Compositions that protect cells from oxidative and mitochondrial stress

A composition and cell technology, which can be used in drug combinations, skin care preparations, cosmetics, etc., to solve problems such as genome instability, DNA protection and repair ability decline, etc.
CN112423726APending Publication Date: 2021-02-26努其杜有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
努其杜有限公司
Publication Date
2021-02-26

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Abstract

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACT1 peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, beta-lapachone, beta-hydroxy-beta-methyl-butyrate, bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol,dinoprost, ellagic acid, (-)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-alfa-glycyrrhetinic acid, 18-beta-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (Na AD), nicotinic acid mononucleotide (Na MN), parsley (petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Delta prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).
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Description

technical field

[0001] The present invention relates to novel compositions commonly used for oral or topical application to alleviate the effects of aging.

[0002] In particular, the present invention relates to compositions and methods for enhancing cellular tolerance to DNA damage, oxidative stress, mitochondrial dysfunction, or enhancing DNA repair capacity. Background technique

[0003] Decreased DNA protection and repair capacity is an important cause of genome instability. Genome instability in turn may lead to diseases such as cancer, the risk of which increases exponentially with age.

[0004] Protecting DNA and other vital cellular mechanisms from damage and repairing it when damage occurs is critical for highly functioning cells. This protection and repair of cells is often associated with youth and health. Furthermore, these protective and repair functions decline in somatic cells with age and are responsible for the decline of most cellular and tissue functio...

Claims

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