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Method for preparing polyhexamethylene biguanidine hydrochloride

A technology of polyhexamethylene biguanide hydrochloride and hexamethylene biguanide diamine, which can be used in botany equipment and methods, chemicals for biological control, animal repellants, etc., and can solve cumbersome processes and high costs , toxicity of raw materials and other issues, to achieve the effect of mature technology, low cost and simple process

Active Publication Date: 2011-02-02
上海高聚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a kind of preparation method of polyhexamethylene biguanide hydrochloride in view of the toxicity of raw materials in the prior art, complicated process and high cost. The polymer has completely non-toxic, non-irritating, The characteristics of corrosion, the preparation method is simple, and the cost is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0017] a, preparation of hexamethylene biguanide intermediate

[0018] Put 160 kilograms of dicyandiamide, 228 kilograms of triethylenediamine and 22.8 kilograms of purified water into the reaction kettle, heat and react at 80°C for 1 hour, then raise the temperature to 150°C for 1.5 hours to obtain hexamethylene Biguanide;

[0019] b. Polymerization reaction

[0020] Cool the hexamethylene biguanide diamine obtained in the above steps to 50°C and add hydrochloric acid to lower the pH value from about 11 to 7.0, then add 73 kg of hydrochloric acid at one time, heat up to 150°C and react for 2 hours to obtain hydrochloric acid 402 kg of polyhexamethylene biguanide, the output rate is 92%.

[0021] C. Prepare the solution

[0022] The obtained polymer melt is transferred into a hydrolysis tank, and purified water is added to prepare a 20% solution.

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Abstract

The invention discloses a method for preparing polyhexamethylene biguanidine hydrochloride. Dicyanamide and triethylene diamine are used as raw materials, and water is used as an initiator; and an intermediate product generated by polymerization is continuously reacted and polymerized with hydrochloric acid to generate the polyhexamethylene biguanidine hydrochloride. The polyhexamethylene biguanidine hydrochloride has the characteristics of excellent sterilization effect, no toxicity or harm, simple process and low cost.

Description

technical field [0001] The invention relates to a polymer and a preparation method thereof, in particular to a preparation method of polyhexamethylene biguanide hydrochloride. Background technique [0002] The application of guanidine disinfectants has a history of more than 50 years, from 1,6-bis(n-p-chlorohexidine) hexane (also known as chlorhexidine, chlorhexidine) to polyhexaethylene, which was used in the 1950s. Methyl biguanide salts, because of their low degree of polymerization, have weak bactericidal efficacy, high toxicity and irritation, and bacteria are prone to drug resistance, so they have gradually begun to withdraw. Since the 1990s, the international community has begun to develop polyalkenyl guanidine salts with higher bactericidal efficacy, and polyalkenyl guanidine phosphate and polyalkenyl guanidine hydrochloride have been developed. Polyalkenyl guanidine phosphate is highly toxic (LD50>2000mg / kg) and irritating to eyes, skin and mucous membranes due ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A01P1/00C08G73/00
Inventor 余刚
Owner 上海高聚生物科技有限公司
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