A kind of pharmaceutical composition for promoting gastrointestinal motility function and application thereof

A technology for gastrointestinal motility and medicine, which is applied in the field of medicine to achieve the effects of easy acceptance, promotion of gastrointestinal motility and less toxic and side effects

Active Publication Date: 2017-01-25
方海丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By searching domestic and foreign literature, there is no literature report that locust-7-O-rhamnoglucoside promotes gastrointestinal motility

Method used

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  • A kind of pharmaceutical composition for promoting gastrointestinal motility function and application thereof
  • A kind of pharmaceutical composition for promoting gastrointestinal motility function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of Robin-7-O-rhamnoglucoside

[0017] Take 2kg of thistle herb, extract twice with 22L of 80% (v / v) ethanol under hot reflux, each time for 2 hours, collect the extract, recover the ethanol under reduced pressure until there is no alcohol smell, place it at room temperature, centrifuge, and collect the precipitate. The above precipitate was degreased with dichloromethane. Add 1L of 5% sodium hydroxide solution to the precipitate after degreasing, then add 0.5L of ethanol, stir to dissolve, filter, take the filtrate, adjust the pH to 6-7 with 35% concentrated hydrochloric acid, precipitate the precipitate, suction filter, filter the cake separately After being fully washed with 50% (v / v) ethanol and distilled water, dried and pulverized, the acaciacin-7-O-rhamnoglucoside was obtained with a content of 97.9% (W / W).

Embodiment 2

[0019] Take 2 kg of thistle medicinal material, crush it into a coarse powder, add 25 L of 70% (v / v) ethanol (containing 1% sodium hydroxide) to warm and extract three times, each time for 6 hours, collect the extract, and recover the ethanol under reduced pressure to nothing. Alcoholic taste, put it at room temperature, adjust the pH to 6-7 with glacial acetic acid, precipitate out, collect the precipitate, and degrease the precipitate with ether. Add 0.2L of 10% sodium hydroxide solution to the precipitate after degreasing, then add 0.5L of ethanol, stir to dissolve, filter, take the filtrate, adjust the pH to 6-7 with glacial acetic acid, precipitate the precipitate, filter with suction, and filter the cake with 50 % (v / v) ethanol and distilled water are fully washed, dried and pulverized to obtain acaciacin-7-O-rhamnoglucoside with a content of 94.2% (W / W).

[0020] In addition, the present inventors designed and implemented pharmacodynamic animal experiments to observe th...

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PUM

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Abstract

The invention discloses a medicinal composition with a gastrointestinal peristalsis promoting function, and its application. The composition is prepared by using an active component and auxiliary materials, and the active component comprises acacetin-7-O-rhamnose glucoside. The medicinal composition has an obvious intestinal peristalsis acceleration effect, and can be developed to form digestion aiding or constipation treatment medicines to be clinically applied.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for promoting gastrointestinal motility and its application. Background technique [0002] Gastric peristalsis starts in the stomach and advances toward the pylorus, occurring once every 15-20 seconds, and each peristaltic wave takes 1 minute to reach the pylorus, and the peristaltic wave can discharge part of the chyme into the duodenum; intestinal peristalsis is a The circular muscle and the longitudinal muscle contract in a coordinated and continuous manner, which occurs in the small intestine and spreads to the distal end of the intestine at a speed of 0.5-2.0 cm per second. The direction is advanced, and the chyme is decomposed and pushed forward, and then a new segmental movement is started. Both gastric and intestinal motility are regulated by electrophysiological activity, neural afferents, and hormones. [0003] Gastrointestina...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P1/14A61P1/10
Inventor 方海丽王秀萍蔺秀香
Owner 方海丽
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