Antimicrobial compositions

An antimicrobial and composition technology, applied in the direction of drug combination, biocide, chemicals for biological control, etc.

Active Publication Date: 2011-11-16
MANUKA HEALTH NEW ZEALAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for Manuka honey to be effective, frequent application or ingestion is required

Method used

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  • Antimicrobial compositions
  • Antimicrobial compositions
  • Antimicrobial compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0169] Example 1 - Antimicrobial Composition A (Powder Composition Comprising α-Cyclodextrin)

[0170] Manuka honey was mixed with α-cyclodextrin at a ratio of 45.0%wt / 55.0%wt, and then prepared into a powder.

[0171]60.0 g of Manuka honey and 61.3 g of α-cyclodextrin were added to a 1 L beaker, 128.7 ml of water was added thereto, and the composition was homogenized at 6000 rpm for 5 minutes. After that, water was added so that the solid content was 20.0%wt.

[0172] The resulting suspension was spray-dried (drying gas temperature: 160°C) to obtain a powder of antimicrobial composition A.

Embodiment 2

[0173] Example 2 - Antimicrobial Composition B (Powder Composition Comprising Gamma-Cyclodextrin)

[0174] Manuka honey is mixed with γ-cyclodextrin in the ratio of 45.0%wt / 55.0%wt, and then prepared into powder with the same method as the preparation method of antimicrobial composition A described in Example 1 above (i.e. into an antimicrobial composition B).

Embodiment 3

[0175] Example 3 - Antimicrobial Composition Solution C (Solution Containing α-Cyclodextrin)

[0176] 14.5454 g of antimicrobial composition A and 8.0 g of α-cyclodextrin were dissolved in water to make up to 100 mL, thereby generating antimicrobial composition solution C.

[0177] The manuka honey content in antimicrobial composition solution C (from antimicrobial composition A) was 6.55% w / v.

[0178] The alpha-cyclodextrin from antimicrobial composition A was 8.0% w / v, while the alpha-cyclodextrin added alone was 8.0% w / v. The total alpha cyclodextrin is therefore 16.0% w / v.

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Abstract

This invention provides antimicrobial compositions containing methylglyoxal and material with methylglyoxal contained (such as manuka honey). The antimicrobial activity of methylglyoxal, or material with a methylglyoxal presence, is maintained and / or enhanced by mixing methylglyoxal or material with a methylglyoxal presence with cyclodextrin. Methods of preparing such compositions, including powder composition, and methods of using such compositions are also provided.

Description

field of invention [0001] The present invention relates to antimicrobial compositions. In particular, the present invention relates to antimicrobial compositions comprising methylglyoxal and cyclodextrins, including antimicrobial compositions comprising one or more methylglyoxal-containing materials and one or more cyclodextrin-containing materials. Antimicrobial compositions comprising Manuka honey as one or more methylglyoxal-containing materials, and cyclodextrins are specifically contemplated. Background of the invention [0002] Manuka Honey is a natural honey produced by bees collecting nectar from the Manuka shrub (Leptospermum scoparium) that grows throughout New Zealand. This species is also found in Australia, where the honey is known by different names such as Jellybush honey. It contains active ingredients that exhibit stability in the presence of heat, light, gastric juice, enzymes, etc. Manuka honey has been reported to inhibit the growth of Staphylococcus a...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K31/121A61K31/724A61P31/04A01N25/22A01N35/02A01N65/28A01P3/00A23L3/349A23L21/25A61K31/11A61K35/644
CPCA61K31/121A23B7/154A61K35/644A23L3/3463A61K31/724A61K35/64A23L3/3499A61K36/61A61P17/02A61P31/00A61P31/04A61K2300/00A61K35/63A01N35/02A01N43/16A23L3/34635A61K45/06
Inventor 寺尾启二城文子中田大介
Owner MANUKA HEALTH NEW ZEALAND
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