34results about How to "Stimulus responsive" patented technology

A composite magnetic gel microsphere for surficial biological macromolecular template blot, based on template blot (molecular blot) technique, is prepared from the different biological macromoleculae as template molecule and different metals (or their oxides) as magnetic component through reverse-phase seed suspension polymerization. Its advantages are less consumption of template moleculae and high adsorption capacity. It can be used for separating biological macromoleculae with more precision and simple process.

The invention discloses triphenylamine derivatives represented by a formula (I) as well as a preparation method and an application thereof in piezochromic organogel. The preparation method comprises the following steps of: mixing an intermediate, para-hexadecyloxy benzaldehyde and sodium methoxide, dissolving with absolute ethyl alcohol, stirring and reacting for 3 hours at room temperature, and separating the reaction liquid after the reaction is complete so as to obtain the triphenylamine derivatives represented by formula (I). The piezochromic organogel is a micromolecule organogel material with multiple simulation responsiveness. The piezochromic organogel is simple in synthesis method, convenient in preparation, strong in simulation responsiveness, and can be applied to fields such as a sensor, anti-fake, store and display.

The invention relates to a multi-responsive polymer nanocarrier with a rapid cell penetrating characteristic. The nanocarrier is formed by self-assembling of a multi-responsive amphipathic triblock copolymer, the nanocarrier adopts an onion structure sequentially comprising an acid-responsive PLLA core, cyanine molecules with a near infrared absorption characteristic, a hydrogen-peroxide-responsive PPI (polyphenyl isocyanide) intermediate layer and a left-handed spiral hydrophilic PPI hydrophilic chain from inside to outside sequentially, wherein the structure of the multi-responsive amphipathic triblock copolymer is shown in the general formula in the specification, R1 is a group with stimulation responsiveness, and R2 is a chiral PEG hydrophilic chain; x ranges from 20 to 50, y ranges from 20 to 50, and z ranges from 30 to 80. The multi-responsive polymer nanocarrier can be used for transporting hydrophobic dye molecules and medicine molecules, can rapidly and efficiently penetrate cell membranes, has multiple stimuli-responsiveness, realizes programmable controlled release of medicines and has a chemical-photothermal collaborative treatment characteristic.

The invention relates to the technical field of polymer material synthesis, in particular to a glutathione-responsive temperature-sensitive hydrogel, a preparation method and its application, comprising the following steps: combining a RAFT chain transfer agent, a monomer, and a cross-linking agent And the initiator is uniformly mixed in the polymerization bottle according to the molar ratio of 1:200:0.37:0.4, and then reacted at 70°C for 8 hours after freezing and evacuating three times to remove oxygen; the polymerization product is chemically deposited in n-hexane, and vacuum-dried to obtain The polymer PON is ready for use; the polymer PON is dissolved in water at 4°C, and the temperature is raised to obtain a glutathione-responsive hydrogel. This glutathione-responsive thermosensitive hydrogel is prepared The hydrogel prepared by the method is in a solution state at low temperature, and when the temperature reaches 37 ° C, the hydrogel is formed in situ, and the hydrogel will be decomposed into a solution state after dropping glutathione (GSH) solution, and It cannot be gelled again, has good biocompatibility, and has great application potential in tumor areas with abundant glutathione secretion.

The invention provides a liposome, a preparation method thereof, a liposome assembly body and a carrier liposome complex body. The liposome provided by the present invention has the structure of formula (I), the L group is the liposome part on the left and the phosphorylcholine structure on the right, and the two are connected by a specific L group to form a liposome with a specific structure. The liposome of formula (I) provided by the present invention has properties such as long circulation, stimuli responsiveness, and targeting, and has multiple modifiable sites, which can be used to prepare biological agents with various functions, and provide More convenient options.