3results about How to "Reducing ROS levels" patented technology

The present application relates to the technical field of biological medicine, and particularly relates to a composition for protecting cochlear spiral ganglion neurons and application thereof. The composition comprises Panax notoginseng saponins (PNS) and Polygonatum sibiricum polysaccharide (PSP). Research shows that the composition can significantly improve the survival rate of neurons, promote neurite growth, reduce the level of reactive oxygen species, inhibit cell apoptosis, and promote autophagy by regulating the PI3K / AKT signaling pathway, thereby effectively resisting ototoxicity damage induced by aminoglycoside antibiotics. The present application further provides the use of the composition in the preparation of a drug for preventing or treating sensorineural hearing loss.

The invention discloses an application of a Cu / Zn-ZIF (Cu / Zn-ZIF) material in strengthening anaerobic digestion of organic wastes, which comprises the following steps of: adding a bionic metal organic framework material Cu / Zn-ZIF with a Cu (II) / Zn (II) bimetal active center into an anaerobic digestion system of the organic wastes, and simulating a catalytic mechanism of natural copper-zinc superoxide dismutase; oriented removal is carried out on excessive active oxygen generated by induction of exogenous disturbance factors and endogenous factors in the anaerobic digestion process, oxidative stress mediated by the active oxygen is reduced, the activity and metabolic stability of key functional microorganisms such as methanogenic archaea are maintained, the endurance capacity of an anaerobic digestion system to exogenous impact is remarkably improved, and the purpose of improving the anaerobic digestion efficiency is achieved. The methane yield and the stability of the anaerobic digestion system are synergistically improved. The method is simple and convenient to operate, low in operation cost and high in applicability, is suitable for stable operation of a newly-built anaerobic digestion facility, is also suitable for shock resistance strengthening transformation of an existing device, and has good environmental benefits and economic values.

This invention relates to the field of biomaterials technology, and more particularly to a method for preparing cRGD-targeted peptide-modified biomimetic nanovesicles derived from endothelial progenitor cells. The preparation method includes the following steps: S1, preparing EPC-NVs; S11, isolating, culturing, and identifying EPCs; S12, preparing EPCs-NVs; S13, modifying and identifying EPC-NVs with cRGD; S2, preparing ADM-Fe 3+ @PA / Ge lma hydrogel: S21, Fe synthesized in an environment with a pH of 10 at a molar ratio of 1:3. 3+ @Original catechin aldehyde solution; S22, Fe from the combined vehicle 3+ @The original catechuic aldehyde solution was mixed with ADM, and after multiple centrifugal washings, the prepared photocurable gelatin (Ge lmA) precursor solution was added; S23, Fe was carried out by ultrasonic cavitation. 3+ @PA's ADM is uniformly dispersed; S24, a double cross-linked hydrogel is formed by irradiation with 416nm blue light and self-assembly of ADM. This method provides a novel biodelivery system with pro-angiogenic, antioxidant, and antibacterial properties, improving the wound treatment effect for diabetes.