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58 results about "Catechin gallate" patented technology

Composition for skin external application containing gallocatechin gallate for moisturizing effect on the skin

The present invention relates to a composition for external skin application having a skin-moisturizing effect, which comprises gallocatechin gallate as an active ingredient. More particularly, the composition for external skin application comprises gallocatechin gallate as an active ingredient to activate peroxisome proliferator activated receptor isoform alpha (PPAR-α), to stimulate expression of filaggrin and involucrin that are skin-moisturizing factors, and thus to provide excellent anti-drying and skin-moisturizing effects. More particularly, the composition for external skin application may further comprise theobromine and quercetin in addition to gallocatechin gallate to maximize such effects.
Owner:AMOREPACIFIC CORP

Traditional Chinese medicine for treating diabetes

The invention provides a medicine for treating diabetes. The medicine uses ginseng, Radix Ophiopogonis, Chinese yam, Rhizoma Anemarrhenae, Ligustri Lucidi Fructus, Yetbadetajo Hert, roasted Rhizoma Atractylodis Macrocephalae, Radix Astragali, Peach Seed, Radix Paeoniae Rubra, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, unprepared rehmannia root, Cortex Lycii and Trichosanthis Radix as raw materials, or uses ginseng, Ephedrine alkaloid, Cattail Pollen flavone, Radix Angelicae Pubescentis, beta-oleyl alcohol of Leaf of Tasmanian Bluegum, Angelica polymorpha Maxim, Radix Puerariae, Rhizoma Anemarrhenae, Ligustri Lucidi Fructus, Yetbadetajo Hert, roasted Rhizoma Atractylodis Macrocephalae, Peach Seed, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, Radix Scrophulariae, Cortex Lycii and Herba Leonuri as raw materials, or uses ginseng, epigallocatechin gallate, Myricaria laxiflora, Angelica polymorpha Maxim, Radix Ophiopogonis, Yetbadetajo Hert, white peony root, Peach Seed, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, Radix Scrophulariae, Cortex Lycii, Radix Scutellariae, Corsvenor Momordica Fruit and mulberry leaf as raw materials, or uses ginseng, tea polyphenol, konjak, Chaenomeles Speciosa(sweet) Nakai, Radix Ophiopogonis, Yetbadetajo Hert, Peach Seed, Chinese yam, Medicinal Cyathula Root, Cortex Moutan, Chinese magnoliavine, berberine, 3-6 parts of Radix Scrophulariae, mulberry leaf, Cortex Lycii, unprepared rehmannia root and Trichosanthis Radix as raw materials. The medicine has simple and unique formula and preparation method.
Owner:张默

Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer

The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of therapeutically effective amount of catechins, a group of polyphenols found in green tea, and Capsicum extracts. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins and Capsicum extracts, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.
Owner:PURDUE RES FOUND INC

Green tea compositions

Disclosed herein are green tea plant material extracts, and methods of using the extracts, comprising at least one green tea catechin selected from the group consisting of epi-gallocatechin, catechin, epicatechin, epigallocatechin-3-gallate, gallocatechin gallate, epicatechin-3-gallate, catechin gallate, and gallocatechin, wherein the compositions of the disclosure provide greater bioavailability of at least one green tea catechin.
Owner:PLANDAI BIOTECH INC

Preparation method of fully substituted acetylate of epigallocatechin-gallate (EGCG)

The invention discloses a preparation method of fully substituted acetylate of epigallocatechin-gallate (EGCG) by taking EGCG as materials. The acetylate of EGCG obtained by the existing method has different substituting degree until full substituted substance and the fully substituted acetylate has low purity, which is adverse for further research and application. The invention takes EGCG and acetylation reagent as substrates, an acetylate reaction happens in the presence of an organic solvent and a pyridine catalyst, the mole ratio between EGCG and the acetylate reagent is controlled within the range of 1:80-200, and the fully substituted acetylate of EGCG is generated by the reaction and the products are purified then. The invention can obtain fully substituted acetylate with high purity, which is convenient for further research and application.
Owner:TEA RES INST CHINESE ACAD OF AGRI SCI

Method for preparing high-purity gallnut catechin gallate (GCG)

The invention relates to a method for preparing high-purity gallnut catechin gallate (GCG). The method comprises the steps of firstly, taking a green tea polyphenol sample, and adding solvent for dissolution; then taking a proper amount of a tea polyphenol dissolving sample, placing the tea polyphenol dissolving sample in a closed container, and conducting high temperature conversion; then taking conversion liquid, conducting separation with a rapid preparative liquid chromatography, and collecting GCG fraction; making the fraction be subjected to evaporation and concentration, so that a GCG monomeric compound crude product is obtained; finally, taking a proper amount of the crude product, and adding solvent for dissolution; conducting separation and purification on the monomeric compound crude product with a high pressure preparative liquid chromatography, and collecting GCG fraction; then making the fraction be subjected to rotary evaporation and concentration, freeze-drying and vacuum drying, so that a GCG monomeric compound is obtained. According to the method, the high temperature conversion method is adopted, and the content of gallnut catechin gallate (GCG) in a green tea polyphenol solution is raised.
Owner:ZHEJIANG MEASUREMENT SCI RES INST

Application of epicatechin gallate and derivatives thereof for treating or preventing myocardial infarction and other ischemic heart diseases

InactiveCN101984965APharmacological pre-adaptation functionPharmacological postconditioningOrganic active ingredientsCardiovascular disorderReperfusion injuryCvd risk
The invention relates to an application of natural compound epicatechin gallate obtained from tea and derivatives thereof for treating or preventing myocardial infarction and other ischemic heart diseases. The compound is used for preventing the myocardial injury of the heart caused by ischemia-reperfusion, and is a medicament for potentially treating or preventing the heart ischemia / reperfusion injury. Particularly, the compound has a novel effect on protecting the heart and has a function that the enhancement of the myocardial contractility does not depend on the increase of the concentration of calcium ions in myocardial cells. In the invention, it is discovered that the epicatechin gallate (ECG) and the derivatives thereof have pharmacological pre-adaptation functions and have pharmacological post-adaptation functions for the first time, thus the ECG and the derivatives thereof are possibly novel medicaments for treating or preventing myocardial infarction and other ischemic heart diseases. The ECG and the derivatives thereof not only can be used for clinically treating congestive heart diseases through pharmacological post-adaptation but also can be used for medically preventing the patient who suffers from myocardial infarction and then is cured from being subjected to myocardial infarction again through pharmacological pre-adaptation.
Owner:ZHEJIANG HISUN PHARMA CO LTD

New application of catechin compound and gallic acid combination to preparation of hyperuricemia treatment medicine

The invention discloses combined application of gallnut catechin or catechin gallate or gallnut catechin gallate and salt capable of being pharmaceutically accepted and gallic acid to treating hyperuricemia. A catechin compound has the strong in-vitro inhibition effect on xanthine oxidase, the serum uric acid level of a mouse suffering from hyperuricemia can be obviously reduced, and the catechin compound can serve as a potential xanthine oxidase inhibitor and a uric acid reduction medicine to be used for treating hyperuricemia and gout or gout complications caused by hyperuricemia.
Owner:江苏凯吉生物科技有限公司 +1

Application of epigallocatechin gallate in preparing product for preventing and treating human mammary cancer disease

InactiveCN101269063APrevention levelReduce active medicinal effectOrganic active ingredientsAntineoplastic agentsDiseaseGallocatechin-3-gallate
The invention discloses the new drug use of EGCG ((Epigallocatechin-3-gallate) and the isomeride GCG (Gallocatechin-3-gallate) and particularly relates to the application of EGCG and GCG in the products of preventing and treating human breast cancers. EGCG and GCG play a better role in reducing the level of VEGF, HGF or OPN in the blood of a human breast cancer patient, lowering enzyme activity of MMP-9 and MMP-2 and preventing and treating human breast cancer.
Owner:YANTAI UNIV

Production of non-polymerized katechin composition

The present invention relates to a method for making the non-polymeric catechin composition which comprises reduced non-polymeric catechin gallate ration and increased non-polymeric gallnut catechin ratio in the non-polymeric catechin and increased caffeinum amount and is highly prepared. The method adds the water-soluble composition extracted from the green tea by water into the column filled with synthetic adsorbent with a solution amount 0.5 to 20 (v / v) relative to the synthetic adsorbent, leads to the non-polymeric catechin in the water-soluble composition adsorb and is executed with washing with water 1 to 10 (v / v) times relative to the synthetic adsorbent, and then is executed by 10 to 95vol 5.675405e-307thanol water with 0.5 to 20 (v / v) times of the filling volume amount of the synthetic adsorbent.
Owner:KAO CORP

Raw Pu'er tea grade and quality evaluation method

A Pu'er tea grade and quality evaluation method comprises the steps that a raw Pu'er tea test sample liquid to be tested is prepared; efficient liquid-phase chromatographic conditions are adopted; a chromatogram of nutgall catechin gallate is made; the raw Pu'er tea test sample liquid to be tested is used as a detection object, and the positions of reference ingredients in a raw Pu'er tea test sample are identified; chromatographic peaks are acquired, the number of the chromatographic peaks marked in the test sample is at least eight, and the calculated sum of the content percentages of the chromatographic peak areas in the whole chromatographic peak area is greater than or equal to 65%. The Pu'er tea grade and quality evaluation method can relatively and objectively evaluate the Pu'er tea grade and quality, enables the raw Pu'er tea grade evaluation and quality analysis to be objective and accurate, is convenient and easy to operate and can be widely applied to grade and quality analysis of raw compressed Pu'er tea and products containing above 40% of raw Pu'er tea usage amount so as to meet the demand for modernized Pu'er tea production.
Owner:云南白药天颐茶品有限公司

Extract from oil palm leaves comprising phenolic acids

InactiveCN102123720AReduce or avoid oxidative stressSenses disorderNervous disorderGallic acid esterOxidative stress
Provided is a composition comprising an extract from oil palm leaves characterized in that the extract comprises (-)-catechin gallate, ferulic acid, and phenolic acids such as gallic acid and protocatechuic acid and a method for producing said extract comprising the steps of (a) extracting the dried or fresh oil palm leaves with a solvent, (b) filtering the extract obtained in (a), (c) contacting the filtered extract from (b) with an chromatographic medium which selectively adsorbs a fraction containing (-)-catechin gallate, ferulic acid, and phenolic acids, (d)eluting the said fraction from the chromatographic medium using a solvent, (e) drying the eluted fraction obtained in step (d). Also claimed is the use of the composition for reducing or preventing oxidative stress in mammals and poultry.
Owner:NOVARTIS AG

Novel tannase and application thereof

InactiveCN102719413AHighly solubleEnzyme activity has no effectHydrolasesFermentationEscherichia coliChlorogenic acid
The invention discloses a novel tannase. An amino acid sequence of the tannase is shown as SEQ ID NO.3. The invention further discloses a cDNA of the novel tannase, and a nucleotide sequence of the cDNA is shown as SEQ ID NO.1. The invention further discloses an expression vector containing the novel tannase cDNA, recombinant tannase, a preparation method of the recombinant tannase and degradation application of the recombinant tannase by taking propyl gallate, tannic acid, epicatechin gallate, epigallocatechin-3-gallate, chlorogenic acid, rosmarinic acid and ethyl ferulate as substrates. The novel tannase and recombinant tannase have soluble expression in an escherichia coli expression system with high efficiency, and the recombinant tannase has efficient degradation effect on tannic acid, epicatechin gallate, epigallocatechin-3-gallate, chlorogenic acid, rosmarinic acid and ethyl ferulate.
Owner:SUN YAT SEN UNIV

Novel application of catechin compounds in preparation of medicaments for treating hyperuricemia

The invention discloses gallocatechin, catechin gallate or gallocatechin gallate and application of its pharmaceutically acceptable salts in treating hyperuricemia. The catechin compounds has high in-vitro inhibitory action on xanthine oxidase, also can evidently decrease serum uric acid levels in mice with hyperuricemia, and can serve as a potential xanthine oxidase inhibitor and a potential uric-acid-lowering medicament to treat hyperuricemia and gout or gout complications caused by hyperuricemia.
Owner:江苏凯吉生物科技有限公司 +1

Use of catechin and epicatechin compounds for up-regulation of expression level of microRNA-126

The invention belongs to the field of medicines or health products, and particularly relates to the use of catechin and epicatechin compounds in the preparation of drugs for up-regulating the expression level of microRNA-126. As found by researches, catechin, catechin gallate, gallocatechin, (-)-gallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallatecan up-regulate the expression level of the microRNA-126, and can be used for treating tumors, asthma, inflammatory bowel disease, vascular inflammation, hypertension, type 2 diabetes mellitus, diabetic nephropathy or diabetic retinopathy.
Owner:CATCH BIO SCI & TECH

Sunless tanning

This invention relates to a topical sunless tanning composition, in particular a topical sunless tanning composition which provides an immediate colour effect. There is much interest in effectuating a tan via cosmetic means. Most prominent among the sunless tanning agents is dihydroxyacetone (DHA, which is also chemically known as 1,3-dihydroxy-2-propanone). However, a problem with using DHA to tan the skin is the length of time it takes for the skin to develop colour (from 3 to 12 hours after application in general). Thus, in a first aspect of the invention, a topical sunless tanning composition is provided, the topical sunless tanning composition comprising: (a) 0.01-10, preferably 0.1-5 w / w a polyphenol selected from the group consisting of (+)-catechin, (−)-catechin, (+)-epicatechin, (−)-epicatechin, epigallocatechin gallate, (−)-epigallocatechin, (−)-catechin gallate, epicatechin gallate, or mixtures thereof; (b) A peroxidase or laccase (c) 0.0001-3 preferably 0.001-1, most preferably 0.01-1 w / w hydrogen peroxide or a hydrogen peroxide generator when peroxidase is present; and (e) A dermatologically acceptable vehicle.
Owner:CONOPCO INC D B A UNILEVER

Environment-friendly recovered grease decolorizing agent and preparation method thereof

The invention provides an environment-friendly recovered grease decolorizing agent and a preparation method thereof. The environment-friendly recovered grease decolorizing agent is prepared from the following ingredients: water washing acidification rice hull ash, non-water washing-acidification rice hull ash, carbonized soybean hull ash, chitosan, dodecyl dimethyl benzyl ammonium chloride, epigallocatechin gallate, dilauryl thiodipropionate, sorbic acid, butyl p-hydroxybenzoate, ethyl alcohol, hydrochloric acid and water. The preparation method is characterized in that firstly, the chitosan, the hydrochloric acid and the water are mixed, and the mixture is stirred by a magnetic stirrer to obtain a solution A; the sorbic acid, the butyl p-hydroxybenzoate and the ethyl alcohol are mixed and stirred to obtain a solution B; then, the rest ingredients, the solution A and the solution B are mixed, and are then stirred by the magnetic stirrer to be put into a drying box to be dried. The environment-friendly recovered grease decolorizing agent has the advantages that the decolorizing can be fast and effectively performed; meanwhile, partial metal ions are removed; the peroxide value is reduced; the recovered grease quality is improved; in addition, the preparation method is simple and is suitable for industrial production.
Owner:广州市耀长远能源科技有限公司

Hollow capsule and preparation method thereof

The invention discloses a hollow capsule. The hollow capsule is prepared from, by weight, 10-20 parts of dendrobium officinale powder, 5-10 parts of ganoderma lucidum powder, 5-10 parts of epi-gallo-catechin-gallate, 10-20 parts of edible gelatin, 5-15 parts of glycerin, 1-10 parts of edible pigment lemon yellow and 10-60 parts of purified water. The invention further discloses a preparation method of the hollow capsule. The hollow capsule integrates health-care components of dendrobium officinale, ganoderma lucidum and epi-gallo-catechin-gallate with effects of edible gelatin and medical glycerin, when the hollow capsule is filled with other health-care food and medicines, common people can conveniently take in components, beneficial to human bodies, of dendrobium officinale, ganoderma lucidum and epi-gallo-catechin-gallate when eating food or taking medicine.
Owner:HUIZHOU JINHENG IND MOLD DESIGN PARTNERSHIP ENTERPRISE GENERAL PARTNERSHIP

High-stability pigment derivative and preparation method thereof

ActiveCN111034902ASolve the problem of poor color stabilitySteady redFood ingredient as colourFood dryingBleachPerylene derivatives
The invention discloses a high-stability pigment derivative, and the number-average molecular weight of the pigment derivative is 523-168Da. In the structural unit, the content of epicatechin is 5-30%, the content of catechin is 3-75%, the content of gallocatechin is 1-13%, the content of epigallocatechin is 1-5%, the content of catechin gallate is 1-16%, and the content of epicatechin gallate is2-17%. The pigment derivative provided by the invention belongs to a natural anthocyanin derivative, is not influenced by the chemical balance of salt, chalcone, Quinoid alkali and methanol pseudo-base, can keep stable red in an acidic to neutral (pH 1.0-7.0) solution, and is not influenced by pH, oxygen, a reduced bleaching agent and temperature. The problem of poor color stability of natural anthocyanin is solved.
Owner:SHANTOU UNIV

Preparation method of gallate with high content of epigallocatechin

The invention relates to a preparation method of gallate with a high content of epigallocatechin. Powdery gallate with a high content of epigallocatechin is obtained by the steps of dissolving, loading to a column, eluting, concentrating, crystallizing, purifying and the like by taking tea polyphenol of gallate containing epigallocatechin as the raw material. The content of gallate of epigallocatechin is greater than or equal to 98%. In a production process, no toxic solvents are used, so that the production process is environmentally friendly, the solvent handling capacity is small, and the operation is simple and feasible. Ester catechins EGCG, GCG and ECG can be separated at one time, so that the gallate is good in effect, high in efficiency, high in content, short in crystallizing time, hard to oxidize, good in color and luster and high in purity.
Owner:HUBEI ZHONGXIN BIOTECH CO LTD

Tea polyphenols products for ceasing smoking and treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer

This invention relates to methods of aiding smoking cessation and / or treating and / or preventing smoking addition or methods of treating and / or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in aiding smoking cessation and / or treating and / or preventing smoking addition or treating and / or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.
Owner:TAIPEI MEDICAL UNIV

Preparation method of ECG (epigallocatechin gallate) monomer

The invention relates to a preparation method of an ECG (epigallocatechin gallate) monomer. The preparation method comprises the following steps of separating the ECG in tea leaves by column chromatography and crystallizing methods, wherein a filler adopted by the column chromatography is a high molecular polymer which is formed by self-assembly, polymerizing and dilution of one of methacrylic acid, acrylic acid, itaconic acid and 4-vinylbenzoic acid and the ECG. The preparation method has the advantages that the specific recognition capability on the ECG is realized, and the extraction rate and purity of the ECG monomer are high.
Owner:HUNAN AGRICULTURAL UNIV

Antibacterial agent

The invention relates to an antibacterial agent which comprises 3-5 parts of a 5% silver nitrate solution, 6-10 parts of a cationic antibacterial agent, 2-5 parts of epigallocatechin gallate, 15-20 parts of ethyl alcohol, 4-6 parts of mint and 50-70 parts of water. A method comprises the following steps: dissolving epigallocatechin gallate and mint in ethyl alcohol at 50-60 DEG C, thereby obtaining an organic phase; adding the cationic antibacterial agent into the organic phase, continuously stirring and fully mixing, thereby obtaining a mixed solution; and adding the 5% silver nitrate solution and water, blending and fully mixing, thereby obtaining an aqueous agent. According to the invention, the cationic antibacterial agent is combined with the epigallocatechin gallate and 5% silver nitrate solution, so that the antibacterial rate is obviously increased and is as high as 100%.
Owner:李忠泽 +2

Compositions comprising l-theanine, proanthocyanidin/s and a catechin and uses thereof

InactiveUS20190117606A1Pleasant tasting beverageGood health profileOrganic active ingredientsNervous disorderCLARITYProanthocyanidin
The present invention relates to compositions including L-theanine, proanthocyanidin(s); and a catechin selected from the group consisting of epigallocatechin gallate, epigallocatechin, epicatechin gallate, epicatechin and combinations thereof. The compositions may be used to treat, prevent, or provide mental clarity following a period of time after consumption. The present invention also relates to methods of treatment, and methods of manufacture and use of said composition.
Owner:ALPHAGEN NZ LTD

Compositions and treatments of bacterial vaginosis

Bacterial vaginosis is treated using methods and compositions that include one or more plant polyphenols as active ingredients. Preferred routes of administration of contemplated plant polyphenols include topical and oral administration, and particularly preferred plant polyphenols are prepared from green tea (e.g., Polyphenon E) and / or may include (−)-epigallocatechin gallate, (−)-epicatechin gallate, (−)-epigallocatechin, and (−)-epicatechin.
Owner:EPITOME PHARM INC +1

Preparation method of gallocatechin gallate

The invention discloses a preparation method of gallocatechin gallate, which comprises the following steps: by taking EGCG (epigallocatechin gallate) as a raw material, adding an acid solution with a certain concentration according to a proper proportion for dissolving, conducting gradually heating and stirring to react for a certain time, and conducting cooling to room temperature; adding alkali liquor with the same concentration to adjust the pH to be nearly neutral to obtain a solution after reaction; gradually adding the reacted solution into a treated chromatographic column filled with PS-DVB microspheres, and then conducting eluting with an alcoholic solution until no obvious GCG flows out; receiving eluate according to the outflow volume per 0.5 column volume, performing thin-layer detection and selecting the eluate containing the target component; and conducting concentration and alcohol removal, then conducting standing and crystallization to obtain gallocatechin gallate. Therefore, a more efficient way is provided for preparing high-purity GCG.
Owner:JIANGSU TIANSHENG PHARMA
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