49 results about "Muscle regeneration" patented technology

The invention relates to a traditional Chinese medicine composition for treating burns and scalds, which is prepared from spur root and jade grape root according to a certain compatibility, and has the following effects: pain relieving: aching feeling is relieved or even disappears within 15 minutes; convergence: seepage of tissue fluid can be stopped within two hours; bacteriostasis: after the ointment is used, wounds which are just burnt and scalded or fester for several months can be gradually healed, and necrotic tissues can scab and fall off; skin grafting is not needed for burn and scald patients, scar tissue hyperplasia is avoided, and the disability rate of the patients is greatly reduced.

The present disclosure is directed to methods of treatment, including treatment of a myopathy by administering to a subject in need thereof an elastase inhibitor in combination with a glucocorticoid. The present disclosure is also directed to pharmaceutical compositions that include an elastase inhibitor that can be used in such treatment.

The subject invention pertains to a novel method for treating Peripheral Arterial Disease (PAD) by leveraging the angiogenic potential oftype 2 cytokines IL-4 and IL-13 to enhance the efficacy of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) and induced endothelial cells derived from fibroblasts (iECs). This present invention aims at enhancing the muscle regeneration and revascularization for obese and diabetes individuals.

The invention discloses application of poplatin in preparation of a medicine for treating muscle injury. The research finds that the poplatin has the effects of promoting mouse myoblast differentiation and promoting mouse muscle regeneration under various pathological conditions such as acute injury, obesity, diabetes mellitus and hereditary dystrophy.

The invention belongs to the technical field of biology, and discloses an application of sodium crotonate in the aspect of regulating and controlling muscle development, and an application of sodium crotonate in serving as and / or preparing a medicine for regulating and controlling muscle development. The invention discloses the dual effects of sodium crotonate in skeletal muscle development regulation for the first time, and provides a new potential target and a chemical intervention approach for muscle regeneration and treatment of atrophic myopathy and metabolic muscle diseases. On the other hand, the sodium crotonate is a low-toxicity metabolite, can be used in conventional solution preparation and injection modes, and has application prospects.

To provide an effective and safe composition for promoting muscle regeneration.SOLUTION: A composition for promoting muscle regeneration contains ergothioneine, and may optionally further contain ascorbic acid 2-glucoside and / or ascorbic acid.SELECTED DRAWING: None

This invention relates to methods for increasing the regeneration of a skeletal muscle that comprise increasing the concentration of Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) in the skeletal muscle. The concentration of MANF may be increased by administering to the individual MANF, a nucleic acid encoding MANF, or a cell expressing MANF. This may be useful in the treatment of skeletal muscle damage or disease, for example in individuals with an age-related reduction in skeletal muscle regenerative capacity.

Provided is a composition for preventing, improving, or treating muscular disorders including sulfonamide-based compounds or salts thereof. According to the present disclosure, the sulfonamide-based compounds or salts thereof may prevent inhibition of differentiation of myoblasts by regulating the expression of PHF20 and YY1. Accordingly, since the composition may prevent or alleviate muscle loss, promote muscle regeneration, and improve muscle exercise function, balance ability, and grip strength recovery ability through increased muscles and changes in ratio of muscle fibers, the composition may be effectively used for therapeutic agents, foods, or feeds for preventing, improving or treating muscle disorders, and improving muscle functions or muscle mass.

The invention also discloses application of the bovine-derived SYPL2 gene in regulation and control of animal muscle development and regeneration. According to the invention, the SYPL2 gene is found to be a key regulatory factor for muscle development, and an intervention strategy based on the gene is developed, so that a part of technical problems are effectively solved, and an innovative solution is provided for livestock breeding and muscle regeneration medicine. The invention discovers that the SYPL2 gene has high specific expression in bovine skeletal muscle tissues for the first time, and has the capability of promoting proliferation and differentiation of bovine myoblasts cultured in vitro. More importantly, when the bovine SYPL2 gene overexpression plasmid is locally injected into a mouse with acute muscle injury, a remarkable muscle injury regeneration and repair treatment effect is shown, so that a brand new target and a solution are provided for livestock molecular breeding and muscle regeneration medicine; and an important basis is provided for improving the production efficiency of animal husbandry and developing a novel muscle repair therapy.

The present invention relates to the use of a hemp seed extract for preventing or ameliorating muscle diseases by promoting myoblast differentiation or muscle regeneration. In the present invention, the hemp seed extract may exhibit preventive or therapeutic effects on various muscle diseases by increasing muscle mass, strengthening muscle power, improving muscle function, and enhancing exercise performance, and also has an effect of improving muscle function in healthy individuals in addition to treating muscle diseases.

The utility model belongs to the technical field of new application materials and discloses a multifunctional composite wound application which comprises a breathable surface layer, an absorption layer arranged at the bottom of the breathable surface layer, a slow release layer arranged at the bottom of the absorption layer, a first gel layer arranged at the bottom of the slow release layer and a reminding layer arranged on the outer side of the breathable surface layer. The carbon nano tube composite fabric fiber conduction network has the effects of rapidly absorbing overflowing blood, rotten liquid and pus micromolecules, promoting absorption of the pus on the wound surface, keeping the wound surface dry, releasing bio-based micromolecules with a healing function to be attached to the wound surface, promoting wound healing, relieving swelling and pain, relieving itching and relieving scars, and has the effects of relieving swelling and pain and relieving scars. The polypeptide type carbon nano-silver gel not only has gum adhesiveness, but also has a good bonding effect with human skin, and also has the effects of sterilizing, resisting inflammation and promoting tissue regeneration.

The application discloses a kind of northern Shaanxi white cashmere goat muscle satellite cell separation and purification method, the present application uses northern Shaanxi white cashmere goat fetus dorsal longest muscle tissue as test material, by aseptic pretreatment, tissue block inversion adherent culture, primary subculture culture Combination of compound technology of hierarchical differential adherent purification, stably obtain the 5th generation muscle satellite cell.The present application optimizes and adapts culture system and purification process, overcomes the defects of low cell yield, serious interference of mixed cells, activity and poor purity of traditional preparation method.At the same time, the present application also adopts RT-PCR molecular identification and immunofluorescence staining combined with multi-level verification method, from gene and protein level Bidirectional verification cell specificity and differentiation potential, accurately determine the biological properties of cell.The present application process is simple, good stability and repeatability, can efficiently prepare northern Shaanxi white cashmere goat muscle satellite cell, provides important technical support for cashmere goat germplasm resource conservation, muscle development mechanism and muscle regeneration related research.

The present application relates to the technical field of external use of traditional Chinese medicine, in particular to an external use synthetic traditional Chinese medicine composition for treating osteomyelitis, sinus tract and stubborn ulcer and a preparation method thereof, which comprises, by weight, 10-15 parts of honeysuckle, 10-15 parts of dandelion, 10-12 parts of purple flower ground ivy, 6-10 parts of Chinese cork tree, 6-10 parts of bitter apricot seed, 5-8 parts of red root of sophora, 5-8 parts of Chinese angelica, and 1-4 parts of borneol; the present application is applicable to the infection period and the repair period, realizes the integration of anti-inflammatory, bacteriostasis, muscle regeneration and repair, adopts low-temperature ultrasonic extraction, avoids high-temperature damage to heat-sensitive components, has stronger and more stable efficacy, the formula contains blood-activating and stasis-removing components such as red root of sophora, Chinese angelica, frankincense and myrrh, can promote the penetration of the medicine into deep tissues, has a remarkable effect on the sinus tract and osteomyelitis wound, is a pure traditional Chinese medicine for external use, does not add hormones and antibiotics, is mild in nature, and is suitable for long-term use.

The present invention relates to a peptide having the activities of inhibiting sarcopenia, promoting muscle growth, and inhibiting fatty liver. The peptide according to the present invention can promote the proliferation of muscle cells and the differentiation thereof into muscle fibers, has a muscle regeneration effect even under conditions of muscular atrophy, and can significantly inhibit the expression of fat synthesis-related genes / proteins in hepatocytes. Thus, the peptide according to the present invention is expected to be effectively used for inhibiting sarcopenia, promoting muscle growth, and inhibiting fatty liver.

The invention provides an application of miR-183 and miR-96 in promotion of skeletal muscle regeneration. The invention provides application of a miR-183 up-regulating agent, a miR-96 up-regulating agent and / or an SLC25A51 down-regulating agent in preparation of a medicine for promoting muscle regeneration and / or treating or preventing skeletal muscle aplastic disorder related diseases. The invention also provides a pharmaceutical composition containing the miR-183 up-regulating agent, the miR-96 up-regulating agent and / or the SLC25A51 down-regulating agent, a composition, a kit, a related screening method and the like.

The disclosure relates to compositions and biomimetic scaffolds and methods of using to treat improve, promote and accelerate the healing of bone regeneration, muscle regeneration, or a combination thereof in a subject. The methods comprise implanting said compositions and biomimetic scaffolds in a subject.

The invention discloses a composition for promoting myotube formation and maintaining muscle health. The problem that in the prior art, leucine or a simple combination of leucine and other BCAA is poor in muscle regeneration promoting effect is solved. A composition for promoting myotube formation and maintaining muscle health includes leucine, isoleucine, and alpha-ketoglutaric acid. The invention proves that the combination of the three has a remarkable combination effect in promoting myoblasts to differentiate into myotubes. The test data shows that the differentiation promoting effect of the combination of the three components is obviously better than that of any single component or double component combination, and the cell proliferation test proves that the composition has no obvious influence on the proliferation of C2C12 myoblasts and even eliminates toxic interference at high concentration. It is shown that the beneficial effect of promoting the increase of myotube number is specifically achieved by enhancing the differentiation process of cells rather than simple proliferation promoting action and pointing to more mature muscle function formation, and therefore the composition can be applied to the situation that muscle regeneration needs to be promoted, and muscle atrophy is improved or prevented.

The present invention relates to the use of mesenchymal stem cells to reduce inflammation and immune responses for neuromuscular injuries and limb transplants. A particular preferred embodiment relates to use of mesenchymal stem cells that are modified to express interleukin-10 in limb transplantation surgery. In particular embodiments, the present invention also provides a method of improving nerve and muscle regeneration and functional outcome for limb transplantation in a mammalian limb transplant recipient by administering to the limb transplant recipient a therapeutic amount of mesenchymal stem cells.

The present invention relates to a phenol-modified decellularized muscle tissue-derived extracellular matrix (MEM) for muscle regeneration and a method for preparing same. The phenol group-modified decellularized MEM of the present invention is characterized by containing components similar to original proteins of muscle tissue for muscle regeneration and forming a hydrogel having a stable porous nanofiber structure through dimerization crosslinking between phenol groups, wherein the hydrogel can effectively treat muscle injury or muscle diseases by being administered or implanted into muscle tissue without causing side effects such as an immune response or liver or kidney dysfunction.

A method for reducing muscle atrophy and / or promoting muscle regeneration in a subject at risk of muscle atrophy comprises orally administering a nutritional composition containing at least one of protein, fat, and carbohydrate, and bovine milk-isolated exosomes containing intact exosomes.In certain embodiments, the subject suffers from malnutrition, acquired immune deficiency syndrome (AIDS), cancer, diabetes, chronic obstructive pulmonary disease (COPD), amyotrophic lateral sclerosis (ALS), non-alcoholic fatty liver disease (NAFLD), or burn injury, or is receiving clinical treatment with corticosteroids.

Provided is a traditional Chinese medicine decoction for injury and bone healing, comprising the following materials: Astragali Radix, Acanthopanacis Cortex, Sambucus williamsii, Notoginseng Radix et Rhizoma, Alismatis Rhizoma, Polygoni Multiflori Caulis, Pheretima, Achyranthis Bidentatae Radix, Persicae Semen, Angelicae Sinensis Radix, Rehmanniae Radix, Platycodonis Radix, Bupleuri Radix, Pinelliae Rhizoma Praeparatum, Rhei Radix et Rhizoma, Magnoliae Officinalis Cortex, and Glycyrrhizae Radix et Rhizoma. The method for preparing the decoction comprises: weighing the materials and putting the materials into a decoction pot; adding 800 mL of purified water into the decoction pot to soak the materials for 30 min; decocting the liquid in the decoction pot until the volume is reduced to 300 mL, and extracting the decoction; cooling the decoction to a proper temperature, i.e., 35-37 °C. The decoction for injury and bone healing has effects of healing internal and external injuries, promoting bone and muscle regeneration, activating blood circulation to remove blood stasis, warming meridians to dredge collaterals, eliminating dampness and reducing swelling, relieving pain and stopping bleeding, breaking hard masses to dissipate stagnation, dispelling wind-cold to relieve arthralgia and pain, and strengthening tendons and bones. The decoction for injury and bone healing is particularly suitable for the physical characteristics of modern people caused by a diet rich in fatty meats and excessive sweet foods, excessive phlegm-dampness, and low physical activity.

This invention discloses the use of FNDC1 protein to promote skeletal muscle regeneration and treat muscle development-related diseases. Researchers found that when C2C12 cells were treated with FNDC1 protein, the ability of myotubes to fusion increased with increasing concentrations of the recombinant FNDC1 protein, indicating that FNDC1 protein can promote myogenic differentiation. Furthermore, treatment of CTX mice with FNDC1 protein revealed that it promoted muscle regeneration. This suggests that FNDC1 protein can be used to prepare drugs and feeds for treating skeletal muscle dysplasia.

The invention discloses a medicine composition for treating qi stagnation and blood stasis type closed fracture. The medicine composition is prepared from aspongopus, gaultheria yunnanensis, radix angelicae sinensis, sambucus williamsii, radix hedysari, actinidia chinensis root, root of sambucus chinensis, pseudo-ginseng, peach kernel, safflower, processed semen strychni, hematoxylon, native copper, akebiaquinata, fructus aurantii and rhizoma drynariae root. Aiming at the qi stagnation and blood stasis type closed fracture, the medicine composition with the effects of searching for toxins, removing qi, dissipating blood, stopping blockage, setting bones, promoting tissue regeneration and activating meridians to stop pain is adopted, both symptoms and root causes can be treated, the symptoms such as swelling and pain can be rapidly relieved, fracture healing can be promoted, local qi and blood circulation can be improved, and the recurrence risk can be reduced. The traditional Chinese medicine composition is suitable for qi stagnation and blood stasis type closed fracture patients, and is especially suitable for people needing overall conditioning and avoiding repeated attack.

The invention discloses injectable conductive anti-adhesion hydrogel and a preparation method and application thereof, hydrogel raw materials comprise a phytic acid doped hydrazide group-containing gelatin-based conductive polymer, an aldehyde group-containing amphiphilic block copolymer and a catalyst, and the three raw materials are mixed under body temperature and physiological conditions and then subjected to in-situ crosslinking to form the hydrogel. The hydrogel has the characteristics of rapid gelling, self-healing, injectability, electric conduction, oxidation resistance and the like. In-vivo experiments show that the hydrogel can significantly inhibit postoperative abdominal adhesion, reduce inflammatory response and remove active oxygen; meanwhile, the hydrogel can promote collagen deposition, angiogenesis and muscle regeneration, is suitable for abdominal wall defect repair and postoperative adhesion prevention, and solves the problem that an existing material is difficult to give consideration to adhesion prevention and repair promotion.

A method for treating muscular dystrophy of a subject comprising administrating a N-formyl peptide receptor (FPR) agonist to the subject and compositions therefore. An FPR agonist may be used to target the FPR2-mediated pro-resolving pathway, thus facilitating the clearance of inflammation, reducing inflammatory response, enhancing repair processes, enhancing regenerative capacity in muscles, and otherwise improving prognosis of muscular dystrophy.

A skin cream that combines skin care with skin and muscle regeneration through its ingredients. characterized by that the skin cream protects the skin from environmental influences and supports and improves skin and muscle function, and regenerates especially during sporting activities, which is achieved through the following ingredients: - Magnesium and calcium in liposomes, creatine, arginine, hydrolyzed peptides for improved skin and muscle function and regeneration - especially during sports activities - with or without carrot oil, walnut extract and DHA (docosahexaenoic acid) in microdoses as a possible additional tanning effect - Vitamin E, vitamin C derivative, coenzyme Q10 as antioxidants - Panthenol, hyaluronic acid, squalane, argan oil, jojoba oil for skincare - Citrus and coconut herbs for a Mediterranean fragrance

The present invention relates to use of a growth factor, augmenter of liver regeneration (GFER) protein or GFER protein derivative for enhancing muscle function and regulating metabolism for the prevention, amelioration or treatment of muscle loss and muscle-related diseases caused by aging.

The invention discloses a lactobacillus plantarum WY2401 for promoting muscle growth and development and application of the lactobacillus plantarum WY2401. The lactobacillus plantarum is used for preparing medicines for treating and / or preventing skeletal muscle injury, promoting muscle regeneration or improving muscle functions, the lactobacillus plantarum WY2401 is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC NO.M2025499. The lactobacillus plantarum WY2401 can be used for preparing medicines for treating and / or preventing skeletal muscle injury, promoting muscle regeneration or improving muscle functions. The invention relates to application of lactobacillus plantarum WY2401 in preparation of functional food, health care products or probiotic supplements for promoting muscle regeneration or improving muscle functions, application of lactobacillus plantarum in preparation of a model for improving muscle development and / or promoting muscle regeneration, and application of the model in screening of drugs and health care products. Or clinical diagnosis and evaluation of a treatment scheme. The invention discloses a new action mechanism of the lactobacillus plantarum WY2401, so that application is developed.

The invention provides intelligent responsive DNA hydrogel capable of releasing cytokines as required to efficiently promote muscle regeneration as well as a preparation method and application of the intelligent responsive DNA hydrogel, and belongs to the technical field of genetic engineering medicines. The intelligent responsive DNA hydrogel with a three-dimensional network is constructed by implementing reasonable DNA sequence design and an optimized cross-linking method, and the network can effectively encapsulate cell factors capable of promoting tissue repair and remodeling. The hydrogel can respond to characteristic change of ATP concentration fluctuation in a local tissue microenvironment, so that release of cell factors is accurately controlled, and proliferation and differentiation of muscle cells are promoted. The intelligent responsive DNA hydrogel has excellent biocompatibility, creates a more comprehensive and safer microenvironment, and is used for promoting muscle regeneration. The'on-demand release 'ability not only improves the treatment effect, but also reduces the non-targeting effect, thereby significantly improving the safety and controllability of regeneration treatment.