88 results about "Ferrocene derivatives" patented technology

Compositions including an iron containing fuel additive and a solid carrier are disclosed. Methods of preparing tablet forms of the compositions are also disclosed. The iron containing fuel additive may be ferrocene and / or substituted ferrocene derivatives. The compositions are useful for handling and rapidly solvating the iron containing fuel additive in a fuel such as gasoline.

The present invention relates to a ferrocene-based fire extinguishing composition. The ferrocene-based fire extinguishing composition comprises ferrocene, a ferrocene derivative, or a combination thereof at a content of 25 mass % or more; when in use, a pyrotechnic agent is used as a heat source and a power source, the pyrotechnic agent is ignited, and the high temperature generated by the combustion of the pyrotechnic agent is utilized to make a fire extinguishing composition produce a large amount of fire extinguishing substance, which is sprayed out together with the pyrotechnic agent, so as to achieve the purpose of extinguishing a fire. Compared with a conventional fire extinguishing composition, a more efficient and safer fire extinguishing composition is provided.

The invention relates to a synthetic method of ferrocene derivatives. Ferrocene is used as a raw material for the ferrocene derivatives. The ferrocene derivatives which can be used for labeling special nucleotides are prepared by steps of: treating the ferrocene with a lithium reagent and bis(pinacolato)diboron to obtain a halogenated ferrocene; performing Friedel-Crafts acylation, Clemmensen reduction and hydrolysis under an alkaline condition to obtain a halogenated ferrocene alkyl alcohol; reacting with nitrophenyl chloroformate and N-hydroxy succinimide to obtain ferrocene succinimide carbonate; condensing with an alcohol amine reagent to obtain a ferrocene alkylolamide carbonate; performing substitution, oxidation, and other reactions by reacting with a phosphoramidite reagent to obtain a phosphorous ferrocene reagent; reacting with 5-chloromercuri-2'-deoxyuridine to obtain a deoxyuridine phosphorous ferrocene reagent; modifying the 5' end of the deoxyuridine through DMT-C1 to obtain a DMT-modified deoxyuridine phosphorous ferrocene reagent; and finally performing substitution by reacting with the phosphoramidite reagent. The method has operation safety, convenience, high product purity and high yield. The method has a wider application scope than other synthetic methods.

An enhanced anaerobic adhesive composition containing microencapsulated metal ions is disclosed. Microencapsulated metal ions, such as iron oxide, copper naphthenate, cobalt naphthenate, ferrocene, and ferrocene derivatives, act as bonding sites in the composition, such that the composition achieves more complete polymerizations in a shorter curing time. The curing properties and the cure quality are significantly improved by the inclusion of microencapsulated metal ions. The composition can be used to bond metal and plastic substrates.

The invention provides a method for synthesizing a novel beta-cyclodextrin derivative modified by radicals containing oxazoline by using beta-cyclodextrin, and also provides a method for modifying the surface of common silica gel into hydrogenated silica gel and bonding the cyclodextrin derivative to the hydrogenated silica gel by using appropriate small molecules. An oxazoline derivative ligand used in the method provided by the invention has a very good rigid structure and a chiral recognition site, and is beneficial for improving the separation selectivity of a chiral selector to an enantiomer, and expanding the separation range of chiral compounds. According to the methods provided by the invention, 6-deoxy-6-R,S-(4-phenyl)-4,5-dihydrogen oxazoline-beta-cyclodextrin and 6-deoxy-6-R,S-(4-pyridine p-toluene sulfonate methyl)-4,5-dihydrogen oxazoline-beta-cyclodextrin are synthesized respectively by virtue of simple and easy operation steps, and are bonded to the hydrogenated silica gel to prepare a hydrogenated silica gel stationary phase. The whole synthetic route is simple in operation and mild in reaction condition, and the product is easy to purify and high in yield. The methods provided by the invention are applied to chiral separation, and are used for performing qualitative researches on certain chiral aromatic alcohols, ferrocene derivatives, amino acid and mandelic acid derivatives and chiral drugs in a polar organic mode and a reversed phase mode.

The invention relates to a ferrocene derivative shown as a formula (IA) or a formula (IB) or a pharmaceutically-acceptable salt or a solvate and a medicinal composition thereof. In the formula, R is independently selected from hydrogen, halogen, a cyano-group, a nitro-group, alkyl with 1 to 6 carbon atoms, alkoxy with 1 to 6 carbon atoms, hydroxyl-alkyl with 1 to 6 carbon atoms, halogenated alkyl with 1 to 6 carbon atoms, halogenated alkoxy with 1 to 6 carbon atoms, or alkoxy with 1 to 6 carbon atoms; Z is selected from O, S or NR1; R1 is hydrogen or alkyl with 1 to 6 carbon atoms independently; n is an integer of 0 to 5. The invention further provides a preparation method and medical application of the compound shown as the formula (IA) or the formula (IB) or the pharmaceutically-acceptable salt thereof. The compound has very high restraining activity specific to a lung cancer cell line A549, a colorectal carcinoma cell line HCT116 and / or a breast cancer cell line MCT-7, has broad-spectrum anti-cancer activity, and can be taken as a candidate compound or a lead compound for treating tumor diseases or cancer diseases. The derivative is shown in the description.

The invention discloses a method of synthesizing an alkylated ferrocene derivative; the method comprises: mixing ferrocene, an alkylation reagent, an organic solvent and a supported solid catalyst, adding the mixture into a high-pressure reactor, charging nitrogen at normal temperature to 0.5-2.5 MPa, sealing, heating to 80-250 DEG C, and stirring for reacting for 2-6 h; after reacting, filtering the reaction mixed liquid, vacuum-distilling the filtrate, and concentrating to obtain the alkylated ferrocene derivative. The defects that traditional process products are difficult to separate and reuse and cause high pollution and corrosion are overcome. The obtained alkylated ferrocene derivative is applicable to diesel combustion supporting, emission particulate matter trap regeneration and other fields.

The present invention relates to the ferrocene derivative represented by formula (IA) or formula (IB), or to the pharmaceutically acceptable salt or solvate thereof and to the pharmaceutical composition thereof. Wherein, R is independently selected from H, halogen, cyano, nitro, C1-C6 alkyl, C1-C6 alkoxy, hydroxy-C1-C6 alkyl, halo-C1-C6 alkyl, halo-C1-C6 alkoxy or C1-C6 alkoxy-C1-C6 alkoxy; Z is selected from O, S or NR1, wherein R1 is independently H or C1-C6 alkyl; n is an integer from 0 to 5. The present invention also provides a method and the pharmaceutical application thereof for preparing the compounds represented by formula (IA) or formula (IB) or the pharmaceutically acceptable salts thereof. The compounds have a strong inhibitory activity against human lung cancer cell line A549, colorectal cancer cell line HCT116 and / or breast cancer cell line MCF-7.

A fuel additive which contains ferrocene and / or a ferrocene derivative and lecithin. A solid fuel additive which contains from 80 to 99% by mass of ferrocene and / or a ferrocene derivative and from 1 to 20% by mass of lecithin. A granular fuel additive which contains from 78 to 99% by mass of ferrocene and / or a ferrocene derivative, from 0.9 to 20% by mass of lecithin and from 0.1 to 2% by mass ofwater. A liquid fuel additive which contains a mineral oil containing ferrocene and / or a ferrocene derivative and lecithin dissolved therein, wherein the content of ferrocene and / or a ferrocene derivative is from 2 to 5% by mass and the content of lecithin is from 5 to 50% by mass. These fuel additives are employed in such a manner as to control the concentration of ferrocene and / or a ferrocene derivative to 1 to 50 ppm and the concentration of lecithin to 0.01 to 500 ppm in the fuel.

The invention relates to a 3D printing material and a preparation method thereof. The 3D printing material comprises the following raw materials: toluene, carbon disulfide, a ferrocene derivative, nano-titanium dioxide, gamma-aminopropyl triethoxysilane, 2-chlorophenyl ethylene oxide, ethyl 2-chloromethylbenzoate, 1, 4-dichloro-2-butene, graphene oxide, 1-ethyl-3-methylimidazolium tetrafluoroborate, epoxy acrylate, 2, 6-di-tert-butyl-4-methylphenol, 2-(2'-hydroxy-3', 5'-di-tert-phenyl)-5-benzotriazole chloride, nano-calcium carbonate powder and benzoyl peroxide. The 3D printing material has the advantages of rapid shaping, electric conduction, high impact resistance, high strength and high tensile strength. The 3D printing material also has the advantage of degradability, thus being an environment-friendly material.

The invention discloses a method for synthesizing alkylated ferrocene derivatives. The method comprises the following steps: mixing ferrocene, an alkylating agent, an organic solvent and a supported solid catalyst, adding the mixture into a high pressure reactor, filling nitrogen to reach 0.5-2.5MPa at normal temperature, heating to the temperature of 80-250 DEG C in a closed mode, stirring and reacting for 2-6 hours; filtering the reacted mixed solution after the reaction is ended, performing reduced pressure distillation and concentration on the filtrate, thereby obtaining the alkylated ferrocene derivatives. According to the method disclosed by the invention, the defects that the traditional process products are difficult to separate and recycle, high in pollution degree and highly corrosive and the like are overcome. The prepared alkylated ferrocene derivatives can be applied to the fields of diesel combustion-supporting and exhaust particle filter regeneration.

The invention relates to a fuel additive, belonging to a fuel additive technology field. The fuel additive is uniquely composed of polyoxyethylene dioleate, hydrocarbons, ferrocene or ferrocene derivatives and water. The fuel additive has good chemical stability, and in a combustion process, the fuel additive can raise combustion efficiency of fuel, saves energy, can effectively reduce discharge capacity of harmful substances, such as CO and NOx, and can reduce environment pollution.