39 results about "Increase muscle mass" patented technology

The present invention relates to the field of biotechnology and discloses a probiotic composition for alleviating sarcopenic obesity and its use. The composition comprises at least two of Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium animalis subsp. lactis; wherein the Lactobacillus plantarum has a deposit number of CGMCC No. 25839; the Lactobacillus rhamnosus has a deposit number of CGMCC No. 26968; and the Bifidobacterium animalis subsp. lactis has a deposit number of CGMCC No. 27998. The composition of the present invention can increase muscle mass, improve muscle tissue morphology, increase adenosine triphosphate, and inhibit abnormal weight gain, thereby effectively preventing and treating sarcopenic obesity.

This invention relates to the field of biotechnology, and more particularly to a swelling-promoting seahorse oil and its application in the preparation of anti-sarcopenia products. Obtained using a supercritical carbon dioxide extraction process, the swelling-promoting seahorse oil of this invention has been experimentally verified to inhibit muscle degradation, promote muscle cell activation and differentiation, increase muscle mass, and enhance muscle strength and endurance. Furthermore, it exerts its effects through dietary supplementation with no significant adverse reactions, and can be used to prepare anti-sarcopenia related foods, health products, or pharmaceuticals to meet the muscle health maintenance needs of the elderly.

The present invention relates to a composition for the improvement and treatment of muscle diseases and cachexia, wherein diflunisal has the effect of promoting the differentiation and proliferation of myogenic cells, and further has the effect of improving and treating cachexia induced by chronic diseases such as muscle diseases or cancer through effects such as increased muscle mass and recovery of muscle strength.

It was confirmed that probiotic metabolites of the present invention protect muscle cells and promote differentiation of muscle fibers. In addition, it was confirmed in an animal model of muscle atrophy or sarcopenia induced by dexamethasone that probiotic metabolites increased muscle mass and muscle function, inhibited expression of factors associated with muscle degradation, and increased expression of factors associated with muscle synthesis and regeneration. It was confirmed that probiotic metabolites contribute to alleviation of muscle atrophy by regulating sugar, amino acid, and fatty acid metabolism altered by dexamethasone.

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.

The present disclosure provides BET inhibitors of the formula: wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods of treating a patient comprising administering a bromo- and extra-terminal (BET) domain inhibitor for the treatment of FSHD which modulates DUX4 expression. In some embodiments, the present methods comprise using one or more BET inhibitors as a therapeutic agent for the treatment of FSHD patients including patients who are being treated with one or more palliative treatments such as therapy and / or agents which lead to increased muscle mass.

The present invention concerns a method for preventing muscle injuries and / or fatigue in a subject comprising the step of simultaneously, separately, or sequentially administrating to a subject in need thereof an effective amount of i) at least 20-Hydroxyecdysone, ii) at least rosavin, iii) at least one Medium-chain triglycerides (MCTs) and unsaturated fatty acid enriched oil, and iv) optionally a pharmaceutically acceptable carrier.

The present invention relates to a peptide having muscle formation-promoting activity, anti-obesity activity, fatty liver-inhibiting activity, or anti-diabetic activity, and to a use thereof. Specifically, the peptide of the present invention exhibits activities of inhibiting muscle loss, increasing muscle mass, promoting lipid degradation in hepatocytes or adipocytes, suppressing insulin resistance signaling, or enhancing insulin sensitivity signaling. The peptide of the present invention can be effectively used as an active ingredient in a pharmaceutical composition or a food composition for treating, preventing, or alleviating muscle diseases, obesity, fatty liver, or diabetes.

The present invention relates to the use of a hemp seed extract for preventing or ameliorating muscle diseases by promoting myoblast differentiation or muscle regeneration. In the present invention, the hemp seed extract may exhibit preventive or therapeutic effects on various muscle diseases by increasing muscle mass, strengthening muscle power, improving muscle function, and enhancing exercise performance, and also has an effect of improving muscle function in healthy individuals in addition to treating muscle diseases.

This application relates to animals or cells possessing a myostatin gene, wherein 12 base pairs of the second exon of the myostatin gene are deleted. This application may also include compositions capable of manipulating the deletion of 12 base pairs of the myostatin gene to construct animals or cells. This application also relates to the use of this composition for increasing muscle mass.

The present invention relates to a composition comprising an Alox5 inhibitor for preventing or treating sarcopenia, and comprises a material that targets Alox5 so as to inhibit the expression or activation thereof, and thus improves muscular performance, increases muscle mass and cross-sectional areas of muscle fibers, and reduces the expression of myoatrophy regulators, thereby effectively preventing, alleviating and treating sarcopenia.

The present invention relates to a composition for increasing muscle mass, improving muscle function, or preventing or treating muscle disease, comprising Phocaeicola vulgatus or cultures thereof. In addition, the present invention relates to a method for increasing muscle mass, improving muscle function,, or preventing or treating muscular disease, comprising administering or taking a composition comprising Phocaeicola vulgatus or a culture thereof as an active ingredient to an individual in need. The Phocaeicola vulgatus of the present invention has the outstanding effect of increasing muscle strength, increasing muscle weight, and increasing muscle fiber.

The present invention provides a polypeptide consisting of the sequence of SEQ ID NO: 1, or a variant thereof consisting of a sequence at least 85% identical to SEQ ID NO: 1, for use in the prevention and / or treatment of a muscle disease or disorder. The present invention also provides a nucleic acid sequence encoding the polypeptide, a gene construct comprising the nucleic acid sequence, or an expression vector comprising the gene construct, for said use. The polypeptide, nucleic acid sequence, gene construct, or expression vector of the present invention may be administered in the form of a pharmaceutical composition, together with at least one pharmaceutically acceptable excipient, diluent, or carrier. The present invention also provides non-therapeutic methods for improving muscle function and / or increasing muscle mass in a subject.

The invention provides novel antibodies that bind to activin type IIB receptor (ActRITB), or activin type IIA receptor (ActRIIa) or both. The antibodies block ligand binding to the receptors and modulate downstream signaling. The invention also provides novel compositions and methods for treating a metabolic disorder, improving glycemic control, promoting increased muscle mass, and reducing adipose tissue and treating osteoarthritis. The methods and compositions are used to treat type 2 diabetes.

Disclosed are methods of improving weight loss, reducing body weight, reducing body fat mass, reducing muscle loss, reducing muscle atrophy, reducing muscle weakness, increasing muscle mass, and / or increasing muscle strength in a patient being treated with a GLP-1 receptor agonist, by administering to the patient a compound of formula (I) or a pharmaceutically acceptable salt thereof. Combinations of a GLP-1 receptor agonist and a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in improving weight loss, reducing body weight, reducing body fat mass, reducing muscle loss, reducing muscle atrophy, reducing muscle weakness, increasing muscle mass, and / or increasing muscle strength in a patient are also provided.

Myogenic compounds identified in egg yolk and synthetic derivatives thereof, nutraceutical compositions of one or more of these myogenic compounds and synthetic derivatives thereof and use of these compounds and nutraceutical compositions in increasing muscle mass in mammals are provided.

To provide compounds to increase muscle mass, muscle oxidative capacity, and muscle function and to treat muscular dystrophy, in particular limb girdle muscular dystrophy type 2A / R1 / D1, compositions including the compounds, and treatment methods.SOLUTION: The present invention provides a compound having the chemical structure of formula (I), and a composition comprising the compound or a pharmaceutically acceptable salt or solvate thereof.SELECTED DRAWING: None

Disclosed are methods of improving weight loss, reducing body weight, reducing body fat mass, reducing muscle loss, increasing muscle mass, and / or increasing muscle strength in a subject being treated with a GLP-1 receptor agonist, by administering to the subject a compound of formula (I) or a pharmaceutically acceptable salt thereof. Combinations of a GLP-1 receptor agonist and a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in improving weight loss, reducing body weight, reducing body fat mass, reducing muscle loss, reducing muscle atrophy, reducing muscle weakness, increasing muscle mass, and / or increasing muscle strength in a subject are also provided.

The present invention relates to a composition for enhancing exercise performance, increasing muscle mass, improving muscle function, or preventing or treating muscular disease, comprising Polygonum multiflorum Thunberg extract. The extract of the present invention has the effect of enhancing muscle strength, increasing muscle mass, improving exercise performance, and the like.

To provide a Lactobacillus paracasei NB23 strain and its uses for increasing muscle mass and preventing metabolic syndrome.SOLUTION: The present invention discloses a Lactobacillus paracasei NB23 strain and its uses for increasing muscle mass and preventing metabolic syndrome. The Lactobacillus paracasei NB23 strain is deposited at the Food Industry Research and Development Institute in Hsinchu City, Taiwan, under the deposit number BCRC911201. By administering the Lactobacillus paracasei NB23 strain or a metabolite thereof to an individual, the effect of effectively treating or preventing diseases associated with muscle loss or insufficient muscle mass, metabolic syndrome, and diseases related thereto can be achieved.SELECTED DRAWING: Figure 1

This invention belongs to the field of nutritional supplement technology, specifically relating to a hemp seed dietary fiber composition, its products, and applications. The composition comprises hemp seed dietary fiber; based on the total weight of the raw materials (100%), the hemp seed dietary fiber accounts for 10% to 50% of the total weight. This invention uses hemp seed, a food and medicine homology source, as the active ingredient in the composition, ensuring high safety. This composition achieves synergistic effects through multiple mechanisms, including improving gut health, regulating glucose and lipid metabolism, and modulating the FFAR2-RYR-MYOG pathway. It can significantly improve muscle function and increase muscle mass, effectively preventing and improving sarcopenia. It is particularly suitable for the elderly and those intolerant to high-protein diets or with insulin resistance, solving the problems of limited effectiveness, low compliance, and high safety risks associated with existing intervention methods.

The present invention relates to compositions and methods for altering body composition in an individual, wherein the alteration in body composition is both an increase in muscle mass and a decrease in fat mass. The present invention also relates to compositions and methods for decreasing fat mass in an individual. The compositions and methods also increase muscle volume and lean body mass in an individual. The present invention also relates to compositions comprising a GDF8 inhibitor and an activin A inhibitor, and the use of such compositions to treat diseases and conditions characterized by increased fat mass and / or decreased muscle volume.

Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein.

The present invention relates to a composition for preventing, alleviating or treating sarcopenia, containing D-ribo-2-hexulose as an active ingredient. D-ribo-2-hexulose of the present invention is a sweetener capable of replacing sugar, is harmless to the human body and does not cause side effects in normal cells so as to be safe for the human body, inhibits the degradation of myoproteins, and can exhibit muscle strengthening effects by increasing muscle mass, and thus the present invention is expected to be effectively usable in the prevention, alleviation or treatment of sarcopenia.

This disclosure provides myostatin and activin A peptide immunogen constructs, compositions and methods for their use in, for example, maintaining and improving muscle physiology (e.g., increasing muscle mass, strength, function, tone or endurance), preventing and treating muscular or musculoskeletal injury, preventing and treating a disorder associated with muscle loss or insufficient muscle growth, and / or preventing and treating muscle wasting diseases.

Compositions and methods of use for a compound having a chemical structure of Formula (I) and / or Formula (VII), or a pharmaceutically y acceptable salt or solvate thereof, to increase muscle mass, muscle oxidative capacity, and muscle function and to treat muscular dystrophy, in particular limb girdle muscular dystrophy type 2A / R1 / D1 are disclosed.

The present invention relates to a composition for increasing muscle mass, improving muscle function, or preventing or treating muscle disease, comprising micheliolide or a pharmaceutically acceptable salt thereof. In addition, the present invention relates to a method for increasing muscle mass, improving muscle function, or preventing or treating muscular disease, comprising administering or taking a composition comprising micheliolide or a pharmaceutically acceptable salt thereof as an active ingredient to an individual in need. The micheliolide of the present invention has the outstanding effect of increasing muscle strength, increasing muscle weight, and increasing muscle fiber.

The amber extract of the present invention is believed to have a motor function improving effect, a muscle mass increasing effect, a muscle strength enhancing effect, an energy production promoting effect, an endurance improving effect, and an anti-fatigue effect. The above-mentioned effects can be achieved by using preparations, particularly food, drink, nourishment, pharmaceutical compositions, and the like, containing an amber extract as an active ingredient. According to the present invention, by using a preparation containing an amber extract as an active ingredient, it is possible to provide a composition capable of enhancing muscle mass and muscle strength, improving exercise function and endurance, and resisting fatigue.

Provided are myogenic compounds identified in egg yolk and their synthetic derivatives, nutritional supplement compositions of one or more of these myogenic compounds and their synthetic derivatives, and the use of these compounds and nutritional supplement compositions in increasing muscle mass in mammals.

The present invention relates to a composition for ameliorating and treating a muscle disease and cachexia, which includes diflunisal. The diflunisal has an effect of promoting the differentiation and proliferation of myoblast cells, and also has an effect of ameliorating and treating cachexia caused by muscle diseases or chronic diseases such as cancer through effects such as increasing muscle mass, recovering muscle strength, and the like.