Enteric-coated medicament combination containing epigallocatechin gallate
A technology of epigallocatechin and gallate, applied in the field of pharmaceutical preparations, can solve the problems such as the limited range of bioavailability improvement, and achieve the effect of slowing down degradation
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Embodiment 1-3
[0038] The tablet core composition is evenly mixed, and an appropriate amount of 95% ethanol is added to make a soft material, granulated and dried. For granulation, add 0.4% by weight of magnesium stearate and 0.2% by weight of micronized silica gel, mix well, and compress into tablets (about 0.3g / tablet) to obtain tablet cores.
[0039] Table 1 Tablet core composition
[0040]
[0041] Coating: According to the conventional preparation method of coated tablets, the obtained tablet cores are coated with the coating liquid with the ingredients shown in Table 2 in the coating pan.
[0042] Table 2 Coating Solution-I
[0043] Element
[0044] Element
Embodiment 4-6
[0046] According to Table 3, the ingredients were evenly mixed and filled into the enteric-coated capsule shell.
[0047] Table 3 Filling powder
[0048]
Embodiment 7-9
[0050] According to Table 4, the ball core composition was evenly mixed, and an appropriate amount of water solution was added to prepare a plastic wet material, and pellets were made by extrusion-spheronization, and dried to obtain a ball core.
[0051] Table 4 pellet core composition
[0052]
[0053]
[0054] Coating: According to the conventional preparation method, the obtained pellet cores are coated with the coating liquid with the ingredients shown in Table 5 in a coating pan or a fluidized bed.
[0055] Table 5 Coating Solution-II
[0056] Element
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