8 results about "Glycyrrhetin" patented technology

The invention discloses liquiritigenin and isoliquiritigenin produced by directionally converting liquiritin and isoliquiritigenin through lactobacillus plantarum CCFM1275 and application of the liquiritigenin and the isoliquiritigenin. Researches show that the lactobacillus plantarum CCFM1275 can grow in a fermentation base material rich in a licorice extract, and liquiritin and isoliquiritin in licorice can be converted into liquiritigenin and isoliquiritigenin respectively, so that utilization of active ingredients of liquiritin and isoliquiritigenin by an organism is facilitated, and the effect of the licorice extract is improved. Compared with the licorice root extract, the fermented licorice root postbiotics obtained by fermenting and converting the licorice root extract through the lactobacillus plantarum CCFM1275 can further improve the effects of the licorice root extract in the aspects of reducing liver lipid accumulation, lowering lipid and resisting aging, can be used for preparing products with the effects of preventing and / or treating fatty liver and obesity and / or resisting aging, and has a huge application prospect.

The invention provides a compound feed additive for relieving stress response of marine fishes, which is prepared by the following steps: mixing raw materials such as hermetia illucens protein and the like to prepare a premix, and embedding the premix by using a lac-glycyrrhizic acid system to prepare lac microcapsules; then modifying the fucoidin by adopting glycyrrhizin and gamma-linolenic acid, embedding rhodosporidium palustris and bacillus pumilus by using the fucoidin to prepare compound bacterium nano-particles, and finally mixing the lac microcapsules and the compound bacterium nano-particles in proportion. According to the invention, excessive secretion of cortisol of marine fish can be effectively inhibited, hermetia illucens protein provides rich nutrition and reduces muscle decomposition, and compound microorganisms are beneficial to maintaining intestinal microecological balance and improving the utilization rate of nutrition. The prepared compound feed additive can be directly splashed into a culture or transportation water body or added into a feed, so that the stress reaction of the marine fish is effectively relieved, the survival rate of the marine fish is increased, and powerful support is provided for culture of the marine fish.

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACTI peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (−)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley (Petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

The invention discloses Pickering emulsion gel based on medicine-adjuvant integration and a preparation method and application thereof.The preparation method comprises the steps that ethylene glycol chitosan is added into a whey protein solution and stirred to be uniform, then glycyrrhizic aldehyde is added, stirring and mixing are conducted, and a whey protein-ethylene glycol chitosan-glycyrrhizic aldehyde composite solution is obtained; mixing the gastrodia elata volatile oil with clove oil, and performing ultrasonic homogenization to obtain an oil phase; adding the oil phase into a whey protein-ethylene glycol chitosan-glycyrrhizic aldehyde composite solution, carrying out high-speed shearing emulsification to obtain an emulsion, then refrigerating the emulsion, and inducing whey protein to denature and gelatinize to form the Pickering emulsion gel. Based on the idea of integration of medicines and auxiliary materials, the whey protein is used as a particle stabilizer, the main medicinal components of gastrodia elata volatile oil and clove oil are used as a mixed oil phase, the dosage of the auxiliary materials is reduced, and through screening of an emulsion gel aqueous phase, the prepared Pickering emulsion is compact in gel texture and high in stability, has a slow release effect on the medicinal components, and can be used for preparing the medicinal composition. The long-acting sleep improvement effect can be realized.

The present disclosure provides a food composition for use in a method for treating and / or preventing and / or reducing the severity and / or reducing the relapse of otitis externa in a companion animal in need thereof, wherein the said food composition includes, as the sole active agents, glycyrrhizin and curcuminoid.

The invention belongs to the technical field of biological pharmacy, and provides application of glycyrrhizin in preparation of a medicine for treating white matter injury. Animal experiment results show that the HMGB1 inhibitor Gly can obviously improve rat WMI pathological changes, reduce rat brain white matter region HMGB1 expression, obviously reduce the number of rat brain white matter region NG2 + Olig2 + double positive cells and improve rat WMI afterbrain white matter region OLs differentiation disorder; the myelination disorder of the white matter region of the rat after WMI can be improved, and the number of myelination axons of the rat is obviously increased; and the learning ability and the spatial memory ability of the rats are improved. It is clear that Gly can inhibit expression of HMGB1, and an effective technical means is provided for treatment of white matter damage.

The invention relates to a buffered aqueous composition comprising fluticasone propionate dissolved therein in a concentration of at least 20 µg / mL, wherein the composition further comprises a saponin component selected from the group consisting of escin, glycyrrhizin, and Quillaja saponaria extract, a buffer adjusted to a pH of from 4 to 8; and the surfactant poloxamer P407 in a con- centration of from 2.5 to 15 %w / v. The invention further relates to the use of the composition in the treatment of inflammatory and / or allergic conditions of the human body.

The present application relates to a polysaccharide modified drug phospholipid complex, wherein the drug phospholipid complex is prepared from a drug and a phospholipid, the drug includes oxymatrine and glycyrrhizin, and the polysaccharide modification is that the drug phospholipid complex is first modified by chitosan, and then the drug phospholipid complex coated with chitosan is modified by hyaluronic acid. The polysaccharide modified drug phospholipid complex of the present application can enhance the drug accumulation in tumor cells through synergistic effect and active targeting, and significantly improve the anti-tumor effect of the drug.