78 results about "Muscle regeneration" patented technology

Described herein are avian follistatin products, and methods for producing such products, in which such products are effective for a variety of conditions, including increasing muscle mass. Avian follistatin products described herein are packaged as dietary supplements or nutritional supplements are useful in muscle regeneration.

Therapeutic compositions of microspheres for application to wounds and / or lesions for accelerating wound healing and muscle regeneration. The microspheres are made up of non-biodegradable material having a substantial surface charge. The therapeutic composition further includes a pharmaceutically acceptable carrier in which the microspheres are insoluble and a container for holding the composition. The therapeutic composition further contains pharmacologic agents or biologics that accelerate the wound healing process.

The present inventors studied the effects of inhibiting the IL-6 signaling pathway on muscle cell growth. As a result, they discovered that, administering an IL-6 inhibitor can promote the adhesion, proliferation, and differentiation of satellite cells and therefore muscle regeneration.

The present invention relates to a method of treating and / or ameliorating one or more symptoms of sarcopenia and age-related muscle degeneration in a mammal.

An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.

The present invention relates to the field of nutritional support for individuals and reducing the effects of muscle conditions caused by high levels of physical activity. In particular, the invention provides dietary formulations, compositions comprising these formulations and uses of these compositions to support the body's muscle regeneration process.

The invention provides a clinical nutrient formulation special for sarcopenia, comprising, by weight, 18-30 parts of proteins, 9-13 parts of fat, 40-52 parts of carbohydrates, 4-8 parts of dietary fibers, 0.6-1.2 parts of macro elements, 0.01-0.03 part of trace elements, 0.005-0.02 part of fat-soluble vitamins, 0.005-0.20 part of water-soluble vitamins, 0.2-1 part of dietary essences, 0.07-4 partsof medicinal and edible ingredients, 0.1-1 part of natural plant compounds, and 0.03-0.6 part of new resource foods. The invention also provides a preparation method of the clinical nutrient formulation special for sarcopenia. The clinical nutrient formulation special for sarcopenia herein can meet the demand of a patient with sarcopenia for comprehensive balanced nutrition, can also improve bodyquality of the patient with sarcopenia and promote myodynamia recovery and muscle regeneration.

Disclosed are a bifunctional peptide having the capability to permeate cells and the capability to regenerate muscles and the use thereof. Advantageously, the bifunctional peptide has a function of regenerating muscle cells and thus is useful for the prevention or treatment of diseases affecting muscle regeneration, and additionally has the capability to permeate cells and thus eliminates the necessity to adhere an additional peptide or add other agent or drug for cell permeation of the peptide, thereby finally exerting an efficient muscle generation effect. Thus, the bifunctional peptide can be easily applied to various surgical regenerative treatments and can shorten the treatment period.

The invention relates to a traditional Chinese medicine prepration for treating arthrosis like crane knees. The traditional Chinese medicine prepration comprises the following raw materials: raw astragalus membranaceus, dendrobium nobile, roasted carapax trionycis, cortex phellodendri, mulberry twig, red peony root, pawpaws, folium artemisiae argyi, caulis sinomenii, lycopodium clavatum, nux vomica, fructus forsythia, periostracum cicada, safflower carthamus, puerarin and curcuma zedoary. The traditional Chinese medicine prepration disclosed by the invention has the efficacies of expelling the wind, promoting diuresis, invigorating the circulation of blood, reducing swelling, clearing away heat and toxic materials, easing tension of a joint, strengthening tendons and bones, activating meridians to stop pain and the like, and is capable of removing tumidness as soon as possible, relieving pain, restoring detoxication and elimination functions of the liver and kidneys, thoroughly removing impeded blood flow, promoting new muscle regeneration of the knee, promoting free movement of double knees, adjusting micro-circulation, thoroughly relieving the symptoms such as knee joint ache, stiff limbs and tumidness, and adjusting the endocrine function disorder, and thus the arthrosis like crane knees are finally cured thoroughly.

The invention discloses a skeletal muscle total-organ acellular matrix and derivative medical products thereof as well as a preparation method and a using method of the skeletal muscle total-organ acellular matrix and the derivative medical products thereof. The skeletal muscle total-organ acellular matrix completely preserves a three-dimensional and parallel-arrangement skeletal muscle basement membrane ultramicro structure of the skeletal muscle, a blood vessel matrix network, a muscle-muscle tendon junction, bioactive constituents such as a number of growth factors, hyaluronic acid, glycosaminoglycans, laminin and the like and high-affinity muscle-derived stem cells, and has certain mechanical strength and toughness; thorough decellularization effect is achieved, no obvious immunological rejection is caused, and no ethical and moral issues are caused, therefore, the skeletal muscle total-organ acellular matrix is a skeletal muscle regeneration bracket and platform with the most advantages reported till now. The prepared skeletal muscle total-organ acellular matrix and various derivative medical products thereof can be used for constructing and regenerating skeletal muscles in vitro and in vivo, are suitable for repairing various scoped skeletal muscle defects of all parts, and can be used for hopefully solving the large-scope skeletal muscle defect repairing and muscle generation problem which is still complicated clinically at present.

The present invention relates to the use of antibodies recognizing Fetal Antigen-1 (FA1 / dlk1) for the detection and isolation of cell populations in mammalian muscle. In one embodiment, myogenic progenitor cells are detected in developing, diseased or regenerating muscle. In another embodiment, muscle stem and progenitor myogenic progenitor cells are isolated from muscle tissue or from cultures containing muscle cells. The isolated cells may be used for transplantation, drug screening, production of cell type specific antibodies, and gene therapy and discovery. Transplantation of these cells may provide treatments for degenerative diseases of muscle, and for regeneration of muscle following trauma or ischemia such as myocardial infarction.

The present invention describes an antigen-binding construct comprising a first agent which binds to a stem cell specific marker molecule and a second agent which binds to a tissue specific marker molecule. In particular, the invention describes a construct wherein the tissue specific marker is a muscle specific marker molecule. Such a construct may be used in a pharmaceutical composition for use in muscle regeneration or heart disease.

A method of treating red blood cells of a human patient has the steps of activating an acoustic shock wave generator or source to emit acoustic shock waves and subjecting a vascular system containing red blood cells and surrounding muscle tissue peripherally through an extremity of a patient to the acoustic shock waves by stimulating the extremity wherein the extremity is positioned within a path of the emitted shock waves and away from a geometric focal volume or point of the emitted shock waves. The methods also treat muscle tissue of aging patients, from muscle regeneration or athletes for legal performance enhancement without drugs.

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

The invention provides a drug for promoting myoblast proliferation and improving myoblast autophagy level, which is characterized in that the active ingredient of the drug is DNA tetrahedron. The invention also provides a new drug for promoting muscle regeneration, which is prepared by taking a DNA tetrahedron as an active ingredient and adding pharmaceutically acceptable auxiliary materials. Theinvention provides the new application of the DNA tetrahedron in preparation of muscle regeneration promoting drugs, and the DNA tetrahedron has a very good application prospect.

The invention discloses a Chinese herbal preparation for treating uterine bleeding after drug abortion, which is made from following raw materials in weight proportion: 2 to 6 parts of astragalus root, 1.5 to 4 parts of agrimony, 0.9 to 2 parts of Chinese angelica, 2 to 4 parts of leonurine, 0.3 to 0.9 part of powdered notoginseng root, 1.5 to 3 parts of portulaca, 1 to 3 parts of redroot gromwell root, 0.8 to 2 parts of aspidium, 0.6 to 2 parts of bitter orange and 0.6 to 2 parts of dried rehmannia root. The invention integrates the functions of Qi supporting and blood enriching, muscle regeneration and hemostasis and heat clearing and blood cooling and cures uterine bleeding after drug abortion with safety, reliability and without pain and can obviously increase complete abortion rate and reduce bleeding quantity of the uterine to shorten bleeding time and avoid twice curettage.

In various embodiments, the present disclosure provides a method of treating a subject using laminin or a composition that includes laminin. In one embodiment, the method is used to enhance muscle regeneration, maintenance, or repair in a subject. In another embodiment, the method is used to promote wound healing. The method, in yet another embodiment, is used to prevent or reduce muscle damage or injury. In specific implementations of these methods, the laminin or composition that includes laminin is administered in a therapeutically effective amount. In some implementations, the laminin is a complete laminin protein. In other implementations, the laminin is a laminin fragment, a laminin derivative, or a laminin analogue.

The invention discloses a skeletal muscle whole organ acellular matrix, its derived medical products, such as particles, fluidized compositions, gels and active peptides, and preparation and use methods of the matrix and the medical products. The skeletal muscle whole organ acellular matrix completely reserves the skeletal muscle three-dimensional parallelly-arrayed skeletal muscle basement membrane ultra-structure, the vascular matrix network and muscle-tendon joints, reserves large amounts of bioactive components comprising growth factors, hyaluronic acid, glycosaminoglycan, laminins and the like, is highly affinity to muscle-derived stem cells, has the advantages of certain mechanical strength and toughness, thorough decellularization, no obvious immunological rejection, and no ethical or moral issues, and is a skeletal muscle regeneration scaffold and platform having the most advantages reported so far. The prepared skeletal muscle whole organ acellular matrix and its derived medical products can be used for the in-vitro and in-vivo construction and regeneration of the skeletal muscles, are suitable for restoring the skeletal muscle coloboma of various positions in various ranges, and are expected to solve the large-range skeletal muscle coloboma restoration and muscle regeneration problems.

The invention relates to a muscle regeneration agent, which belongs to the field of the plastic surgery. The muscle regeneration agent is an injection-type muscle regeneration agent which is prepared by the following steps: under the protection of the cell wall-degraded fusion agent, newt cells with regeneration ability in the animal kingdom are fused with the wall-degraded cells of tested mice to realize the growth of bulgy histiocytes, the histiocytes growing after the fusion of degraded cell walls of newt cells are further accepted, and are prepared into the injection-type muscle regeneration agent with the cell wall-degraded fusion agent and the injection solvent after in vitro expansion. The muscle regeneration agent can be used for nose augmentation, chin augmentation and breast augmentation by the injection method (in one or more steps) in the plastic surgery. Muscle tissues can grow and bulge at the injection positions to the designed effect after injection. The injection method can also be applied to eliminating wrinkles and avoiding wrinkles from appearing in a long term.

Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration andmethods of increasing muscle mass are also provided herein.

The invention relates to a theaflavin muscle-strengthening dietary nutritional supplement and a preparation method thereof. The functional ingredient of the supplement is a mixture of four main monomers, including theaflavin (TF), theaflavin-3-gallate (TF3G), theaflavin-3'-gallate (TF3'G), and theaflavin gallate-3,3'-digallate (TFDG). The dietary nutritional supplement according to the invention helps promote muscle regeneration, inhibit muscle protein degradation, inhibit oxidative damage to muscle protein, promote survival of muscle cells and improve exercise performance, and has excellent wide application value.

The invention relates to a quick medicine solution for curing injuries. Its primary prescription is: langdu root, ledebouriella root, beads of pangolin scale, herb of diverse wormwood, Chinese teasel root, dahurian angelica root, redroot gromwell, myrrh, lianchi, mastic, dragon's blood, herb of garden balsam, notoperygium root, earthworm, immortal grasses, rib strengthening grass, notoginseng, astragalus root, argyi leaf, bunge prickly ash, scallion, wine, yellow wine, vinegar and halite. The invention mainly cures: injuries. The product can help the wound without inflammation after operation. And it has special effect for curing mastitis, hyperplasia of mammary glands. It also can be applied to cure open wounds, biting wounds, freezing wounds, and so on. And the invention has merits of pain easing, blood activating, detoxification, and the muscle regeneration ability is strong.

An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

Provided is an agent developed to be capable of alleviating and suppressing muscle atrophy or muscle mass reduction, even for the elderly and even without requiring exercise, by inducing myogenesis. Provided is a composition for treating or preventing disorders or diseases associated with muscle atrophy, or for promoting muscle regeneration, the composition containing, as an active ingredient, a myogenesis inducing agent composed of miR-199 or an DNA that contains an miR-199 gene encoding the miR-199.

The invention provides an ointment for treating burns and a preparation method thereof. The ointment is prepared by decocting a component A, a component B and a component C, wherein the component A is prepared from radix rehmanniae, buffalo horn powder, honeysuckle, coptis root and baical skullcap root; the component B is prepared from dwarf lilyturf tuber, amur corktree bark, cape jasmine fruit and liquorice; the component C is prepared from garlic, folium mori, potato skins, sodium chloride, borneol and sesame oil. The ointment is a pure traditional Chinese medicine preparation prepared by carrying out compatibility on various cold traditional Chinese medicines and other medicinal materials and decocting the medicines by a unique process, has the functions of clearing away heat, easing pains, drawing out pus, diminishing inflammation, activating blood, removing stasis to dredge collaterals, removing blood stasis, protecting skins and mucosae and promoting muscle regeneration, does not have side effects, lessens the symptoms after taking an effect, has obvious curative effects and can timely eliminate pains of patients and return perfect skins to the patients.

The invention provides a porcupine oil agent for treating burns and scalds and skin erosion. The agent contains porcupine oil, wherein the porcupine oil is oil extracted from porcupine tissue. The porcupine oil agent also contains the following components in parts by weight: 100-300 parts of porcupine oil, 6-8 parts of rheum officinale, 3-5 parts of borneol, 8-12 parts of clove, 6-8 parts of bulbus fritillariae cirrhosae, 5-8 parts of sanguisorba officinalis, 5-8 parts of plantain herb and 5-8 parts of radix scutellariae. The preparation method comprises the steps of crushing the rheum officinale, the borneol, the clove, the bulbus fritillariae cirrhosae, the sanguisorba officinalis, the plantain herb and the radix scutellariae separately, and then mixing with the porcupine oil evenly. The porcupine oil agent has the functions of clearing heat, diminishing inflammation, promoting blood circulation to remove blood stasis, eliminating stagnation, activating collaterals, alleviating pain, removing swelling, promoting muscle regeneration and removing a scar, and is used for treating burns and scalds, and the effective rate reaches 95.93%.

Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and / or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.

The invention relates to a muscle regeneration promoting medicine for treating burns and scalds. The muscle regeneration promoting medicine comprises the following components: 5-15 parts of carbonized hair, 8-15 parts of cottonrose hibiscus, 3-10 parts of hairyvein agrimony, 5-10 parts of cockroach, 6-10 parts of red peony root, 15-20 parts of Impatiens textori Miq, 5-15 parts of elephant hide, 15-20 parts of borneol and 10-20 parts of pearl powder. The muscle regeneration promoting medicine for treating the burns and the scalds is purely herbal external liniment or spray, and has the characteristics of low cost, quick effect, good therapeutic effect and no toxic side effects.

Described herein are avian follistatin products, and methods for producing such products, in which such products are effective for a variety of conditions, including increasing muscle mass. Avian follistatin products described herein are packaged as dietary supplements or nutritional supplements are useful in muscle regeneration.