Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
162 results about "Gallocatechin gallate" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Gallocatechin gallate (GCG) is the ester of gallocatechin and gallic acid and a type of catechin. It is an epimer of epigallocatechin gallate (EGCG). In a high temperature environment, an epimerization change is likely to occur, because heating results in the conversion from EGCG to GCG. According to the referenced study the resulting GCG (the epimer of EGCG) results in even lower dietary cholesterol absorption than occurs with EGCG. While this may be a beneficial outcome with respect to cholesterol reduction activity, for those wishing to maximize the EGCG content of green tea infusions, it is still appropriate to use high temperatures, as long as it is taking into account that extreme conditions will lead to small reductions in total EGCG, for example a 12.4% reduction in total EGCG when heated for 30 minutes straight at 100 degrees Celsius.
Method for preventing and treating avian influenza in human
A method and composition for preventing and treating Avian Influenza in Humans utilizes an effective quantity of polyphenolic(s) and / or its derivatives in combination with a carrier. The anti-avian influenza ingredient having a composition selected from the group consisting of theaflavin, theaflavin-3,3′-digallate, theaflavin-3-monogallate, theaflavin-3 gallate, theaflavin-3′-gallate, thearubigin, gallic acid, tannic acid, (−)-epigallocatechin gallate (EGCG), (−) epigalloatechin (EGC), (+)-epicatechin (EC), (−)-gallocatechin gallate (GCG), and catechin.
Owner:SICAN VENTURES
Gallocatechin gallate-containing composition
InactiveUS20060134286A1Strong antibacterial activitySafely and effectively reducingAntibacterial agentsOrganic active ingredientsGallic acid esterMedicine
The present invention provides a safe and highly effective antibacterial composition without impairing the flavor of foods or drinks, which composition is used in products such as foods and oral care goods which are mainly to be taken into human or animal bodies or mainly to be used in the oral cavity. The composition according to the present invention contains gallocatechin gallate as an agent for enhancing the activity of antibacterial catechins in which the antibacterial activity of the antibacterial catechins against Streptococcus mutans is particularly enhanced. The composition according to the present invention can be produced by mixing the antibacterial catechins with gallocatechin gallate. Alternatively, it can be produced as a composition comprising a synthetic adsorbent-adsorbed fraction as the main component, which is obtained by subjecting a solvent-extract from tea leaves to an adsorption treatment with the use of a synthetic adsorbent selected from among aromatic compound-based synthetic adsorbents and methacrylic compound-based synthetic adsorbents.
Owner:SUNTORY HLDG LTD
Lipidosome encapsulating epigallocatechin gallate and preparation method thereof
ActiveCN103610642AImprove stabilitySmall particle sizeOrganic active ingredientsAntinoxious agentsCholesterolLipid Body
The invention discloses a lipidosome encapsulating epigallocatechin gallate and a preparation method process. The lipidosome consists of the following components: soya bean lecithin, cholesterol, epigallocatechin gallate, buffer liquor and tween-80. The preparation method disclosed by the invention is simple in process and the EGCG lipidosome is prepared by a reverse evaporation method, and ultrasonic treatment is carried out on the lipidosome by a water bath ultrasonic instrument till the system is stable. The method can remarkably improve the stability of the EGCG lipidosome, and the grain size of the lipidosome can be effectively controlled and the encapsulation efficiency can be effectively improved by adjusting the ratio of the lipid components and the buffer liquor through the technical steps such as magnetic stirring, ultrasonic treatment and rotary evaporation. The EGCG lipidosome disclosed by the invention develops the application range of lipidosome, and the lipidosome is used as a carrier to encapsulate EGCG, so that the lipidosome is simple in preparation process, lower in demand on equipment, convenient to popularize and apply and can be industrially produced.
Owner:CHINA JILIANG UNIV
Compositions and methods for treating traumatic brain injury
ActiveUS20140170211A1Symptoms improvedPromote healingBiocideKetone active ingredientsL-GlutaminTaurine
The disclosure provides compositions treating traumatic brain injuries such as concussions. In one embodiment, the composition comprises phosphatidylserine, phosphatidylcholine, quercetin, astaxanthin, R-alpha lipoic acid, N-acetyl cysteine, taurine, L-glutamine, carnitine, D-ribose, creatine, epigallocatechin gallate, melatonin, ginkgo leaf extract, curcumin and L-glycine. The disclosure also provides methods for treating traumatic brain injuries such as concussions by administering an effective amount of the compositions described within.
Owner:HAVN LIFE SCI INC
Highly-antioxidant highly-crosslinked ultra-high molecular weight polyethylene artificial joint material and preparation method thereof
ActiveCN107754013AImprove antioxidant capacityNo adverse effect on crosslink densityTissue regenerationProsthesisPalmitoyl chlorideCompression molding
The invention discloses a highly-antioxidant highly-crosslinked ultra-high molecular weight polyethylene artificial joint material and a preparation method thereof. The artificial joint material is composed of a polyphenol antioxidant epigallocatechin gallate or lipid-soluble epigallocatechin gallate doped biocompatible ultra-high molecular weight polyethylene modified by palmitoyl chloride esterification, and is prepared by irradiation crosslinking after compression molding. The preparation method specifically comprises the following steps: doping the antioxidant with the ultra-high molecularweight polyethylene; performing compression molding; and performing irradiation crosslinking. The oxidation resistance of the irradiation crosslinked ultra-high molecular weight polyethylene is obviously improved under the condition that the crosslinking efficiency is not reduced. Meanwhile, due to the addition of the polyphenol antioxidant, the tensile property and impact strength of the material are not influenced, so that the overall service performance of the joint material is improved, and the service time is prolonged.
Owner:SICHUAN UNIV
Method for identifying quality of Biluochun tea
InactiveCN102455283AThe method is simple and effectiveAccurate methodComponent separationColor/spectral properties measurementsGallateEvaluation data
The invention discloses a method for identifying the quality of Biluochun tea, which comprises the following steps of: after soaking the Biluochun tea, scanning the soaked solution by using an ultraviolet and visible spectrophotometer; and, after leaching and extracting another Biluochun tea, measuring the contents of epigallocatechin, epigallocatechin epicatechol gallate, epicatechin and epicatechin epicatechol gallate in the tea from the leached and extracted solution by adopting a high efficiency liquid chromatography. According to the method disclosed by the invention, a technology for identifying the quality of the Biluochun tea is established by adopting (a technology that spectrum and chromatograph are combined) spectrum and chromatograph analysis; the comprehensive evaluation data of green tea quality is provided; the method has the characteristics of being accurate, reliable, simple, convenient and efficient; and the method can be popularized and applied in the field of the green tea quality counterfeit identifying technology.
Owner:NANJING AGRICULTURAL UNIVERSITY
Use of lotus procyanidin as advanced glycosylation end product formation inhibitor
InactiveCN103070400AHigh inhibition rateEnhanced inhibitory effectMilk preparationFood preparationAdditive ingredientAdduct
The present invention discloses a use of lotus procyanidin as an advanced glycosylation end product formation inhibitor. The drug composition adopting the lotus procyanidin as a main active component comprises the following nature active component extracts, by weight, 70-80% of lotus procyanidin, 10-20% of a synergist such as VE, VC, epigallocatechin gallate (EGCG), cysteine and other ??complexes, and 5-10% of other nature extracts such as a lotus leaf extract, a ginkgo leaf extract and the like. According to the present invention, a high performance liquid chromatography method is adopted to detect a methylglyoxal removing effect of the lotus procyanidin and the main structure unit thereof (catechin), wherein methylglyoxal is an important intermediate substance during an advanced glycosylation end product formation process; a high performance liquid chromatography / multi-stage mass spectrometry method is adopted to identify adducts of four catechin and methylglyoxal and adducts of nine lotus procyanidin and methylglyoxal; and results show that lotus procyanidin provides good inhibition effects for advanced glycosylation end product formation in simulated physiological environments and simulated food systems.
Owner:HUAZHONG AGRI UNIV
Application of epigallocatechin-3-gallate in preparation of antitumor drug
InactiveCN102526022AIncrease lethalityGrowth inhibitionOrganic active ingredientsAntineoplastic agentsCancer cellGallate
The invention belongs to the fields of medicine and gene engineering, relates to a new medicinal application of epigallocatechin-3-gallate EGCG, and particularly relates to an application of epigallocatechin-3-gallate in the preparation of antitumor drugs. Cell experiments demonstrate that the epigallocatechin-3-gallate is a CYPJ inhibitor, and has the capability of inhibiting liver cancer cell growth; a large dose of EGCG basically has no toxicity to liver, kidney and heart. Experiment results also show that when EGCG is added into a culture solution of tumor cells, the proliferation of tumor cells is inhibited; the tumor cells are blocked at the G1 stage; the activity of CYPJ is inhibited; the activation of an Erk signal path by CYPJ protein is blocked. The epigallocatechin-3-gallate of the invention can be used for the preparation of antitumor drugs, especially anti-liver cancer drugs; and the drugs are designed aiming at cell target points, and drug resistance is not easy to generate.
Owner:FUDAN UNIV
Green tea, multivitamin, mineral and herb based hair and male facial skin formulas
InactiveUS20050106263A1Growth inhibitionImprove efficiencyBiocidePeptide/protein ingredientsPhysiologyBLACK TEA EXTRACT
The present invention is a natural formulation for treatment of male, female and adolescent pattern hair loss. The formulation contains a combination of Green Tea leaf extract, Polyphenols, Epigallocatechin Gallate (EGCG), Vitamin E, Folic Acid, Copper (as Amino Acid Chelate), B12, Zinc (as Oxide), Calcium Pantothenate, Niacin, Biotin, Riboflavin, Thiamine, and optionally Inositol, Black Tea Extract and Nettle Extract. The various extracts are prepared according to traditional procedures, and then combined in a suitable formulation for administration to the patient for treatment of male, female and adolescent pattern hair loss.
Owner:DONMEZ YUCEL
Composition for skin external application containing gallocatechin gallate for moisturizing effect on the skin
InactiveUS20090176810A1Skin stimulationGood effectBiocideCosmetic preparationsAdditive ingredientFilaggrin
The present invention relates to a composition for external skin application having a skin-moisturizing effect, which comprises gallocatechin gallate as an active ingredient. More particularly, the composition for external skin application comprises gallocatechin gallate as an active ingredient to activate peroxisome proliferator activated receptor isoform alpha (PPAR-α), to stimulate expression of filaggrin and involucrin that are skin-moisturizing factors, and thus to provide excellent anti-drying and skin-moisturizing effects. More particularly, the composition for external skin application may further comprise theobromine and quercetin in addition to gallocatechin gallate to maximize such effects.
Owner:AMOREPACIFIC CORP
Bottleable green tea beverage
ActiveUS20070224332A1Add flavorGreat tasteWort preparationProtein composition from eggsGreen tea extractEpigallo-catechin gallate
With the object of providing a bottleable green tea beverage for selling hot, a bottleable green tea beverage was prepared, which is a bottleable green tea beverage containing a green tea extract obtained by extracting green tea leaves, wherein the content in epigallocatechin gallate and gallocatechin gallate is 380 mg / l to 1500 mg / l as a total value, the content of glutamic acid is 20 mg / l to 120 mg / l, the diff-use transmittance is 1.0% or less, and the pH is 5 to 7.
Owner:SHOKUHIN SANGYO HIGH SEP
Method and composition for preventing and treating avian influenza in poultry
InactiveUS20080075795A1Preventing and treating avian influenzaOrganic active ingredientsBiocideGallic acid esterAdditive ingredient
A method and composition for preventing and treating Avian Influenza utilizes an effective quantity of polyphenolic(s) and its derivatives in combination with a carrier. The anti-avian influenza ingredient having a composition selected from the group consisting of theaflavin, theaflavin-3,3′-digallate, theaflavin-3-monogallate, theaflavin-3 gallate, theaflavin-3′-gallate, thearubigin, gallic acid, tannic acid, (−)-epigallocatechin gallate (EGCG), (−)epigalloatechin (EGC), (+)-epicatechin (EC), (−)-gallocatechin gallate (GCG), and catechin.
Owner:ABATTIS BIOLOGIX
Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer
InactiveUS20050031716A1Good treatment effectReduce adverse effectsBiocideHydroxy compound active ingredientsCancer preventionCapsicum extract
The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of therapeutically effective amount of catechins, a group of polyphenols found in green tea, and Capsicum extracts. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins and Capsicum extracts, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.
Owner:PURDUE RES FOUND INC
Bottleable green tea beverage
ActiveUS7972644B2Increase concentrationFunction increaseWort preparationProtein composition from eggsGreen tea extractEpigallo-catechin gallate
Owner:SHOKUHIN SANGYO HIGH SEP
Egcg stabilized gold nanoparticles and method for making same
ActiveUS20130129618A1Organic active ingredientsHeavy metal active ingredientsNanoparticleRoom temperature
The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from epigallocatechin Gallate (EGCg), which is a polyphenols- or flavanoids-rich plant material that can be obtained from green tea. The EGCg is an an antioxidant reducing agent derived from green tea. The gold nanoparticles of the invention can be radioactive or non radioactive and are formed via a simple room temperature fabrication method. In preferred embodiment method of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with EGCg in a buffer, such as deionized water. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a coating of EGCg. The thermodynamically feasible redox couple of AuCl4-EGCg leading to the reduction of AuCl4- by EGCg to form gold nanoparticles. In another embodiment, pre-cooled gold salt and EGCg solutions form multi-layered EGCg coated particles.
Owner:UNIVERSITY OF MISSOURI
Preparation method and application of epigallocatechin gallate
ActiveCN103145679AImprove efficiencyOrganic active ingredientsOrganic chemistryAlcoholGreen tea extract
The invention relates to a preparation method and an application of epigallocatechin gallate. The method comprises the following steps of: adding alcohol to green tea, and extracting to obtain green tea extraction liquid; purifying the green tea extraction liquid to obtain a green tea extract; purifying the green tea extract to obtain a crude extract of epigallocatechin gallate; and recrystallizing the crude extract of epigallocatechin gallate to obtain epigallocatechin gallate. The method provided by the invention can be used for effectively preparing epigallocatechin gallate, and the product can be used for preparing a medicine, a healthcare food or food for preventing and treating anemia.
Owner:WUHAN HUADA PHARMA
Purified green tea extract
A purified green tea extract is improved in bitterness and aftertaste.The purified green tea extract, which comprises satisfying the following conditions:(1) a ratio of a sum of content weights of (A) myricetin, (B) quercetin and (C) kaempferol to a sum of content weights of (D) epigallocatechin gallate and (E) gallocatechingallate, ((A)+(B)+(C)) / ((D)+(E)), is from 0.0000001 to 0.010,(2) a sum of content weights of (D) the epigallocatechin gallate and (E) the gallocatechin gallate in non-polymer catechins, ((D)+(E))), is from 0.01 to 29 wt %, and(3) a percentage of gallate body in the non-polymer catechins is from 0.01 to 49 wt %.
Owner:KAO CORP
Preparation method of acetylated epigallocatechin gallate
The invention discloses a preparation method of acetylated epigallocatechin gallate. The preparation method comprises the following steps of taking dissolved EGCG (epigallocatechin gallate) as a raw material; adding an acetylating reagent and an esterification catalyst; performing acetylization reaction on EGCG at 0-120 DEG C while stirring; after reacting for 1-24 hours and when a system becomes from a yellow turbid liquid into a transparent hazel liquid, ending the acetylization reaction; and purifying to obtain the acetylated epigallocatechin gallate. The preparation method of the acetylated epigallocatechin gallate has the characteristics that the acetylation is complete, the conversion rate is higher than 98%, and the yield is high.
Owner:宜昌绿源生物技术有限公司
Green tea compositions
InactiveUS20170246235A1Improve bioavailabilityOrganic active ingredientsTea extractionBioavailabilityGallate
Disclosed herein are green tea plant material extracts, and methods of using the extracts, comprising at least one green tea catechin selected from the group consisting of epi-gallocatechin, catechin, epicatechin, epigallocatechin-3-gallate, gallocatechin gallate, epicatechin-3-gallate, catechin gallate, and gallocatechin, wherein the compositions of the disclosure provide greater bioavailability of at least one green tea catechin.
Owner:PLANDAI BIOTECH INC
Method for preparing nanofiltration membrane by electrostatic spraying and product thereof
ActiveCN108201790AImprove hydrophilicityFlat surfaceMembranesWater/sewage treatment bu osmosis/dialysisUltrafiltrationPolymer
The present invention provides a method for preparing a nanofiltration membrane by electrostatic spraying. The method is characterized by comprising step 1) of dissolving a pH buffering agent in waterto obtain a pH buffer solution, and adjusting the pH to 7.5 to 9.5; step 2) of dissolving reactive small molecules in the solution obtained in the step 1), and preparing a spray liquid; wherein the reactive small molecules are one or more of tannic acid, pyrogallol, catechol, catechin, 1, 2, 4-pyrogallol, epigallocatechin gallate, epigallocatechin and dopamine hydrochloride; step 3) of electrostatically spraying the solution obtained in step 2) onto a polymer ultrafiltration membrane wrapping a receiving roller of a device, and obtaining the nanofiltration membrane by removal. The nanofiltration membrane can be prepare by the one-step method, the method is simple and easy to implement, and zero discharge of waste liquid is achieved in the preparation process.
Owner:NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
Dietary and natural product management of negative side effects of cancer treatment
ActiveUS11020372B2Protect a patient's normal cells, tissuesProtects patientKetone active ingredientsEster active ingredientsTolerabilitySulforaphane
Owner:UNIV OF FLORIDA RES FOUNDATION INC
Medicine for preventing hemorrhagic disease of grass carps
ActiveCN102908342AGood control effectNo drug residueOrganic active ingredientsAntiviralsPediatricsVirus
The invention relates to a medicine for preventing hemorrhagic disease of grass carps. The invention provides a medicine for preventing the hemorrhagic disease of grass carps. The medicine is characterized by comprising epigallocatechin gallate. The medicine can be used for well preventing the death of the grass carps caused by the virus hemorrhagic disease of the grass carps, thus greatly improving the aquaculture of the grass carps, and increasing the survival rate in the transportation process.
Owner:SHANGHAI OCEAN UNIV
Synthetic epigallocatechin gallafe (EGGG) analogs
InactiveCN104024213APrevent proliferationImprove the level ofOrganic chemistryOrganic compound preparationMedicinal chemistryMetabolic disorder
Owner:THE HONG KONG POLYTECHNIC UNIV
Nutraceutical combination for prevention and treatment of type 2 diabetes
InactiveUS20150056297A1Avoid typingHeavy metal active ingredientsBiocideDietary supplementVitamin B12
A dietary supplement in capsule or tablet form includes a source of zinc in an amount equivalent to 6 mg to 40 mg of zinc chloride; optionally a source of chromium in an amount equivalent to 100 micrograms to 1000 micrograms of chromium picolinate; optionally from 4 micrograms to 100 micrograms of Vitamin B12; optionally an extract or powdered form of American Ginseng in an amount that provides from 20 mg to 200 mg of ginsenoside(s), or 20 mg to 200 mg of isolated or synthesized ginsenoside(s); optionally an oil, extract or powdered form of cinnamon bark in an amount that provides 1000 mg to 5000 mg of methylhydroxychalcone polymer; optionally 2 mg to 50 mg lutein; and optionally green tea extract in an amount that provides from 200 mg to 4000 mg of epigallocatechin gallate or 200 mg to 4000 mg of isolated or synthesized epigallocatechin gallate.
Owner:LIU CHARLES H
Anti-saccharification composition and preparation method thereof
ActiveCN110574927AAnti-glycation hasAnti-agingProtein composition from fishOrganic chemistryChemical compoundAging resistance
The invention discloses an anti-saccharification composition and a preparation method thereof. The composition specifically comprises the following components in parts by weight: 1%-30% of apples, 1%-25% of red pomegranate, 0.5%-20% of herba lophatheri powder, 0.5%-20% of skipjack tuna oligopeptide, 0.5%-20% of grapes, 0.5%-10% of blackcurrants, 0.1%-10% of mulberries, 0.1%-10% of kudzuvine roots,0.1%-10% of sea buckthorn, 0.1%-10% of black raw ginger, 0.01%-5% of epigallocatechin gallate, and the balance of auxiliary materials. The composition can be used to prepare tablets, granules, capsules, soft capsules, powder or oral liquid and other dosage forms. Functional compounds, functional foods and traditional Chinese medicines are combined, on the basis of the metabolic mechanism of the human body, all-around saccharification resistance is achieved, and meanwhile the effects of oxidation resistance, aging resistance, inflammation resistance, whitening and the like are achieved.
Owner:北京姿美堂生物技术股份有限公司
Preparation method of nano-epigallocatechin gallate (EGCG)
InactiveCN109316450ARestricted slow releaseFull bioavailabilityAntibacterial agentsPowder deliveryFreeze-dryingBiocompatibility Testing
The invention discloses a preparation method of nano-epigallocatechin gallate (EGCG). The preparation method comprises the following steps of step one, weighing certain mass of chitosan and adding into a 1 percent glacial acetic acid solution, heating, stirring for dissolving to obtain a chitosan solution; filtering while hot to obtain a solution A; step two, weighing certain mass of EGCG and adding into the solution A to obtain a solution B; step three, slowly adding a sodium tripolyphosphate solution C into the solution B, and carrying out high-speed stirring while adding to obtain nano EGCGsuspension; step four, adding 2 percent mannitol serving as a freeze-drying protective additive into the nano EGCG suspension, uniformly mixing and carrying out freeze drying to obtain a nano EGCG lyophilized product. The EGCG nanoparticles prepared by the preparation method disclosed by invention have the characteristics of good biocompatibility, biodegradation and the like; in addition, slow release of the EGCG can be effectively restricted, the action time in vivo is prolonged and further the bioavailability of the EGCG is played more fully.
Owner:江苏瑾辉生物科技有限公司
Treatment of Proliferative Disorders
The present invention relates to a method and composition for treating safely (in a non-toxic way) disease or disorder exhibiting excessive cellular proliferation comprising administering to a patient needing such treatment, a composition comprising curcumin (derived from turmeric), epigallocatechin-3-gallate (EGCG, enriched in green tea), glucosinolates (enriched in cruciferous vegetables) and / or derivatives thereof, such as sulforaphane (SFN), alone or combined with a ketogenic diet or a modified ketogenic diet. Also the current invention relates to a composition comprising medium chain triglycerides, Epigallocatechin-3-gallate, curcumin, compositions comprising glucosinolates and / or derivatives thereof, such as sulforaphane (SFN). The invention provides that administering a composition comprising curcumin, EGCG, glucosinolates, alone or combined with a ketogenic diet or a modified ketogenic diet targets malignant cells leading to decrease cellular proliferation and increase survival of the subject treated with the current invention.
Owner:UNIV OF FLORIDA RES FOUNDATION INC
Epigallocatechin gallate-loaded folate-targeted carrier as well as preparation method and application thereof
ActiveCN108273068AReduce oxidation rateReducing ROS levelsOrganic active ingredientsInorganic non-active ingredientsSide effectPolyethylene glycol
The invention relates to an epigallocatechin gallate-loaded folate-targeted carrier, which is prepared from zeolite imidazole skeleton, epigallocatechin gallate embedded in the zeolite imidazole skeleton, and folic acid-polyethylene glycol modified on the zeolite imidazole skeleton by means of an amido bond. The invention also relates to a preparation method and application of the epigallocatechingallate-loaded folate-targeted carrier. The folate-targeted carrier enhances the antioxidant effect of the epigallocatechin gallate, not only solves the problem of low utilization rate of the tea polyphenol epigallocatechin gallate, but also reduces the toxic and side effects of cancer treatment, and enables medical therapy to have targeting ability.
Owner:ZHEJIANG UNIV
Method for purifying epigallo catechin gallate (EGCG)
ActiveCN102276570APurification scalePurified and robustOrganic chemistryChromatographic separationStationary phase
The invention discloses a method for separating and purifying epigallo catechin gallate (EGCG) by using a simulated moving bed (SMB) chromatography. The method is characterized in that: a tea leaf extract, which is tea polyphenol, is adopted as a raw material; EGCG is separated and purified by using an SMB chromatography system. According to the method, fundamental zones of the SMB are set as an eluting zone, a refining zone and an absorbing zone. The eluting zone is independent. Octadecylsilane chemically bonded silica ODS is adopted as a stationary phase, a mixed solution of alcohol and water is adopted as a mobile phase, and SMB separation are carried out two times upon a tea polyphenol raw material liquid, wherein one time is for removing impurities which are hard to elute, and the other time is for removing impurities which are easy to elute. The product is processed through a solvent removing process, such that the EGCG product is obtained. With the method, EGCG can be stably, continuously, and automatically purified from tea polyphenol in large scale, and with high efficiency. The recycling rate of the product is above 94%, and the purity of the product is above 96%. According to the invention, the stationary phase and the mobile phase can be repeatedly utilized, such that the cost is reduced. The invention belongs to green and environment-friendly separation engineering.
Owner:UNIV OF SCI & TECH LIAONING
New application of catechin compound and gallic acid combination to preparation of hyperuricemia treatment medicine
ActiveCN104983729AStrong in vitro inhibitory effectLower serum uric acid levelsOrganic active ingredientsSkeletal disorderSerum igeGallic acid ester
The invention discloses combined application of gallnut catechin or catechin gallate or gallnut catechin gallate and salt capable of being pharmaceutically accepted and gallic acid to treating hyperuricemia. A catechin compound has the strong in-vitro inhibition effect on xanthine oxidase, the serum uric acid level of a mouse suffering from hyperuricemia can be obviously reduced, and the catechin compound can serve as a potential xanthine oxidase inhibitor and a uric acid reduction medicine to be used for treating hyperuricemia and gout or gout complications caused by hyperuricemia.
Owner:江苏凯吉生物科技有限公司 +1
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com