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Hydrogel-hydrophobic Janus particle and preparation method thereof

A hydrogel, hydrophobic technology, applied in the field of microemulsion, can solve the problems of instability of microemulsion, achieve good biocompatibility and biodegradability, avoid direct contact, and solve the effect of instability

Active Publication Date: 2017-04-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiencies in the prior art, the present invention provides a hydrogel-hydrophobic Janus particle and its preparation method to solve the problems of microemulsion instability and the like

Method used

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  • Hydrogel-hydrophobic Janus particle and preparation method thereof
  • Hydrogel-hydrophobic Janus particle and preparation method thereof
  • Hydrogel-hydrophobic Janus particle and preparation method thereof

Examples

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Embodiment 1

[0039] Example 1: Preparation of hydrogel-hydrophobic Janus particles

[0040] (1) First, the flow-focusing PDMS microfluidic device used in the present invention is produced by soft photolithography: a layer of photosensitive material is coated on the silicon substrate, and a part of the area is exposed through a mask, and the photosensitive material imaging agent is used to obtain the microfluidic device on the silicon substrate. The channel structure, this channel structure has an inner phase inlet, an outer phase inlet and an outlet, and the outer phase inlet is divided into two channels and is symmetrically distributed on the left and right sides of the inner phase inlet; then use PDMS (polydimethylsiloxane ) materials to replicate the channel structure, and bond PDMS and glass substrates to make microfluidic devices through plasma and heat treatment; finally, surface hydrophobic treatment is carried out on the microfluidic devices to obtain flow-focusing PDMS microfluidic...

Embodiment 2

[0044] Example 2: Preparation of hydrogel-hydrophobic Janus particles

[0045](1) Dissolve 10.5 mg of sodium carbonate in 1 ml of water to obtain an alkaline solution; dissolve 80 mg of shellac in the above-mentioned alkaline solution to obtain a shellac solution; then dissolve 10 mg of sodium alginate in the above-mentioned shellac solution to obtain a mixed solution; finally, 0.2 mg calcium carbonate nanoparticles were dispersed into the above mixed solution by ultrasonic to obtain the final mixed solution.

[0046] Take 1ml of the final mixed solution prepared in step (2) as the internal phase, and pass it into the internal phase inlet of the flow-focusing PDMS microfluidic device prepared in Example (1). Take 2ml of the fluorinated ether solution containing 0.9wt% PEG-Krytox-PEG surfactant (the molar mass concentration of HFE7500 is 3mol / L) and pass it into the flow focusing PDMS microfluidic device prepared in Example (1) as the external phase The foreign entrance. Then...

Embodiment 3

[0048] Example 3: Preparation of hydrogel-hydrophobic Janus particles

[0049] (1) Dissolve 16.5 mg of sodium carbonate in 1 ml of water to obtain an alkaline solution; dissolve 160 mg of shellac in the above-mentioned alkaline solution to obtain a shellac solution; then dissolve 20 mg of sodium alginate in the above-mentioned shellac solution to obtain a mixed solution; finally, 2 mg of calcium carbonate nanoparticles were dispersed into the above mixed solution by ultrasonic to obtain the final mixed solution.

[0050] Take 1ml of the final mixed solution prepared in step (2) as the internal phase, and pass it into the internal phase inlet of the flow-focusing PDMS microfluidic device prepared in Example (1). Get 10ml of the fluorinated ether solution containing 1.2wt% PEG-Krytox-PEG surfactant (the molar mass concentration of HFE7500 is 3.5mol / L) as the external phase into the flow-focusing PDMS microfluidic device prepared in Example (1). The outer phase entrance of the d...

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Abstract

The invention discloses a hydrogel-hydrophobic Janus particle and a preparation method thereof. In the method, a toxic-free solvent and a bio-compatible material are used for preparing the hydrogel-hydrophobic Janus particle. The method includes the steps of: dissolving the hydrogel biomaterial and the hydrophobic biomaterial in water, and generating mono-dispersed emulsion with a flow-focusing micro-fluidic device; changing external conditions to separate a hydrophobic organic high-molecular phase out and form a hydrophobic semi-sphere around drops; adding an ionic substance, which can be crosslinked with the hydrogel material, so that the hydrogel phase is crosslinked with the ionic substance to form hydrogel semi-sphere, and finally, the two organic high-molecular phases are subjected to molecule winding during phase separation so as to form an integrated structure, thus obtaining the hydrogel-hydrophobic Janus particle. The particle has high stability and is controllable in size. As a surfactant, the particle can solve the problem such as instability of a micro-emulsion and the like.

Description

technical field [0001] The invention relates to the field of microemulsions, in particular to a hydrogel-hydrophobic Janus particle and a preparation method thereof. Background technique [0002] Most food, cosmetics and health products are microemulsions mixed with water and oil, and microemulsions have a wide range of applications in the fields of food, cosmetics and health products. Further research on these microemulsions is of great significance, which can promote the development of new products, increase the added value of products, and generate new economic benefits. Mixed microemulsions usually need to be prepared by inputting energy from the outside by means of vibration, stirring, homogenization, etc. These emulsions are inherently unstable, and they tend to return to the phase separation state and reach the initial state with the minimum interfacial energy. Surfactants are amphiphilic molecules that have both hydrophilic and hydrophobic parts and are often used t...

Claims

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Application Information

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IPC IPC(8): B01F17/00C09K23/00
CPCC09K23/00C09K23/018
Inventor 陈东许忠斌王悦荟黄兴孙泽勇
Owner ZHEJIANG UNIV
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