A full-link whitening and freckle-removing liposome and a preparation method thereof

Abstract

The present application relates to the field of cosmetic technology, and more particularly to a full-link whitening and freckle-removing liposome and a preparation method thereof, the liposome comprising the following components: an aqueous phase, a membrane material and an oil phase. In the preparation process, 4-butyl resorcinol, nonapeptide-1, acetylchitosamine and ascorbic acid tetraisopalmitate are combined to form a full-link effect of signal inhibition-synthesis blockage-blocked conversion-metabolic acceleration, and a multi-target whitening and freckle-removing system is constructed. In addition, tranexamic acid, hydrolyzed yeast protein and schizophyllan are combined to synergistically make the finished product have excellent soothing and moisturizing effects. Furthermore, the finished product is prepared into a liposome capable of encapsulating active ingredients, which effectively improves the stability of the active ingredients, prevents their oxidation and inactivation, and the liposome structure is highly similar to the human cell membrane, is easy to penetrate the keratin layer gap, realizes targeted delivery to the deep layer of the epidermis, and makes the active ingredients truly act on the required site.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a full-chain whitening and spot-removing liposome and its preparation method. Background Technology

[0002] Pigmentation is a common skin problem with complex and diverse causes, mainly related to ultraviolet radiation, genetic factors, endocrine disorders, and unhealthy lifestyle habits. The core mechanism lies in the abnormal production, transport, and metabolism of melanin. Ultraviolet radiation activates the activity of tyrosinase in melanocytes, promoting excessive melanin synthesis. As we age, skin metabolism slows down, leading to excessive accumulation of melanin on the skin's surface, forming various pigmentation spots such as melasma, freckles, and age spots. This is accompanied by dull skin tone, dryness, and dehydration, severely affecting skin appearance and health. Liposomes, as vesicles with a structure similar to biological membranes, possess excellent biocompatibility and safety. They can simultaneously encapsulate both water-soluble and lipid-soluble active ingredients. Their unique biomembrane-like structure gives them high skin affinity and permeability, enabling efficient delivery of encapsulated active substances and penetration through the stratum corneum, thereby achieving sustained-release and targeted action of active ingredients in the basal layer of the skin.

[0003] However, existing liposome-based whitening and spot-removing products still suffer from insufficient whitening effect across the entire process and poor synergistic effect of hydration, failing to meet the multiple needs of both full-process whitening and spot removal and deep hydration. Therefore, providing a liposome capable of achieving full-process whitening and spot removal and its preparation method has become an urgent technical problem to be solved. Summary of the Invention

[0004] To address the problems existing in the prior art, the purpose of this invention is to provide a full-chain whitening and freckle-removing liposome and its preparation method.

[0005] The objective of this invention can be achieved through the following technical solutions: The first aspect of this invention provides a full-chain whitening and freckle-removing liposome, comprising the following components by weight: 62.02-86.55 parts of aqueous phase, 1.5-5 parts of membrane material, and 15.7-33.5 parts of oil phase; The aqueous phase, by weight, comprises the following parts of raw materials: 8-12 parts deionized water, 2-5 parts vitamin B derivatives, 1-3 parts amino acid derivatives, 1-3 parts glucose derivatives, 0.02-0.05 parts active peptides, 1-2.5 parts protein active substances, 1-2 parts polysaccharide active substances, and 48-59 parts glycerol; The membrane material comprises, by weight, the following parts of raw materials: Polyglycerol-10 myristate 1.5-2 parts; The oil phase, by weight, comprises the following parts of raw materials: It includes 3-6 parts squalane, 4-6 parts synthetic ester, 2-4 parts vegetable oil, 0.5-1 part vitamin E derivative, 3-10 parts 4-butylresorcinol, 0.2-0.5 parts plant extract, 2-3 parts vitamin C derivative, and 1-3 parts bisabolol; The aforementioned 4-Butylresorcinol competitively inhibits tyrosine binding sites by forming coordination bonds with copper ions at the active center of TYR, thereby enhancing inhibitory selectivity. In other words, this component can effectively block the first step of the conversion of tyrosine to dopa, and also has a certain inhibitory effect on the subsequent steps of the conversion of dopa to dopaquinone, thus comprehensively inhibiting melanin synthesis.

[0006] As a preferred embodiment of the present invention, the membrane material further includes 2-4 parts of lecithin or 3-4 parts of hydrogenated lecithin.

[0007] As a preferred embodiment of the present invention, the vitamin B derivative includes nicotinamide or panthenol; The amino acid derivatives include ergothioneine or tranexamic acid; The glucose derivatives include acetyl glucosamine or ascorbate glucoside; The active peptide includes any one of oligopeptide-1, nonapeptide-1, and palmitoyl tetrapeptide-7; The protein-based active ingredients include any one of hydrolyzed yeast protein, hydrolyzed rice protein, and hydrolyzed jojoba protein. The polysaccharide active ingredients include Tremella fuciformis polysaccharide or schistosome.

[0008] Preferably, the vitamin B derivative includes nicotinamide; The amino acid derivatives include tranexamic acid, also known as tranexamic acid, which competitively inhibits the binding of plasminogen to keratinocyte surface receptors, blocks plasmin-mediated inflammatory cascade reactions, reduces matrix metalloproteinase-9 (MMP-9) activity, and alleviates inflammation and inflammation-induced pigmentation. The glucose derivatives include N-acetylglucosamine, which can promote hyaluronic acid synthesis, enhance stratum corneum hydration, inhibit α-glucosidase activity, regulate the differentiation cycle of keratinocytes, and shorten the metabolic cycle of abnormal pigmentation. In addition, N-acetylglucosamine can also regulate the phagocytosis and processing ability of keratinocytes on melanosomes by affecting intercellular signal transduction, thereby further promoting pigment metabolism. The active peptides include nonapeptide-1. Nonapeptide-1, as a competitive antagonist of α-melanocyte stimulating hormone, binds with high affinity to the MC1R receptor on the surface of melanocytes. It can block the cAMP-PKA-CREB signaling pathway, inhibit the transcription of TYR and TRP-1 genes from the source, and also reduce the cAMP level and downregulate TYR mRNA expression in B16F10 cells. It binds to the seventh transmembrane domain of the MC1R receptor, prevents G protein coupling, thereby inhibiting adenylate cyclase activity, reducing cAMP production, and ultimately reducing CREB phosphorylation level, inhibiting the transcription of melanin production-related genes, and achieving skin whitening from the root. The protein-based active ingredients include hydrolyzed yeast protein, which contains small molecule peptides, amino acids, B vitamins, minerals, and β-glucan. It can promote filaggrin expression, enhance the synthesis of natural moisturizing factors, and improve the hydration capacity of the stratum corneum, thereby providing a strong moisturizing effect to the skin. In addition, hydrolyzed yeast protein can also balance the skin microecology and relieve external irritation, and has a certain soothing effect on the skin, making it suitable for sensitive skin. The polysaccharide active ingredients include schizophyllan, which can inhibit the release of inflammatory mediators such as IL-1α, IL-8, and PGE2, and quickly soothe skin redness and itching. In addition, its rich polyhydroxy structure can form a water-locking film to effectively lock in skin water molecules and maintain the hydration of the stratum corneum for a long time. At the same time, schizophyllan can also promote the differentiation of keratinocytes and accelerate skin cell renewal, fundamentally strengthening the skin barrier.

[0009] As a preferred embodiment of the present invention, the synthetic ester includes caprylic / capric triglyceride; The vegetable oil includes any one of sea buckthorn fruit oil, jojoba seed oil, and camellia seed oil. The vitamin E derivatives include tocopherol acetate or tocopherol succinate; The plant extracts include any one of arbutin, glycyrrhizin, and centella asiatica extract; The vitamin C derivatives include ascorbate tetraisopalmitate or ascorbate palmitate.

[0010] Preferably, the vegetable oil includes jojoba seed oil; The vitamin E derivatives include tocopherol acetate; The plant extract includes glycyrrhizin; The vitamin C derivatives include ascorbyl tetraisopalmitate. After being hydrolyzed by skin esterases, ascorbyl tetraisopalmitate releases active vitamin C and plays a dual role. Specifically, on the one hand, it can reduce dopaquinone to dopa, blocking the oxidative polymerization of melanin; on the other hand, it can inhibit the phosphorylation of Rab14, a protein related to melanosome transport, reducing pigment deposition. In addition, ascorbyl tetraisopalmitate can also participate in the synthesis of collagen, enhance skin elasticity, and at the same time, as an antioxidant, it can scavenge free radicals in the skin and reduce the stimulation of melanocytes by oxidative stress.

[0011] A second aspect of this invention provides a method for preparing a full-chain whitening and spot-removing liposome, comprising the following steps: (1) Preparation of aqueous phase: Glycerin and deionized water are mixed, and then the remaining aqueous phase components are added in sequence and stirred evenly under controlled temperature and speed to obtain the aqueous phase; (2) Preparation of oil phase: After mixing the membrane material, squalane, synthetic ester, vegetable oil and vitamin E derivative, 4-butylresorcinol, plant extract, vitamin C derivative and bisabolol are added in sequence and stirred at controlled temperature and speed to obtain the oil phase; (3) Preparation of liposome finished product: The oil phase is added to the aqueous phase under stirring and then stirred and ultrasonically treated to obtain the colostrum. The colostrum is then introduced into a microfluidic homogenizer for homogenization to obtain the liposome finished product.

[0012] As a preferred technical solution of the present invention, the temperature and speed control in step (1) are 45-50℃ and 400-450r / min.

[0013] As a preferred technical solution of the present invention, the temperature and speed control in step (2) are 70-80℃, the speed is 330-350r / min, and the time is 0.5-1h.

[0014] As a preferred technical solution of the present invention, the stirring speed in step (3) is 2000-2200 r / min; the speed at which the oil phase is added to the water phase is 5-6 mL / min; the stirring time is 20-25 min; the ultrasonic treatment power is 320-350 W and the time is 5-6 min; the homogenization pressure is 230-250 MPa and the number of times is 3-5.

[0015] The third aspect of this invention provides an application of a full-chain whitening and spot-removing liposome in cosmetics, wherein the liposome is added at 1-10% of the total mass of the cosmetic.

[0016] The beneficial effects of this invention are: (1) Nonapeptide-1 effectively inhibits melanin production at its source by blocking signaling pathways and inhibiting the transcription of melanin-related genes; 4-Butylresorcinol enhances the inhibitory selectivity by competitively inhibiting tyrosine binding sites, and can also block tyrosine conversion and subsequent conversion steps, thereby inhibiting melanin synthesis; Acetyl glucosamine has the effect of shortening the metabolic cycle of abnormal pigmentation and accelerating pigment metabolism and excretion; Ascorbate tetraisopalmitate has the effect of interrupting melanin oxidation and polymerization and reducing the stimulation of oxidative stress on melanocytes; Therefore, the four components can form a full-link effect of signal inhibition, synthesis blocking, conversion blocking, and metabolic acceleration, thus constructing a multi-target whitening and spot-removing system.

[0017] (2) The tranexamic acid selected in this invention mainly plays the role of reducing inflammation, while hydrolyzed yeast protein provides strong moisturizing effect and relieves external irritation to the skin. Schizotypalin, by inhibiting the release of inflammatory mediators and locking in water, works synergistically with tranexamic acid and schizotypalin to further enhance the system's efficacy. Therefore, the finished product obtained from this process has excellent soothing and moisturizing effects.

[0018] (3) The present invention prepares a liposome morphology that can encapsulate active ingredients, which effectively improves the stability of active ingredients and prevents them from being oxidized and deactivated. Moreover, the structure of liposomes is highly similar to that of human cell membranes, making it easy to penetrate the gaps in the stratum corneum and achieve targeted delivery to the deep layer of the epidermis, so that the active ingredients can truly act on the desired site. Detailed Implementation

[0019] The technical solution of the present invention is illustrated below through specific examples. It should be understood that the one or more method steps mentioned in the present invention do not preclude the existence of other method steps before or after the combined steps, or the insertion of other method steps between these explicitly mentioned steps; it should also be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, unless otherwise stated, the numbering of each method step is merely a convenient tool for identifying each method step, and not for limiting the order of the method steps or defining the scope of the present invention. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of the present invention.

[0020] To better understand the above technical solutions, exemplary embodiments of the present invention are described in more detail below. While exemplary embodiments of the present invention are shown, it should be understood that the present invention can be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided to enable a more thorough understanding of the present invention and to fully convey the scope of the invention to those skilled in the art.

[0021] The nonapeptide-1 used in this invention was purchased from Hangzhou Gutuo Biotechnology Co., Ltd. The hydrolyzed yeast protein used, model YLKM5596, was purchased from Hubei Yiling Biotechnology Co., Ltd. The schistosome used was purchased from Wuhan Smike Biotechnology Co., Ltd. The tranexamic acid used was purchased from Jinan Rongzheng Chemical Co., Ltd. The above will not be repeated hereafter; the present invention will be further described below with reference to the following embodiments.

[0022] Example 1 A full-chain whitening and freckle-removing liposome, by weight, comprises the following components: 75.7 parts of aqueous phase, 5 parts of membrane material, and 23.3 parts of oil phase; The aqueous phase, by weight, comprises the following parts of raw materials: 10 parts deionized water, 3 parts vitamin B derivative, 1 part amino acid derivative, 1 part glucose derivative, 0.03 parts active peptide, 2.5 parts protein active substance, 1 part polysaccharide active substance, and 57.17 parts glycerol; The vitamin B derivative is nicotinamide, the amino acid derivative is tranexamic acid, the glucose derivative is acetyl glucosamine, the active peptide is nonapeptide-1, the protein active ingredient is hydrolyzed yeast protein, and the polysaccharide active ingredient is schistosome. The membrane material comprises 2 parts of polyglycerol-10 myristate and 3 parts of lecithin; The oil phase, by weight, comprises the following parts of raw materials: It includes 4.5 parts squalane, 6 parts synthetic ester, 3 parts vegetable oil, 0.5 parts vitamin E derivative, 5 parts 4-butylresorcinol, 0.3 parts plant extract, 2 parts vitamin C derivative, and 2 parts bisabolol; The synthetic ester includes caprylic / capric triglyceride, the plant oil includes jojoba seed oil, the vitamin E derivative includes tocopheryl acetate, the plant extract includes glycyrrhizin, and the vitamin C derivative includes ascorbate tetraisopalmitate. The preparation method of the full-link whitening and spot-removing liposomes includes the following steps: (1) Preparation of aqueous phase: Glycerin and deionized water are mixed, and then the remaining aqueous phase components are added in sequence. The mixture is stirred evenly at a controlled temperature of 75℃ and a controlled speed of 450r / min to obtain the aqueous phase. (2) Preparation of oil phase: After mixing the membrane material, squalane, synthetic ester, vegetable oil and vitamin E derivative, 4-butylresorcinol, plant extract, vitamin C derivative and bisabolol are added in sequence and stirred at 77℃ and 330r / min for 1h to obtain the oil phase. (3) Preparation of liposome finished product: The oil phase was added to the aqueous phase at a speed of 5 mL / min under stirring at 2100 r / min and then stirred for 20 min. The mixture was then sonicated at 320 W for 5.5 min to obtain the colostrum. The colostrum was then introduced into a microfluidic homogenizer and homogenized 5 times under a pressure of 250 MPa to obtain the liposome finished product.

[0023] Example 2 A full-chain whitening and spot-removing liposome, by weight, comprises the following components: 75.5 parts of aqueous phase, 5 parts of membrane material, and 22 parts of oil phase; The aqueous phase, by weight, comprises the following parts of raw materials: 10 parts deionized water, 2 parts vitamin B derivative, 1 part amino acid derivative, 1 part glucose derivative, 0.02 parts active peptide, 1 part protein active substance, 1.5 parts polysaccharide active substance, and 58.98 parts glycerol; The vitamin B derivative is nicotinamide, the amino acid derivative is tranexamic acid, the glucose derivative is acetyl glucosamine, the active peptide is nonapeptide-1, the protein active ingredient is hydrolyzed yeast protein, and the polysaccharide active ingredient is schistosome. The membrane material comprises 1.5 parts of polyglycerol-10 myristate and 3.5 parts of hydrogenated lecithin; The oil phase, by weight, comprises the following parts of raw materials: It includes 6 parts squalane, 4 parts synthetic ester, 3 parts vegetable oil, 0.5 parts vitamin E derivative, 3 parts 4-butylresorcinol, 0.5 parts plant extract, 2 parts vitamin C derivative, and 3 parts bisabolol; The synthetic ester includes caprylic / capric triglyceride, the plant oil includes jojoba seed oil, the vitamin E derivative includes tocopheryl acetate, the plant extract includes glycyrrhizin, and the vitamin C derivative includes ascorbate tetraisopalmitate. The preparation method of the full-link whitening and spot-removing liposomes includes the following steps: (1) Preparation of aqueous phase: Glycerin and deionized water are mixed, and then the remaining aqueous phase components are added in sequence. The mixture is stirred evenly at 70°C and 400r / min to obtain the aqueous phase. (2) Preparation of oil phase: After mixing the membrane material, squalane, synthetic ester, vegetable oil and vitamin E derivative, 4-butylresorcinol, plant extract, vitamin C derivative and bisabolol are added in sequence. The mixture is stirred at 80℃ and 340r / min for 0.5h to obtain the oil phase. (3) Preparation of liposome finished product: The oil phase was added to the aqueous phase at a speed of 6 mL / min under stirring at 2000 r / min and then stirred for 25 min. The mixture was then sonicated at 350 W for 5 min to obtain the colostrum. The colostrum was then introduced into a microfluidic homogenizer and homogenized 3 times under a pressure of 230 MPa to obtain the liposome finished product.

[0024] Example 3 A full-chain whitening and freckle-removing liposome, by weight, comprises the following components: 73.6 parts of aqueous phase, 5 parts of membrane material, and 25.2 parts of oil phase; The aqueous phase, by weight, comprises the following parts of raw materials: 10 parts deionized water, 5 parts vitamin B derivatives, 3 parts amino acid derivatives, 3 parts glucose derivatives, 0.05 parts active peptides, 1.8 parts protein active substances, 2 parts polysaccharide active substances, and 48.75 parts glycerol; The vitamin B derivative is nicotinamide, the amino acid derivative is tranexamic acid, the glucose derivative is acetyl glucosamine, the active peptide is nonapeptide-1, the protein active ingredient is hydrolyzed yeast protein, and the polysaccharide active ingredient is schistosome. The membrane material comprises 2 parts of polyglycerol-10 myristate and 3 parts of lecithin; The oil phase, by weight, comprises the following parts of raw materials: It includes 3 parts squalane, 4 parts synthetic ester, 3 parts vegetable oil, 1 part vitamin E derivative, 10 parts 4-butylresorcinol, 0.2 parts plant extract, 3 parts vitamin C derivative, and 1 part bisabolol; The synthetic ester includes caprylic / capric triglyceride, the plant oil includes jojoba seed oil, the vitamin E derivative includes tocopheryl acetate, the plant extract includes glycyrrhizin, and the vitamin C derivative includes ascorbate tetraisopalmitate. The preparation method of the full-link whitening and spot-removing liposomes includes the following steps: (1) Preparation of aqueous phase: Glycerin and deionized water are mixed, and then the remaining aqueous phase components are added in sequence. The mixture is stirred evenly at 80℃ and 425r / min to obtain the aqueous phase. (2) Preparation of oil phase: After mixing the membrane material, squalane, synthetic ester, vegetable oil and vitamin E derivative, 4-butylresorcinol, plant extract, vitamin C derivative and bisabolol are added in sequence and stirred at 70℃ and 350r / min for 1h to obtain the oil phase. (3) Preparation of liposome finished product: The oil phase was added to the aqueous phase at a speed of 5.5 mL / min under stirring at 2200 r / min and then stirred for 23 min. The mixture was then sonicated at 335 W for 6 min to obtain the colostrum. The colostrum was then introduced into a microfluidic homogenizer and homogenized 4 times under a pressure of 240 MPa to obtain the liposome finished product.

[0025] Comparative Example 1 Compared to Example 1, Comparative Example 1 did not add nonapeptide-1, and the reduction was made up by 4-butylresorcinol, acetyl glucosamine and ascorbate tetraisopalmitate in proportion to the parts, while the rest remained unchanged.

[0026] Comparative Example 2 Compared with Example 1, Comparative Example 2 did not add 4-butylresorcinol. The reduction was made up by nonapeptide-1, acetyl glucosamine and ascorbate tetraisopalmitate in proportion to the parts, while the rest remained unchanged.

[0027] Comparative Example 3 Compared with Example 1, no acetyl glucosamine was added in Comparative Example 3. The reduction was made up by nonapeptide-1, 4-butylresorcinol and ascorbate tetraisopalmitate in proportion to the parts, while the rest remained unchanged.

[0028] Comparative Example 4 Compared with Example 1, Comparative Example 4 did not contain ascorbic acid tetraisopalmitate. The reduction was made up by nonapeptide-1, 4-butylresorcinol and acetyl glucosamine in proportion to the amount of ascorbic acid, while the rest remained unchanged.

[0029] Comparative Example 5 Compared with Example 1, Comparative Example 5 did not add tranexamic acid, and the reduction was made up by hydrolyzed yeast protein and schistosome in proportion, while the rest remained unchanged.

[0030] Comparative Example 6 Compared with Example 1, no hydrolyzed yeast protein was added in Comparative Example 6. The reduction was made up by tranexamic acid and schistosome in proportion, while the rest remained unchanged.

[0031] Comparative Example 7 Compared with Example 1, Comparative Example 7 did not add schistosin, and the reduction was made up by tranexamic acid and hydrolyzed yeast protein in proportion, while the rest remained unchanged.

[0032] Test Example 1 Whitening and freckle-removing effect test: Referring to T / ZHCA 001-2018 "Test Method for Whitening and Freckle-removing Efficacy of Cosmetics", liposomes prepared in Examples 1-3 and Comparative Examples 1-4 were added to emulsion bases with the same matrix to prepare test samples (the amount of liposomes added was 3wt% of the test sample), and the whitening and freckle-removing effect test was conducted. Volunteers were randomly divided into 7 groups. Qualified subjects were selected according to the inclusion and exclusion criteria to ensure that the final number of valid cases in each test area was 30. The test was conducted under the same conditions, and the test results are shown in Table 1.

[0033] Table 1. Results of Whitening and Spot-Removing Effect Tests As can be easily seen from Table 1, the ITA° values ​​of Examples 1-3 of the present invention gradually increase, and can be increased to over 30 after 4 weeks of use. Compared with Comparative Examples 1-4, it is obvious that the results are not good regardless of the addition of any one of 4-butylresorcinol, nonapeptide-1, acetyl glucosamine and ascorbate tetraisopalmitate. This indicates that the aforementioned four raw materials added in the present invention can effectively construct a multi-target whitening and spot-removing system, so that the prepared liposomes have significant whitening and spot-removing effects.

[0034] Test Example 2 Hydrating efficacy test: Liposomes prepared in Examples 1-3 and Comparative Examples 5-7 were added to emulsion bases with the same matrix to prepare test samples (liposome addition amount was 3wt% of the test sample). Referring to QB / T 4256-2011, 72 eligible volunteers were randomly invited and randomly divided into 6 groups. The same Corneometer CM825 was used to test the skin stratum corneum moisture content of each group before and 2h and 4h after use. The average value of each group's results was taken, and the skin moisture content growth rate was calculated using the following formula: Skin moisture content growth rate (%) = [(Skin stratum corneum moisture content after use - Skin stratum corneum moisture content before use) / Skin stratum corneum moisture content before use] × 100%; The test results are shown in Table 2.

[0035] Table 2 Results of Hydration Efficacy Test As can be seen from Table 2, the present invention uses tranexamic acid, hydrolyzed yeast protein and schistosome in combination, which can synergistically give the finished product excellent soothing and moisturizing effects.

[0036] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. The illustrative expressions of the above terms in this specification should not be construed as necessarily referring to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. In addition, those skilled in the art can combine and integrate the different embodiments or examples described in this specification.

[0037] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A full-chain whitening and freckle-removing liposome, characterized in that, By weight, it comprises the following components: 62.02-86.55 parts of aqueous phase, 1.5-5 parts of membrane material, and 15.7-33.5 parts of oil phase; The aqueous phase, by weight, comprises the following parts of raw materials: 8-12 parts deionized water, 2-5 parts vitamin B derivatives, 1-3 parts amino acid derivatives, 1-3 parts glucose derivatives, 0.02-0.05 parts active peptides, 1-2.5 parts protein active substances, 1-2 parts polysaccharide active substances, and 48-59 parts glycerol; The membrane material comprises, by weight, the following parts of raw materials: Polyglycerol-10 myristate 1.5-2 parts; The oil phase, by weight, comprises the following parts of raw materials: Squalane 3-6 parts, synthetic ester 4-6 parts, vegetable oil 2-4 parts, vitamin E derivative 0.5-1 part, 4-butylresorcinol 3-10 parts, plant extract 0.2-0.5 parts, vitamin C derivative 2-3 parts, bisabolol 1-3 parts.

2. The end-to-end whitening and freckle-removing liposome according to claim 1, characterized in that, The membrane material also includes lecithin or hydrogenated lecithin.

3. The end-to-end whitening and freckle-removing liposome according to claim 2, characterized in that, The lecithin is 2-4 parts by weight, and the hydrogenated lecithin is 3-4 parts by weight.

4. The end-to-end whitening and freckle-removing liposome according to claim 2, characterized in that, The vitamin B derivative includes nicotinamide, the amino acid derivative includes tranexamic acid, the glucose derivative includes acetyl glucosamine, the active peptide includes nonapeptide-1, the protein active ingredient includes hydrolyzed yeast protein, and the polysaccharide active ingredient includes schistosome.

5. The end-to-end whitening and freckle-removing liposome according to claim 1, characterized in that, The synthetic ester includes caprylic / capric triglyceride, the plant oil includes jojoba seed oil, the vitamin E derivative includes tocopheryl acetate, the plant extract includes glycyrrhizin, and the vitamin C derivative includes ascorbate tetraisopalmitate.

6. A method for preparing a full-chain whitening and freckle-removing liposome as described in any one of claims 2-5, characterized in that, Includes the following steps: (1) Preparation of aqueous phase: Glycerin and deionized water are mixed, and then the remaining aqueous phase components are added in sequence and stirred evenly under controlled temperature and speed to obtain the aqueous phase; (2) Preparation of oil phase: After mixing the membrane material, squalane, synthetic ester, vegetable oil and vitamin E derivative, 4-butylresorcinol, plant extract, vitamin C derivative and bisabolol are added in sequence and stirred at controlled temperature and speed to obtain the oil phase; (3) Preparation of liposome finished product: The oil phase is added to the aqueous phase under stirring and then stirred and ultrasonically treated to obtain the colostrum. The colostrum is then introduced into a microfluidic homogenizer for homogenization to obtain the liposome finished product.

7. The method for preparing the full-chain whitening and freckle-removing liposomes according to claim 6, characterized in that, The temperature and speed control in step (1) are 45-50℃ and 400-450r / min.

8. The method for preparing the full-chain whitening and freckle-removing liposomes according to claim 6, characterized in that, The temperature and speed control in step (2) are 70-80℃, the speed is 330-350r / min, and the time is 0.5-1h.

9. The method for preparing the full-chain whitening and freckle-removing liposomes according to claim 6, characterized in that, The stirring speed in step (3) is 2000-2200 r / min; the speed at which the oil phase is added to the water phase is 5-6 mL / min; the stirring time is 20-25 min; the ultrasonic treatment power is 320-350 W and the time is 5-6 min; the homogenization pressure is 230-250 MPa and the number of times is 3-5.

10. The application of the full-chain whitening and spot-removing liposome as described in any one of claims 2-5 in cosmetics, wherein the liposome is added at 1-10% of the total mass of the cosmetic.

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