preparation method thereof, adopts a W1 / O / W double emulsion phase structure design, encapsulates reduced glutathione in an acidic inner water core, stabilizes an oil phase by using hydrogenated lecithin and sorbitan sesquioleate, and constructs a lamellar gel network in an outer water phase containing tranexamic acid, so as to realize a sub-micron dispersion system with a particle size D50 of 0.30-0.80 microns, a polydispersity index of 0.15-0.25 and a viscosity of 2.0-8.0 Pa seconds, the encapsulation rate of glutathione is not less than 70%, and the headspace oxygen content is not higher than 1.0%, three technical contradictions of a high yield viscoelastic structure and a low shear damage inner core integrity coupling conflict, a smooth low skin feeling and a high barrier anti-oxidation and anti-leakage coexistence problem and a low surface activity sensitive skin compatibility and a sub-micron low PDI dispersion stability are solved, and the application has wide application values of improving uneven skin color, lightening color spots, brightening skin color and soothing and repairing.

The present disclosure is generally directed to solutions comprising tranexamic acid (TXA). The invention is also directed to the use of the solutions comprising tranexamic acid provided herein for the treatment of hemorrhage in a subject.

The invention provides a recombinant collagen patch for treating facial dermatitis and eczema and fading pigmentation and a preparation method of the recombinant collagen patch. The application comprises a base material layer and a functional composition loaded on the base material layer, wherein the functional composition comprises recombinant human collagen III, an anti-inflammatory active component and a whitening active component. Wherein the anti-inflammatory active component is a compound of ganoderma sinensis spore powder zymolyte, dipotassium glycyrrhizinate and asiaticoside in a specific mass ratio, and the whitening active component is an alpha-arbutin-ferulic acid condensate and a compound of tranexamic acid and glabridin in a specific mass ratio. And the base material layer is alginate-sodium carboxymethyl cellulose composite hydrogel which is modified by gamma-ray irradiation. Through the synergistic effect of all the active ingredients and the optimized preparation process, the multiple effects of resisting inflammation, repairing a barrier and fading hyperpigmentation are achieved, and the product is good in biocompatibility and remarkable in effect.

This invention discloses a tetrahedral framework nucleic acid complex carrying tranexamic acid and its applications. The complex is formed by mixing tetrahedral framework nucleic acid and tranexamic acid; the molar ratio of tetrahedral framework nucleic acid to tranexamic acid is 1:(150-170). Research shows that the tetrahedral framework nucleic acid can successfully bind to tranexamic acid and exhibits a significant synergistic effect; the complex can effectively reduce melanin content, inhibit skin pigmentation, and protect skin structure, thus improving skin pigmentation-related diseases. This invention provides a novel tranexamic acid delivery strategy, offering a new technical means for developing products that effectively improve skin pigmentation and protect skin structure.

This invention provides a novel method for producing crystals composed of ibuprofen and tranexamic acid. [Solution] A method for producing crystals consisting of ibuprofen and tranexamic acid, (1 ) An aqueous solution containing ethanol at a concentration of 65 w / w% or more and less than 100 w / w%, containing ibuprofen and Add a mixed powder of ibuprofen and tranexamic acid, or add the aqueous solution to the mixed powder, The ratio of the content of the aqueous solution to the total mass of fen and tranexamic acid is 0.09 mL. (1) To obtain a mixture that is 1 / g or more, and (2) To produce the crystals from the obtained mixture. A manufacturing method that includes [the ingredient].

The invention discloses a tranexamic acid and peptomidol composition and a preparation. The composition is formed by compounding tranexamic acid and peptidomil, the tranexamic acid and the peptidomil have a synergistic effect, the whitening and freckle-removing effects on skin are better, a preparation containing the composition has better skin compatibility, better stability and an in-vitro release effect during use, and the composition can be used for preparing freckle-removing and whitening cosmetics or medicines.

To provide a tranexamic acid -, ascorbic acid -, calcium pantothenate -, L-cysteine - and pyridoxine hydrochloride-containing tablet suppressed in discoloration and free from tableting trouble.SOLUTION: The tablet contains a granulated material A and a granulated material B and has a water content of ≤ 2%, wherein the granulated material A contains tranexamic acid and calcium pantothenate, the granulated material B contains ascorbic acid, and the granulated materials A and B separately contain L-cysteine and pyridoxine hydrochloride.SELECTED DRAWING: None

The invention provides a polyphosphate polymer as well as a preparation method and application thereof. The polyphosphate polymer is prepared from the following raw materials: monoamino polyether, cyclic anhydride containing carbon-carbon double bonds, conjugated diolefin containing monohydroxyl and a phosphate esterification reagent. The product polyphosphate polymer provided by the invention can effectively disperse various pigments including water-based titanium dioxide, and has the advantages of good dispersity and good stability.

The present invention relates to a solid composition, an ibuprofen slow release improving agent, and a method for improving slow release of ibuprofen. The present invention addresses the problem of providing a solid composition containing ibuprofen and tranexamic acid, the dissolution persistence of which is improved. [Solution] A solid composition containing (A) ibuprofen, (B) at least one substance selected from the group consisting of dextromethorphan and salts thereof, and (C) tranexamic acid.

The invention relates to a method for preparing trans-tranexamic acid through hydrogenation of aminomethylbenzoic acid, which comprises preparation of a metal Ru-based catalyst and transposition of a tranexamic acid cis-trans mixture, and belongs to the technical field of application of catalytic hydrogenation. The method specifically comprises the following steps: (1) preparing a supported metal Ru-based catalyst by using a surfactant-assisted alkali precipitation and liquid phase reduction method; and (2) mixing aminomethylbenzoic acid with water, adding concentrated sulfuric acid and a catalyst, and carrying out hydrogenation in a hydrogen atmosphere to obtain a tranexamic acid cis-trans mixture. (3) the cis-trans mixture is subjected to transposition under the high-temperature alkaline condition, and high-purity trans-tranexamic acid is obtained. The preparation method of the catalyst is simple and convenient, the surfactant cooperates with the fumed silica carrier to effectively regulate and control the size and stability of Ru nano-particles, the specific surface area of active sites is increased, the cycle service life of the active sites is prolonged, the conversion rate of aminomethylbenzoic acid reaches up to 100%, the yield of trans-tranexamic acid after transposition is close to 100%, and the catalyst has very high industrial application value.

The application discloses a preparation method of pyrazoline, which comprises the following steps: (1) mixing a ketone hydrazine raw material with a Lewis acid catalyst, and heating to perform a reaction to obtain a reaction mixture; and (2) cooling and filtering the reaction mixture, and purifying to obtain a pyrazoline product. In the application, the Lewis acid catalyst acts as an electron pair acceptor, coordinates with a nitrogen atom or an oxygen atom in the ketone hydrazine, and activates the ketone hydrazine molecule; the activated ketone hydrazine molecule is more prone to intramolecular cyclization reaction, and forms a pyrazoline ring; the Lewis acid does not provide a proton, and thus the hydrolysis of the ketone hydrazine and side reactions caused by a protonic acid catalyst are avoided, and the selectivity and yield of the product are improved; in addition, the Lewis acid catalyst can be filtered and recycled for reuse, meets the principle of green chemistry, and reduces environmental pollution and resource waste; and the preparation method has low requirements on reaction conditions, is simple to operate, and is suitable for industrial production.

The invention discloses a tranexamic acid tablet and a preparation method thereof. The tranexamic acid tablet comprises tranexamic acid, corn starch, polyvinyl alcohol, low-substituted hydroxypropyl cellulose and hydrogenated castor oil. The preparation method of the tranexamic acid tablet comprises the following steps: preparing a polyvinyl alcohol aqueous solution as an adhesive, adding hydrogenated castor oil into the polyvinyl alcohol aqueous solution, carrying out wet granule preparation, fluidized drying and granule finishing on tranexamic acid, corn starch and low-substituted hydroxypropyl cellulose by using the adhesive in a fluidized granulation coating machine, mixing dry granules with magnesium stearate, and tabletting. The tranexamic acid tablet prepared by the preparation method disclosed by the invention is free from sticking and astringent rushing problems, solves the problem that the tranexamic acid medicine is relatively fast to dissolve out and release, and relieves the irritation to gastrointestinal tracts; the technological operation is simple, the production efficiency is high, and industrial production is facilitated; the quality is consistent with that of a reference preparation, clinical substitution of the reference preparation is realized, the treatment cost is reduced, and the accessibility of a patient is improved.

A polymer modification method comprises: (a) contacting a polymer with at least one carboxylic acid selected from C2-C40 aliphatic, aromatic, or cyclic acids; (b) introducing free radicals via thermal, photochemical, or chemical decomposition; (c) adding at least one nitrogen compound; and (d) optionally incorporating a metallocene catalyst. The method enhances polymer properties (tensile strength, elongation, impact resistance) by 25-250%, reduces energy consumption 20-45% compared to virgin production, and enables processing of mixed polymer wastes. Applications include automotive components (20-40% recycled content), food-grade packaging (up to 35% recycled HOPE), construction materials, and waste valorization. The predictive radical chemistry enables controlled property enhancement through mathematical correlation between radical concentration, reaction kinetics, and polymer modification degree.

This invention belongs to the field of oil-based drilling fluid technology for oil and gas field drilling, specifically relating to a water-in-oil drilling fluid with a synergistic thickening effect of temperature and pressure and its application. The drilling fluid comprises a base oil phase, a brine phase, organic clay, a high-temperature resistant emulsifier, a wetting agent, a thickening regulator, a flow stabilizer, an alkaline substance, a filtration loss reducer, a plugging material, and a weighting material. The thickening regulator is a compound composition of a cyclic polyacid or its modified organic cyclic acid and an amidation product of an organic amine, possessing a multi-branched or network structure, which can significantly improve the low-shear rate viscosity and dynamic shear force of the drilling fluid under high temperature and high pressure. The plugging material in this invention is a temperature-sensitive intelligent polymer microsphere with temperature-responsive characteristics, capable of shrinking and agglomerating at high temperatures to achieve adaptive plugging. The drilling fluid of this invention exhibits excellent rheological stability, suspension capacity, and plugging performance under high temperature and high pressure conditions, making it suitable for the development of deep, ultra-deep, and extra-deep oil and gas wells.

The invention relates to the technical field of medical instruments, and discloses a hemostatic hydrophilic polyurethane foam dressing and a preparation method thereof. The dressing is prepared by mixing and foaming a hemostatic hydrophilic prepolymer and a functional foaming mixture according to the mass ratio of (1: 2)-(2: 1), the hemostatic hydrophilic prepolymer is obtained by reacting polyether polyol, isocyanate, tranexamic acid, a chain extender and an antioxidant; the functional foaming mixture is prepared by mixing polyether glycol, a surfactant, a foam stabilizer and purified water. The tranexamic acid directly reacts with the polyether polyol, the isocyanate and the like to prepare the hemostatic hydrophilic prepolymer, the prepared polyurethane foam dressing has an excellent hemostatic function, meanwhile, the good liquid absorption rate and the anti-adhesion effect of polyurethane foam are not affected, and wound healing can be effectively promoted.

The application belongs to the technical field of organic synthesis, and more particularly relates to a method for efficiently preparing tranexamic acid. The preparation method comprises the following steps: pretreating aminomethylbenzoic acid, then performing hydrogenation reaction, conversion reaction, decolorization and impurity removal, and crude product concentration. According to the application, the starting material is purified, and the conditions of hydrogenation reaction and conversion reaction are optimized, so that each reaction can be effectively controlled to smoothly proceed, the reaction energy consumption is low, the reaction time is greatly shortened, the purity of the obtained tranexamic acid is high, and the yield is good.

The application relates to a preparation method of a biotin intermediate cyclic anhydride, which comprises the following steps: under the condition of a catalyst, carrying out a dehydration reaction on a cyclic acid metal salt (II) and acetic anhydride in an aromatic hydrocarbon solvent to generate the cyclic anhydride (I). The method replaces the cyclic acid in the current process with the cyclic acid metal salt with better stability, omits the use of hydrochloric acid in the production of the cyclic acid, reduces the side reaction in the cyclic anhydride synthesis reaction process, effectively improves the purity and yield of the cyclic anhydride, and has a wide industrial application prospect.