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Skin-whitening and freckle-removing formula and preparation method for gel thereof

A whitening and freckle-removing gel technology, which is applied in the field of medicine and chemical industry, can solve the problems of unseen preparation methods, achieve the effects of reducing irritation and thick film feeling, stable physical state, and rapid absorption

Inactive Publication Date: 2014-01-22
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the published patents and documents, there is no report on the relevant preparation method

Method used

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  • Skin-whitening and freckle-removing formula and preparation method for gel thereof
  • Skin-whitening and freckle-removing formula and preparation method for gel thereof
  • Skin-whitening and freckle-removing formula and preparation method for gel thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Preparation:

[0033] 1. Take 15 grams of EGCG, add 150 grams of water, and stir evenly at 25°C to obtain solution A.

[0034] 2. Take 25 grams of dipotassium glycyrrhizinate, add 300 grams of water, heat to 60°C, stir and mix to form a transparent gel matrix.

[0035] 3. Take 20 grams of propylene glycol and 0.5 grams of sodium benzoate, and add them to the above-mentioned gel matrix at 60°C under constant stirring to obtain solution B.

[0036] 4. Heat solution B to 60°C, add it to solution A at 55°C, add 500 grams of water, and mix well under stirring conditions.

[0037] 5. Stir the above mixed solution for 30 minutes, mix well and cool to 5°C to obtain a colorless and transparent gel product. The total amount is 1000g, divided into 50 sticks, each 20g, the content of EGCG is 1.5%, and the content of dipotassium glycyrrhizinate is 2.5%.

Embodiment 2

[0039]

[0040] Preparation:

[0041] 1. Take 20 grams of EGCG, add 200 grams of water, and stir evenly at 25°C to obtain solution A.

[0042] 2. Take 20 grams of dipotassium glycyrrhizinate, add 240 grams of water, heat to 60°C, stir and mix to form a transparent gel matrix.

[0043] 3. Take 20 grams of glycerin and 0.5 grams of sodium benzoate, and add them to the above-mentioned gel matrix at 60°C under constant stirring to obtain solution B.

[0044] 4. Heat solution B to 60°C, add it to solution A at 55°C, add 500 grams of water, and mix well under stirring conditions.

[0045] 5. Stir the above mixed solution for 30 minutes, mix well and cool to 5°C to obtain a colorless and transparent gel product. The total amount is 1000g, divided into 50 sticks, each stick is 20g, the content of EGCG is 2.0%, and the content of dipotassium glycyrrhizinate is 2.0%.

Embodiment 3

[0047]

[0048] 1. Take 15 grams of EGCG, add 150 grams of water, and stir evenly at 25°C to obtain solution A.

[0049] 2. Take 20 grams of dipotassium glycyrrhizinate, add 250 grams of water, heat to 60°C, stir and mix to form a transparent gel matrix.

[0050] 3. Take 20 grams of glycerin and 150.5 grams of polyquaternium salt, and add them to the above-mentioned gel matrix at 60°C under constant stirring to obtain solution B.

[0051] 4. Heat solution B to 60°C, add it to solution A at 55°C, add 550 grams of water, and mix evenly under stirring conditions.

[0052] 5. Stir the above mixed solution for 30 minutes, mix well and cool to 5°C to obtain a colorless and transparent gel product. The total amount is 1000g, divided into 50 sticks, each stick is 20g, the content of EGCG is 1.5%, and the content of dipotassium glycyrrhizinate is 2.0%.

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Abstract

The invention relates to a skin-whitening and freckle-removing formula and a preparation method for gel with the formula, and belongs to the field of pharmaceutical chemicals. The formula comprises high-purity EGCG (epigallocatechin gallate) and dipotassium glycyrrhizinate. The formula is characterized in that the mass ratio of EGCG to dipotassium glycyrrhizinate is (2 to 1) to (1 to 3), preferably (1 to 1) to (1 to 2), and the gel prepared by a dipotassium glycyrrhizinate hydrate, namely a gel matrix can be used for whitening skin and removing freckles. The preparation method has the advantages of high pharmaceutical activity, remarkable freckle-removing and inflammation-diminishing effects, simple process, stable state and the like, and is suitable for industrial production.

Description

technical field [0001] The invention discloses a formula for whitening and removing freckles and a preparation method of the gel, belonging to the field of medicine and chemical industry. Background technique [0002] Due to the pollution of the living environment and excessive work pressure, modern people's skin is more prone to wrinkles, cortical aging, darkening and lack of luster, and some people have pigmentation and allergic inflammation on the face. The formation of spots is caused by the deposition of melanin, and the production of melanin is affected by a variety of enzymes in the cell, among which tyrosinase is the main rate-limiting enzyme, which is a copper-containing aerobic enzyme. In the reaction process of converting acid into dopa, aerobic free radicals must participate. Therefore, inhibiting the activity of tyrosinase or eliminating free radicals necessary for synthesis can block the production of melanin, gradually whiten the skin and dissolve spots. [...

Claims

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Application Information

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IPC IPC(8): A61K8/63A61K8/49A61K8/04A61K31/353A61K31/704A61K47/28A61K9/06A61Q19/02A61P29/00A61P17/00
Inventor 魏元刚杨永安钟慧金显友易铭袁继文黄全书季浩
Owner JIANGSU TIANSHENG PHARMA
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