36results about How to "Reducing ROS levels" patented technology

A method and system used for treating proliferative disorders using carotenoids, carotenoid analogs, and/or carotenoid derivatives. The method and system may be used for chemoprevention and/or chemotherapy. The method and system may induce apoptosis in target cells, tissues, and/or organs. The analog, derivative, or intermediate may be administered to a cell, a group of cells, a tissue, an organ or a subject, such that at least a portion of the undesirable consequences of the proliferative disorder are thereby reduced.

The invention provides a nursing composition containing symbiotic bacterium combined fermented products, for resisting ageing and repairing skin, essence lotion, a preparation method of the nursing composition containing symbiotic bacterium combined fermented products, for resisting ageing and repairing skin, and an application of the essence lotion. The nursing composition containing symbiotic bacterium combined fermented products, for resisting ageing and repairing skin comprises the symbiotic bacterium combined fermented products, decarboxy carnosine HCl, palmitoyl pentapeptide-4, tocopheiyl acetate, a pale butterflybush flower extract, resveratrol, a pomegranate fruit extract and a narcissus bulb extract, wherein symbiotic bacteria of the symbiotic bacterium combined fermented productscomprise combination of schizophyllum commune, thermus thermophilus, microzymes and lactobacilli, and fermentation raw materials of the symbiotic bacterium combined fermented products comprise combination of rice, coix lacryma-jobi ma-yuen seeds, ginseng, kelp and raspberries. Through synergistic compounding of effective active components of the symbiotic bacterium combined fermented products andthe like, the nursing composition containing symbiotic bacterium combined fermented products, for resisting ageing and repairing skin can condition and repair skin ageing resistant routes of oxidation resistance, saccharification resistance, blue light resistance, collagen synthesis promotion and the like, so that cell vitality is protected, and the skin has the capacity for resisting exogenous environmental factors.

The invention discloses a new application of isopentene-based flavonoids compound IAA (isoangustone A) in a drug. The new application disclosed by the invention is as follows: pharmaceutically acceptable salt, ester, solvolyte, stereoisomers, tautomers, prodrugs and a mixture of the salt, the ester, the solvolyte, the stereoisomers, the tautomers and prodrugs are applied in the following aspects: 1) preparing an anti-inflammatory bowel disease drug; 2) preparing a drug for preventing and/or treating colorectal cancer; 3) preparing an eucaryon colorectal cancer cell apoptosis inducer; and 4) preparing an NF-kB (nuclear factor-kappa B) signal inhibitor. The compound IAA can obviously induce the colon cancer cell apoptosis, and inhibit the activity of colon cancer cell and inflammation signals, and also can obviously alleviate the colon inflammation induced by dextran sulfate.

The invention relates to an application of high voltage electric filed in fruitage, in particular to a method for treating tomato with an alternative electric field. The method of the invention solves such critical problems of the prior art as long time for treating tomato under a constant high voltage electrostatic field , complicated operation and big electricity leakage while a high voltage is loaded. The tomatoes are placed in a high voltage alternative electric field environment at a frequency of 40kHz, an electric field intensity of 200kV/m and treated for 2 hours at a time, which can delay the ripening process of fruitage such as reddening and softening. The invention has the effects of deferring the hardness of fruitage, the decrease of soluble sugar content in the fruitage and chlorophyll content in fruit peel, the rising of titratable acid and lycopene content, etc.

The invention relates to a folic acid targeting vector loading the single-substituted epigallocatechin gallate palmitate. The folic acid targeting vector comprises a zeolite imidazole skeleton, single-substituted epigallocatechin gallate palmitate embedded in the zeolite imidazole skeleton as well as folic acid-polyethyleneglycol modified on the zeolite imidazole skeleton by virtue of an amido bond. The invention also relates to a preparation method and application of the folic acid targeting vector loading the single-substituted epigallocatechin gallate palmitate. By adopting the folic acid targeting vector, the antioxidant effect of the single-substituted epigallocatechin gallate palmitate is improved, not only can the problem that the utilization rate of the single-substituted epigallocatechin gallate palmitate is low be solved, but also the toxic and side effect in treating the cancer can be reduced, and the treatment of a drug has targeting performance.

The invention belongs to the technical field of biology and discloses an anti-aging exosome-SOD (superoxide dismutase) nano preparation and a preparation method thereof. According to a strategy of combination of an extrusion method and saponin, SOD enzyme molecules are loaded into exosome, and an action effect and an action mechanism of the nano preparation in senescence resisting are systematically evaluated by taking the prepared SOD@EXO nano preparation as a nano drug and taking N2 wild type caenorhabditis elegans as a model organism. By loading of SOD in the exosome, catalytic activity of natural enzymes is kept, and remarkable advantages such as half-life period prolonging, immunogenicity reducing and membrane permeability improving are achieved as compared with performances of natural SOD. The nano preparation is high in drug-loading capacity and capable of realizing stable drug release, and the low-immunogenicity high-catalytic-activity exosome-superoxide dismutase nano preparation is constructed finally to prolong the half-life period of SOD molecules and improve anti-aging treatment effects remarkably.

The invention belongs to the technical field of tissue repair medicines, and particularly relates to application of a TGF-beta inhibitor in preparation of a medicine for treating diabetic foot. Aiming at the problems that cells are easy to apoptosis and the treatment effect of cell transplantation is not lasting when the cells are used for treating the diabetic foot, the invention provides the application of the TGF-beta inhibitor in preparing the medicine for treating the diabetic foot, and the TGF-beta inhibitor is proved to be capable of promoting the cells to maintain the mitochondrial membrane potential to be stable under the conditions of high glucose and low nutrition; and the intracellular active oxygen level is reduced, so that the cells maintain good proliferative activity and vascularization function. The function-enhanced endothelial cells obtained through induction and domestication culture of the TGF-beta inhibitor can survive for a long time in limbs of the ischemic diabetic foot of a mouse and form new vessels, and the treatment effect of endothelial cell transplantation on the ischemic diabetic foot is improved. According to the invention, the application range of the TGF-beta inhibitor is widened, a more effective method is provided for the cell therapy of diabetic foot, and the TGF-beta inhibitor has a good prospect.

The invention relates to a flavonoid derivative with a ROCK kinase inhibiting effect, belongs to the technical field of organic synthetic medicines, and solves the technical problems that the existingglaucoma treating medicines are poor in effect, especially effective therapeutic medicines for treating glaucoma with normal intraocular pressure lack, and medicines for treating diabetic retinopathy, such as conbercept and ranibizumab, can only be applied to the later stage of a disease, are ineffective for the early stage of the disease and destroy the protective effect of VEGF on a normal retinal tissue after long-term use. A technical scheme for solving the problems is achieved by providing a compound shown as a formula I. Experimental results show that the compound has the significant ROCK kinase inhibiting effect, can effectively reduce the intraocular pressure, protect retinal ganglion cells, reduce the retinal reactive oxygen level and inhibit retinal angiogenesis, and provides anovel medication choice for clinical treatment of the glaucoma and the diabetic retinopathy.

The invention discloses breast-milk infant formula goat milk powder capable of improving immunity and a preparation method thereof, and belongs to the technical field of food. The infant formula goatmilk powder mainly comprises the following raw materials: raw goat milk, high-oil desalted goat whey powder, goat whey protein powder, low-trans fatty acid compound vegetable oil, compound oligosaccharide, compound fruit and vegetable powder and various nutrient substances. The proportion of amino acids contained in the formula goat milk powder is closer to that of breast milk, the immunity of infants is improved through reasonable compatibility of various nutrient substances, and the burden of the digestive system of the infants is relieved; the invention further relates to the preparation method of the formula goat milk powder. The preparation method comprises the steps of raw goat milk acceptance and purification, pre-pasteurization, wet mixing, preheating, homogenization, sterilization, concentration, spray drying, dry mixing and the like, the operation is simple, and the process is easy to control; the formula goat milk powder is suitable for infants, and the preparation method issuitable for preparing the formula goat milk powder.

The invention relates to a preparation method of a pH-sensitive antioxidant nano-carrier. The preparation method comprises the following steps: (1) dissolving chitosan in distilled water to obtain a chitosan solution; (2) completely dissolving N-acetyl-L-histidine in dimethyl sulfoxide, and then adding N, N'-diimidazole; evaporating the solution to dryness after stirring, adding the chitosan solution and performing stirring, and performing freeze-drying after dialysis to obtain N-acetyl-L-histidine grafted chitosan; (3) taking coupling agents EDC and NHS, and adding N-acetylcysteine after uniform stirring to obtain carboxyl-activated N-acetylcysteine; and (4) mixing the N-acetyl-L-histidine grafted chitosan with the carboxyl-activated N-acetylcysteine, and then adding the mixture into a TEMED/HCI buffer solution; and reacting for 6-10h under magnetic stirring, performing dialysis by using a dialysis bag, and then carrying out freeze-drying treatment to obtain the pH-sensitive antioxidant nano-carrier. The antioxidant nano-carrier prepared by the invention can promote the survival of stem cells, and efficiently delivers and releases drugs in an acidic microenvironment in a targeted manner.