34results about How to "Stimulus responsive" patented technology

A composite magnetic gel microsphere for biological macromolecualr template blot, based on the template blot (molecular blot) technique, is prepared from different biological macromolaculate as template molecule and different metals (or their oxides) as magentic component through reversed-phase suspension polymerization. It can be used for separating biological macromoleculae with high precision and simple process.

The invention discloses a phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and a preparation method thereof. The phenylboronic acid hydrogel-based sugar-sensitive microneedle pad comprises a base and a microneedle array which is located on the base, wherein the base and microneedles are mainly prepared from a vinyl phenylboronic acid monomer and a vinyl monomer through free radical copolymerization; microneedle bodies and the base can both be used for embedding insulin drugs; the phenylboronic acid monomer is selected from 3-acrylamidophenylboronic acid, and the vinyl monomeris selected from N-isopropyl acrylamide and N-vinyl pyrrolidone. The preparation method disclosed by the invention is simple; the obtained phenylboronic acid hydrogel-based sugar-sensitive microneedlepad is regular in structure, has good mechanical performance, is capable of effectively piercing the skin, has stimulus responsiveness to glucose concentration, and is capable of regulating the release rate and the dosage of insulin according to blood sugar concentrations and effectively preventing a risk of hypoglycemia caused by excessive release of the insulin.

The invention discloses a nanometer drug delivery system which is self-assembled on the basis of grafting dendrimers modified by short-chain alkane to natural polysaccharide and has a pH-responsive performance, belonging to the field of biomedical materials. The drug delivery system comprises aldehydated hydrophilic natural polysaccharide, dendrimers modified by short-chain alkane, an antitumor drug and a targeting ligand for specific tumor identification; the natural polysaccharide and the dendrimers modified by short-chain alkane are formed into a amphiphilic compound through hydrazone bonds; a hydrophobic drug is wrapped inside a cavity of a self-assembled body by means of the hydrophilicity and the hydrophobicity; the targeting ligand for specific tumor identification and drug-loaded nanoparticles are physically mixed to promote the delivery of the drug in tumor tissues and cells. The nanometer delivery system having the pH-responsive performance can realize active targeting and passive targeting, is beneficial for accumulation of the drug in a tumor site, and can make an intelligent response to a slightly acid environment of lysosome/endosome in the tumor cells, thus releasing the drug and realizing the delivery of the drug in the tumor cells, and therefore, the nanometer delivery system is a multifunctional tumor targeted drug delivery system.

The invention relates to a preparation method of supramolecular quadruple hydrogen-bond ureido-pyrimidinone (UPy) unit modified polyvinyl chloride (PVC) special resin. UPy-containing acrylate crosslinking agents are used for modifying PVC, and UPy-containing styrene crosslinking agents are used for modifying the PVC. Compared with the existing crosslinking agents, the crosslinking agents selectedfor use in the method have the beneficial effects that UPy quadruple hydrogen-bond system can form a self-complementary quadruple hydrogen-bond interaction, and is good in stability, strong in self-polymerization ability and very high in binding constant; furthermore, the strong non-covalent cross-linking effect is reversible and has a self-recovery ability; high molecular polymers are formed by means of self-assembly through the interaction of non-covalent hydrogen bonds; the combination of repeating units is based on the interaction of the hydrogen bonds, so that the repeating units can be separated and recombined under appropriate conditions and are reversible; therefore, the PVC polymer not only has the properties of the traditional polymers, but also has the excellent characteristicsof stimulative responsibility, self-repairing property, easy processing and the like, and can be used as special resin for smart materials and self-healing materials.

The invention discloses multifunctional self-repairing hydrogel,a preparation method thereof and applicationof themultifunctional self-repairing hydrogelin detection of biogenic amine.The preparationmethod comprises the steps thatpolyethylene glycolendcapped bysalicylaldehydeis taken and dissolved in a buffer solution, fully shocking is conducted at the room temperature, polyethylene imine is added, evenly mixing is conducted, and the self-repairing hydrogel is obtained.After destroying,original performance of the self-repairing hydrogel recovers completely at the room temperature within 60s,a storage modulus reaches 104Pa, a loss modulus is 103Pa, and pH and ion responsiveness functions are achieved together. According to theprepared hydrogel, the excellent mechanical property is achieved, many functions such as rapid self-repair, ion response, pH response and biogenic amine detection are also achieved,the application range of a polyethylene glycol based self-repairing hydrogel material is widened, and the hydrogel is expected to be applied to food storage, self-repairing materials, fluorescent printing and other industries.

The invention discloses a multi-stimulation responsive stigmasterol derivative low-molecular-mass gelator, organic gel and preparation methods of the low-molecular-mass gelator and the organic gel. The stigmasterol-based glycine ferrocene amide gelator is prepared through a three-step synthesis reaction including esterification, BOC removal and amidation for the first time with stigmasterol with arigid framework used as a gelator construction parent, glycine used as a linking arm and ferrocene containing an oxidation activity group as a reaction group, and the problem of lack of research on construction of a super-molecular gel system with stigmasterol and ferrocene derivatives as gelators in the prior art is solved. An organic gel material of the gelator has properties of thixotropy, ultrasonic response, thermal response and alcohol solvent stimulation response besides oxidation stimulation response expected to be obtained through introduction of the ferrocene group, and the gel is expected to have potential value in the aspects of sensors, solvent recognition and the like.

The invention provides a liposome, a preparation method thereof, a liposome assembly and a carrier liposome complex. The liposome provided by the invention has the structure of formula (I), the left side of the L group is the liposome part, and the right side is the choline phosphoric acid structure, and the two are connected with specific L groups to form the liposome with specific structure. Theliposome of the formula (I) provided by the invention has the properties of long circulation, stimulation response, targeting and the like, and has multiple modifiable sites, can be used for preparing biological preparations with various functions, and provides more convenient choices for diagnosis and treatment of diseases.

The invention relates to the technical field of plant nutrition, in particular to a plant enzyme responsive controlled-release fertilizer and a preparation method thereof, and a plant enzyme responsive nano-carrier and a preparation method thereof. The carrier comprises modified carboxymethyl polysaccharide and an amino modified halloysite nanotube, and a nano-composite carrier with a core-shell structure is formed through esterification reaction. Plant nutrient substances (chemical fertilizers, trace elements and plant growth regulators) are loaded in the tube cavity of the nanotube in a negative pressure adsorption manner, and then the outer layer of the nanotube is coated with a layer of degradable modified carboxymethyl polysaccharide with good biocompatibility through chemical grafting, so that the stability of the fertilizer is improved. The nano-carrier can directly enter crop bodies through plant leaf surfaces, the outer-layer wall material of the nano-carrier is cracked through plant active enzymes in the bodies, so that mesopores or lumen ports in the surface of the nano-carrier are opened, and nutrient substances in lumens are released.

The invention relates to a hydrogen peroxide responsive polymer nano-carrier with a fluorescence ratio characteristic. The nano-carrier is of a spherical micelle structure, and is formed by self-assembling of an amphiphilic block copolymer with hydrogen peroxide responsiveness and ratiometric fluorescence imaging characteristics. The structural formula of the amphiphilic block copolymer having hydrogen peroxide responsiveness and ratiometric fluorescence imaging characteristics is as follows: R1 is a group having hydrogen peroxide responsiveness; R2 is a group with an aggregation-induced emission effect; R3 is a PEG hydrophilic chain; and R5 is a group with strong positive charges. The nano-carrier disclosed by the invention can be used for loading, transporting and program releasing of hydrophobic dye molecules and drug molecules as well as cell imaging and fluorescent molecular probes.

The invention discloses a t-butyloxycarboryl protected acid-sensitive epoxy monomer, the chemical formula of which is shown as one of formulas (1) to (3), and R3 is one of formulas A to D. The invention also discloses a synthesis method of the t-butyloxycarboryl protected acid-sensitive epoxy monomer, and application of the t-butyloxycarboryl protected acid-sensitive epoxy monomer in preparation of t-butyloxycarboryl protected acid-sensitive polymer. The acid-sensitive epoxy monomer with the tert-butyloxycarboryl protection, provided by the invention, can respond to a pH value, especially an acidic environment, so that an obtained polymer material has stimuli responsiveness. Therefore, the tert-butyloxycarboryl protected acid-sensitive polymer can be used in the field of chemical amplification of photoresists, so that the acid-sensitive polymer is endowed with more functionality and higher additional value.

The invention relates to a preparation method of an intelligent supramolecular aquagel for detecting formaldehyde in interior decoration and wastewater, which comprises the following steps: (1) weighing alpha-cyclodextrin powder, and adding ultrapure water to prepare an alpha-cyclodextrin water solution; (2) adding a Tyloxapol liquid, and adding ultrapure water to prepare a Tyloxapol water solution; and (3) taking the alpha-cyclodextrin water solution and Tyloxapol water solution, adding ultrapure water until the alpha-cyclodextrin concentration in the gel is 90-130 mg.mL<-1> and the Tyloxapol concentration is 15-50 mg.mL<-1>, carrying out ultrasonic dispersion, and standing. The preparation method is simple, and the used raw materials have favorable biocompatibility and are friendly to application environments. The intelligent supramolecular aquagel has the advantages of low cost and no toxic byproducts.

The invention relates to a monitoring device and a monitoring method for bacterium/cell growth. The monitoring device comprises a monitoring station and a three-electrode system, in the three-electrode system, a working electrode is a medical polypyrrole electrode, a saturated reference electrode is a calomel electrode, and a counter electrode is a platinum sheet; the test method comprises the following steps: selecting proper frequency and alternating voltage on a medical polypyrrole electrode through an alternating-current impedance technology to obtain an impedance spectrum of bacterial/cell growth, and selecting a proper analog circuit to simulate the impedance spectrum so as to achieve the purpose of monitoring the bacterial/cell growth. The monitoring method is easy to operate and low in cost.

The invention relates to a crown ether-containing HBC compound and its preparation and application. The general formula of the compound is formula: I or II. Preparation: Suzuki coupling reaction between the substituted hexaphenylbenzene intermediate and the monomer is used to obtain the oxidation precursor, and the precursor is catalyzed by ferric chloride to perform Scholl oxidation ring closure to obtain the target compound. The invention can be used as an excellent self-assembled unit molecule in the fields of biological materials, selective separation materials, chiral response materials and the like; the synthesis of raw materials has the advantages of simple method and mature preparation process, and has good application prospects.