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Enteric-coated medicament combination containing epigallocatechin gallate

A technology of epigallocatechin and gallate, applied in the field of pharmaceutical preparations, can solve the problems such as the limited range of bioavailability improvement, and achieve the effect of slowing down degradation

Active Publication Date: 2010-10-27
JIANGSU SUZHONG PHARM GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with piperine as an absorption enhancer, the increase in bioavailability is limited, and it is obviously not feasible to increase bioavailability by fasting for a long time

Method used

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  • Enteric-coated medicament combination containing epigallocatechin gallate
  • Enteric-coated medicament combination containing epigallocatechin gallate
  • Enteric-coated medicament combination containing epigallocatechin gallate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0038] The tablet core composition is evenly mixed, and an appropriate amount of 95% ethanol is added to make a soft material, granulated and dried. For granulation, add 0.4% by weight of magnesium stearate and 0.2% by weight of micronized silica gel, mix well, and compress into tablets (about 0.3g / tablet) to obtain tablet cores.

[0039] Table 1 Tablet core composition

[0040]

[0041] Coating: According to the conventional preparation method of coated tablets, the obtained tablet cores are coated with the coating liquid with the ingredients shown in Table 2 in the coating pan.

[0042] Table 2 Coating Solution-I

[0043] Element

[0044] Element

Embodiment 4-6

[0046] According to Table 3, the ingredients were evenly mixed and filled into the enteric-coated capsule shell.

[0047] Table 3 Filling powder

[0048]

Embodiment 7-9

[0050] According to Table 4, the ball core composition was evenly mixed, and an appropriate amount of water solution was added to prepare a plastic wet material, and pellets were made by extrusion-spheronization, and dried to obtain a ball core.

[0051] Table 4 pellet core composition

[0052]

[0053]

[0054] Coating: According to the conventional preparation method, the obtained pellet cores are coated with the coating liquid with the ingredients shown in Table 5 in a coating pan or a fluidized bed.

[0055] Table 5 Coating Solution-II

[0056] Element

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PUM

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Abstract

The invention discloses an enteric-coated medicament combination containing epigallocatechin gallate or extract (tea polyphenol) of epigallocatechin gallate, comprising one or more units, each unit contains a core, and the outer periphery of the core is wrapped with at least a membrane layer or a capsule casing of enteric-coated material. In addition, the invention further discloses a preparationmethod and the application of the medicament combination. The enteric-coated medicament combination containing epigallocatechin gallate or extract (tea polyphenol) of epigallocatechin gallate can be well absorbed by alimentary canal, and the biological utilization is greatly improved.

Description

technical field [0001] The present invention relates to pharmaceutical preparation technology, more specifically, to an enteric-coated pharmaceutical composition containing epigallocatechin gallate or an extract (tea polyphenol) containing epigallocatechin gallate and its Preparation method and use. Background technique [0002] Epigallocatechin gallate (EGCG, CAS No.: 989-51-5) is a catechin component extracted from plants (mainly tea leaves), and its structure is as follows: [0003] [0004] The purity of epigallocatechin gallate (EGCG) is generally above 80%. Epigallocatechin gallate has a wide range of pharmacological effects. Has anti-tumor effect (the main mechanism of action is to induce tumor cell apoptosis, induce tumor cell cycle arrest, inhibit tumor cell invasion and metastasis, inhibit telomerase activity, etc.); anti-atherosclerosis; protective effect on myocardial injury ; Protective effect on myocardial ischemia-reperfusion injury; Protective effect on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K31/353A61K47/32A61K47/34A61K47/38A61K47/42A61P9/00A61P9/10A61P13/12A61P25/16A61P31/22A61P35/00
Inventor 欧阳强林萍朱重经王光凤郭建明
Owner JIANGSU SUZHONG PHARM GRP CO LTD
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