277results about How to "High kill rate" patented technology

A sterilizing method and apparatus for destroying live microorganisms including viruses in fluent material, such as air and water, in large volume. As a preferred embodiment of this invention, air is drawn, from the inlet 1, through the inlet filter unit 3 and into the circuitous sterilizing chamber 10 that is irradiated by numbers of UV lamp tubes 15, and through the discharging filter unit 13 and then out through outlet 11. A sample window 12 is built in for quality supervision. Visual inspection windows 5 and UV sensors 6 are provided for easy supervision and auto-control. The sterilizing chamber 10 also includes flow resistant reducing feature 7 and internal reflecting surfaces 9.

This invention relates to certain non-silicone resin cured rubber articles that are made from at least a majority by weight of non-silicone vulcanized rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as resin curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of non-silicone rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate resin cured rubber articles made therefrom.

The invention described herein contains two aspects, usable together or separately, that address the needs in the art described above, namely a first aspect that relates to the provision of a transportable water purification system that can be contained on a passenger transport vehicle, and that can use, but does not require, continuous, real-time monitoring, and a second aspect that relates to the use of UV purification of the water as it is uploaded to the passenger transport vehicle after a single pass through the UV chamber.

The invention provides a pure plant type antibacterial cleanser and a preparation method thereof. The cleanser is prepared from a Chinese medicinal plant preparation, alkyl polyglucoside, coco glucoside amphoteric surfactant, polyol, acidity regulator, flavor, and deionized water. The pure plant preparation is used as the raw material, so the pure plant type antibacterial cleanser is mild in usability, low in irritation and high in efficiency, and can be used safely, and used for sterilizing the surfaces of household rooms, clothes, kitchen ware, gymnasium equipment, infant toys and the like. According to the cleanser, the raw material system has a synergistic effect, and the pure plant type antibacterial cleanser is high in stability and water solubility, low in toxicity, can be washed easily, does not have irritation, and can be applied to the surfaces of various objects.

This invention relates to certain non-silicone vulcanized rubber articles that are made from at least a majority by weight of vulcanized styrene butadiene rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as peroxide curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of styrene butadiene rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate cured rubber articles made therefrom.

The invention belongs to the technical field of clean rooms, in particular relates to a clean room with a non-thermal plasmas air disinfection purifier. The clean room comprises an air purification unit, a reactor power, a fan, the clean room, a fresh air system, a controller, an air return trench, an air filter, a static pressure box, a return air pipe and a grating floor. The air purification unit is installed in the static pressure box arranged above the clean room to form an airtight environment; the air purification unit is a plasma reactor, is internally provided with a plurality of nickel-chromium metal wires or metal bands which are arranged in parallel according to equal distance in the same plane to prepare a positive electrode, two ends of the air purification unit are fixed in a corresponding groove or convex part on a conductive rail for preventing micro-discharge, and a switch tube in the reactor power is arranged by a single-end flyback inverter. The invention provides the clean room, which has the advantages of comprehensive air purification and disinfection effect, high efficiency, low energy consumption, low noise, simple structure, maintenance cost saving and long service life and can be applied to an industrial or biological clean room.

The invention relates to specific chimeric antigen receptor T cells targeting CD19, and a preparation method and clinical application thereof. The present invention constructs a specific chimeric antigen receptor targeting CD19 and immune response cells modified by the chimeric antigen receptor based on a targeted human CD19 single-chain antibody sequence. The novel modified immune response cells can effectively target and attack a plurality of tumor cells, especially tumor cells with positive CD19 expressiion, and can be used to prepare a preparation for the treatment of tumors. The method for preparing the modified immune response cells targeting CD19 is simple, and the obtained modified immune response cells targeting CD19 have a high killing rate on tumor cells. Clinical verification shows that: after a million-grade low-dose back transfusion, patients with recurrent and refractory advanced CD19-positive lymphoma get a significant clinical symptom relief after two weeks of treatment, almost complete relief curative effect is obtained on the 77th day, and no fever caused by cytokine release syndrome and any neurotoxic side effect occur.

The present invention is directed to methods for applying bovine foot and hoof treatment compositions having two or more specific and complimentary antimicrobial components in a hoof bath just prior to use to work more effectively. These antimicrobial components may include antimicrobial inorganic salts of certain heavy metals, cationic agents, peroxides, aldehydes, fatty acids, iodines or other suitable compounds effective in the killing of microorganisms.

The invention relates to a method of photoeradication of cellular and acellular organisms including the steps of providing a surface acting agent containing benzalkonium chloride in association with a cellular or acellular organism, the surface acting agent disorienting a membrane structure so that said membrane no longer functions as an effective osmotic barrier; providing a photosensitive material in association with the cellular or acellular organism; and applying light in association with the cellular or acellular organism to cause a disruption of the organism. The method according to the present invention may be utilized in invitro and invivo treatment protocols for infections, sterilization procedures, cancer cell eradication, virus and fungus eradication, spore eradication, and biofilm organism eradication. Additional aspects of the invention include particular combinations of photosensitive materials and surfactants for use in photodynamic therapies.

The invention discloses a cleaning agent for a washing machine slot. The cleaning agent comprises the following components in percentage by weight: 55-68% of sodium carbonate, 20-30% of sodium percarbonate, 1-6% of a bleaching activator, 0.1-0.6% of a binary compound enzyme, 0.3-2% of a surfactant, 2-8% of calcium carbonate and 2-8% of sodium silicate. The cleaning agent for the washing machine slot, disclosed by the invention, can effectively remove dirt from the washing machine slot, is non-corrosive to a washing machine, can effectively kill and inhibit harmful bacteria and avoid secondary pollution to clothes, and meanwhile is inirritative and safe to human bodies.

The invention discloses a heat-resisting antibacterial thermoplastic polyurethane elastomer. The heat-resisting antibacterial thermoplastic polyurethane elastomer consists of the following components by weight percent: 25 to 40 percent of thermoplastic polyurethane, 10 to 20 percent of heat-resisting resin, 5 to 12 percent of antibacterial agent, 15 to 25 percent of polyolefin resin, 20 to 30 percent of filling oil, 1 to 10 percent of nano talcum powder, 0.4 to 3 percent of composite antioxidant and 0.1 to 2 percent of lubricating agent. According to the prepared heat-resisting antibacterial thermoplastic polyurethane elastomer, a heat-resisting agent is added, so that on the basis of guaranteeing the original high elasticity of the thermoplastic polyurethane elastomer, the heat resistance of the material is improved; and when the heat-resisting antibacterial thermoplastic polyurethane elastomer is applied to a bathroom accessory water pipe product, after being used at a high temperature for a long time, the fracturing phenomenon is avoided. By adding the antibacterial agent, the bacterial killing rate is high, the speed is high, the long-term efficacy is good, and the heat-resisting antibacterial thermoplastic polyurethane elastomer is applied to the fields such as bathroom hoses, tap water pipes and the like.

A stomach-action molluscicide, which includes a metal complexone and a suitable additive for enhancing the molluscicidal activity of the metal complexone. The additive may be selected from a surfactant or an additional source of ferric ions. Examples of the surfactant include sodium dodecyl sulphate or sorbitan monostearate, while an example of the additional source of ferric ions is ferric orthophosphate.

The invention relates to a double-specific chimeric antigen receptor T cell as well as a preparation method and application thereof. The double-specific chimeric antigen receptor double-specifically targeting human NKG2DL and human CD47 is constructed on the basis of human NKG2D and human SIRPalpha molecules as well as an immune response cell modified with the double-specific chimeric antigen receptor. The novel modified immune response cell can effectively realize targeting attack of multiple tumor cells, particularly positive tumor cells expressing NKG2DL and CD47 and can be used for preparing preparations for treating tumor. The preparation method of the immune response cell modified with the double-specific chimeric antigen receptor double-specifically targeting NKG2DL and CD47 comprises simple steps, the obtained immune response cell modified with the double-specific chimeric antigen receptor double-specifically targeting NKG2DL and CD47 has high specific killing rate for tumor cells.

The invention relates to a making method of instant fresh sea cucumber, which is characterized by comprising the following steps: opening the abdomen of a fresh and live sea cucumber, completely removing internal organs, washing with clear water, placing into manganese salt solution which is 1-10 times the weight of the sea cucumber, adding an organic acid for adjusting the pH value to 4.0-6.0, placing the whole into a microwave sterilizer for microwave heating to 40-75 DEG C, and performing heat insulation treatment for 5-60 minutes; taking the sea cucumber out of the solution, and using ethanol solution containing 0.1-1% of tea polyphenol and 0.1-10% of propolis for impregnation or spraying the ethanol solution on the outer surface and the outer surface of the body wall of the sea cucumber; and performing compound modified atmosphere packaging on the sea cucumber so as to get the instant fresh sea cucumber. The instant fresh sea cucumber made through the method is low in loss of nutritional ingredients, the heat denaturation of protein is avoided, the instant fresh sea cucumber further has good taste and no fishy and astringency smell, and is convenient to preserve and take, simple in processing technology, short in period and low in energy consumption, and subsidiary ingredients can further increase the health care function of the sea cucumber while being used for processing.

A method and apparatus for calibrating such a spot beam antenna by use of scanned spot beam signal characteristics measured by a plurality of ground based navigation receivers is disclosed.

The invention discloses a method for preparing polyhexamethylene biguanidine hydrochloride. Dicyanamide and triethylene diamine are used as raw materials, and water is used as an initiator; and an intermediate product generated by polymerization is continuously reacted and polymerized with hydrochloric acid to generate the polyhexamethylene biguanidine hydrochloride. The polyhexamethylene biguanidine hydrochloride has the characteristics of excellent sterilization effect, no toxicity or harm, simple process and low cost.

The invention belongs to the field of biological medicines, and relates to application of Bcl-xL inhibitor and oncolytic virus to preparation of anti-tumor medicines. It is found for the first time that Bcl-xL inhibitor can be used for preparing oncolytic virus anti-tumor synergist. The invention meanwhile relates to a pharmaceutical composition containing Bcl-xL inhibitor and oncolytic virus, a medicine suit containing Bcl-xL inhibitor and oncolytic virus, and application of Bcl-xL inhibitor and oncolytic virus to treatment of tumors, especially tumors not sensitive to oncolytic virus.

The invention described herein contains two aspects, usable together or separately, that address the needs in the art described above, namely a first aspect that relates to the provision of a transportable water purification system that can be contained on a passenger transport vehicle, and that can use, but does not require, continuous, real-time monitoring, and a second aspect that relates to the use of UV purification of the water as it is uploaded to the passenger transport vehicle after a single pass through the UV chamber.

The invention relates to a quick-frozen bamboo shoot production method, comprising the following steps: (1) treatment of raw materials, namely, selecting fresh bamboo shoots and removing impurities; (2) sterilization, namely, carrying out routine sterilization on the treated bamboo shoots; (3) quick-freezing, namely, quick-freezing the bamboo shoots one by one with a quick-freezing machine, controlling the quick-frozen temperature at -30 to -35 DEG C, and discharging the bamboo shoots when the center temperature of the bamboo shoots drops below -18 DEG C; (4) ozone water ice-plating, namely, the quick-frozen bamboo shoots are soaked in ozone ice water for 7-20 seconds at an oxidation reduction potential of 300mv-600mv, and then quickly taking out the bamboo shoots; and (5) packaging, namely, vacuum-packaging the ozone ice-plated bamboo shoots, wherein, the oxidation reduction potential of the ozone water is 500mv, and the bamboo shoots are soaked in the ozone water for 10 seconds. The application of the method greatly reduces the total number of bacteria of bamboo products, effectively maintains the freshness of the bamboo products, prolongs the shelf life and reduces the contents of toxic and harmful substances.

The invention relates to a device for propagating and shielding natural enemies of pests in the field, comprising a greenhouse framework and a thin film covering the greenhouse framework. The pest-preventing gauze, the skirt-edge film, the rolling film and the sun-shading net are used to simulate the shielding environment suitable for the natural enemies of pests to survive and propagate. The invention also relates to a method for preventing and treating pests by adopting the device. According to the method, the conventional method for killing by spraying pesticide is used first, and then the natural enemies of pests, which are propagated in the device, are used to kill the pests having strong pesticide resistance after being killed by adopting the conventional method for killing. The method combines the chemical prevention and treatment means with the biological prevention and treatment means. Compared with the prior art, the method has the advantages of improving the pest killing rate, prolonging the pest killing period and reducing the pollution to the environment.

High concentration, that is, strong antimicrobial treatment materials such as high concentration aqueous ammonia solutions or even liquid ammonia may be applied to a foodstuff without deleterious effects by controlling the temperature of the foodstuff at or immediately after the time of contact with the antimicrobial treatment material. In particular, ice crystals are maintained at or just below the surface of the foodstuff at or immediately after the time of contact with the antimicrobial treatment material. The ice crystals in the foodstuff inhibit absorption of the antimicrobial treatment material into the foodstuff.

The present invention discloses a magnetic nanocomposite for inhibiting / treating cancer and a method for fabricating the same. The magnetic nanocomposite comprises a core formed of a plurality of magnetic nanoparticles made of ferric ferrous oxide (Fe3O4); a shell made of a carboxy-functionalized polyaniline; and an anti-tumor medicine bound to the external surface of the shell. The method of the present invention fast fabricates the magnetic nanocomposite in a simple way. The medicine of the present invention has a longer half life and a better thermal stability. The present invention disperses the water-insoluble medicine in water uniformly to decrease the biological rejection. Moreover, the magnetic nanocomposite of the present invention is guided to the nidus by an external magnetic field to increase the local concentration of the medicine and provide an effective chemotherapy. Therefore, the present invention has competitive advantage over the conventional BCNU.

The invention relates to a coding amino acid sequence of an armed chimeric antigen receptor capable of specifically knocking out and targeting the SARS-CoV-2 virus SPIKE protein constructed by SARS-CoV-2 virus RNA polymerase, an immune response cell modified by the amino acid sequence, preparation methods and applications. The recombinant vector of the armed chimeric antigen receptor targeting theSARS-CoV-2 virus SPIKE can be constructed by knocking out the SARS-CoV-2 virus RNA polymerase, and a method using the recombinant vector to modify the immune response cell is also constructed; and the obtained novel functional immune response cell can effectively target and attack various viruses. The preparation method of the immune response cell modified by the armed chimeric antigen receptor targeting the SARS-CoV-2 virus SPIKE is simple in step; and the obtained immune response cell targeting the virus SPIKE and modified by virus replication-dependent RNA polymerase has obvious killing effects on coronavirus.

The invention relates to an immunomodulatory specific chimeric antigen receptor cell as well as a preparation method and application thereof. According to the invention, a recombinant vector of a chimeric antigen receptor of immune checkpoint regulation (PD1 or TIGIT) combined with specifically targeting human NKG2DL, and is used for modifying immune response cells; the obtained novel functionalized immune response cell can effectively target and attack various tumors, and a preparation for treating malignant tumors is prepared. Engineering immune cells modified by the chimeric antigen receptors of immune checkpoint regulation (PD1 or TIGIT) combined with specifically targeting human NKG2DL is adopted, inactivation of immune cells induced by inhibition factors is inhibited, immune escape of tumor cells is prevented, and antitumor activity can be obviously improved.

The invention belongs to the field of biomedicine and relates to synergistic antitumor drug, in particular to application of antitumor drug like DNA-PK (DNA-dependent protein kinase, DNA-PK) inhibitors and oncolytic viruses in preparing antitumor drug. It is found for the first time that the antitumor drug like the DNA-PK inhibitor with various targets can be used for preparing oncolytic virus antitumor synergists. The invention further relates to a drug composition containing the antitumor drug and the oncolytic viruses, drug sets comprising the antitumor drug and the oncolytic viruses and application of the antitumor drug and the oncolytic viruses in treating tumor, especially for tumor insensitive to the oncolytic viruses.

The invention provides a soil disinfecting method, which uses micro-nano bubble ozone water with the ozone concentration of 70-10 mg / L for spraying soil for disinfection and disinfects the soil by combining an ozone sterilization technology with a micro-nano bubble technology. According to the soil disinfecting method, ozone is produced by an ozone generator, the ozone is quickly dissolved into water through a micro-nano bubble generating device, and the soil to be treated is sprayed or irrigated so as to kill harmful pathogenic microorganisms in the soil, thus achieving an aim of disinfecting the soil. By the soil disinfecting method, soil-borne diseases are effectively prevented and treated, pesticide residues are avoided, and a standard for green production of crops is met.

The invention provides a method for extracting and preparing a natural, safe and high-efficiency plant natural preservative by using bamboo leaves as raw materials and integrating an ultrasonic auxiliary extraction technology, a membrane separation technology, a composite solvent continuous countercurrent extraction technology, a vacuum concentration technology, and the like. The preservative can be widely applied to fruits, vegetables, food, medicines, feed, cosmetics, and the like, and particularly, the preservative has broad antibacterial spectrum and small additive amount and belongs to clarification type preservatives in beverages. After the preservative is added to beverage products, the preservative cannot influence the color, the flavor and the taste of the products, thus the preservative has obvious application advantages.

The invention discloses a chimeric antibody and an immunocyte. The chimeric antibody provided by the invention has an amino acid sequence containing a target antibody, a transmembrane domain segment of a HLA-A2 (Human Leukocyte Antigen-A2) molecule and an intracellular domain segment of a CD3 compound protein zeta chain in sequence from a terminal N to a terminal C. The chimeric antibody can be expressed on the surfaces of any cells, when the chimeric antibody is expressed on the surface of an immunocyte, the immunocyte is endowed with a specific immunity by virtue of the target antibody on the chimeric antibody, and thus, the chimeric antibody provided by the invention can be specifically combined with a plurality of antigens along with different target antibodies in the chimeric antibody. The chimeric antibody, a single-domain antibody and an immunocyte for expressing the chimeric antibody, provided by the invention, are about to have broad application prospects in the cellular immunotherapy.

The invention discloses a preparation method and application of a hyaluronic acid modified ruthenium nano photo-thermal material. The preparation method comprises the following steps: firstly, enabling hyaluronic acid and cysteine hydrochloride to carry out an amidation reaction so as to obtain cysteine modified hyaluronic acid; secondly, enabling the cysteine modified hyaluronic acid to react with ruthenium chloride under reaction of sodium borohydride, thereby obtaining a water-soluble hyaluronic acid modified ruthenium nano photo-thermal material. The preparation method is easy in preparation raw material obtaining, simple in process and small in environment pollution; meanwhile, the hyaluronic acid has the property of targeting cancer cells with over-expressed CD44, so that a high-efficiency photo-thermal material with a targeting function can be prepared, and the material has an application value in cancer treatment; due to targeting photo-thermal treatment of the hyaluronic acidmodified ruthenium nano photo-thermal material, the cancer cell killing rate is increased, and the material has wide application prospects in photo-thermal treatment, functional materials, tissue engineering, and the like.