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Application of manganese titanate nano material as mimic enzyme active material

A manganese titanate nanometer and nanomaterial technology, applied in the directions of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problem of insufficient killing ability of cancer cells, and solve the problem of easy formation of manganese oxide or manganese hydroxide precipitation, reducing Side reactions, the effect of improving system stability

Active Publication Date: 2021-03-26
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of limited concentration of substrates in response to existing chemokinetic therapy and insufficient ability to kill cancer cells, the purpose of the present invention is to provide a manganese titanate nanomaterial as a material for simulating enzyme activity and based on its excellent Application of Mimic Enzyme Activity to Kill Tumor Cells

Method used

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  • Application of manganese titanate nano material as mimic enzyme active material
  • Application of manganese titanate nano material as mimic enzyme active material
  • Application of manganese titanate nano material as mimic enzyme active material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Step (1): Mix 1.25mmol n-tetrabutyl titanate with 16mL ethylene glycol and stir to form solution A; mix 1.25mmol manganese sulfate monohydrate with 4mL ethylenediamine and stir to form solution B; Under stirring, the above solution A and solution B are completely mixed to form solution C;

[0079] Step (2): Slowly add 5mL of ultrapure water dropwise to the above solution C under vigorous stirring, then transfer it to a 50mL stainless steel autoclave with a polytetrafluoroethylene liner, and react at 200°C for 24h After that, cool down to room temperature naturally. The product was collected by centrifugation and washed several times with ethanol and water to remove impurities. Finally, a light yellow powder is obtained by drying in a vacuum oven, which is two-dimensional manganese titanate nanosheets.

[0080] figure 1 It is the various basic characterization diagrams of the two-dimensional manganese titanate nanosheets prepared through the steps of Example 1.

[00...

Embodiment 2

[0087] Compared with Example 1, the main difference is that the solvothermal temperature is 150° C., and the solvothermal time is 18 hours (the solvothermal temperature is reduced, and the solvothermal time is reduced).

[0088] Step (1): Mix 1.25mmol n-tetrabutyl titanate with 16mL ethylene glycol and stir to form solution A; mix 1.25mmol manganese sulfate monohydrate with 4mL ethylenediamine and stir to form solution B; Under stirring, the above solution A and solution B are completely mixed to form solution C;

[0089] Step (2): Slowly add 5mL of ultrapure water dropwise to the above solution C under vigorous stirring, then transfer it to a 50mL stainless steel autoclave with a polytetrafluoroethylene liner, and react at 150°C for 18h After that, cool down to room temperature naturally. The product was collected by centrifugation and washed several times with ethanol and water to remove impurities. Finally, a light yellow powder is obtained by drying in a vacuum oven, whi...

Embodiment 3

[0091] Compared with Example 1, the main difference is that the solvothermal temperature is 250° C., and the solvothermal time is 30 h (the solvothermal temperature increases and the solvothermal time increases).

[0092] Step (1): Mix 1.25mmol n-tetrabutyl titanate with 16mL ethylene glycol and stir to form solution A; mix 1.25mmol manganese sulfate monohydrate with 4mL ethylenediamine and stir to form solution B; Under stirring, the above solution A and solution B are completely mixed to form solution C;

[0093] Step (2): Slowly add 5mL of ultrapure water dropwise to the above solution C under vigorous stirring, then transfer it to a 50mL stainless steel autoclave with a polytetrafluoroethylene liner, and react at 250°C for 30h After that, cool down to room temperature naturally. The product was collected by centrifugation and washed several times with ethanol and water to remove impurities. Finally, a light yellow powder is obtained by drying in a vacuum oven, which is t...

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Abstract

The invention belongs to the technical field of anti-cancer nano materials, and provides a manganese titanate nano material. The manganese titanate nano material has mimic enzyme activity and can killcancer cells on the basis of the mimic enzyme activity and cascade reaction of various mimic enzyme activities, thereby overcoming the defects of insufficient anti-cancer ability, difficulty in killing cancer cells and the like of the traditional chemodynamic therapy (CDT).

Description

technical field [0001] The invention belongs to the technical field of anti-cancer nano material development, and relates to the use of a manganese titanate nano material for anti-cancer based on the simulated enzyme activity. Background technique [0002] Cancer, also known as malignant tumor, refers to a disease caused by the abnormal proliferation of cells, which has the property of invading other tissues or organs of the body, and the related mechanisms controlling cell proliferation are out of balance. For humans, there are currently more than one hundred known types of cancer, and it has long been considered an incurable disease, which greatly endangers the safety of human life and reduces the quality of human life. Current clinical treatments for cancer include surgery, chemotherapy, and radiotherapy. Surgical treatment can only remove the cancer tissue in the early stage, but large area recurrence and metastasis may still occur several years after the operation. Ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/32A61K9/00A61P35/00B82Y5/00C01G45/00
CPCA61K33/32A61K9/0019A61P35/00C01G45/00B82Y5/00C01P2002/72C01P2002/85C01P2004/01C01P2004/03C01P2004/04C01P2004/20C01P2006/60
Inventor 高欣宇陈万松徐倩倩刘又年赵森峰
Owner CENT SOUTH UNIV
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