50 results about "Quinolinic acid" patented technology

The invention relates to the technical field of health-care products, in particular to an anti-aging composition. The anti-aging composition is prepared from, by weight, 3-5 parts of nicotinic acid, 1-9 parts of methyl donor, 15-20 parts of tryptophan or 8-10 parts of quinolinic acid, 0.3-0.5 part of resveratrol and 8-10 parts of soluble magnesium. The composition containing the components can effectively improve the level of in-vivo NAD+ and accordingly keep PARP1 not damaged. The resveratrol further improves the gene repairing effect in the human body by improving the effect of the PARP1 from another perspective, and finally a strong anti-aging purpose is achieved.

A chemical mechanical polishing aqueous dispersion, including: (A) inorganic particles; (B) at least one type of particles selected from the group consisting of organic particles and organic-inorganic composite particles; (C) at least one compound selected from the group consisting of quinolinecarboxylic acid, quinolinic acid, a divalent organic acid (excluding quinolinic acid), and a hydroxyl acid; (D) at least one compound selected from the group consisting of benzotriazole and benzotriazole derivatives; (E) an oxidizing agent; and (F) water, the chemical mechanical polishing aqueous dispersion containing the component (A) in an amount of 0.05 to 2.0 wt% and the component (B) in an amount of 0.005 to 1.5 wt%, having a ratio (W A / W B ) of the amount (W A ) of the component (A) to the amount (W B ) of the component (B) of 0.1 to 200, and having a pH of 1.0 to 5.0. chemical mechanical grinding method adopting the chemical mechanical polishing aqueous dispersion and kit for concocting the the chemical mechanical polishing aqueous dispersion.

The invention provides a quinolinic acid production method. Quinolinic acid is produced through the following steps: preparing quinoline acid copper through an oxidizing reaction, treating an oxidation reaction mother liquid, preparing quinoline acid sodium through an alkaline hydrolysis reaction, decolouring, preparing quinolinic acid through an acid separation reaction, and treating an acid separation reaction mother liquid. The oxidation reaction mother liquid, alkaline hydrolysis reaction filter cake washing water and the acid separation reaction mother liquid are comprehensively and effectively treated; active ingredients, including copper ions, quinolinic acid and the like, in each mother liquid and washing water are recycled and are utilized into the production of the next batch of the quinolinic acid; the control on an acid separation reaction is optimized, and the yield of the quinolinic acid is improved. When the active ingredients are applied, the recycled copper oxide and the recycled basic copper carbonate are purified; the yield of the quinoline acid is improved; meanwhile, the purity of the quinoline acid is ensured; refining steps of the quinoline acid are reduced; the production cost is reduced. Through the treatment of each mother liquid and the application of the washing water, water resources are saved; the wastewater discharge is reduced; the pressure on the environment is relieved.

The present invention relates generally to a method of modulating cellular functioning. More particularly, the present invention relates to a method of modulating B cell functioning, for example B cell proliferation, utilising an IDO- mediated tryptophan metabolite as herein defined (particular examples of such IDO-mediated tryptophan metabolites include 3-hydroxykynurenic acid, 3-hydroxyanthranilic acid, picolinic acid, quinolinic acid and tranilast). The method of the present invention is useful, inter alia, in the treatment and / or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate B cell functioning such as antibody production, autoimmune conditions and B cell proliferation and neoplasias. In a related aspect, the present invention is directed to a method of therapeutically and / or prophylactically treating rheumatoid arthritis via the administration of the above-mentioned compounds.

The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.

The invention relates to a method for removing aluminum from ferrophosphorus slag after lithium extraction of waste lithium iron phosphate and a preparation method of battery-grade iron phosphate. The method for removing aluminum comprises the following steps: mixing ferrophosphorus slag obtained after lithium extraction of waste lithium iron phosphate, elemental iron, acid and water, and carrying out an acid leaching reaction to prepare slurry A; mixing the slurry A with an aluminum removal agent, carrying out an aluminum removal reaction, and then removing solids to obtain aluminum-removed ferrophosphorus liquid; the aluminum removal agent is selected from at least one of picolinic acid compounds, quinolinic acid compounds and isoquinoline-3-formic acid compounds. The organic aluminum removal agent can be complexed with iron and aluminum to form metal organic complex precipitates with different solubility, the solubility difference of iron and aluminum can be effectively amplified, and preferential precipitation of aluminum is ensured so that aluminum impurities are effectively removed, the product purity of iron phosphate is improved, and the high yield of iron phosphate can be ensured. In addition, the method for removing aluminum is easy to operate, low in equipment investment, environmentally friendly, controllable in quality and easy to industrialize.

The present invention relates to a microorganism capable of producing quinolinic acid, and to a method for producing same utilizing the microorganism.

The invention discloses a biosynthesis method of a nicotinamide adenine dinucleotide compound. A synthesis path provided by the invention takes chorismic acid as a starting point, under the action ofPhzD protein, a transamination rearrangement reaction is carried out to generate amino deoxy isobranched acid, pyruvic acid is removed from amino deoxy isobranched acid under the catalysis of the PhzEprotein to generate 2,3-dihydro-3-hydroxyanthranilicacid, 2,3-dihydro-3- hydroxyanthranilicacid is catalyzed to generate 3-hydroxyanthranilicacid by adopting a specific enzyme, quinolinic acid is generated from 3-hydroxyanthranilicacid through an oxidation ring-opening rearrangement reaction under the action of nabC protein, and then enters an NAD remediation way to finish NAD synthesis. According to the present invention, the coupling between the NAD synthesis and the tryptophan or aspartic acid synthesis is removed, and the chorismic acid widely exists in various life forms, and has less influence on other life essential metabolic pathways.

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACT1 peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, beta-lapachone, beta-hydroxy-beta-methyl-butyrate, bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol,dinoprost, ellagic acid, (-)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-alfa-glycyrrhetinic acid, 18-beta-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (Na AD), nicotinic acid mononucleotide (Na MN), parsley (petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Delta prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

The invention discloses a quinoline compound and a synthetic method and application thereof. The structure is as follows: on the basis of a traditional quinolinic acid structure, a pyrazol structure is introduced to form a new quinolinic acid derivative. The synthetic method of the quinoline compound in the invention is simple and feasible, and mass production is easy to implement. The quinoline compound of the invention has a good weed control effect and has a good effect on weeds having resistance.

The present invention relates to a recombinant microorganism producing quinolinic acid, more particularly, a microorganism producing quinolinic acid and having attenuated activity or eliminated activity of a protein having a sequence of SEQ ID NO: 1 and a method of producing quinolinic acid by using the recombinant microorganism.

The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.

The present invention relates to a process for the synthesis of Moxifloxacin of Formula (I) and salts thereofby means of a process providing the coupling reaction of 1-cyclopropril-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo -3-quinolinic acid or ester thereof with (4aS, 7aS) -octahydro-1H-pyrrole[3,4-b]pyridine using a magnesium salt.

The invention provides a quinolinic acid production method. Quinolinic acid is produced through the following steps: preparing quinoline acid copper through an oxidizing reaction, treating an oxidation reaction mother liquid, preparing quinoline acid sodium through an alkaline hydrolysis reaction, decolouring, preparing quinolinic acid through an acid separation reaction, and treating an acid separation reaction mother liquid. The oxidation reaction mother liquid, alkaline hydrolysis reaction filter cake washing water and the acid separation reaction mother liquid are comprehensively and effectively treated; active ingredients, including copper ions, quinolinic acid and the like, in each mother liquid and washing water are recycled and are utilized into the production of the next batch of the quinolinic acid; the control on an acid separation reaction is optimized, and the yield of the quinolinic acid is improved. When the active ingredients are applied, the recycled copper oxide and the recycled basic copper carbonate are purified; the yield of the quinoline acid is improved; meanwhile, the purity of the quinoline acid is ensured; refining steps of the quinoline acid are reduced; the production cost is reduced. Through the treatment of each mother liquid and the application of the washing water, water resources are saved; the wastewater discharge is reduced; the pressure on the environment is relieved.