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335 results about "Epigallocatechin-3-O-gallate" patented technology

Infobox references. Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin. EGCG, the most abundant catechin in tea, is a polyphenol under basic research for its potential to affect human health and disease.

Nutraceutical composition and method of use for treatment / prevention of cancer

The invention describes a nutraceutical composition and method for preventing / treating cancer comprised of A) quinones (2,3-dimethoxy-5-methyl-1,4-benzoquinone, thymoquinone, tocopherolquinone) B) compounds capable of maximizing oxidative mitochondrial function preferably riboflavin, FAD, FMN, 6,7-Dimethyl-8-(1-D-ribityl)lumazine, ribitol, 5,6-dimethylbenzimidazole, tetrahydrobiopterin, vitamin B1, lipoic acid, biotin, vitamin B6, vitamin B12, folate, B3, C and pantothenate C) lactic acid dehydrogenase inhibitors; 2′,3,4′5,7-pentahydroxyflavone, epigallocatechin gallate, quercetin, citric acid, rosemary, black walnut, clove, nutmeg, licorice root, coriander, cinnamon, ginger root, myrrh gum and green tea D) alkalizing agents: aloe vera, chlorella, wheat grass, apple cider vinegar, burdock root, kudzu root, alfalfa, barley grass, spirulina, parsley leaf, calcium, magnesium, potassium or bicarbonate salts E) potent tumoricidal herbs; gromwell root, wild yam, beth root, teasel root, balm of gilead bud, frankincense, bakuchi seed, dichroa root, kochia seed, kanta kari, sweet myrrh, galbanum, garcinia fruit, mace, white sage and tumoricial plant derived constituents: gambogic acid, shikonin, diosmin or boswellic acid F) an antiproliferative herb (speranskia or goldenseal) and G) a pharmaceutically acceptable carrier.
Owner:FLORIDA A&M UNIVERSITY

Satiety promoting beverage and use in a diet to moderate food consumption

InactiveUS20060188548A1Encourage their consumptionIncrease volumeBiocideMilk preparationFiberRegimen
A satiety promoting beverage and a weight control regimen using it are described comprising: fiber, protein, sweetener and preferably calcium and a catechin, such as purified epigallocatechin gallate derived from green tea. The ingredients are employed in amounts sufficient that a single serving provides a feeling of satiety, both initially and after a period of at least one hour. In a preferred form, a serving of the beverage will comprise fiber in an amount sufficient to supply from 10 to 30% of the DV for fiber; milk protein in an amount sufficient to supply from 4 to 10 grams protein; calcium in an amount sufficient to supply from 10 to 40% of the DV for calcium; a low calorie sweetener and, preferably, the catechin in an amount sufficient to supply from 2 to 4 cup equivalents. The ingredients are homogenized and packaged to provide a smooth textured beverage with a creamy mouthfeel and from about 50 to about 150 calories per serving of from about 4 to 12 ounces. A Fullness Index of greater than 4, and preferably 5 is evidence of both very high volume to calorie and (fiber plus protein) to calorie ratios.
Owner:LIGHTFULL FOODS INC A DELAWARE

Protein and fruit juice product

The invention is a product that produces a feeling of satiety, suppresses appetite and promotes a higher metabolic rate, while providing nutrients for a balanced meal in a fruit flavored meal substitute. The product for weight management comprises fruit juice and protein, and further comprises green tea extract comprising epigallocatechin gallate. The product can be made to further comprise caffeine at a level over and above that provided by the green tea extract, and added calcium. Other aspects of the invention include methods to provide a human with a product that aids in the feeling of satiety and contributes to weight management, comprising administering to a human in need thereof the food product described.
Owner:LIMITED THE

Nutrient pharmaceutical formulation comprising polyphenols and use in treatment of cancer

A nutrient pharmaceutical formulation composition useful for treating cancer comprising ascorbic acid, L-lysine, L-proline and at least one polyphenol compound selected from the group consisting of epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, catechin and the use of the composition in treating cancer and other tumors are provided.
Owner:MATTHIAS RATH

Lipidosome encapsulating epigallocatechin gallate and preparation method thereof

The invention discloses a lipidosome encapsulating epigallocatechin gallate and a preparation method process. The lipidosome consists of the following components: soya bean lecithin, cholesterol, epigallocatechin gallate, buffer liquor and tween-80. The preparation method disclosed by the invention is simple in process and the EGCG lipidosome is prepared by a reverse evaporation method, and ultrasonic treatment is carried out on the lipidosome by a water bath ultrasonic instrument till the system is stable. The method can remarkably improve the stability of the EGCG lipidosome, and the grain size of the lipidosome can be effectively controlled and the encapsulation efficiency can be effectively improved by adjusting the ratio of the lipid components and the buffer liquor through the technical steps such as magnetic stirring, ultrasonic treatment and rotary evaporation. The EGCG lipidosome disclosed by the invention develops the application range of lipidosome, and the lipidosome is used as a carrier to encapsulate EGCG, so that the lipidosome is simple in preparation process, lower in demand on equipment, convenient to popularize and apply and can be industrially produced.
Owner:CHINA JILIANG UNIV

Tea extract-containing microemulsion, preparation method and applications thereof

The present invention discloses a tea extract-containing microemulsion, a preparation method and applications thereof. The tea extract-containing microemulsion comprises the following components by weight: 0.1% to 8% of tea extract, 30% to 70% of oil phase, 0.05% to 0.5% of synergistic agent, 10% to 50% of emulsifier, 0% to 20% of co-emulsifier and 1% to 5% of water; wherein the synergistic agent is ascorbic acid or / and citric acid, the tea extract is epigallocatechin gallate or / and theaflavin-3, 3'-digallate. The present invention also provides the preparation method and applications of the tea extract-containing microemulsion. The tea extract containing microemulsion has characteristics of uniform, transparent, stable property, strong oxidation resistance, and simple and controllable preparation method.
Owner:杭州远圣茶能科技有限公司

Method for preparing high-purity monomer epigallocatechin gallate from processed leftovers of tea leaves

The invention relates to a method for preparing high-purity monomer epigallocatechin gallate from processed leftovers of tea leaves. The method comprises the following steps of: extracting tea polyphenol, namely performing enzymolysis of the processed leftovers, which serve as raw materials, of fresh tea leaves, pruned tea leaves and non-fermented tea leaves by adding complex enzyme which consists of cellulose, protease and pectinase to extract the tea polyphenol; and separating a catechin out for purifying, namely precipitating the tea polyphenol by using a mixed precipitant which consists of CaCl2 and ZnCl2, performing primary separation by a macroporous resin chromatographic column, and performing secondary purification by the macroporous resin chromatographic column to obtain the high-purity monomer epigallocatechin gallate (EGCG). According to the method, chloroform is not used, the join from the extraction process to the refining and purification processes is compact, and the quality and yield of the product are high.
Owner:GUANGXI JIKANG BIO TECH

Anti-allergic soothing composition and anti-allergic soothing emulsion and preparation method thereof

ActiveCN108186472AProtective barrierModerationCosmetic preparationsAntipyreticGlycyrrhiza inflata root extractTheanine
The invention relates to the field of cosmetics, and particularly relates to an anti-allergic soothing composition and an anti-allergic soothing emulsion and a preparation method thereof. The anti-allergic soothing composition mainly comprises a first active component, stephania tetrandra extract, theanine and epigallocatechin gallate in weight ratio of 0.3-1.5:0.1-0.5:0.8-1.2:0.8-1.2. The first active component includes sophora japonica root extract, glycyrrhiza inflata root extract and scutellaria baicalensis root extract. The components of the anti-allergic soothing composition have a synergistic enhancement effect, and have effects of effectively reducing the adverse effect caused by stimulation, protecting the skin barrier, relieving itching and relieving pain, and soothing the skin;biological polysaccharide and active small molecules are in mutual synergy and slow release for longer lasting action to repair the sensitive skin.
Owner:JIANGSU DEHE BIOTECH

Method for preparing antibacterial nanofibre composite membrane by utilizing electrostatic spinning and application thereof

The invention belongs to the fields of nano material preparation technique and biological material, in particular to a method for preparing an antibacterial EGCG (Epigallocatechin Gallate)_Cu(II) / PVA (Polyvinyl Alcohol) nanofibre composite membrane by utilizing electrostatic spinning and an application thereof. The method of the invention comprises the following steps of weighing copper sulfate and EGCG according to a ratio; dissolving in distilled water; regulating the pH value to prepare an EGCG_Cu (II) complex; mixing the EGCG_Cu (II) complex and PVA according to a ratio; and generating the EGCG_Cu (II) / PVA nanofibre composite membrane by utilizing an electrostatic spinning technique. The invention has the advantage that the sterilizing rate on escherichia coli can reach 99%. The nanofibre composite membrane has the advantages of good toughness and biocompatibility, and wide application prospects in the field of the biological materials.
Owner:TONGJI UNIV

Low-temperature storage liquid for cells, sodium alginate gel, cell gel, preparation method, use method and application thereof

The invention belongs to the technical field of storage, regeneration and repair of cells and discloses low-temperature storage liquid for cells. The low-temperature storage liquid is mainly preparedfrom the following components in percent by mass: 0.8%-1.5% of mannitol, 2%-3% of human serum albumin, 3%-7% of low-molecular dextran, 0.1-0.3% of glutathione, 0.5%-2% of epigallocatechin gallate, 3%-5% of adenosine, 0.5%-1% of glucose, 0.8% of NaCl, 0.2% of KCl, 0.1% of CaCl2 and the balance of water. The invention also provides sodium alginate gel, which contains sodium alginate, calcium chloride, hyaluronic acid and the low-temperature storage liquid for the cells and the like, and also provides cell gel and a preparation method thereof as well as application of the low-temperature storageliquid for the cells, the sodium alginate gel and the cell gel. The invention has the advantages that the low-temperature storage liquid for the cells can maintain cell activity for longer time at temperature of 2-8 DEG C, the sodium alginate gel can be used as temporary short-term storage materials of cells from various sources and brackets of cell tissue engineering, and the cell gel can be usedas a medical wet wound dressing and can be used for repairing soft tissues, refractory-healing wound skins and mucosal wound injuries.
Owner:CHENGDU YUANSHAN BIOTECH CO LTD

Use of lotus procyanidin as advanced glycosylation end product formation inhibitor

The present invention discloses a use of lotus procyanidin as an advanced glycosylation end product formation inhibitor. The drug composition adopting the lotus procyanidin as a main active component comprises the following nature active component extracts, by weight, 70-80% of lotus procyanidin, 10-20% of a synergist such as VE, VC, epigallocatechin gallate (EGCG), cysteine and other ??complexes, and 5-10% of other nature extracts such as a lotus leaf extract, a ginkgo leaf extract and the like. According to the present invention, a high performance liquid chromatography method is adopted to detect a methylglyoxal removing effect of the lotus procyanidin and the main structure unit thereof (catechin), wherein methylglyoxal is an important intermediate substance during an advanced glycosylation end product formation process; a high performance liquid chromatography / multi-stage mass spectrometry method is adopted to identify adducts of four catechin and methylglyoxal and adducts of nine lotus procyanidin and methylglyoxal; and results show that lotus procyanidin provides good inhibition effects for advanced glycosylation end product formation in simulated physiological environments and simulated food systems.
Owner:HUAZHONG AGRI UNIV

(-)-Epigallocatechin gallate derivatives for inhibiting proteasome

(-)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (-)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formula 10, wherein R1 is selected from the group of -H and C1 to C6 acyl group; R2, R3, and R4 are each independently selected from the group of -H, -OH, and C1 to C6 acyloxyl group; and at least one of R2, R3, or R4 is -H. The derivatives of (-)-EGCG that is at least as potent as (-)-EGCG. The carboxylate protected forms of (-)-EGCG and its derivatives are found to be more stable than the unprotected forms, which can be used as proteasome inhibitors to reduce tumor cell growth.
Owner:WAYNE STATE UNIV +3

Catechin Adjuvants

InactiveUS20070082073A1Ameliorate immunosuppressive effectImprove morbidityBiocidePhosphorous compound active ingredientsAdjuvantMortality rate
A combination cancer therapy based upon catechins, the major biologically active polyphenol in plant products, including green tea extract, and one or more chemotherapeutic agents. A common complication of cancer chemotherapy is neutropenia, and in spite of advances in its prophylactic management is a major cause of risk for the development of serious microbial infections leading to increased morbidity and mortality in both humans and animals. The use of cathechins such as those found in green tea (Camellia sinensis), including but not limited to epigallocatechin gallate (EGCG) as nontoxic adjuvant to aid in the prevention of opportunistic microbial infections in patients undergoing immunosuppressive chemotherapy is a novel application. Also contemplated are methods using catechins to ameliorate the immunosuppressive effects of cancer chemotherapy by administering the compound to a patient in need thereof.
Owner:FLORIDA VETERINARY SPECIALIST & CANCER TREATMENT CENT +1

Near-infrared light response nanoparticle and controlled release system

The invention discloses a near-infrared light response nanoparticle which comprises a nano-carrier, a nano-carrier entrapped substance, a photosensitizer and a near-infrared light response phase change material for packaging, wherein the nano-carrier entrapped substance comprises an H2S donor and an anticancer drug. Hydrophobic DATS, hydrophilic indocyanine green and epigallocatechin gallate are encapsulated into mesoporous polydopamine nanoparticles by utilizing the amphiphilic property of myristyl alcohol, and finally, the MPDA-ICG / DATS / EGCG@TD nanoparticles are obtained. After the nano system is irradiated by near-infrared laser, ICG in the nano system can effectively convert NIR into heat; and the phase change material TD responds to temperature rise and is changed into liquid from solid, so that rapid release of DATS and EGCG is promoted.
Owner:GUANGDONG PROV MEDICAL INSTR INST

Novel compositions containing polyphenols

The present invention is directed to compositions containing at least a polyphenol and polyethylenglycol, to products such as food, beverages, dietary supplements, feed, pharmaceuticals and personal care products containing such a composition as well as to the use of polyethylenglycol for masking the bitter taste of such polyphenols. The polyphenols are preferably selected from the group consisting of epigallocatechin gallate, resveratrol, hydroxytyrosol, oleuropein, polyphenols present in green tea extracts, catechins, polyphenols present in extracts of red grape skin, polyphenols present in olives and / or olive waste water, and their mixtures.
Owner:DSM IP ASSETS BV

Process for selective production of theaflavin

The present invention provides a method for selective production of theaflavin in large amounts at high yield, and in an easy and inexpensive manner. Specifically, it relates to a method for selective production of theaflavin whereby a processed plant extract containing epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate is combined with a plant cell culture having peroxidase activity for selective production of theaflavin.
Owner:HAMAMATSU FOUNDATION FOR SCIENCE & TECHNOLOGY PR

Skin-whitening and freckle-removing formula and preparation method for gel thereof

InactiveCN103520013AHigh activitySignificant anti-freckle and anti-inflammatory effectCosmetic preparationsOrganic active ingredientsStable stateMass ratio
The invention relates to a skin-whitening and freckle-removing formula and a preparation method for gel with the formula, and belongs to the field of pharmaceutical chemicals. The formula comprises high-purity EGCG (epigallocatechin gallate) and dipotassium glycyrrhizinate. The formula is characterized in that the mass ratio of EGCG to dipotassium glycyrrhizinate is (2 to 1) to (1 to 3), preferably (1 to 1) to (1 to 2), and the gel prepared by a dipotassium glycyrrhizinate hydrate, namely a gel matrix can be used for whitening skin and removing freckles. The preparation method has the advantages of high pharmaceutical activity, remarkable freckle-removing and inflammation-diminishing effects, simple process, stable state and the like, and is suitable for industrial production.
Owner:JIANGSU TIANSHENG PHARMA

Green tea, multivitamin, mineral and herb based hair and male facial skin formulas

The present invention is a natural formulation for treatment of male, female and adolescent pattern hair loss. The formulation contains a combination of Green Tea leaf extract, Polyphenols, Epigallocatechin Gallate (EGCG), Vitamin E, Folic Acid, Copper (as Amino Acid Chelate), B12, Zinc (as Oxide), Calcium Pantothenate, Niacin, Biotin, Riboflavin, Thiamine, and optionally Inositol, Black Tea Extract and Nettle Extract. The various extracts are prepared according to traditional procedures, and then combined in a suitable formulation for administration to the patient for treatment of male, female and adolescent pattern hair loss.
Owner:DONMEZ YUCEL

Antioxidant eye drops

The antioxidant eye drops is a topical ophthalmic formulation that contains four nutraceuticals (namely, astaxanthin, resveratrol, pyruvate and epigallocatechin gallate (EGCG)) having antioxidant, anti-inflammatory, and chelating activity in a carbomer gel carrier. The active ingredients can reduce oxidative stress through free radical scavenging and chelating activity. The carrier is composed of a solution of deionized water containing about 0.4% Carbopol 980 NF, 5.7% sorbitol. 0.01% cetrimide, 0.01% EDTA, and sodium chloride and sodium hydroxide in adequate amounts to adjust both the viscosity and the pH of the topical carrier to pH 7.0-7.4. Use of the formulation may delay the development of cataracts, reduce retinal degeneration, and maintain normal tear flow in dry eye due to the antioxidant, anti-inflammatory, and chelating activity of the active ingredients.
Owner:KADOR PETER F

Method utilizing microwave assisted lipase catalysis to synthesize esterification modified EGCG

The invention relates to a method utilizing microwave assisted lipase catalysis to synthesize esterification modified EGCG (Epigallocatechin Gallate), and belongs to the biosynthesis filed of organic compounds. The method is characterized in that EGCG and fatty acid vinyl ester are taken as raw materials to synthesize the esterification modified EGCG through the co-action of microwave radiation and lipase catalysis in an organic solvent system, so that the product can be obtained. The method provided by the invention comprehensively utilizes the advantages of both the microwave radiation and the lipase catalysis, so as to achieve the effect which is not achieved by the lipase catalysis under a conventional heating condition. With the action of the microwave radiation, the reaction system can be uniformly affected by a microwave field, the heating rate of the system is high, the temperature is kept stable, the reaction is obviously accelerated, the reaction rate is improved, and the reaction time is greatly shortened. Therefore, the synthesis method provided by the invention is efficient and fast, and is consistent with the requirements of green chemistry.
Owner:JIANGNAN UNIV

Production method of Tieguanyin first-rank black tea

The invention discloses a production method of Tieguanyin first-rank black tea. The production method comprises the following main procedures: selecting Tieguanyin tea seedlings, maintaining the Tieguanyin tea seedlings, picking Tieguanyin fresh leaves, airing, withering, rolling, fully fermenting, drying, compacting and molding, drying by a plurality of procedures and the like. According to the production method, the Tieguanyin first-rank black tea is prepared by specific tea seedling cultivation, specific tea picking time, unique treatment of airing fields and unique withering, rolling and full fermentation processes through combining with a creative process of drying for the plurality of procedures; the produced Tieguanyin first-rank black tea keeps the mellowness of Tieguanyin and the aroma of black tea, has the comprehensive effects of Tieguanyin green tea and the black tea, and has the effects of detoxifying, helping to digest and removing greasy taste, anti-aging, preventing cancers, soothing the nerves and harmonizing the stomach. The taste of the Tieguanyin first-rank black tea produced by the method provided by the invention is not diluted after being brewed for a plurality of times. The black tea produced by the method produced by the method keeps Tieguanyin theine (EGCG (Epigallocatechin Gallate)) and tea phenol and keeps the mouth feel of traditional handmade high-grade black tea.
Owner:陈秋黎

Enteric-coated medicament combination containing epigallocatechin gallate

The invention discloses an enteric-coated medicament combination containing epigallocatechin gallate or extract (tea polyphenol) of epigallocatechin gallate, comprising one or more units, each unit contains a core, and the outer periphery of the core is wrapped with at least a membrane layer or a capsule casing of enteric-coated material. In addition, the invention further discloses a preparationmethod and the application of the medicament combination. The enteric-coated medicament combination containing epigallocatechin gallate or extract (tea polyphenol) of epigallocatechin gallate can be well absorbed by alimentary canal, and the biological utilization is greatly improved.
Owner:JIANGSU SUZHONG PHARM GRP CO LTD +1

Composite capable of preventing bacteria, viruses, oxidation and pigment deposition

The invention discloses a composite capable of preventing bacteria, viruses, oxidation and pigment deposition, which is characterized by being prepared from the following raw materials in proportion by weight: 0.1-10 of epigallocatechin gallate (EGCG), 0-10 of chlorogenic acid, 0-10 of asiaticoside and 0-10 of ginkgolide. The invention also discloses application of the composite in preparing drugs, health-care food and cosmetics, which are capable of preventing bacteria, viruses, oxidation and pigment deposition. The composite of the invention has favorable safety, is suitable for curing respiratory tract infection, condyloma acuminatum, herpes progenitalis, chromatosis and other diseases, simultaneously has anti-oxidation and skin whitening functions, protects cells and DNA from being damaged, can prevent and cure dementia and chloasma, and also can be used for cancer adjuvant therapy.
Owner:JIANGSU KANION PHARMA CO LTD

Epigallocatechin gallate glycoside derivative and application thereof

According to the formula (I), a epigallocatechin gallate glycoside derivative and a pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition containing thesame as an active ingredient, and an anti-cancer composition in combination with an anti-cancer drug are provided. Compared with the anti-cancer drug alone, the combination of the EGCG derivative andthe anti-cancer drug has better tumor inhibiting effect. The invention further discloses the application of the compounds in preparing the anti-tumor pharmaceutical composition and the preparation.
Owner:YUNNAN AGRICULTURAL UNIVERSITY

Method for separating EGCG from tea

The invention relates to a method for extracting epigallocatechin gallate (EGCG) from tea raw materials. The method comprises the following steps: soaking tea raw materials in warm water, extracting, making the extract liquid go through a macroporous resin column, then making the extract liquid go through a polyamide resin column, condensing the obtained liquid, crystallizing, carrying out suction filtration, washing, and drying in vacuum so as to obtain the EGCG. Tea raw materials are soaked in warm water, water with a temperature higher than the soaking temperature is used to carry out spray-extraction, and then a continuous column chromatography method is adopted to purify the extract. The continuous column chromatography method comprises the following steps: loading macroporous resin into a column, making the extract liquid go through the column to obtain an ethanol analysis liquid with a concentration of 15 to 30%, then making the ethanol analysis liquid go through a polyamide resin column, using ethanol with a concentration of 70 to 85% to carry out elution so as to obtain an elution liquid of EGCG, removing ethanol from the elution liquid, and carrying out condensation and crystallization so as to obtain the finished EGCG product. The EGCG content of the product can reach 98% or more, and the yield can reach 80% or more.
Owner:HUNAN AGRICULTURAL UNIV

Method for extracting epigallocatechin gallate from oil-tea-cake

The invention discloses a method for extracting epigallocatechin gallate from oil-tea-cake. The method comprises the following steps of: (1) smashing an oil-tea-cake as a raw material, adding a solvent to carry out percolation extraction, collecting percolate, recovering the solvent, filtering and collecting filtrate; (2) feeding the filtrate for macroporous resin column chromatography, eluting the column by using 20-30% (v / v) of ethanol after rinsing the column, tracking and detecting by utilizing thin-layer chromatography and collecting ethanol eluent; (3) concentrating the ethanol eluent, adding organic acid into the concentrated solution, standing to crystallize; (4) dissolving the obtained crystals by using a mixed solvent 1, carrying out silicagel column chromatography, firstly washing the column by utilizing the mixed solvent 1, then washing the column by utilizing a mixed solvent 2 and collecting the eluent of the mixed solvent 2; and (5) concentrating the eluent obtained in the step (4), adding the organic acid and a little high-purity epigallocatechin gallate into the concentrated solution, standing, crystallizing, drying the crystals to obtain. The method disclosed by the invention has the advantages that the process is simple and easy to control; the eluent consumption is little; the yield is high and the production cost in low.
Owner:GUILIN SANBAO PHARMA
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