Phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and preparation method thereof

A technology of hydrogel-based sugar-sensitive microneedles and hydrogel-based sugar, which is applied in the field of phenylboronic acid hydrogel-based sugar-sensitive microneedles and its preparation, which can solve safety risks, polymer accumulation, and inability to prevent hypoglycemia Risk and other issues, to achieve the effect of preventing the risk of hypoglycemia, simple preparation process conditions, and improving the accuracy of administration

Inactive Publication Date: 2019-04-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the use of these types of microneedles, there are still some problems, such as inaccurate dose control and the inability to prevent the risk of hypoglycemia. Frequent use of dissolvable microneedles may lead to a large accumulation of polymers in the body. risk

Method used

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  • Phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and preparation method thereof
  • Phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and preparation method thereof
  • Phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050]6.1mg 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 51.6mg 3-acrylamidophenylboronic acid, 244.5mg N-isopropylacrylamide and 0.03ml N- Mix vinylpyrrolidone, add 0.1ml of n-butanol to dissolve, transfer to the microneedle mold, centrifuge at 4000rpm for 10min, and carry out photoinitiated polymerization under the conditions of ultraviolet wavelength 356nm, power 100w, and light time 1.5h to obtain phenylboric acid water Gel-based sugar-sensitive microneedle patch. The prepared microneedle patch is immersed in deionized water for 3-7 days to remove unreacted monomers and replace the solvent, and then soaked in insulin solution to load insulin. After loading, dry and store in a desiccator.

Embodiment 2

[0052] 4.2mg N,N-methylenebisacrylamide, 6.1mg 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 51.6mg 3-acrylamidophenylboronic acid, 241.5 Mix mg N-isopropylacrylamide and 0.03ml N-vinylpyrrolidone, add 0.1ml n-butanol to dissolve, transfer to the microneedle mold, centrifuge at 4000rpm, 10min, at UV wavelength 356nm, power 100w, light time 1.5h By photoinitiating polymerization under certain conditions, the phenylboronic acid hydrogel-based sugar-sensitive microneedle patch can be obtained. The prepared microneedle patch is immersed in deionized water for 3-7 days to remove unreacted monomers and replace the solvent, and then soaked in insulin solution to load insulin. After loading, dry and store in a desiccator.

Embodiment 3

[0054] 20.8mg N,N-methylenebisacrylamide, 6.1mg 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 51.6mg 3-acrylamidophenylboronic acid, 229.3 Mix mg N-isopropylacrylamide and 0.03ml N-vinylpyrrolidone, add 0.1ml n-butanol to dissolve, transfer to the microneedle mold, centrifuge at 4000rpm, 10min, at UV wavelength 356nm, power 100w, light time 1.5h By photoinitiating polymerization under certain conditions, the phenylboronic acid hydrogel-based sugar-sensitive microneedle patch can be obtained. The prepared microneedle patch is immersed in deionized water for 3-7 days to remove unreacted monomers and replace the solvent, and then soaked in insulin solution to load insulin. After loading, dry and store in a desiccator.

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Abstract

The invention discloses a phenylboronic acid hydrogel-based sugar-sensitive microneedle pad and a preparation method thereof. The phenylboronic acid hydrogel-based sugar-sensitive microneedle pad comprises a base and a microneedle array which is located on the base, wherein the base and microneedles are mainly prepared from a vinyl phenylboronic acid monomer and a vinyl monomer through free radical copolymerization; microneedle bodies and the base can both be used for embedding insulin drugs; the phenylboronic acid monomer is selected from 3-acrylamidophenylboronic acid, and the vinyl monomeris selected from N-isopropyl acrylamide and N-vinyl pyrrolidone. The preparation method disclosed by the invention is simple; the obtained phenylboronic acid hydrogel-based sugar-sensitive microneedlepad is regular in structure, has good mechanical performance, is capable of effectively piercing the skin, has stimulus responsiveness to glucose concentration, and is capable of regulating the release rate and the dosage of insulin according to blood sugar concentrations and effectively preventing a risk of hypoglycemia caused by excessive release of the insulin.

Description

technical field [0001] The patent of the invention belongs to the technical field of polymer materials, and specifically relates to a phenylboronic acid hydrogel-based sugar-sensitive microneedle patch and a preparation method thereof. Background technique [0002] Diabetes is a metabolic disease characterized by high blood sugar. Diabetic patients are in a state of high blood sugar for a long time, which will cause chronic damage to various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves, and finally endanger life. In 2017, the number of diabetic patients in the world has reached 425 million, of which there are 114.4 million diabetic patients in my country. Patients with type 1 and advanced type 2 diabetes need long-term infusion of exogenous insulin to maintain blood glucose within the normal range. Traditional insulin injection therapy will cause pain, poor patient compliance, and multiple daily injections may lead to local necrosis of the skin, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K38/28A61K9/70A61K47/32A61P3/10
CPCA61K9/0021A61K9/703A61K38/28A61K47/32A61M37/0015A61M2037/0053A61P3/10
Inventor 俞豪杰王立陈翔
Owner ZHEJIANG UNIV
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