A kind of liposome, its preparation method, liposome assembly and carrier liposome complex

A liposome and CH2 technology, applied in liposome delivery, drug combination, chemical instruments and methods, etc., can solve the problems of non-environmental stimuli responsiveness, poor repeatability, and low drug concentration, and achieve reliable Control the film forming temperature, broad application prospects, promote the effect of cell internalization
CN110540551BActive Publication Date: 2022-04-22吉林省思睿德生物科技有限责任公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
吉林省思睿德生物科技有限责任公司
Publication Date
2022-04-22

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Abstract

The invention provides a liposome, a preparation method thereof, a liposome assembly body and a carrier liposome complex body. The liposome provided by the present invention has the structure of formula (I), the L group is the liposome part on the left and the phosphorylcholine structure on the right, and the two are connected by a specific L group to form a liposome with a specific structure. The liposome of formula (I) provided by the present invention has properties such as long circulation, stimuli responsiveness, and targeting, and has multiple modifiable sites, which can be used to prepare biological agents with various functions, and provide More convenient options.
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Description

technical field

[0001] The invention relates to the technical field of drug carriers, in particular to a liposome, a preparation method thereof, a liposome assembly and a liposome complex carrying a load. Background technique

[0002] At present, liposomes have been widely used as drug carriers. Adriamycin-liposomes, daunorubicin-liposomes, and paclitaxel-liposomes have been on the market for many years. For a long time, liposomes as drug carriers have faced the following four key problems:

[0003] (1) Targeted delivery problem: currently clinically used liposomes (represented by DPPC and DSPE liposomes) compound drugs mainly use the EPR effect of the tumor site for passive targeted enrichment. However, this passive targeting is not selective and easily interfered by the complex physiological environment. In addition, depending on the pure EPR effect, the drug concentration in the lesion is often low. In order to achieve effective treatment, it is necessary to increase th...

Claims

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