Tetrameric macrocyclic trinuclear iron complex containing sulfur-sulfur bonds and in-situ synthesis method thereof

Abstract

The invention discloses a tetrameric macrocyclic trinuclear iron complex containing sulfur-sulfur bonds and an in-situ synthesis method thereof. A chemical formula of the iron complex is [Fe3(L1) 5H2O], wherein H8L1 is a macrocyclic ligand formed by four 3,3'-di(5-mercapto-1,2,4-triazole) through sulfur-sulfur bonds. The in-situ synthesis method of the iron complex comprises the following steps: (1) weighing 0.04-0.05 g of 3,3'-di(5-mercapto-1,2,4-triazole) and 0.08-0.09 g of ferric nitrate nonahydrate Fe(NO3)3 9H2O, mixing them in a 8-9 mL dimethylformamide and enabling the mixed solution tobe subjected to stirring reacction at room temperature for 6-7 hours; (2) filtering the mixed solution, placing the filtrate in a beaker, and executing natural volatilization at room temperature to obtain single-crystal-grade black flaky crystals. The iron complex has a potential application value on the aspects of bacterium and tumor resistance, targeted release as a carrier and the like, and themethod has the wide application prospect on the aspect of in-situ synthesis of macrocyclic metal complexes containing sulfur-sulfur bonds.

Description

technical field [0001] The invention relates to an iron complex, in particular to a sulfur-sulfur bond-containing tetramerized macrocyclic trinuclear iron complex and an in-situ synthesis method thereof. Background technique [0002] In situ reaction is one of the hotspots in coordination chemistry research. Although there are many literature reports on in situ reactions, no 3,3'-bis(5-mercapto-1,2,4-triazole) is oxidized to form tetrameric macromolecules containing sulfur-sulfur bonds. A report on the formation of trinuclear iron complexes by ring ligands. [0003] Sulfur-containing triazoles are widely used as intermediates in medicine, pesticides and other fields, and their complexes with metal ions also have good antibacterial and anticancer activities. When a compound containing a sulfur-sulfur bond reaches a tumor cell, a sulfur-sulfur bond breaking reaction will occur due to glutathione present in a large amount in the cell, therefore, by 3,3'-bis(5-mercapto-1 , 2,...

AI Technical Summary

Problems solved by technology

Although there are many literature reports on in situ reactions, no 3,3'-bis(5-mercapto-1,2,4-triazole) is oxidized to form tetrameric macromolecules containing sulfur-sulfur bonds. Cyclic Ligands and Formation of Trinuclear Iron Complexes Report

Images