Traditional chinese medicine decoction for injury and bone healing, and method for preparing same

Traditional Chinese medicine decoctions made from herbs such as Astragalus membranaceus have solved the problem of poor efficacy in treating fractures and sprains in Western medicine, achieving rapid healing and functional recovery, and are suitable for the physical characteristics of modern people.

WO2025236378A1PCT designated stage Publication Date: 2025-11-20HUANG JUNXIONG
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Patent Information

Application Number
PCT/CN2024/103650
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-05-13
Filing Date
2024-07-04
Publication Date
2025-11-20

AI Technical Summary

Technical Problem

Current Western medicine treatments for fractures and sprains are not very effective, with slow healing and a high risk of complications after surgery. Traditional Chinese medicine formulas are not comprehensive enough to meet the needs of modern people, resulting in slow or incomplete healing of injuries.

Method used

It is formulated with Chinese herbs such as Astragalus membranaceus, Acanthopanax senticosus, Sambucus chinensis, and Panax notoginseng, and is prepared into a decoction through decoction. It has the effects of promoting blood circulation, relieving pain, and promoting bone and muscle regeneration, and is suitable for the physical characteristics of modern people.

Benefits of technology

It significantly accelerates fracture healing, reduces complications, and improves functional recovery at the injury site. It is suitable for modern people's diet and exercise habits and has effects such as promoting blood circulation, removing blood stasis, warming the meridians and dredging collaterals, relieving pain and stopping bleeding.

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Abstract

Provided is a traditional Chinese medicine decoction for injury and bone healing, comprising the following materials: Astragali Radix, Acanthopanacis Cortex, Sambucus williamsii, Notoginseng Radix et Rhizoma, Alismatis Rhizoma, Polygoni Multiflori Caulis, Pheretima, Achyranthis Bidentatae Radix, Persicae Semen, Angelicae Sinensis Radix, Rehmanniae Radix, Platycodonis Radix, Bupleuri Radix, Pinelliae Rhizoma Praeparatum, Rhei Radix et Rhizoma, Magnoliae Officinalis Cortex, and Glycyrrhizae Radix et Rhizoma. The method for preparing the decoction comprises: weighing the materials and putting the materials into a decoction pot; adding 800 mL of purified water into the decoction pot to soak the materials for 30 min; decocting the liquid in the decoction pot until the volume is reduced to 300 mL, and extracting the decoction; cooling the decoction to a proper temperature, i.e., 35-37 °C. The decoction for injury and bone healing has effects of healing internal and external injuries, promoting bone and muscle regeneration, activating blood circulation to remove blood stasis, warming meridians to dredge collaterals, eliminating dampness and reducing swelling, relieving pain and stopping bleeding, breaking hard masses to dissipate stagnation, dispelling wind-cold to relieve arthralgia and pain, and strengthening tendons and bones. The decoction for injury and bone healing is particularly suitable for the physical characteristics of modern people caused by a diet rich in fatty meats and excessive sweet foods, excessive phlegm-dampness, and low physical activity.
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Description

A traditional Chinese medicine decoction for treating bone fracture and a preparation method thereof TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine decoction for treating bone fracture and a preparation method thereof. BACKGROUND

[0002] Fracture and contusion are sudden diseases that harm the human body. With the rapid development of social economy, the expansion of industrialization, the fast pace of life and work, and the convenience of transportation, the proportion of sprains and fractures is increasing day by day. People often suffer great harm to the body in a few seconds of accidents. In clinical western medicine treatment, surgery is generally combined with antibacterial and anti-inflammatory drug treatment. However, the drug treatment of western medicine is mostly auxiliary treatment and cannot completely and effectively achieve the effect of treating fracture. The postoperative integration and reduction mainly rely on self-recovery, and the healing is slow. Moreover, complications such as redness, severe pain, and loss of appetite are prone to occur after surgery, which seriously affects the physical and mental health and rehabilitation of people. Therefore, surgery treatment cannot meet the requirements of patients. In order to get rid of the pain caused by fracture, prevent joint adhesion and joint capsule contracture, and make the function of the injured limb recover to the normal state before fracture as soon as possible, a better traditional Chinese medicine formula and preparation need to be selected.

[0003] According to traditional Chinese medicine, the main reasons for delayed healing after bone fracture surgery are stagnation of Qi and blood stasis, deficiency of Qi and blood, deficiency of liver and kidney, blood vessel damage after injury, blood flowing out of the vessel, stasis and obstruction, unsmooth meridians, and stagnation of Qi. If the injured muscles and bones are not nourished by Qi and blood for a long time, new bones will not grow. After injury, the body consumes Qi and blood, or the body is weak in Qi and blood. If the blood is deficient, the bones will lose nourishment, and if the Qi is deficient, the body cannot transport and distribute essence to the fracture. Therefore, new bone growth at the fracture site is slow or does not occur. Liver governs tendons, and kidney governs bones. Liver stores blood, and kidney stores essence. Liver and kidney are of the same origin, essence and blood are mutually generated, and deficiency of liver and kidney and deficiency of essence and blood lead to malnutrition of muscles and bones, resulting in no new bone growth.

[0004] At present, there are many traditional Chinese medicines on the market for treating cardiovascular and cerebrovascular diseases and contusion. These medicines have the effects of promoting blood circulation, removing blood stasis, relieving pain, and stopping bleeding, but their formulas are not comprehensive enough, and the effect on the change of modern human physical characteristics is not great. SUMMARY

[0005] The technical problem to be solved by the present application is to provide a traditional Chinese medicine decoction for treating bone fracture and a preparation method thereof, which has remarkable effect, is simple to make, removes blood stasis, promotes blood circulation, relieves pain, and quickly sets broken bones.

[0006] To solve the above-mentioned technical problems, the technical solution provided by the present invention is as follows: a traditional Chinese medicine formula for bone injury and healing, comprising the following raw materials: Astragalus membranaceus 5-10g, Acanthopanax senticosus 5-10g, Sambucus chinensis 10-20g, Panax notoginseng 5-10g, Alisma plantago-aquatica 5-10g, Polygonum multiflorum 5-10g, Pheretima aspergillum 5-10g, Achyranthes bidentata 5-10g, Prunus persica 5-10g, Angelica sinensis 5-10g, Rehmannia glutinosa 5-10g, Platycodon grandiflorus 5-10g, Bupleurum chinense 3-10g, Pinellia ternata (processed) 5-10g, Rheum palmatum 5-10g, Magnolia officinalis 5-10g, Glycyrrhiza uralensis 5-10g.

[0007] Furthermore, the ingredients include the following: Astragalus membranaceus 5g, Acanthopanax senticosus 10g, Sambucus chinensis 20g, Panax notoginseng 10g, Alisma plantago-aquatica 10g, Polygonum multiflorum 5g, Pheretima aspergillum 10g, Achyranthes bidentata 5g, Prunus persica 10g, Angelica sinensis 5g, Rehmannia glutinosa 5g, Platycodon grandiflorus 5g, Bupleurum chinense 3g, Pinellia ternata (processed) 5g, Rheum palmatum 5g, Magnolia officinalis 5g, and Glycyrrhiza uralensis 5g.

[0008] A method for preparing a traditional Chinese medicine decoction for bone healing includes the following steps:

[0009] Step 1: Weigh the medicine according to the mass ratio of claim 1 or 2 and put it into the medicine pot;

[0010] Step 2: Add 800ml of purified water to the decoction and soak the herbs for 30 minutes;

[0011] Step 3: After reducing the liquid in the decoction to 300ml, drain the liquid.

[0012] Step 4: Cool the liquid to a suitable temperature, i.e., 35-37℃.

[0013] The advantages of this invention compared to existing technologies are as follows: The bone-setting decoction of this invention has the effects of treating internal and external injuries, promoting bone and muscle regeneration, invigorating blood circulation and removing blood stasis, warming the meridians and unblocking collaterals, dispelling dampness and reducing swelling, relieving pain and stopping bleeding, breaking up hard masses and dissolving nodules, dispelling wind and cold and relieving pain, and strengthening tendons and bones. It is especially suitable for the physical characteristics of modern people, who tend to consume a lot of fatty and sweet meats, have heavy phlegm and dampness, and lack physical activity. Detailed Implementation

[0014] The following is a detailed description of a traditional Chinese medicine decoction for bone healing and its preparation method according to the present invention.

[0015] The formulation of this invention:

[0016] Astragalus membranaceus is sweet in taste and slightly warm in nature; it enters the spleen and lung meridians; it tonifies the spleen, raises yang and lifts prolapse, benefits the defensive qi and consolidates the exterior, promotes urination, and promotes tissue regeneration and detoxification.

[0017] Acanthopanax bark is pungent and bitter in taste, and warm in nature; it enters the liver and kidney meridians; it has the functions of dispelling wind and dampness, tonifying the liver and kidneys, strengthening tendons and bones, and promoting diuresis and reducing swelling; it is used for rheumatic arthralgia, weakness of tendons and bones, delayed walking in children, physical weakness and fatigue, edema, and beriberi.

[0018] Sambucus williamsii Hance, bitter and sweet, neutral; expelling wind, promoting diuresis, activating blood and relieving pain. It is used for treating rheumatic arthralgia, lumbago, edema, pruritus, urticaria, postpartum dizziness, contusion and swelling, fracture and hemorrhage.

[0019] Panax notoginseng, sweet and slightly bitter, warm; meridian tropism: liver and stomach; it has the effect of removing blood stasis, stopping bleeding, reducing swelling and relieving pain; it is used for hemoptysis, hematemesis, metrorrhagia, postpartum hemorrhage, chest and abdominal pain, contusion and swelling.

[0020] Alisma orientalis (Sam.) Juzep, sweet and bitter, cold; kidney and bladder meridian tropism; it has the effect of promoting diuresis, removing dampness, reducing heat and reducing turbidity; it is used for dysuria, edema, diarrhea, oliguria, dizziness and dyspnea, stranguria and pain, hyperlipidemia.

[0021] Caulis Polygoni Multiflori, sweet and slightly bitter, neutral; heart and liver meridian tropism; it has the effect of nourishing heart and relieving anxiety, expelling wind and dredging collaterals; it is used for insomnia, dreaminess, blood deficiency and body pain, numbness of skin, rheumatic arthralgia and pruritus.

[0022] Earthworm, salty and cold; liver, spleen and bladder meridian tropism; it has the effect of clearing heat and relieving convulsion, dredging collaterals, relieving asthma and promoting diuresis; it is used for high fever, convulsion, epilepsy, joint pain, numbness of limbs, hemiplegia, pulmonary heat, asthma and oliguria.

[0023] Radix Achyranthis Bidentatae, bitter, sweet and sour, neutral; liver and kidney meridian tropism; it has the effect of removing blood stasis, tonifying liver and kidney, strengthening bones and joints, promoting diuresis and reducing stranguria; it is used for amenorrhea, dysmenorrhea, lumbago and knee pain, weakness of bones and joints, stranguria, edema, headache, dizziness, toothache, acne, hematemesis and metrorrhagia.

[0024] Peach Kernel, bitter and sweet, neutral; heart, liver and large intestine meridian tropism; it has the effect of activating blood and removing blood stasis, moistening intestines and promoting defecation, relieving cough and asthma; it is used for amenorrhea and dysmenorrhea, abdominal mass, lung abscess and intestinal abscess, contusion and injury, constipation, cough and asthma.

[0025] Angelica sinensis, sweet and pungent, warm; liver, heart and spleen meridian tropism; it has the effect of tonifying blood and activating blood, regulating menstruation and relieving pain, moistening intestines and promoting defecation; it is used for blood deficiency and emaciation, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, cold abdominal pain, rheumatic arthralgia, contusion and injury, abscess and carbuncle, constipation. Wine Angelica has the effect of activating blood and regulating menstruation; it is used for amenorrhea and dysmenorrhea, rheumatic arthralgia and contusion and injury.

[0026] Radix Rehmanniae, sweet and bitter, cold; heart, liver and lung meridian tropism; it has the effect of clearing heat and cooling blood, nourishing yin and producing saliva; it is used for fever with dry mouth and thirst, yin deficiency and internal heat, bone and labor heat, internal heat and diabetes, hematemesis, metrorrhagia, rash and skin eruption.

[0027] Platycodon grandiflorum, bitter and pungent, neutral; lung meridian tropism; it has the effect of promoting lung and throat, removing phlegm and pus; it is used for cough and phlegm, chest stuffiness, sore throat and hoarseness, lung abscess and pus.

[0028] Radix Bupleuri, slightly cold in nature, bitter and pungent in taste, belongs to the meridians of the liver and gallbladder, and has the functions of soothing the liver and gallbladder, dispersing qi and relieving depression, and dissipating fire. It is used to treat liver depression and qi stagnation, chest and rib pain, prolapse of the anus, uterine prolapse, and irregular menstruation.

[0029] Rhizoma Pinelliae, pungent and warm, belongs to the meridians of the spleen, stomach, and lung, and has the functions of drying dampness and resolving phlegm. It is used to treat excessive phlegm and cough, dizziness with phlegm, wind-phlegm dizziness, and headache due to phlegm.

[0030] Radix et Rhizoma Rhei, bitter and cold in nature, belongs to the meridians of the spleen, stomach, and large intestine, and has the functions of purging and attacking accumulation, clearing heat and purging fire, cooling blood and detoxifying, and removing blood stasis and unblocking the channels. It is used to treat accumulation and constipation, blood-heat hematemesis and epistaxis, red eyes and swollen throat, toxic sores, burns and scalds, blood stasis, and damp-heat dysentery, jaundice, and stranguria.

[0031] Cortex Magnoliae Officinalis, bitter and pungent in taste, and warm in nature, belongs to the meridians of the spleen, stomach, lung, and large intestine, and has the functions of drying dampness and resolving phlegm, and promoting digestion and relieving fullness. It is used to treat dampness accumulation in the middle energizer, abdominal fullness and vomiting, food accumulation and qi stagnation, abdominal distension and constipation, and phlegm-dampness cough.

[0032] Radix Glycyrrhizae, sweet in taste, and neutral in nature, belongs to the meridians of the heart, lung, spleen, and stomach, and has the functions of tonifying the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving acute and chronic pain, and harmonizing various drugs. It is used to treat spleen and stomach deficiency, fatigue, palpitation and shortness of breath, cough with excessive phlegm, abdominal and limb pain, and abscesses and sores, and can also relieve drug toxicity and virulence.

[0033] The specific implementation process of the present application, a kind of traditional Chinese medicine decoction for injury and bone setting and its preparation method, is as follows:

[0034] Take Radix Astragali 5g, Cortex Catalpa 10g, Ilex 20g, Panax Notoginseng 10g, Alisma 10g, Caulis Polygoni Multiflori 5g, Earthworm 10g, Radix et Rhizoma Bistortae 5g, Semen Persicae 10g, Radix Angelicae Sinensis 5g, Radix Rehmanniae 5g, Platycodon 5g, Radix Bupleuri 3g, Rhizoma Pinelliae 5g, Radix et Rhizoma Rhei 5g, Cortex Magnoliae Officinalis 5g, and Radix Glycyrrhizae 5g and put them into a medicine pot. Add 800ml of clean water to the medicine pot and soak the medicine for 30 minutes. Decant the medicine liquid after boiling the liquid in the medicine pot to 300ml. Cool the medicine liquid to 35-37℃, which is suitable for oral sensation, and take it immediately after meals once a day.

[0035] Clinical diagnosis of typical cases

[0036] 1. Chen XX, male, 26 years old, humerus fracture, after reduction and fixation, injury and bone setting prescription was given every other day for 15 doses (a total of 15 doses) 45 days later, review, callus growth was good, no swelling and pain, can move, blood circulation temperature was normal.

[0037] 2. Luo XX, male, 28 years old, femur fracture, after reduction and fixation, injury and bone setting prescription was given every other day for 15 doses (a total of 15 doses) 45 days later, review, callus growth was good, no swelling and pain, can move, blood circulation temperature was normal.

[0038] 3. Cheng XX, male, 14 years old, proximal humerus fracture, after reduction and fixation, injury bone-setting recipe (for minors, half dose as appropriate) every other day (15 doses in total) for 45 days, review after 45 days, callus growth is good, can move, no swelling and pain, blood circulation temperature is normal.

[0039] 4. Li XX, female, 68 years old, left shoulder arthritis, swelling and pain, difficulty in movement, commonly known as frozen shoulder, after 8 doses of injury bone-setting recipe, good movement, no swelling and pain, blood circulation temperature is normal.

[0040] 5. Li XX, female, 50 years old, right proximal femoral neck fracture, after reduction and fixation, injury bone-setting recipe every other day (20 doses in total) for 45 days, review after 45 days, callus growth is good, no swelling and pain, blood circulation temperature is normal.

[0041] 6. Zeng XX, female, 41 years old, left femoral fracture, after reduction and fixation, injury bone-setting recipe every other day for 15 doses, review after 45 days, callus growth is good, no swelling and pain, blood circulation temperature is normal.

[0042] 7. Zheng XX, female, 22 years old, L3, 4 lumbar disc herniation, after 8 doses of injury bone-setting recipe, no swelling and pain, normal movement.

[0043] 8. Li XX, female, 61 years old, cervical spondylitis, after 8 doses of injury bone-setting recipe, no swelling and pain, no dizziness, normal movement.

[0044] 9. Yuan XX, female, 62 years old, lumbar 1, 2, 3, 4, osteoarthritis, after 8 doses of injury bone-setting recipe, no swelling and pain, blood circulation temperature is normal, normal movement.

[0045] 10. Zhang XX, male, 65 years old, left knee rheumatoid arthritis, right elbow, right shoulder, right thumb and index finger rheumatoid arthritis, left toe gout, unable to move, swelling and pain, after 10 doses of injury bone-setting recipe, no swelling and pain, normal movement, blood circulation temperature is normal, clinical cure.

[0046] 11. Wang XX, male, 61 years old, chest pain (coronary heart disease), intermittent attack, inconvenient movement, chest pain, after injury bone-setting recipe every other day (10 doses in total), no chest pain and shortness of breath, normal movement, clinical cure.

[0047] 12. Lei XX, female, 57 years old, cerebral infarction, dizziness and headache, left corner of the mouth is crooked, aphasia, after injury bone-setting recipe every other day (30 doses in total), no dizziness and headache, left corner of the mouth is not crooked, can simply answer and talk, clinical cure.

[0048] The above describes the present application and its embodiments, which are not limited, and if a person skilled in the art is inspired by it, without departing from the purpose of the present application, similar structural ways and embodiments can be designed without creativity, which should belong to the protection scope of the present application.

Claims

1. A traditional Chinese medicine prescription for treating bone fracture, characterized in that: It comprises the following raw materials: Radix Astragali 5-10g, Radicis Acanthopanacis Senticosi 5-10g, Corni Officinalis 10-20g, Panacis Majoris 5-10g, Alismatis 5-10g, Caulis Polygoni Multiflori 5-10g, Pheretima 5-10g, Radicis Bidentatae 5-10g, Semen Persicae 5-10g, Angelicae Sinensis 5-10g, Rehmanniae 5-10g, Platycodi 5-10g, Radix Bupleuri 3-10g, Rhizoma Pinelliae Praeparatum 5-10g, Radix et Rhizoma Rhei 5-10g, Magnoliae Officinalis 5-10g, Glycyrrhizae 5-10g. ​ 2. The traditional Chinese medicine prescription for treating bone fracture and injury according to claim 1, characterized in that: It comprises the following raw materials: Radix Astragali 5g, Radicis Acanthopanacis Senticosi 10g, Corni Officinalis 20g, Panacis Majoris 10g, Alismatis 10g, Caulis Polygoni Multiflori 5g, Pheretima 10g, Radicis Bidentatae 5g, Semen Persicae 10g, Angelicae Sinensis 5g, Rehmanniae 5g, Platycodi 5g, Radix Bupleuri 3g, Rhizoma Pinelliae Praeparatum 5g, Radix et Rhizoma Rhei 5g, Magnoliae Officinalis 5g, Glycyrrhizae 5g.

3. A method for preparing a Chinese medicinal decoction for treating bone fracture injury, characterized in that: It comprises the following steps, Step 1, according to the mass ratio of claim 1 or 2, the medicine is weighed and put into the medicine pot; Step 2, 800ml of clean water is added into the medicine pot, and the medicine is soaked for 30 minutes; Step 3, the liquid in the medicine pot is boiled until 300ml, and then the medicine liquid is drained out; Step 4, the medicine liquid is cooled to a proper taste, i.e. 35-37℃.

Citation Information

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