The invention relates to an ibuprofen end group-containing polyethylene glycol medicine macromonomer and a synthesis method thereof, belonging to the technical field of pharmaceutical chemistry and synthesis thereof. The macromonomer is white powder, is soluble in N,N-dimethylformamide, methylene dichloride, chloroform, dioxane, dimethyl sulfoxide, distilled water or phosphoric acid PBS buffer solution, is not soluble in petroleum ether or aether, and has a structure as shown in the specification, wherein n is an integral number in a interval of 45-224. Under the catalysis condition, polyethylene glycol reacts with ibuprofen acyl chloride to synthesize the crude macromonomer, and then the crude macromonomer is purified to obtain the finished macromonomer, wherein the raw material ibuprofen acyl chloride is synthesized by referencing the known literatures. The macromonomer has the advantages of long half-life period, good water-solubility, little dosage, low toxicity and small thrill on intestines and stomach, contains degradable ester bonds, and is especially suitable for being used as an active component of ibuprofen slow-release drugs.