The invention provides a special compound feed for mixed-culture fish and relates to the technical field of preparation of culture feeds. The special compound feed comprises the following raw materials in parts by weight: 220-230 parts of rice bran, 220-230 parts of rapeseed meal, 80-100 parts of cottonseed meal, 250-260 parts of soybean meal, 110-130 parts of flour, 220-230 parts of mealies alcohol grains, 20-40 parts of bentonite, 20-40 parts of oil, 95-100 parts of fish meal, 100-110 parts of corn protein powder, 10-20 parts of compound vitamin, 50-70 parts of dicalcium phosphate, 10-20 parts of salt, 5-7 parts of lysine, 1-2 parts of choline and 50-60 parts of a traditional Chinese medicine preparation. Compared with traditional feeds, the special compound feed for the mixed-culture fish has the advantages that the special compound feed contains traditional Chinese medicine components, and traditional Chinese medicine additives and feed carriers are mutually matched to act, so that normal nutritional requirements of various fish are met, furthermore, diseases can be prevented and treated, the immunity of fish is improved, the growth of fish can be further promoted, toxic and side effects are avoided, the risk of drug resistance is avoided, the environmental pollution is avoided, the body resistance can be enhanced, the action is rapid, and the cost is low.