128 results about "Bromoacetic acid" patented technology

The invention discloses amphipathic polyurethane resin based on polysiloxane and a preparation method of the amphipathic polyurethane resin, as well as an anti-bacterial anti-protein performance of the amphipathic polyurethane resin. The preparation method comprises the following steps: carrying out a reaction between tert-Butyl bromoacetate and N-methyldiethanolamine under a certain condition to obtain a quaternary ammonium diol; carrying out cross-link between the quaternary ammonium diol and hydroxymethyl-terminated polydimethylsiloxane; carrying out hydrolysis to obtain the amphipathic polyurethane of which a molecular chain segment has not only a hydrophilic ingredient but also a hydrophobic ingredient. The amphipathic polyurethane has all of the relatively high hydrophilicity of zwitter ions, the low surface energy and dirt discharging superiority of polysiloxane, and the stability of polyurethane, thereby having an excellent practical application value in the anti-bacterial and anti-protein field.

The invention discloses a surface plasma resonance sensing chip and a preparation method and application thereof. The preparation method comprises the steps that firstly, a glass substrate is washed and then dried; secondly, a chromium film is prepared, a gold film is prepared on the chromium film, and a naked gold chip is obtained; thirdly, a solution containing modified bovine serum albumin is dropwise added, the whole chip is paved with the solution, the solution continues to be dropwise added until the whole chip is soaked, and after a sealed vibration reaction is carried out for 0.5-2 hours, washing and drying are carried out; fourthly, a mixed solution of NHS and EDC is dropwise added, the whole chip is paved with the mixed solution, the solution continues to be dropwise added until the whole chip is soaked, and after a sealed vibration reaction is carried out for 15 minutes to 1 hour, washing and drying are carried out; fifthly, a bromoacetic acid solution is dropwise added, the whole chip is paved with the bromoacetic acid solution, the bromoacetic acid solution continues to be added until the whole chip is soaked with the bromoacetic acid solution, after a sealed vibration reaction is carried out for 8-24 hours, washing and drying are carried out, and a blank chip is obtained. According to the preparation method, the surface plasma resonance sensing chip can be obtained within only 2 days and has better homogeneity than a traditional glucan chip which is prepared within 5 days.

The invention provides a method for preparing trifluorobenzene acetic acid. The method comprises: trifluorobromobenzene is used as raw material and magnesium undergo Grignard reaction to generate a Grignard reagent; in the presence of cobalt salt catalyst, the Grignard reagent reacts with bromoacetic acid ester to form trifluorobenzene acetate; under conditions of acid or alkali, the trifluorobenzene acetate is hydrolyzed to form a coarse product of the trifluorobenzene acetic acid; and the coarse product is post-treated to form the trifluorobenzene acetic acid with the concentration of more than 99 percent. The method has the advantages of easily bought raw material, low cost, mild reaction condition, simple operation, environmental protection and easy realization of industrialization, and the product prepared by the method has stable quality, and is easy in mass industrialized production.

A preparation method for magnetic resonance imaging contrast medium gadobutrol comprises the following steps: taking THF as a solvent, taking boron-protected 1, 4, 7, 10-tetraazacyclododecane (I) and 4, 4-dimehtyl-3, 5, 8-trioxabicyclo[5.1.0]octane (II) as raw materials, activating the raw materials by sodium hydride and performing ring-opening condensation to obtain an intermediate (III), performing mild hydrolysis to obtain an intermediate (IV), then successively reacting the intermediate (IV) with chloroacetic acid or bromoacetic acid and gadolinium oxide to prepare gadobutrol, performing desalting on the crude product, recrystallizing to obtain gadobutrol pure product. The preparation method comprises the beneficial effects of being mild in reaction condition, high in selectivity, relatively low in apparatus requirement, simple in technological operation, high in total yield, high in product purity, simple in purification, low in environment protection pressure, and relatively suitable for industrial production.

The invention discloses a cholesterol modified anti-human immunodeficiency virus (HIV) polypeptide medicament and application thereof. The cholesterol modified anti-HVI polypeptide is named CHFI, and the amino acid sequence of the polypeptide is shown as the sequence 2 in a sequence table, wherein the cysteine residue at the 33rd position of the sequence 2 is connected with cholesterol through a thioether bond. Bromoacetic acid cholesterol ester is grafted to the side chain of polypeptide chain cysteine by thioether formation reaction with extremely high chemical selectivity to obtain the CHFI. The CHFI has the important advantages of strong anti-virus activity, targeting property, long half-life period, good water solubility and the like, and is easily synthesized.

A method for producing alpha -mino-gamma -butyrolactone or a salt thereof, which comprises a step wherein methionine and a haloacetic acid, namely chloroacetic acid or bromoacetic acid, are caused to react with each other in a solvent, and which is characterized in that the solvent contains 60% by weight or more of water relative to the total weight of the solvent. By this method, a-amino-?-butyrolactone or a salt thereof can be produced with high yield.

The invention relates to a solid catalyst for synthesizing cyclic carbonate and a preparation method thereof. In the catalyst, mesoporous foam silicon oxide is used as a carrier, bromoacetic acid or iodoacetic acid and an amino-containing imidazole ionic liquid are used as raw materials, and effective fixation of the ionic liquid on the mesoporous foam silicon oxide material can be realized through a two-step reaction so as to obtain the solid catalyst for synthesizing cyclic carbonate. The method is simple to operate, the obtained solid catalyst can be continuously reused through simple treatment after the reaction, thus the service life is long, the pollution is avoided, and the production cost is greatly reduced. By applying the solid catalyst to a process of synthesizing ethylene carbonate or propylene carbonate through a reaction between ethylene oxide or propylene oxide and carbon dioxide, a good catalysis effect is realized, the selectivity of the cyclic carbonate is higher than 95%, and the yield is higher than 85%.

A grassland locoism toxin vaccine for animals raised on grassland is prepared through firstly reaction of bromoacetic acid on N-hydroxysuccinimide to obtain active ester, further, synthesis with swainsonic to obtain N-carboxymethyl swainsoniue, finally condensation with BSA to obtain SW-BSA, then dialysis, freeze-drying and copmletely emulsifying with Folin's assistant to obtain SW vaccine. Its advantages are long active period (12 months), high protextion rate up to 85% or more, and full use of loco weed resource.

The invention provides a preparation method of a nickel metal chromatography medium based on 6B agarose microspheres. The agarose microspheres are activated through epoxy chloropropane to be polymerized with glucan, the superficial area of the agarose microspheres is increased on the condition of not reducing the number of surface hydroxyl groups of the agarose microspheres, the charge effect of the agarose microspheres is effectively reduced through glucan molecules, the activated agarose microspheres are connected with L-asparaginic acid again and subjected to bromoacetic acid treatment, a long lengthened arm is generated, it is ensured that nickel metal can be efficiently combined with recombinant protein, and the purification effect of the medium is improved. The problems that in existing agarose microspheres, the crosslinking step is tedious, the medium coupling ligand density is low after crosslinking, and the agarose physicochemical property affects the purification effect are solved.

The invention provides a PCN metal organic framework and graphene oxide composite adsorption material and a preparation method thereof. The method comprises the following steps: step 1, preparing a PCN metal organic framework by using zirconium chloride and a porphyrin coordination agent as raw materials through a solvothermal process; step 2, by using graphene oxide as a raw material, performingcarboxylation modification treatment on the graphene oxide by using bromoacetic acid to prepare carboxylated graphene oxide; and step 3, realizing effective compounding of the PCN metal organic framework and the carboxylated graphene oxide by using an ultrasonic-assisted stirring process to prepare the metal organic framework and graphene oxide composite adsorption material. The PCN metal organicframework/graphene oxide composite adsorption material provided by the invention has the advantages of high adsorption efficiency, a simple preparation process, a short cycle, few by-products and lowcosts, and has broad application prospects, especially in treatment of acidic uranium-containing wastewater.

The invention belongs to the technical field of fluorescence spectrum detection and analysis, and particularly relates to a visual organic molecular fluorescence probe on the basis of cyanine and a method for preparing the visual organic molecular fluorescence probe. The visual organic molecular fluorescence probe comprises a cyanine fluorophore and benzothiazole groups. The method includes stepsof (1), dropwise adding phosphoryl chloride into N, N'-dimethylformamide to obtain mixtures, then adding the mixtures into bromoacetic acid and carrying out reaction to obtain products II; (2), carrying out reaction on 2, 3, 3'-trimethyl indole and ethyl iodide to obtain products III; (3), dropwise adding piperidine into the products II and the products III and carrying out reaction to obtain products IV; (4), carrying out reaction on the products IV and aminothiophenol at the room temperature to obtain the visual organic molecular fluorescence probe. The visual organic molecular fluorescenceprobe and the method have the advantages that obvious color change of the visual organic molecular fluorescence probe can be seen in natural light or ultraviolet lamps, linear relations between the fluorescence intensity and peroxynitrite negative ions are established, and accordingly the peroxynitrite negative ions can be qualitatively and quantitatively detected; the visual organic molecular fluorescence probe is good in selectivity and high in sensitivity, detection methods are easy to implement, and obvious effects can be realized.

The invention particularly provides a modified starch fluid loss additive for drilling fluids, which is composed of the following components in percentage by weight: 60-80% of natural starch, 3-4% of bromoacetic acid, 5-15% of industrial alcohol, 2-7% of sodium hydroxide, 0.1-0.5% of diethylenetriamine, 0.5-1.0% of glacial acetic acid and the balance of water. The modified starch fluid loss additive for drilling fluids has the advantages of favorable water solubility, favorable compatibility and no biological toxicity, effectively lowers the fluid loss of the drilling fluid, is biodegradable, belongs to an environment-friendly product, satisfies the requirements of safe well drilling, productive formation protection, environment protection and the like for the fluid loss additive for drilling fluids in the oilfield large-scale development process, has the characteristics of low raw material cost, simple preparation method and simple required equipment and conditions, and is easy to implement.

The invention discloses a refining agent for a colored cotton fabric. The refining agent is prepared from, by weight, 10-12 parts of isomeric sodium C13 alcohol polyoxyethylene ether carboxylate, 2-4 parts of folium artemisiae argyi extracts, 3-6 parts of polyethylene naphthalate, 1-3 parts of lipase, 3-5 parts of alkyl polyglycoside, 3-5 parts of polytetramethylene ether glycol, 1-3 parts of bletilla striata extracts, 1-3 parts of bromoacetic acid, 2-4 parts of sodium carbonate, 1-3 parts of purified terephthalic acid, 2-5 parts of rhizoma atractylodis macrocephalae extracts, 2-5 parts of cocamidopropyl betaine, 1-3 parts of tartaric acid and 12-15 parts of water. In this way, the refining agent is good in alkali resistance and capable of effectively removing impurities and oil stains.

The invention discloses an environmental-friendly and alkali-resistant scouring agent, consisting of the following components in parts by weight: 1-2 parts of glycerol monostearate, 4-5 parts of sodium hydroxide, 1-2 parts of tetramethyl ammonium bromide, 4-5 parts of chloroacetic acid, 8-9 parts of iso-alcohol ether, 3-4 parts of bromoacetic acid and 2-4 parts of potassium hydroxide. The environmental-friendly and alkali-resistant scouring agent disclosed by the invention has alkali-resistant and environmental-friendly effects, is good in biodegradability, and contains no APEO (Alkylphenol Ethoxylates) phosphorus or heavy metal.

The invention discloses preparation methods for sitagliptin intermediates including 3-carbonyl-4-(2,4,5-trifluorophenyl)-butyrate (I) and 1-(3-trifluoromethyl-5,6-dihydro-8H-(1,2,4) triazole-(4,3-a) pyrazine-7-)-4-(2,4,5-trifluorophenyl)-1,3-butanedione (II). The preparation method for the intermediate (I) includes the steps of preparing corresponding Grignard reagent by bromoacetate and magnesium powder by means of Grignard reaction, and preparing the intermediate I by means of addition reaction between the Grignard reagent and 2,4,5-trifluoro-benzeneacetonitrile. The preparation method for the intermediate (II) includes the steps of carrying out acylation reaction between bromoacetic acid and III under the action of condensing agent so that IV is prepared, carrying out Grignard reaction between the IV and magnesium powder so that corresponding Grignard reagent V is prepared, and finally preparing the intermediate (II) via addition reaction between the Grignard reagent V and 2,4,5-trifluoro-benzeneacetonitrile in organic solvent. The preparation methods for the sitagliptin intermediates are mild in reaction conditions, simple and convenient in operation and available in raw materials and have excellent industrialized prospect.

The invention discloses a hexahydroisoindole-1-keto compound and a synthetic method thereof. The structure of hexahydroisoindole-1-keto is as a formula (I) or a formula (II), or an enantiomer of the formula (I) or the formula (II), wherein in the formula, R is hydrogen, methyl or aryl; R is hydrogen or methyl; R is benzyl or p-methoxybenzyl; and R is hydrogen, methyl, alkoxycarbonyl, benzoyl or aryl. The synthetic method for the hexahydroisoindole-1-keto comprises that: 2, 4-pentadieneamine is firstly condensed with alpha-bromoacetic acid to generate corresponding alpha-bromoacetamide, and then the alpha-bromoacetamide reacts with aldehyde to obtain the hexahydroisoindole-1-keto under the conditions of proper solvent and temperature in the presence of triphenylphosphine and inorganic alkali. The hexahydroisoindole-1-keto compound and the synthetic method thereof can be used for bioactivity screening or medicament development.

The invention relates to a carboxylic acid betaine type fluorine-containing compound as well as a synthesis method and application thereof. A fluorinated tertiary amine compound as an initial raw material is reacted with tert-butyl bromoacetate to obtain a tert-butyl-protected quaternary ammonium salt product; the tert-butyl-protected quaternary ammonium salt product and triethyl silane are dissolved in anhydrous DCM, trifluoroacetic acid is dropwise added under an ice bath condition, the reaction is continued after the mixture is recovered to the room temperature, reduced pressure distillation is performed to remove a solvent and the trifluoroacetic acid, a product is dissolved by using a hydrochloric acid solution, and then is subjected to freeze-drying, the residual trifluoroacetic acidis removed by replacement, and the carboxylic acid betaine type fluorine-containing compound is finally obtained. The preparation method disclosed by the invention can be used for preparing a fluorinated polymer, the preparation method is simple, the yield is high, the separation is easy, and the purity is high. The compound contains a plurality of chemical active groups such as hydroxyl, amino,carboxyl, acetenyl, azido, and sulfydryl, can be used for labeling a drug, a polymer, a nanocarrier and an implant material, and satisfies the requirements of 19F MRI probe development.

The invention discloses a sex pheromone composition for preventing and controlling argyrogramma agnata, and application thereof, and belongs to the field of biological prevention and control. The massratio of argyrogramma agnate sex pheromone to a sex pheromone halogenated analogue is 1:(0.4-0.8). The sex pheromone is composed of cis-7-dodecenyl acetate, cis-11-hexadecene acetate and cis-11-hexadecene aldehyde. The sex pheromone halogenated analogue is selected from one or more of cis-7-dodecenyl-2-mono-bromoacetic acid ester, cis-7-dodecenyl-2,2,2-trifluoroacetic acid ester, and cis-7-dodecenyl-2,2,3,3,3-pentafluoropropionic acid ester. The sex pheromone composition can more effectively trap and kill the male argyrogramma agnata, the mating frequency is decreased, the propagation rate isdecreased, and the pest population is gradually controlled to be extinct, so that the purpose of pest prevention and control is achieved.

The invention provides a metal-free and environmentally friendly bifunctional porous organic frame catalytic material and a preparation method thereof, and belongs to the field of preparation method of organic porous materials. The preparation method of the bifunctional porous organic frame material comprises that a porous organic frame substrate having pyridine sites is formed by polymerization connection of two organic building units and then is modified with bromoacetic acid to obtain carboxylic acid sites and bromoanion sites. The metal-free bifunctional porous organic frame material can efficiently catalyze the reaction of CO2 with an epoxy compound to form cyclic carbonate under a condition without the existence of a heterogeneous synergistic catalyst; the bifunctional porous organicframe material has the advantages that the preparation method is simple and easy to operate, and the material is non-toxic, friendly to environment and good in reproducibility of catalytic performance.

The invention relates to a green synthetic method for tert-butyl bromoacetate. The method is characterized in that bromoacetic acid and isobutylene are adopted as raw materials in the method, a solid superacid is adopted as a catalyst, and the method includes performing an acid-ester esterification reaction at room temperature under atmospheric pressure in an organic solvent, performing filtration after the reaction is finished to recover the catalyst, distilling filtrate to recover the solvent and distilling to obtain the tert-butyl bromoacetate the content of which is 99.0% or above. The reaction yield is 95% or above. The method is high in yield, good in product quality, low in cost, simple in reaction process operation, basically free of generation of three wastes, low in environment pollution, high in operation safety and suitable for industrial production. The catalyst is easily available and can be used repeatedly.

The invention relates to a preparation method of antibacterial flame-retardant silk fabric, belonging to the field of spinning. Aiming at the problems of bad antibacterial property, unsatisfactory flame-retardant effect and low durability of existing silk fabric, the preparation method provided by the invention comprises the following steps: extracting natural antibacterial substances and lipid substances in honeysuckle and herba andrographitis to obtain antibacterial liquid; with sodium silicate as a flame-retardant substrate and in a bromoacetic acid environment, enabling the sodium silicate to react with carbamide peroxide and phosphoric acid under the catalysis of zinc chloride to obtain a composite flame retardant; mixing the composite flame retardant and adding hydrogen peroxide for blanching to obtain treatment liquid; and soaking silk fabric in the treatment liquid, wherein due to the specific amino acid active group on the surface of the silk fabric and through the excitation of X-ray irradiation, the silk fabric reacts to be combined with the hydroxyl and carboxyl substances in the composite flame retardant and antibacterial substances to obtain antibacterial flame-retardant silk fabric. The silk fabric prepared by the method has the advantages of good flame retardance, durability, strong antibacterial ability and environment-friendly materials.

The invention discloses a silver ion color developing agent and a preparation method thereof, and belongs to the technical field of composite materials. The silver ion color developing agent is prepared by the following steps: adding nano silicon dioxide into ethanol, then adding 3-(2,3-epoxypropoxy)propyl trimethoxysilane, carrying out reflux reactions to obtain a product (GPTMS-SiO2); then adding the obtained GPTMS-SiO2 into ethanol, adding poly(ethylene imine), carrying out reflux reactions to obtain a product (PEI-SiO2); then adding the obtained PEI-SiO2 into distilled water, adding carbon disulfide and potassium carbonate, carrying out reflux reactions at a room temperature to obtain a product (DTC-SiO2), adding the obtained DTC-SiO2 into distilled water, then adding bromoacetic acid and sodium carbonate, and carrying out reflux reactions to obtain a product (BA-SiO2). The prepared silver ion color developing agent has the advantages of fast color developing speed, low detection limit, convenient operation, strong anti-interference performance, and wide pH application range, can be used to detect silver ions in various water bodies, and is suitable for popularization and application.

The present invention belongs to the technical field of pharmaceutical chemical synthesis, and specifically discloses a synthetic method for a 3,3-difluoro-2-oxindole derivative. The method comprises: selecting different aromatic amines and esters of bromoacetic acid fluoride to generate an aromatic amide compound; carrying out a reflux reaction on halohydrocarbon and the aromatic amide compound to obtain the (N)-alkyl protected aromatic amide compound; and adding an accelerant and an organic solvent into the obtained (N)-alkyl protected aromatic amide compound at the temperature of 50-100 DEG C to react for 6-10 hours, and synthesizing the 3,3-difluoro-2-oxindole derivative. According to the synthetic method disclosed by the present invention, the synthetic method is simple to operate without using any metals, the cost is very low, the condition is mild, the conversion rate is high, and the used raw materials are readily available and inexpensive, so that the synthetic method is suitable for being applied to industrial production.

The invention relates to the field of organic synthesis, in particular to a preparation method of pentafluorophenol. The preparation method of pentafluorophenol comprises the steps as follows: 1) pentafluorobenzonitrile and bromoacetic ester are subjected to a coupling reaction in the presence of zinc powder, hydrolysis and decarboxylation are performed under the acid condition, and pentafluoroacetophenone is prepared; 2) pentafluoroacetophenone is subjected to a Baeyer-Villiger reaction in the presence of an oxidizing agent, and pentafluorophenol is prepared after hydrolysis. The preparationmethod of pentafluorophenol comprises simple and short operation steps and is low in production cost, high in industrial operability and suitable for large-scale industrial production.