57 results about "Catechin gallate" patented technology

A method and composition for preventing and treating Avian Influenza in Humans utilizes an effective quantity of polyphenolic(s) and/or its derivatives in combination with a carrier. The anti-avian influenza ingredient having a composition selected from the group consisting of theaflavin, theaflavin-3,3′-digallate, theaflavin-3-monogallate, theaflavin-3 gallate, theaflavin-3′-gallate, thearubigin, gallic acid, tannic acid, (−)-epigallocatechin gallate (EGCG), (−) epigalloatechin (EGC), (+)-epicatechin (EC), (−)-gallocatechin gallate (GCG), and catechin.

The present invention relates to a composition for external skin application having a skin-moisturizing effect, which comprises gallocatechin gallate as an active ingredient. More particularly, the composition for external skin application comprises gallocatechin gallate as an active ingredient to activate peroxisome proliferator activated receptor isoform alpha (PPAR-α), to stimulate expression of filaggrin and involucrin that are skin-moisturizing factors, and thus to provide excellent anti-drying and skin-moisturizing effects. More particularly, the composition for external skin application may further comprise theobromine and quercetin in addition to gallocatechin gallate to maximize such effects.

The invention provides a medicine for treating diabetes. The medicine uses ginseng, Radix Ophiopogonis, Chinese yam, Rhizoma Anemarrhenae, Ligustri Lucidi Fructus, Yetbadetajo Hert, roasted Rhizoma Atractylodis Macrocephalae, Radix Astragali, Peach Seed, Radix Paeoniae Rubra, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, unprepared rehmannia root, Cortex Lycii and Trichosanthis Radix as raw materials, or uses ginseng, Ephedrine alkaloid, Cattail Pollen flavone, Radix Angelicae Pubescentis, beta-oleyl alcohol of Leaf of Tasmanian Bluegum, Angelica polymorpha Maxim, Radix Puerariae, Rhizoma Anemarrhenae, Ligustri Lucidi Fructus, Yetbadetajo Hert, roasted Rhizoma Atractylodis Macrocephalae, Peach Seed, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, Radix Scrophulariae, Cortex Lycii and Herba Leonuri as raw materials, or uses ginseng, epigallocatechin gallate, Myricaria laxiflora, Angelica polymorpha Maxim, Radix Ophiopogonis, Yetbadetajo Hert, white peony root, Peach Seed, Cortex Moutan, Medicinal Cyathula Root, Fructus Arctii, Radix Scrophulariae, Cortex Lycii, Radix Scutellariae, Corsvenor Momordica Fruit and mulberry leaf as raw materials, or uses ginseng, tea polyphenol, konjak, Chaenomeles Speciosa(sweet) Nakai, Radix Ophiopogonis, Yetbadetajo Hert, Peach Seed, Chinese yam, Medicinal Cyathula Root, Cortex Moutan, Chinese magnoliavine, berberine, 3-6 parts of Radix Scrophulariae, mulberry leaf, Cortex Lycii, unprepared rehmannia root and Trichosanthis Radix as raw materials. The medicine has simple and unique formula and preparation method.

A method and composition for preventing and treating Avian Influenza utilizes an effective quantity of polyphenolic(s) and its derivatives in combination with a carrier. The anti-avian influenza ingredient having a composition selected from the group consisting of theaflavin, theaflavin-3,3′-digallate, theaflavin-3-monogallate, theaflavin-3 gallate, theaflavin-3′-gallate, thearubigin, gallic acid, tannic acid, (−)-epigallocatechin gallate (EGCG), (−)epigalloatechin (EGC), (+)-epicatechin (EC), (−)-gallocatechin gallate (GCG), and catechin.

The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of therapeutically effective amount of catechins, a group of polyphenols found in green tea, and Capsicum extracts. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins and Capsicum extracts, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.

Disclosed herein are green tea plant material extracts, and methods of using the extracts, comprising at least one green tea catechin selected from the group consisting of epi-gallocatechin, catechin, epicatechin, epigallocatechin-3-gallate, gallocatechin gallate, epicatechin-3-gallate, catechin gallate, and gallocatechin, wherein the compositions of the disclosure provide greater bioavailability of at least one green tea catechin.

The invention discloses a preparation method of fully substituted acetylate of epigallocatechin-gallate (EGCG) by taking EGCG as materials. The acetylate of EGCG obtained by the existing method has different substituting degree until full substituted substance and the fully substituted acetylate has low purity, which is adverse for further research and application. The invention takes EGCG and acetylation reagent as substrates, an acetylate reaction happens in the presence of an organic solvent and a pyridine catalyst, the mole ratio between EGCG and the acetylate reagent is controlled within the range of 1:80-200, and the fully substituted acetylate of EGCG is generated by the reaction and the products are purified then. The invention can obtain fully substituted acetylate with high purity, which is convenient for further research and application.

The invention relates to an application of natural compound epicatechin gallate obtained from tea and derivatives thereof for treating or preventing myocardial infarction and other ischemic heart diseases. The compound is used for preventing the myocardial injury of the heart caused by ischemia-reperfusion, and is a medicament for potentially treating or preventing the heart ischemia/reperfusion injury. Particularly, the compound has a novel effect on protecting the heart and has a function that the enhancement of the myocardial contractility does not depend on the increase of the concentration of calcium ions in myocardial cells. In the invention, it is discovered that the epicatechin gallate (ECG) and the derivatives thereof have pharmacological pre-adaptation functions and have pharmacological post-adaptation functions for the first time, thus the ECG and the derivatives thereof are possibly novel medicaments for treating or preventing myocardial infarction and other ischemic heart diseases. The ECG and the derivatives thereof not only can be used for clinically treating congestive heart diseases through pharmacological post-adaptation but also can be used for medically preventing the patient who suffers from myocardial infarction and then is cured from being subjected to myocardial infarction again through pharmacological pre-adaptation.

The invention discloses combined application of gallnut catechin or catechin gallate or gallnut catechin gallate and salt capable of being pharmaceutically accepted and gallic acid to treating hyperuricemia. A catechin compound has the strong in-vitro inhibition effect on xanthine oxidase, the serum uric acid level of a mouse suffering from hyperuricemia can be obviously reduced, and the catechin compound can serve as a potential xanthine oxidase inhibitor and a uric acid reduction medicine to be used for treating hyperuricemia and gout or gout complications caused by hyperuricemia.

The invention discloses the new drug use of EGCG ((Epigallocatechin-3-gallate) and the isomeride GCG (Gallocatechin-3-gallate) and particularly relates to the application of EGCG and GCG in the products of preventing and treating human breast cancers. EGCG and GCG play a better role in reducing the level of VEGF, HGF or OPN in the blood of a human breast cancer patient, lowering enzyme activity of MMP-9 and MMP-2 and preventing and treating human breast cancer.

The present invention relates to a method for making the non-polymeric catechin composition which comprises reduced non-polymeric catechin gallate ration and increased non-polymeric gallnut catechin ratio in the non-polymeric catechin and increased caffeinum amount and is highly prepared. The method adds the water-soluble composition extracted from the green tea by water into the column filled with synthetic adsorbent with a solution amount 0.5 to 20 (v/v) relative to the synthetic adsorbent, leads to the non-polymeric catechin in the water-soluble composition adsorb and is executed with washing with water 1 to 10 (v/v) times relative to the synthetic adsorbent, and then is executed by 10 to 95vol 5.675405e-307thanol water with 0.5 to 20 (v/v) times of the filling volume amount of the synthetic adsorbent.

Provided is a composition comprising an extract from oil palm leaves characterized in that the extract comprises (-)-catechin gallate, ferulic acid, and phenolic acids such as gallic acid and protocatechuic acid and a method for producing said extract comprising the steps of (a) extracting the dried or fresh oil palm leaves with a solvent, (b) filtering the extract obtained in (a), (c) contacting the filtered extract from (b) with an chromatographic medium which selectively adsorbs a fraction containing (-)-catechin gallate, ferulic acid, and phenolic acids, (d)eluting the said fraction from the chromatographic medium using a solvent, (e) drying the eluted fraction obtained in step (d). Also claimed is the use of the composition for reducing or preventing oxidative stress in mammals and poultry.

The invention discloses a novel tannase. An amino acid sequence of the tannase is shown as SEQ ID NO.3. The invention further discloses a cDNA of the novel tannase, and a nucleotide sequence of the cDNA is shown as SEQ ID NO.1. The invention further discloses an expression vector containing the novel tannase cDNA, recombinant tannase, a preparation method of the recombinant tannase and degradation application of the recombinant tannase by taking propyl gallate, tannic acid, epicatechin gallate, epigallocatechin-3-gallate, chlorogenic acid, rosmarinic acid and ethyl ferulate as substrates. The novel tannase and recombinant tannase have soluble expression in an escherichia coli expression system with high efficiency, and the recombinant tannase has efficient degradation effect on tannic acid, epicatechin gallate, epigallocatechin-3-gallate, chlorogenic acid, rosmarinic acid and ethyl ferulate.

The invention discloses gallocatechin, catechin gallate or gallocatechin gallate and application of its pharmaceutically acceptable salts in treating hyperuricemia. The catechin compounds has high in-vitro inhibitory action on xanthine oxidase, also can evidently decrease serum uric acid levels in mice with hyperuricemia, and can serve as a potential xanthine oxidase inhibitor and a potential uric-acid-lowering medicament to treat hyperuricemia and gout or gout complications caused by hyperuricemia.

The invention belongs to the field of medicines or health products, and particularly relates to the use of catechin and epicatechin compounds in the preparation of drugs for up-regulating the expression level of microRNA-126. As found by researches, catechin, catechin gallate, gallocatechin, (-)-gallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallatecan up-regulate the expression level of the microRNA-126, and can be used for treating tumors, asthma, inflammatory bowel disease, vascular inflammation, hypertension, type 2 diabetes mellitus, diabetic nephropathy or diabetic retinopathy.

This invention relates to a topical sunless tanning composition, in particular a topical sunless tanning composition which provides an immediate colour effect. There is much interest in effectuating a tan via cosmetic means. Most prominent among the sunless tanning agents is dihydroxyacetone (DHA, which is also chemically known as 1,3-dihydroxy-2-propanone). However, a problem with using DHA to tan the skin is the length of time it takes for the skin to develop colour (from 3 to 12 hours after application in general). Thus, in a first aspect of the invention, a topical sunless tanning composition is provided, the topical sunless tanning composition comprising: (a) 0.01-10, preferably 0.1-5 w/w a polyphenol selected from the group consisting of (+)-catechin, (−)-catechin, (+)-epicatechin, (−)-epicatechin, epigallocatechin gallate, (−)-epigallocatechin, (−)-catechin gallate, epicatechin gallate, or mixtures thereof; (b) A peroxidase or laccase (c) 0.0001-3 preferably 0.001-1, most preferably 0.01-1 w/w hydrogen peroxide or a hydrogen peroxide generator when peroxidase is present; and (e) A dermatologically acceptable vehicle.

The invention provides an environment-friendly recovered grease decolorizing agent and a preparation method thereof. The environment-friendly recovered grease decolorizing agent is prepared from the following ingredients: water washing acidification rice hull ash, non-water washing-acidification rice hull ash, carbonized soybean hull ash, chitosan, dodecyl dimethyl benzyl ammonium chloride, epigallocatechin gallate, dilauryl thiodipropionate, sorbic acid, butyl p-hydroxybenzoate, ethyl alcohol, hydrochloric acid and water. The preparation method is characterized in that firstly, the chitosan, the hydrochloric acid and the water are mixed, and the mixture is stirred by a magnetic stirrer to obtain a solution A; the sorbic acid, the butyl p-hydroxybenzoate and the ethyl alcohol are mixed and stirred to obtain a solution B; then, the rest ingredients, the solution A and the solution B are mixed, and are then stirred by the magnetic stirrer to be put into a drying box to be dried. The environment-friendly recovered grease decolorizing agent has the advantages that the decolorizing can be fast and effectively performed; meanwhile, partial metal ions are removed; the peroxide value is reduced; the recovered grease quality is improved; in addition, the preparation method is simple and is suitable for industrial production.

The invention discloses a high-stability pigment derivative, and the number-average molecular weight of the pigment derivative is 523-168Da. In the structural unit, the content of epicatechin is 5-30%, the content of catechin is 3-75%, the content of gallocatechin is 1-13%, the content of epigallocatechin is 1-5%, the content of catechin gallate is 1-16%, and the content of epicatechin gallate is2-17%. The pigment derivative provided by the invention belongs to a natural anthocyanin derivative, is not influenced by the chemical balance of salt, chalcone, Quinoid alkali and methanol pseudo-base, can keep stable red in an acidic to neutral (pH 1.0-7.0) solution, and is not influenced by pH, oxygen, a reduced bleaching agent and temperature. The problem of poor color stability of natural anthocyanin is solved.

The invention relates to a preparation method of an ECG (epigallocatechin gallate) monomer. The preparation method comprises the following steps of separating the ECG in tea leaves by column chromatography and crystallizing methods, wherein a filler adopted by the column chromatography is a high molecular polymer which is formed by self-assembly, polymerizing and dilution of one of methacrylic acid, acrylic acid, itaconic acid and 4-vinylbenzoic acid and the ECG. The preparation method has the advantages that the specific recognition capability on the ECG is realized, and the extraction rate and purity of the ECG monomer are high.

The invention relates to an antibacterial agent which comprises 3-5 parts of a 5% silver nitrate solution, 6-10 parts of a cationic antibacterial agent, 2-5 parts of epigallocatechin gallate, 15-20 parts of ethyl alcohol, 4-6 parts of mint and 50-70 parts of water. A method comprises the following steps: dissolving epigallocatechin gallate and mint in ethyl alcohol at 50-60 DEG C, thereby obtaining an organic phase; adding the cationic antibacterial agent into the organic phase, continuously stirring and fully mixing, thereby obtaining a mixed solution; and adding the 5% silver nitrate solution and water, blending and fully mixing, thereby obtaining an aqueous agent. According to the invention, the cationic antibacterial agent is combined with the epigallocatechin gallate and 5% silver nitrate solution, so that the antibacterial rate is obviously increased and is as high as 100%.

Bacterial vaginosis is treated using methods and compositions that include one or more plant polyphenols as active ingredients. Preferred routes of administration of contemplated plant polyphenols include topical and oral administration, and particularly preferred plant polyphenols are prepared from green tea (e.g., Polyphenon E) and/or may include (−)-epigallocatechin gallate, (−)-epicatechin gallate, (−)-epigallocatechin, and (−)-epicatechin.

This invention relates to methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.