12 results about "Catechin gallate" patented technology

The invention discloses application of eugenin in preparation of a medicine for treating cerebral arterial thrombosis, and belongs to the technical field of medicines. An in-vivo middle cerebral artery occlusion model is adopted, after reperfusion is conducted for 24 h, the cerebral infarction volume and movement coordination function defect of a mouse are detected to evaluate the treatment effect of eugenin, and activation of microglial cells and survival of neuronal cells are observed through immunofluorescence to clarify the action way of eugenin. Pharmacological activity shows that eugenin can obviously reduce the cerebral infarction volume of a model mouse, improve pathological damage of cells and promote recovery of a motion coordination function, and the action way of eugenin is to promote survival of neuronal cells and inhibit activation of microglial cells. Research results indicate that eugenin has the effect of resisting cerebral arterial thrombosis and can be used as a candidate medicine for developing the cerebral arterial thrombosis resisting medicine.

The invention provides a preparation process of a soothing and repairing type mask, and belongs to the technical field of cosmetics, an intelligent response type cell bionic delivery system is adopted, macrophage membrane vesicles serve as a carrier, a composite repairing kernel, epicatechin gallate, a neuropeptide P substance antagonist and idebenone are wrapped, and by means of the inflammation chemotaxis of a macrophage membrane, the soothing and repairing type mask is prepared. According to the present invention, the active component can actively target the inflammation region, the phase change release core is provided in the weakly acidic microenvironment with the pH value of 5.0-6.0, the targeting property and the permeation efficiency of the active component can be improved, the bottleneck of the traditional passive diffusion can be broken through, and compared with the conventional liposome or nanoparticle, the active component can be accurately delivered to the inflammation core region, the permeation rate can be improved by several times, and the carrier can directly reach the problem core region; according to the method, the utilization rate of effective components is greatly increased, a micro-ecology-immunity-nerve-physical barrier multi-dimensional and systematic synergistic repair network is constructed, full-path fundamental repair from immediate relieving to root strengthening is achieved, and immediate relieving and long-term barrier repair effects are provided.

The application discloses an oral cavity bacteriostatic composition synthesized by using panax notoginseng and tea polyphenol and a preparation method thereof, and relates to the technical field of nano modification. Specifically, metal-polyphenol nano cores are formed by metal ion coordination self-assembly, gallic acid catechin gallate, a core component of tea polyphenol, is synergistically compounded with panax notoginseng saponin R1, and a core-shell structure nanoparticle is constructed by adopting a chitosan-sodium tripolyphosphate ionic gel crosslinking technology. The composition realizes multi-target bacteriostasis (MIC 15.7-22.1 μg / mL) and anti-inflammatory effect (TNF-alpha inhibition rate 75.4-84.2%) on oral cavity pathogenic bacteria (such as streptococcus mutans and porphyromonas gingivalis), simultaneously solves problems of easy oxidation and degradation of EGCG, short retention time and poor penetration of traditional preparations, and provides a green and efficient oral care solution.

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACTI peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (−)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley (Petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

Described herein are compositions (e.g., topical formulations) including andrographolides (ANGL), epigallocatechin gallate (EGCG), or a combination thereof, and methods of making and using the same.

There is described a composition comprising an effective amount of a combination of two or more components selected from a NAD precursor; a NAMPT upregulator; a NQO1 upregulator and a NNMT (nicotinamide N-methyltransferase) downregulator.

There has been need for tea beverages that maintain characteristics thereof while maintaining drinkability even with a low pH. One aspect of the present invention provides a beverage containing diacetyl and catechins, wherein the diacetyl content is at least 20 ppb and less than 10,000 ppb, the contained amount one or more types of catechins selected from epicatechin, catechin, epigallocatechin, gallocatechin, epicatechin gallate, catechin gallate, epigallocatechin gallate, and gallocatechin gallate is at least 1 ppm and less than 500 ppm, and the pH is 5 or lower.

The application discloses a tea characteristic component composition for reducing acrylamide in Maillard reaction, and the composition is prepared by compounding at least three of five substances, i.e., epicatechin (EC), gallocatechin (GC), catechin gallate (CG), theabrine and theaflavine, and the compounded composition has the effect of reducing acrylamide, a by-product of Maillard reaction in food. In the composition of the application, the composition composed of epicatechin (EC), gallocatechin (GC), catechin gallate (CG) and theabrine has the best effect of reducing acrylamide, a by-product of Maillard reaction, and the reduction rate of acrylamide in a simulation system can be up to 75%. The composition of the application can be applied to baked food or fried food, especially baked food such as bread, cookie, potato chip and the like.

This invention provides a method for synthesizing novel natural pigments using phenotypic catechins. Various epicatechins, epigallocatechins, epicatechin gallate esters, and epigallocatechin gallate esters are used as substrates. These are mixed and subjected to a non-enzymatic oxidation reaction under humid and hot conditions to generate a new class of tea pigment compounds. The non-enzymatic oxidation products of the phenotypic catechins are then concentrated under reduced pressure, freeze-dried, extracted, and purified by column chromatography to obtain dimeric catechin pigments. The six novel dimeric catechin pigments obtained by this invention are synthesized using a simple method. The six novel dimeric catechin pigments obtained according to the method of this invention are orange-yellow or orange-red amorphous powders with good color-adjusting capabilities, and can be applied to coloring tea beverages and new-style tea drinks. The discovery of this type of natural pigment contributes to the research on coloring substances during the thermal processing of tea, the improvement of tea liquor color quality, and the development and application in the field of food coloring.

The invention discloses an oral antibacterial composition synthesized from pseudo-ginseng and tea polyphenol and a preparation method of the oral antibacterial composition, and relates to the technical field of nano modification. Specifically, a metal-polyphenol nano core is formed through metal ion coordination self-assembly, a tea polyphenol core component, namely gallocatechin gallate, is synergistically compounded with notoginsenoside R1, and a chitosan-sodium tripolyphosphate ionic gel crosslinking technology is adopted to construct nano particles of a core-shell structure. The composition realizes multi-target bacteriostasis (MIC 15.7-22.1 mu g / mL) and anti-inflammatory effect (TNF-alpha inhibition rate is 75.4-84.2%) on oral pathogens (such as streptococcus mutans and porphyromonas gingivalis), solves the problems that EGCG is easy to oxidize and degrade, the residence time is short, the permeability of a traditional preparation is poor and the like, and provides a green and efficient oral care solution.

The invention discloses a nano-drug for enhancing the transplantation curative effect of stem cell-derived retinal ganglion cells as well as a preparation method and application of the nano-drug. Lithium ions and epicatechin gallate are self-assembled to form a lithium-epicatechin gallate nano-drug; the lithium-epicatechin gallate nano-drug is stable in structure and has strong oxidation and mitochondrial protection effects, the lithium-epicatechin gallate nano-drug and the epicatechin gallate nano-drug have synergistic interaction in function, and the lithium-epicatechin gallate nano-drug not only has dual nerve protection advantages, but also can improve drug stability and treatment effect; furthermore, the lithium-epicatechin gallate nano-drug and the embryonic stem cell-derived ganglion cells are transplanted in a combined manner, so that the survival rate and the neurite protection of the nano-drug under the oxidative stress condition can be remarkably improved, and more effective neuroprotection and functional reconstruction are realized in treatment of retina degenerative diseases such as glaucoma and the like.

A reactivatable wound dressing composition comprising a dehydrated bacterial cellulose matrix derived from kombucha fermentation of organic green tea and Manuka honey. The matrix contains embedded dormant colonies of acetic acid bacteria, residual epigallocatechin gallate from green tea, and methylglyoxal from Manuka honey. The dormant bacterial colonies reactivate upon contact with an aqueous kombucha solution, providing antimicrobial activity against pathogens including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The dehydrated matrix exhibits natural adhesive properties upon rehydration without requiring additional adhesives. Manufacturing methods involve controlled fermentation at specific pH and temperature parameters, followed by dehydration to preserve bacterial viability. The dressing maintains optimal wound environments by retaining moisture while allowing oxygen exchange, stimulates tissue regeneration, and can be die-cut into various anatomical shapes. Applications include treatment of cuts, burns, surgical incisions, chronic wounds, and skin ulcers with extended wear times of 5-10 hours.