88 results about "Ferrocene derivatives" patented technology

Compositions including an iron containing fuel additive and a solid carrier are disclosed. Methods of preparing tablet forms of the compositions are also disclosed. The iron containing fuel additive may be ferrocene and / or substituted ferrocene derivatives. The compositions are useful for handling and rapidly solvating the iron containing fuel additive in a fuel such as gasoline.

An enhanced anaerobic adhesive composition containing microencapsulated metal ions is disclosed. Microencapsulated metal ions, such as iron oxide, copper naphthenate, cobalt naphthenate, ferrocene, and ferrocene derivatives, act as bonding sites in the composition, such that the composition achieves more complete polymerization in a shorter curing time. The curing properties and the cure quality are significantly improved by the inclusion of microencapsulated metal ions. The composition can be used to bond metal and plastic substrates.

The present invention relates to a ferrocene-based fire extinguishing composition. The ferrocene-based fire extinguishing composition comprises ferrocene, a ferrocene derivative, or a combination thereof at a content of 25 mass % or more; when in use, a pyrotechnic agent is used as a heat source and a power source, the pyrotechnic agent is ignited, and the high temperature generated by the combustion of the pyrotechnic agent is utilized to make a fire extinguishing composition produce a large amount of fire extinguishing substance, which is sprayed out together with the pyrotechnic agent, so as to achieve the purpose of extinguishing a fire. Compared with a conventional fire extinguishing composition, a more efficient and safer fire extinguishing composition is provided.

The invention discloses a preparation method of a ferrocenyl carbon nanotube composite material and application thereof and belongs to the technical field of synthesis of inorganic materials. The preparation method of the composite material comprises the following steps: firstly carrying out oxidization and amination on carbon nanotubes and carrying out acylation on ferrocenecarboxylic acid, then taking triethylamine as an acid-binding agent in a dichloromethane solvent, and enabling the carbon nanotubes subjected to amination to react with activated ferrocenylformyl chloride to prepare the composite material. The preparation method of the composit material is simple and is mild in reaction condition; the product is convenient to separate and purify and stable in structure. The composite material takes the carbon nanotubes with large specific surface area and high conductivity as support materials; ferrocenyl derivatives which can be used as electron media and provided with excellent electrochemical reversibility are covalently coupled on the surfaces of the carbon nanotubes, so that the composite material is excellent in effect of redox reaction for electrochemically catalyzing dopamine; the common interference matters including ascorbic acid and uric acid have no interference on detection of dopamine; the composite material is wide in linear response range and high in sensitivity and repeatability for detection of dopamine.

The invention relates to a synthetic method of ferrocene derivatives. Ferrocene is used as a raw material for the ferrocene derivatives. The ferrocene derivatives which can be used for labeling special nucleotides are prepared by steps of: treating the ferrocene with a lithium reagent and bis(pinacolato)diboron to obtain a halogenated ferrocene; performing Friedel-Crafts acylation, Clemmensen reduction and hydrolysis under an alkaline condition to obtain a halogenated ferrocene alkyl alcohol; reacting with nitrophenyl chloroformate and N-hydroxy succinimide to obtain ferrocene succinimide carbonate; condensing with an alcohol amine reagent to obtain a ferrocene alkylolamide carbonate; performing substitution, oxidation, and other reactions by reacting with a phosphoramidite reagent to obtain a phosphorous ferrocene reagent; reacting with 5-chloromercuri-2'-deoxyuridine to obtain a deoxyuridine phosphorous ferrocene reagent; modifying the 5' end of the deoxyuridine through DMT-C1 to obtain a DMT-modified deoxyuridine phosphorous ferrocene reagent; and finally performing substitution by reacting with the phosphoramidite reagent. The method has operation safety, convenience, high product purity and high yield. The method has a wider application scope than other synthetic methods.

Disclosed is an electrochromic display device, including, a first substrate, first electrodes provided on an upper surface of the first substrate, a second substrate provided to be opposed to the first substrate above the first substrate, the second substrate being formed of a transparent material, second electrodes provided on an undersurface of the second substrate, at least a part of the second electrodes being formed of a transparent electrode material, and an electrochromic composition layer provided between the first substrate and the second substrate. The electrochromic composition layer contains an electrochromic composition including a supporting electrolyte, a polar solvent, a leuco dye, a hydroquinone derivative and / or a catechol derivative, a ferrocene derivative, and a compound having a carbonyl group.

An enhanced anaerobic adhesive composition containing microencapsulated metal ions is disclosed. Microencapsulated metal ions, such as iron oxide, copper naphthenate, cobalt naphthenate, ferrocene, and ferrocene derivatives, act as bonding sites in the composition, such that the composition achieves more complete polymerizations in a shorter curing time. The curing properties and the cure quality are significantly improved by the inclusion of microencapsulated metal ions. The composition can be used to bond metal and plastic substrates.

The invention relates to an electrolyte solution for lithium sulfur battery. The electrolyte solution uses solvents comprising one or more than two of chain ether compounds; solutes in the electrolyte solution consist of one or more than two of lithium salts; and one or more than two of ferrocene or ferrocene derivatives account for 0.001-10 wt.%. The electrolyte solution can effectively dissolve irreversible lithium sulfide deposited in charge and discharge of the lithium sulfur battery, so as to achieve the purpose of activation and further improve the stability of lithium sulfur battery.

The invention provides a method for recovering ferrocene derivatives and ammonium perchlorate from a composite solid propellant, which belongs to the field of fabrication of composite solid propellants. The method comprises an immersion step of immersing the composite solid propellant in dichloromethane, 1,2-dichloroethanes or N,N-dimethylacetamide, a distillation step of distilling an organic solvent so as to obtain a crude product of ferrocene derivatives, a purification step of purifying the crude product of ferrocene derivatives through recrystallization or sublimation, an extraction step of using a saturated solution of ammonium perchlorate as an extractant and a recrystallization step for obtaining ammonium perchlorate. According to the invention, the method of organic solvents is utilized in the invention for separation and recovery the active components of ammonium perchlorate and ferrocene derivatives, and a high recovery rate is achieved; implementation process of the invention is simple, and the method is easy to form a flow and has a good industrial prospect.

The invention provides a method for synthesizing a novel beta-cyclodextrin derivative modified by radicals containing oxazoline by using beta-cyclodextrin, and also provides a method for modifying the surface of common silica gel into hydrogenated silica gel and bonding the cyclodextrin derivative to the hydrogenated silica gel by using appropriate small molecules. An oxazoline derivative ligand used in the method provided by the invention has a very good rigid structure and a chiral recognition site, and is beneficial for improving the separation selectivity of a chiral selector to an enantiomer, and expanding the separation range of chiral compounds. According to the methods provided by the invention, 6-deoxy-6-R,S-(4-phenyl)-4,5-dihydrogen oxazoline-beta-cyclodextrin and 6-deoxy-6-R,S-(4-pyridine p-toluene sulfonate methyl)-4,5-dihydrogen oxazoline-beta-cyclodextrin are synthesized respectively by virtue of simple and easy operation steps, and are bonded to the hydrogenated silica gel to prepare a hydrogenated silica gel stationary phase. The whole synthetic route is simple in operation and mild in reaction condition, and the product is easy to purify and high in yield. The methods provided by the invention are applied to chiral separation, and are used for performing qualitative researches on certain chiral aromatic alcohols, ferrocene derivatives, amino acid and mandelic acid derivatives and chiral drugs in a polar organic mode and a reversed phase mode.

The invention relates to a ferrocene derivative shown as a formula (IA) or a formula (IB) or a pharmaceutically-acceptable salt or a solvate and a medicinal composition thereof. In the formula, R is independently selected from hydrogen, halogen, a cyano-group, a nitro-group, alkyl with 1 to 6 carbon atoms, alkoxy with 1 to 6 carbon atoms, hydroxyl-alkyl with 1 to 6 carbon atoms, halogenated alkyl with 1 to 6 carbon atoms, halogenated alkoxy with 1 to 6 carbon atoms, or alkoxy with 1 to 6 carbon atoms; Z is selected from O, S or NR1; R1 is hydrogen or alkyl with 1 to 6 carbon atoms independently; n is an integer of 0 to 5. The invention further provides a preparation method and medical application of the compound shown as the formula (IA) or the formula (IB) or the pharmaceutically-acceptable salt thereof. The compound has very high restraining activity specific to a lung cancer cell line A549, a colorectal carcinoma cell line HCT116 and / or a breast cancer cell line MCT-7, has broad-spectrum anti-cancer activity, and can be taken as a candidate compound or a lead compound for treating tumor diseases or cancer diseases. The derivative is shown in the description.

The invention discloses a method of synthesizing an alkylated ferrocene derivative; the method comprises: mixing ferrocene, an alkylation reagent, an organic solvent and a supported solid catalyst, adding the mixture into a high-pressure reactor, charging nitrogen at normal temperature to 0.5-2.5 MPa, sealing, heating to 80-250 DEG C, and stirring for reacting for 2-6 h; after reacting, filtering the reaction mixed liquid, vacuum-distilling the filtrate, and concentrating to obtain the alkylated ferrocene derivative. The defects that traditional process products are difficult to separate and reuse and cause high pollution and corrosion are overcome. The obtained alkylated ferrocene derivative is applicable to diesel combustion supporting, emission particulate matter trap regeneration and other fields.

The present invention relates to composite compositions for solid propellants including an oxidizing charge, a liquid polyol polymer, a combustion catalyst consisting of a ferrocene derivative, and an aluminum charge. Said aluminum charge is characteristically submicronic, or even nanometric. The present invention also relates to pasty or solid propellant, and to the corresponding solid propellant loads.

The present invention relates to the ferrocene derivative represented by formula (IA) or formula (IB), or to the pharmaceutically acceptable salt or solvate thereof and to the pharmaceutical composition thereof. Wherein, R is independently selected from H, halogen, cyano, nitro, C1-C6 alkyl, C1-C6 alkoxy, hydroxy-C1-C6 alkyl, halo-C1-C6 alkyl, halo-C1-C6 alkoxy or C1-C6 alkoxy-C1-C6 alkoxy; Z is selected from O, S or NR1, wherein R1 is independently H or C1-C6 alkyl; n is an integer from 0 to 5. The present invention also provides a method and the pharmaceutical application thereof for preparing the compounds represented by formula (IA) or formula (IB) or the pharmaceutically acceptable salts thereof. The compounds have a strong inhibitory activity against human lung cancer cell line A549, colorectal cancer cell line HCT116 and / or breast cancer cell line MCF-7.

The invention discloses a multi-stimulation responsive stigmasterol derivative low-molecular-mass gelator, organic gel and preparation methods of the low-molecular-mass gelator and the organic gel. The stigmasterol-based glycine ferrocene amide gelator is prepared through a three-step synthesis reaction including esterification, BOC removal and amidation for the first time with stigmasterol with arigid framework used as a gelator construction parent, glycine used as a linking arm and ferrocene containing an oxidation activity group as a reaction group, and the problem of lack of research on construction of a super-molecular gel system with stigmasterol and ferrocene derivatives as gelators in the prior art is solved. An organic gel material of the gelator has properties of thixotropy, ultrasonic response, thermal response and alcohol solvent stimulation response besides oxidation stimulation response expected to be obtained through introduction of the ferrocene group, and the gel is expected to have potential value in the aspects of sensors, solvent recognition and the like.

A fuel additive which contains ferrocene and / or a ferrocene derivative and lecithin. A solid fuel additive which contains from 80 to 99% by mass of ferrocene and / or a ferrocene derivative and from 1 to 20% by mass of lecithin. A granular fuel additive which contains from 78 to 99% by mass of ferrocene and / or a ferrocene derivative, from 0.9 to 20% by mass of lecithin and from 0.1 to 2% by mass ofwater. A liquid fuel additive which contains a mineral oil containing ferrocene and / or a ferrocene derivative and lecithin dissolved therein, wherein the content of ferrocene and / or a ferrocene derivative is from 2 to 5% by mass and the content of lecithin is from 5 to 50% by mass. These fuel additives are employed in such a manner as to control the concentration of ferrocene and / or a ferrocene derivative to 1 to 50 ppm and the concentration of lecithin to 0.01 to 500 ppm in the fuel.

The present invention discloses a ferrocene derivative used as a photo-oxidation reduction catalyst in photo-polymerization and a composition thereof. The ferrocene derivative is obtained by connecting ferrocene and 1,3-indandione through a carbon-carbon triple bond / double bond and a conjugated bridged molecule; the ferrocene derivative has a D-Pi-A type molecular structure, and relatively strongintramolecular electron transfer ensures that the ferrocene derivative has strong absorption in blue-green regions, so that the ferrocene derivative is an effective photo-oxidation reduction catalyst;and a photo-initiation system formed by the ferrocene derivative, an onium salt photo-initiator and an amine compound can effectively induce free radical photo-polymerization under visible light LEDlight sources.

The invention provides a ferrocene derivative and a preparation method thereof. Compared with the prior art, in the absence of catalyst and additive as well as protection and with toluene as a solvent, a tetra-alkyne substrate reacts with ferrocene at 104-114 DEG C, wherein the reaction process comprises the following steps: cyclization of the tetra-alkyne substrate, generation of a benzyne intermediate through a HDDA reaction, and 4+2 cycloaddition reaction between the highly active benzyne intermediate and the cyclopentadiene of ferrocene to obtain the ferrocene derivative. The method breaksthrough the former knowledge that the ferrocene cannot experience a cycloaddition reaction, and also shows a broader application prospect in chemical production and clinical medicine. Moreover, the preparation method provided by the invention has the advantages of simplicity and convenience, high efficiency and short reaction time.

The invention relates to a colloidal crystal thin film preparation method, in particular to an electrically expandable colloidal crystal thin film preparation method and solves the problem of difficulty in preparation of existing electrically expandable polymer materials. The method includes: step one, monodispersed polystyrene microsphere preparation; step two, ferrocenyl derivative synthesis; step three, electrically expandable colloidal crystal material preparation. The method is used for preparing electrically expandable colloidal crystal thin films.

The invention relates to a 3D printing material and a preparation method thereof. The 3D printing material comprises the following raw materials: toluene, carbon disulfide, a ferrocene derivative, nano-titanium dioxide, gamma-aminopropyl triethoxysilane, 2-chlorophenyl ethylene oxide, ethyl 2-chloromethylbenzoate, 1, 4-dichloro-2-butene, graphene oxide, 1-ethyl-3-methylimidazolium tetrafluoroborate, epoxy acrylate, 2, 6-di-tert-butyl-4-methylphenol, 2-(2'-hydroxy-3', 5'-di-tert-phenyl)-5-benzotriazole chloride, nano-calcium carbonate powder and benzoyl peroxide. The 3D printing material has the advantages of rapid shaping, electric conduction, high impact resistance, high strength and high tensile strength. The 3D printing material also has the advantage of degradability, thus being an environment-friendly material.

The invention discloses a thiopheneamide-substituted chiral phosphine ferrocene derivative represented by a formula (I). A preparation method of the derivative comprises the following steps: (1S)-diphenylphosphino-(2R)-aminoethyl ferrocene represented by a formula (II) and thiophenecarboxylic acid represented by a formula (III) are adopted as raw materials, and are miscibility dissolved in an organic solvent A; N,N'-di(cyclohexyl)carboimide (DCC) is adopted as a catalyst, and a reaction is carried out for 1-4h under a temperature of 0-40 DEG C; and a reaction mixture is subjected to a post-treatment, such that thiopheneamide-substituted chiral phosphine ferrocene represented by the formula (I) is obtained. The compound can be used as a catalyst for an asymmetric [3+2] cycloaddition reaction. The catalyst has high catalytic activity and good stability. The method has the advantages of mild reaction conditions and good yield, and has a good application prospect.

The invention discloses a method for synthesizing alkylated ferrocene derivatives. The method comprises the following steps: mixing ferrocene, an alkylating agent, an organic solvent and a supported solid catalyst, adding the mixture into a high pressure reactor, filling nitrogen to reach 0.5-2.5MPa at normal temperature, heating to the temperature of 80-250 DEG C in a closed mode, stirring and reacting for 2-6 hours; filtering the reacted mixed solution after the reaction is ended, performing reduced pressure distillation and concentration on the filtrate, thereby obtaining the alkylated ferrocene derivatives. According to the method disclosed by the invention, the defects that the traditional process products are difficult to separate and recycle, high in pollution degree and highly corrosive and the like are overcome. The prepared alkylated ferrocene derivatives can be applied to the fields of diesel combustion-supporting and exhaust particle filter regeneration.

The invention relates to a fuel additive, belonging to a fuel additive technology field. The fuel additive is uniquely composed of polyoxyethylene dioleate, hydrocarbons, ferrocene or ferrocene derivatives and water. The fuel additive has good chemical stability, and in a combustion process, the fuel additive can raise combustion efficiency of fuel, saves energy, can effectively reduce discharge capacity of harmful substances, such as CO and NOx, and can reduce environment pollution.

The invention discloses a new construction idea and synthesis method of a ferrocene-lanthanide-series metal compound. The compound has the advantages of being low in cost, mild in reaction condition and convenient to operate during the process. Meanwhile, according to the new application of the compound, a ferrocene derivative with potential biological activity and lanthanide-series metal ions with fluorescence signal tracing are self-assembled, the anti-cancer activity is generated under light induction, and meanwhile a fluorescence signal is obtained. In this way, integrated application of light-control diagnosis and treatment is achieved. The ferrocene-lanthanide-series metal compound has important reference value on development of novel intelligent medicine capable of integrating light-control tumor resistance and motoring.

The invention discloses an application of a 2-acyl-1-dimethylaminomethyl ferrocene derivative in preparation of a drug for targeted treatment of hepatocellular carcinoma. The structural formula of the 2-acyl-1-dimethylaminomethyl ferrocene derivative is shown in the specification, wherein R is halogen. The compound can induce apoptosis of tumor cells and inhibit growth of the tumor cells through active oxygen and cell cycle arrest, and has good selectivity.

The invention discloses a preparation method and application of a novel ferrocene derivative containing free radicals of nitroxide. The ferrocene derivative containing free radicals of nitroxide, pharmaceutically acceptable salt or a pharmaceutically acceptable solvate of the ferrocene derivative, or a pharmaceutical composition is shown in formula (I). The novel ferrocene derivative shown in the formula (I) has very high inhibitory activity on a lung cancer cell line A549 and a breast cancer cell line MCF-7, and can be used as a candidate compound or a lead compound for treatment of cancer, tumor and other diseases.

A biologic testing strip is composed of a basic strip, a working electrode and a counter electrode. On said working electrode there is the envelope substance prepared from cyclodextrin, bioactive enzyme, and electron transferring medium chosen from quinone, methyl blue, methyl violet, and ferrocene or its derivatives. Its advantages are low cost, and high exchangeability and anti-interference power.

The invention relates to an organic metal drug camptothecin-ferrocene and a preparation method thereof, wherein an anticancer natural product camptothecin is used as a raw material, and is combined with ferrocene with anticancer activity to synthesize a novel camptothecin-ferrocene derivative. According to the camptothecin-ferrocene derivative, camptothecin and ferrocene have a good killing effecton cancer cells at the same time, and the combined product can play a role in jointly killing the cancer cells. According to the invention, a natural product medicine camptothecin and ferrocene withanti-cancer activity react to generate the camptothecin derivative with ferrocene at the tail end, and the produced camptothecin-ferrocene derivative combines camptothecin and ferrocene, has a good killing effect on cancer cells, and has a combined anti-cancer effect; and the method is simple in preparation process, and a new thought and method are provided for research and development of novel anti-cancer drugs.