9results about How to "Reducing ROS levels" patented technology

The invention provides a Wujin pig seminal plasma protein crude extract and application of the Wujin pig seminal plasma protein crude extract in an anti-freezing agent and an anti-freezing diluent for freeze preservation of Wujin pig seminal fluid. The Wujin pig seminal plasma protein crude extract is derived from Wujin pig seminal plasma, does not contain other exogenous bioactive substances, has a better freezing protection effect on sperms of Wujin pigs and is safer, and the acrosome integrity rate of frozen sperms of the Wujin pigs can be remarkably increased. According to the present invention, with the anti-freezing diluent, the vitality and the movement performance of the cryopreserved Wujin pig sperm can be significantly improved, the active oxygen level is reduced, the mitochondrial membrane potential and the energy metabolism are improved, and the oxidation resistance is enhanced, such that the vitality of the Wujin pig sperm can be easily improved, and the mitochondrial function can be easily maintained; the research provides key technical support for establishment of a Wujin pig semen cryopreservation technology, and has great practical significance for Wujin pig breeding and population propagation.

The invention relates to the technical field of biology, and provides a composition, a culture solution, a product and a method for promoting embryo ectogenesis. The composition is prepared from 8-Br-cGMP and glycyrrhizic coumarin. The composition can reduce the lipid peroxidation level of embryos and reduce the toxic effect of lipid peroxidation on the embryos. Meanwhile, fat hydrolysis and oxidation energy supply can be promoted, and sufficient energy guarantee is provided for in-vitro development of early embryos. In addition, the composition can effectively reduce the active oxygen level in the embryo and reduce the damage of oxidative stress to the embryo. By adopting the composition disclosed by the invention, the embryo ectogenesis can be promoted, and the in-vitro blastocyst formation rate can be increased.

The invention discloses an edaravone homologue as well as a method and application thereof. The edaravone homologue has a structure shown in a formula (I), in the formula (I), R1 and R2 are substituent groups at any position on a benzene ring, and R1-R2 are the same or different and are independently selected from hydrogen or C1-C3 alkyl. Compared with edaravone, the edaravone homologue disclosed by the invention has the advantages that the oxidative stress level can be more effectively reduced, neuronal apoptosis is inhibited, and cerebral ischemia reperfusion injury is improved. # imgabs0 #

The present application relates to the technical field of biological medicine, and particularly relates to a composition for protecting cochlear spiral ganglion neurons and application thereof. The composition comprises Panax notoginseng saponins (PNS) and Polygonatum sibiricum polysaccharide (PSP). Research shows that the composition can significantly improve the survival rate of neurons, promote neurite growth, reduce the level of reactive oxygen species, inhibit cell apoptosis, and promote autophagy by regulating the PI3K / AKT signaling pathway, thereby effectively resisting ototoxicity damage induced by aminoglycoside antibiotics. The present application further provides the use of the composition in the preparation of a drug for preventing or treating sensorineural hearing loss.

The invention discloses application of 18 beta-glycyrrhetinic acid in preparation of a medicine or cosmetic for treating or repairing skin light injury, and belongs to the technical field of medicines.The medicine or cosmetic prepared from 18 beta-glycyrrhetinic acid for treating or repairing skin light injury can be used for protecting or repairing skin barrier and enhancing skin hydration; epidermis thickening is relieved, keratinization is improved, and inflammatory cell infiltration and corium layer collagenous fiber arrangement are improved; the catalase activity is improved, and the active oxygen level is reduced; fibroblast proliferation and survival are promoted; the expression level of the III type collagen is improved; and the expression levels of MMP2, p53 and p21 are reduced. Besides, animal experiment observation finds that the medicine or the cosmetic prepared from the 18 beta-glycyrrhetinic acid or the extract thereof can be used for improving erythema, induration, scales and pigmentation of skin light injury.

The invention discloses a pyrazolone compound as well as a preparation method and application thereof. The pyrazolone compound has a structure as shown in a formula (I), in the formula (I), R1 and R2 are substituent groups at any position on a benzene ring, and R1-R2 are the same or different and are independently selected from hydrogen or C1-C6 alkyl. Compared with 3-methyl-1-phenyl-2-pyrazoline-5-ketone (EDA), the pyrazolone compound disclosed by the invention can be used for more effectively inhibiting oxidative stress, inhibiting neuronal apoptosis and improving cerebral ischemia reperfusion injury. # imgabs0 #

This invention relates to the field of targeted drug delivery systems, specifically to a glutathione-responsive iron-based nanozyme for anti-atherosclerosis, its preparation method, and its application. The iron-based nanozyme prepared by this invention uses iron oxide nanoparticles as the core, a glutathione-responsive delivery carrier as the intermediate layer, and cationic lipids and platelet membranes as the outer shell. It can effectively escape lysosomes and, in response to the action of glutathione, release the encapsulated iron oxide nanoparticles. In the cytoplasmic environment, it exerts CAT-like enzyme activity, reduces reactive oxygen species levels, and the generated oxygen can alleviate hypoxia in atherosclerotic plaques, thus helping to reduce plaque inflammation, improve plaque stability, and has a positive therapeutic effect on atherosclerosis.

The invention discloses an application of a Cu / Zn-ZIF (Cu / Zn-ZIF) material in strengthening anaerobic digestion of organic wastes, which comprises the following steps of: adding a bionic metal organic framework material Cu / Zn-ZIF with a Cu (II) / Zn (II) bimetal active center into an anaerobic digestion system of the organic wastes, and simulating a catalytic mechanism of natural copper-zinc superoxide dismutase; oriented removal is carried out on excessive active oxygen generated by induction of exogenous disturbance factors and endogenous factors in the anaerobic digestion process, oxidative stress mediated by the active oxygen is reduced, the activity and metabolic stability of key functional microorganisms such as methanogenic archaea are maintained, the endurance capacity of an anaerobic digestion system to exogenous impact is remarkably improved, and the purpose of improving the anaerobic digestion efficiency is achieved. The methane yield and the stability of the anaerobic digestion system are synergistically improved. The method is simple and convenient to operate, low in operation cost and high in applicability, is suitable for stable operation of a newly-built anaerobic digestion facility, is also suitable for shock resistance strengthening transformation of an existing device, and has good environmental benefits and economic values.

This invention relates to the field of biomaterials technology, and more particularly to a method for preparing cRGD-targeted peptide-modified biomimetic nanovesicles derived from endothelial progenitor cells. The preparation method includes the following steps: S1, preparing EPC-NVs; S11, isolating, culturing, and identifying EPCs; S12, preparing EPCs-NVs; S13, modifying and identifying EPC-NVs with cRGD; S2, preparing ADM-Fe 3+ @PA / Ge lma hydrogel: S21, Fe synthesized in an environment with a pH of 10 at a molar ratio of 1:3. 3+ @Original catechin aldehyde solution; S22, Fe from the combined vehicle 3+ @The original catechuic aldehyde solution was mixed with ADM, and after multiple centrifugal washings, the prepared photocurable gelatin (Ge lmA) precursor solution was added; S23, Fe was carried out by ultrasonic cavitation. 3+ @PA's ADM is uniformly dispersed; S24, a double cross-linked hydrogel is formed by irradiation with 416nm blue light and self-assembly of ADM. This method provides a novel biodelivery system with pro-angiogenic, antioxidant, and antibacterial properties, improving the wound treatment effect for diabetes.